Abstract:
PURPOSE:Neuroblastoma is a biological, genetic and morphological heterogeneous tumor with a variable clinical course. NCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily with structural similarities to cell adhesion molecule L1. The aim of this study was to determine the expression of NCAM in neuroblastoma and to compare the results to the findings of a previous study which examined L1 expression in the same group of patients. MATERIALS AND METHODS:NCAM expression was investigated on a tissue array with 66 surgically resected neuroblastoma samples by immunohistochemistry with a monoclonal antibody clone 1B6 and peroxidase method. RESULTS:Strong expression of NCAM was detected in all of the 66 (100%) neuroblastoma tumors in contrast to L1 which was not expressed in all tumors. CONCLUSION:In contrast to L1, which was found to predict favorable outcome, NCAM is universally expressed in neuroblastoma. Therefore NCAM represents a marker for neuroblastomas irrespectively of their stages whereas L1 as an indicator for developing neuronal cells seems to identify more mature stages of this tumor. The high grade of NCAM expression might present a prerequisite for establishment of antibody-based therapies.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Wachowiak R,Rawnaq T,Metzger R,Quaas A,Fiegel H,Kähler N,Rolle U,Izbicki JR,Kaifi J,Till Hdoi
10.1007/s00383-008-2264-zsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
1361-4issue
12eissn
0179-0358issn
1437-9813journal_volume
24pub_type
杂志文章abstract::Congenital obstructive uropathy is associated with significant morbidity and mortality in the human neonate. The pathophysiology of congenital obstructive uropathy is poorly understood. There are very few experimental models of prenatal obstruction of the urinary tract, except in the fetal lamb or inbred rats. Prenata...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1322-4
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:Perianal fistulous disease is present in 10-15% of children with Crohn's disease (CD) and is frequently complex and refractory to treatment, with one-third of patients having recurrent lesions. We conducted a systematic review of the literature to examine the best surgical strategy or strategies for pediatric c...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-017-4067-6
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To compare the effect of home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis. METHODS:This was a randomized controlled trial of patients aged 4-17 with surgically treated perforated appendicitis from January 2011...
journal_title:Pediatric surgery international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00383-018-4343-0
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To review the effectiveness of the longitudinal intestinal lengthening and tailoring (LILT) and serial transverse enteroplasty (STEP) operations in a cohort of patients with short bowel syndrome (SBS). METHODS:We conducted a retrospective analysis of children with SBS treated at our institution from 2004 until...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-019-04468-3
更新日期:2019-06-01 00:00:00
abstract::It has been assumed that only 10% of medical interventions are supported by solid scientific evidence. The aim of this study was to determine the type of research evidence supporting operations in a tertiary referral paediatric surgical unit. All patients admitted over a 4-week period to two surgical firms were enroll...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050332
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND/AIM:Esophageal dilatation, gastroesophageal reflux, and intestinal obstruction have been demonstrated in CDH survivors. Abnormal esophageal and intestinal innervations were recently found in rats and babies with this disease. Our aim was to further characterize these malformations in embryos and fetal rats e...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2788-x
更新日期:2011-02-01 00:00:00
abstract::Adrenocortical tumors (ACT) are rare in childhood. Determination of malignant potential is difficult. To assess the presentation, clinical behaviour, and histology of these tumors in our center, the records of nine patients with ACTs between 1989 and 2000 were analyzed. The age, sex, clinical presentation, investigati...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0727-1
更新日期:2003-08-01 00:00:00
abstract::Management of stage IV rhabdomyosarcoma comprises systemic chemotherapy with local control by conservative surgery and radiotherapy. Abdominal radiotherapy may lead to radiation enteritis causing such serious morbidity as malabsorption, fistulae or stricture formation. The risk increases with the dose of radiation and...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-005-1490-x
更新日期:2005-09-01 00:00:00
abstract::Africa faces a triple burden of disease; HIV, tuberculosis and malaria. Despite this, its population is expected to double over the next 45 years. There is a dire shortage of medical specialists and many countries lack suitably qualified doctors to train medical specialists. Videoconferencing offers the opportunity to...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-2085-5
更新日期:2008-02-01 00:00:00
abstract::New development in the vascular network is a significant process for the proliferation, as well as metastatic expand, of cancer cells that depends on a sufficient provider of oxygen and nutrients and the removal of waste products. New blood and lymphatic vessels form via step called angiogenesis and lymphangiogenesis....
