Abstract:
BACKGROUND/AIM:Esophageal dilatation, gastroesophageal reflux, and intestinal obstruction have been demonstrated in CDH survivors. Abnormal esophageal and intestinal innervations were recently found in rats and babies with this disease. Our aim was to further characterize these malformations in embryos and fetal rats exposed to nitrofen. METHODS:Pregnant rats received either 100 mg nitrofen or vehicle on E9.5. Fetuses were recovered at E15, E18, and E21. Sections of esophagus and small bowel were histochemically stained with acetylcholinesterase (AChE) and immunostained for PGP9.5. PGP9.5 gen protein were measured on E21 and PGP9.5 mRNA on E15, E18 and E21. Comparisons between groups were made with non-parametrics tests. RESULTS:Histochemistry and immunohistochemistry showed deficient innervation in all anatomical areas studied at E15, E18, and E21, and WB confirmed this decrease in E21 fetuses. PGP9.5 messenger was decreased in nitrofen-exposed animals on E18 (esophagus) or E15 (small bowel), and increased on E21 in the esophagus and E18 in small bowel. CONCLUSIONS:Development of the enteric nervous system of the esophagus, stomach, and small bowel is deficient in rat embryos and fetuses exposed to nitrofen. These anomalies could account in part for the long-term gastrointestinal morbidity observed in CDH survivors.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Martínez L,Aras-López R,Lancha S,Vallejo-Cremades MT,Pederiva F,XiaoMei L,Tovar JAdoi
10.1007/s00383-010-2788-xsubject
Has Abstractpub_date
2011-02-01 00:00:00pages
165-73issue
2eissn
0179-0358issn
1437-9813journal_volume
27pub_type
杂志文章abstract:PURPOSE:Human pigmented tissue-engineered skin substitutes represent an advanced therapeutic option to treat skin defects. The inflammatory response is one of the major factors determining integration and long-term survival of such a graft in vivo. The aim of the present study was to investigate the spatiotemporal dist...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3616-5
更新日期:2014-12-01 00:00:00
abstract::Female urethral injuries may cause serious morbidity with loss of the entire urethra in some cases. We review the results of construction of a neourethra by the flipped anterior bladder-tube technique in five girls aged 3-18 years (mean 8 years). All had pelvic fractures and had their initial management elsewhere; fou...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000434
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abstract::Around the 30th week of gestation, patients with gastroschisis (GS) develop chronic inflammatory reactions on the serosal surface of the eventrated loops of intestine that lead to severe hyperfibrinogenemia and hypercoagulability, particularly if they are born prematurely. This result was found on comparison of coagul...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00183729
更新日期:1996-03-01 00:00:00
abstract::Children with chronic idiopathic constipation (CIC) often end up at the surgeon when medical treatments have failed. This opinion piece discusses a recently described pattern of CIC called 'Rapid transit constipation (RTC)' first identified in 2011 as part of surgical workup. RTC was identified using a nuclear medicin...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-019-04587-x
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abstract::Polyorchidism is defined as the presence of more than two testes. We report the case of a 3-year-old boy and review the embryology and surgical management of the condition. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050247
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Postoperative anxiety symptoms are distressing for both family and child. The aim of this study was to examine the prevalence of postoperative anxiety symptoms in children. METHODS:60 children aged 6-12 undergoing surgery were included in the study group. The study group was assessed three times in terms of ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4273-x
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:This study's aim was to assess the use of intravesical injection of botulinum neurotoxin type A (BoNT-A) as a treatment of overactive bladder (OAB) in children. METHODS:A 6-year retrospective study of children who received BoNT-A for OAB was performed. Treatment outcome was classified as complete success (CS),...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-011-3039-5
更新日期:2012-03-01 00:00:00
abstract::A total of 235 children, aged between 7 months and 15 years had bronchoscopy on suspicion of foreign body aspiration. The histories of these patients were studied to examine the diagnostic value of symptoms, signs, and chest x-rays, and rate of negative bronchoscopy. The sensitivity of choking and coughing was high (8...
journal_title:Pediatric surgery international
pub_type: 杂志文章
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1331-3
更新日期:2005-02-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
abstract::The successful management of faecal incontinence can dramatically improve the quality of life of affected children. The introduction of the non-refluxing, catheterisable appendico-caecostomy provides the opportunity to treat previously resistant patients. Over a 6-year period, 29 children had a Malone antegrade contin...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050342
更新日期:1998-07-01 00:00:00
abstract::The presacral cystic teratoma in an infant is reported. The cyst consisted solely of central nervous system tissue. This pathologic finding is extremely rare. A review of the literature reveals no previous report of a teratoma arising in this manner. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0831-2
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:There are many advantages of a SMOF emulsion (SMOF-lipid), such as liver-protective properties and anti-inflammatory effects. The objective of this study was to compare the clinical outcomes of SMOF-lipid with medium-chain triglycerides (MCT) /long-chain triglycerides (LCT) in infants after intestinal surger...
journal_title:Pediatric surgery international
pub_type: 杂志文章,随机对照试验
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更新日期:2019-03-01 00:00:00
abstract::For the assessment of germ-cell maturation of the seminiferous tubules, DNA flowcytometry is a rapid and sensitive method. Phosporus 31P magnetic resonance spectroscopy (MRS) is a non-invasive alternative that demonstrates the metabolic status of the testis, reflecting the type and relative proportion of germ cells in...
journal_title:Pediatric surgery international
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Children with intussusception require rapid and accurate diagnosis to enable timely intervention for satisfactory outcome. Ultrasonography is the recommended standard diagnostic modality; however, abdominal radiography (AR) is still used as an initial investigation. The aim of this study was to investigate t...
journal_title:Pediatric surgery international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00383-020-04767-0
更新日期:2021-01-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-2044-1
更新日期:2008-01-01 00:00:00
abstract::Parasitic infestations, mainly enterobiasis and amoebiasis, and poor toilet training practices are commonly associated with rectal prolapse in developing countries. Injection sclerotherapy is one of the commonly used modalities for treating partial rectal prolapse in children. Various materials are available for such ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1197-4
更新日期:2004-05-01 00:00:00
abstract::Recently, laparoscopic orchidopexy has been accepted as the standard procedure of management for clinically impalpable testes. However, many techniques have been described for the delivery of the mobilized testes. In this report, a new approach is described. The use of a fourth "scroto-peritoneal" port, makes complete...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050372
更新日期:1998-07-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Pediatric surgery international
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更新日期:2015-11-01 00:00:00
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journal_title:Pediatric surgery international
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更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Neuroblastoma is a biological, genetic and morphological heterogeneous tumor with a variable clinical course. NCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily with structural similarities to cell adhesion molecule L1. The aim of this study was to determine the expression of NCAM in n...
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pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-019-04514-0
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Retinoids are essential for fetal and lung development. Beta-carotene(BC) is the main dietary retinoid source and beta-carotene-15,15'-oxygenase-1 and 2 (Bcmo1,2) is the primary enzyme generating retinoid from BC in adult mammalian tissues. Placenta has a major role in the retinol homeostasis in fetal life: ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3621-8
更新日期:2015-01-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-011-2899-z
更新日期:2011-08-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
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更新日期:2020-04-01 00:00:00
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journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3978-y
更新日期:2016-12-01 00:00:00
abstract::Minor degrees of exomphalos have been known to be associated with vitellointestinal duct anomalies. The most frequent association is Meckel's diverticulum. It is unusual for a fistula to be communicating directly with the exomphalos sac. We report five neonates that presented with a fistula on the exomphalos sac over ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00