Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma?


PURPOSE:Neuroblastoma is a biological, genetic and morphological heterogeneous tumor with a variable clinical course. NCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily with structural similarities to cell adhesion molecule L1. The aim of this study was to determine the expression of NCAM in neuroblastoma and to compare the results to the findings of a previous study which examined L1 expression in the same group of patients. MATERIALS AND METHODS:NCAM expression was investigated on a tissue array with 66 surgically resected neuroblastoma samples by immunohistochemistry with a monoclonal antibody clone 1B6 and peroxidase method. RESULTS:Strong expression of NCAM was detected in all of the 66 (100%) neuroblastoma tumors in contrast to L1 which was not expressed in all tumors. CONCLUSION:In contrast to L1, which was found to predict favorable outcome, NCAM is universally expressed in neuroblastoma. Therefore NCAM represents a marker for neuroblastomas irrespectively of their stages whereas L1 as an indicator for developing neuronal cells seems to identify more mature stages of this tumor. The high grade of NCAM expression might present a prerequisite for establishment of antibody-based therapies.


Pediatr Surg Int


Wachowiak R,Rawnaq T,Metzger R,Quaas A,Fiegel H,Kähler N,Rolle U,Izbicki JR,Kaifi J,Till H




Has Abstract


2008-12-01 00:00:00












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    abstract::In the last 2 years, 29 children with nocturnal enuresis were treated in the outpatient departments of the Departments of Urology and Pediatric Surgery of the Aristotle University, Thessaloniki. There were 22 boys and 7 girls aged 7 to 12 years. The clinical examination was normal in all cases. All children had underg...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Yannakoyorgos K,Ioannides E,Zahariou A,Anagnostopoulos D,Kasselas V,Kalinderis A

    更新日期:1998-04-01 00:00:00

  • Complete surgical resection plus chemotherapy prolongs survival in children with stage 4 neuroblastoma.

    abstract::The factors that affect survival in patients with stage 4 neuroblastoma vary. Several prospective and retrospective studies have provided conflicting conclusions regarding the benefit of combining aggressive chemotherapy with complete surgical resection. We analyzed our experience to evaluate the effect of complete su...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Koh CC,Sheu JC,Liang DC,Chen SH,Liu HC

    更新日期:2005-02-01 00:00:00

  • Atypical mycobacterial disease in children: a personal series.

    abstract::Atypical mycobacterial disease is common in children in Australia. Over 22 years, records were kept prospectively by the senior author. The diagnosis was confirmed in 118 patients, either by culture or by the combination of a positive skin test plus typical histology. There were 46 boys and 72 girls with a median age ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Mushtaq I,Martin HC

    更新日期:2002-12-01 00:00:00

  • Laparotomy or drain for perforated necrotizing enterocolitis: who gets what and why?

    abstract::Between 1974 and 1988, 86 newborns with perforated necrotizing enterocolitis (NEC) were treated by either laparotomy (usually involving a bowel resection and a temporary stoma) or a peritoneal drain under local anesthesia. The survival of babies in the laparotomy group was 57% versus 59% in the drained group. However,...

    journal_title:Pediatric surgery international

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    authors: Azarow KS,Ein SH,Shandling B,Wesson D,Superina R,Filler RM

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    journal_title:Pediatric surgery international

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    authors: Niinikoski H,Alanen M,Parvinen T,Aantaa R,Ekblad H,Kero P

    更新日期:2001-07-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Taguchi T,Suita S,Masumoto K,Nada O

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审


    authors: Chusilp S,Li B,Lee D,Lee C,Vejchapipat P,Pierro A

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  • Focal nodular hyperplasia in a child with Beckwith-Wiedemann syndrome.

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    journal_title:Pediatric surgery international

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    authors: Bordeianou L,Ryan DP,Goldstein AM

    更新日期:2005-09-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Yamataka A,Goto S,Kato Y,Koga H,Lane GJ,Okazaki T

    更新日期:2012-09-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Lui KW,Wong HF,Wan YL,Hung CF,Ng KK,Tseng JH

    更新日期:2000-01-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Turowski C,Dingemann J,Gillick J

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Sugito K,Kusafuka T,Hoshino M,Inoue M,Goto H,Ikeda T,Hagiwara N,Koshinaga T,Fukuzawa M,Nakamura M,Shichino H,Chin M,Mugishima H,Saito T,Tanaka Y

    更新日期:2007-12-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Ahmed S,Kardar AH

    更新日期:2000-01-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Wani TM,Hakim M,Ramesh A,Rehman S,Majid Y,Miller R,Tumin D,Tobias JD

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审


    authors: Lee KD,Okazaki T,Kato Y,Lane GJ,Yamataka A

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Bachoo P,Mahomed AA,Ninan GK,Youngson GG

    更新日期:2001-03-01 00:00:00

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    authors: Crichton KG,Cooper JN,Minneci PC,Groner JI,Thackeray JD,Deans KJ

    更新日期:2016-08-01 00:00:00

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    authors: Takahashi H,Kutasy B,Pes L,Paradisi F,Puri P

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Naldan ME,Karayagmurlu A,Ahıskalıoglu EO,Cevizci MN,Aydin P,Kara D

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审


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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Pumberger W,Schaller A,Bernaschek G

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审


    authors: Chye JK,Lim CT,Van der Heuvel M

    更新日期:1997-04-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Kimble RM,Harding JE,Kolbe A

    更新日期:1999-01-01 00:00:00

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章,meta分析,评审


    authors: Miyake H,Seo S,Pierro A

    更新日期:2018-02-01 00:00:00

  • Toldt's fascia flap: a new technique for repairing large diaphragmatic hernias.

    abstract::The most popular techniques for repairing large diaphragmatic defects involve the use of synthetic patches. We present an alternative approach using living tissue. We reviewed our cases of congenital diaphragmatic hernia (CDH) diagnosed within the first 24 h of life from 1991 to 2003. Toldt's fascia (TF) flap was used...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Okazaki T,Hasegawa S,Urushihara N,Fukumoto K,Ogura K,Minato S,Kawashima S,Kohno S

    更新日期:2005-01-01 00:00:00

  • Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung's disease.

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: O' Donnell AM,Puri P

    更新日期:2008-01-01 00:00:00

  • Cardiac rhabdomyoma as an unusual mediastinal mass in a newborn.

    abstract::A newborn case with cardiac rhabdomyoma is presented to discuss the differential diagnosis of mediastinal tumors around the heart in children. The diagnosis of rhabdomyoma can be suggested by modern visualization methods such as computerized tomography, magnetic resonance imaging and echocardiography. However, surgery...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Karnak I,Alehan D,Ekinci S,Büyükpamukçu N

    更新日期:2007-08-01 00:00:00

  • Induction of angiogenic and inflammation-associated dermal biomarkers following acute UVB exposure on bio-engineered pigmented dermo-epidermal skin substitutes in vivo.

    abstract:PURPOSE:Ultraviolet (UV) radiation adversely affects skin health at cellular and molecular levels. Hence, UV radiation can directly induce inflammatory responses in the dermis by inducing erythema, edema, inflammation, dermal fibroblasts alterations, and extracellular matrix modifications. METHODS:Human keratinocytes,...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Micka-Michalak K,Biedermann T,Reichmann E,Meuli M,Klar AS

    更新日期:2019-01-01 00:00:00

  • Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia.

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    journal_title:