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3398-1
更新日期:2013-12-01 00:00:00
abstract::An infant born in the 34th week of gestation weighing 5,355 g with a massive sacrococcygeal (SC) tumor was delivered by elective cesarean section. An ultrasonographic examination showed solid and cystic components in the tumor. Resection was successfully undertaken with insertion of a Nélaton catheter into the rectum ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000451
更新日期:2001-03-01 00:00:00
abstract:UNLABELLED:Necrotizing enterocolitis (NEC) is a serious condition with a high morbidity and mortality commonly affecting premature babies. Data for the impact of the long-term disease burden in developing countries are limited although poor long-term outcome of surgically managed patients has been shown in terms of inc...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2583-8
更新日期:2010-04-01 00:00:00
abstract::The morphogenesis of the external genitalia of human fetuses (16-250 mm crown-rump [CR] length, 6-26 weeks of gestation) obtained after medical termination of pregnancy were studied. Differential development (male/female) started after 50 mm CR length (9 weeks). At that time the external genitalia consisted of a cylin...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01076950
更新日期:1997-07-01 00:00:00
abstract::Colonic interposition is a treatment option in childhood when esophageal replacement (ER) is necessary. We reviewed 18 children who underwent ER by colon between 1984 and 1999. There were 5 with esophageal atresia and 13 with corrosive esophagitis; 15 had long-term follow-up (mean 38 months). Three procedures were per...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000422
更新日期:2000-01-01 00:00:00
abstract::Non-operative management of gastroschisis also known as plastic closure (PC) has been described as an alternative to conventional primary operative closure (POC) or staged silo closure (SSC). The aim of this study was to compare these techniques in neonates with gastroschisis. A retrospective review of neonates with g...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2153-5
更新日期:2008-07-01 00:00:00
abstract::Eight children with Morgagni hernia were operated between January 2000 and May 2005. Medical records of the patients were evaluated retrospectively. Ages of the patients were between 3.5 months and 9 years. The diaphragmatic defect was on the right in all patients except one. One patient had bilateral diapragmatic her...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-006-1750-4
更新日期:2006-10-01 00:00:00
abstract::A small phallus causes great concern regarding genital adequacy. A concealed penis, although of normal size, appears small either because it is buried in prepubic tissues, enclosed in scrotal tissue penis palmatus (PP), or trapped due to phimosis or a scar following circumcision or trauma. From July 1978 to January 20...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0770-y
更新日期:2002-12-01 00:00:00
abstract::Hirschsprung disease is the result of aganglionosis of a variable length of the terminal bowel, which arises from the incomplete colonisation of the embryonic gut by vagal neural crest-derived cells (NCC) that migrate caudally from the pharyngeal gut to the rectum. We have previously shown that a very small group of N...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0868-2
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:Biliary atresia (BA) is characterized by progressive inflammation of the biliary system. This inflammation persists and causes liver fibrosis, although jaundice disappears after Kasai portoenterostomy (KP). We aimed to confirm whether the oral administration of eicosapentaenoic acid (EPA) suppresses liver fibro...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4313-6
更新日期:2018-10-01 00:00:00
abstract::A congenital diaphragmatic hernia (CDH) model was induced in pregnant rats following administration of 100 mg nitrofen. The fetuses were stored and fixed in Bouin's solution for 24 h after caesarean section at term. After fixation, the lungs were dissected out. Immunostaining of the CDH lungs and controls with rabbit ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00180080
更新日期:1996-08-01 00:00:00
abstract::In the published version, the Acknowledgements section was missing a funding note of co-author Dr C Verrill. The corrected version should read as follows. ...
journal_title:Pediatric surgery international
pub_type: 已发布勘误
doi:10.1007/s00383-020-04624-0
更新日期:2020-04-01 00:00:00
abstract::A newborn case with cardiac rhabdomyoma is presented to discuss the differential diagnosis of mediastinal tumors around the heart in children. The diagnosis of rhabdomyoma can be suggested by modern visualization methods such as computerized tomography, magnetic resonance imaging and echocardiography. However, surgery...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-1875-0
更新日期:2007-08-01 00:00:00
abstract::The use of a silo for temporary coverage of exposed viscera for newborns with gastroschisis has allowed gradual reduction of the externalized intestine into the abdominal cavity. However, there has not been an easy way to monitor blood perfusion to the intestine within the silo other than with visual examination. In a...
journal_title:Pediatric surgery international
pub_type: 临床试验,杂志文章
doi:10.1007/s00383-006-1726-4
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies. METHODS:We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent su...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3925-y
更新日期:2016-08-01 00:00:00
abstract:AIM:To determine if follow-up by consultant pediatric surgeons (CPS) affects morbidity due to incarceration (INC) in children with indirect inguinal hernia (IH). METHODS:We educate parents so they can identify possible INC and advise them to attend our emergency department anytime for immediate review by on-call CPS. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00383-011-3005-2
更新日期:2012-01-01 00:00:00
abstract::Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the in...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-2044-1
更新日期:2008-01-01 00:00:00
abstract::Renal and perinephric abscess in children are uncommon. Three basic pathophysiologic mechanisms are involved, namely, hematogenous spread, ascending infection and contamination by proximity to an infected area. Six pediatric patients diagnosed with renal abscess were treated at our institution from 1990-2000. Five pat...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0888-y
更新日期:2003-04-01 00:00:00
abstract::The use of ureteric stents in reimplantation surgery is important. The younger the patient, the more important the stenting of ureters post reimplantation becomes, because even minimal oedema following surgery will produce ureteric obstruction unless stents are in place. JJ stents are now the preferred method of choic...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1205-8
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:In order to evaluate the gubernaculum (GN) abnormalities quantitatively in patients with undescended testes (UDT), the area and attachment site of the gubernaculum were evaluated. PATIENTS AND METHODS:Sixty-seven testes from 61 patients with an undescended testis treated in the past 11 years at our institution...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3597-4
更新日期:2014-11-01 00:00:00
abstract:AIM:We assessed continence after scope-assisted anorectovaginoplasty (SARVP) for female anorectal malformation (FARM). METHODS:Five FARM cases were assessed; cases 1 and 2: cloacal malformation; case 3: urogenital sinus, and rectovestibular fistula (RF); case 4: RF, absent vagina, and sacral anomaly; case 5: covered c...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-012-3141-3
更新日期:2012-09-01 00:00:00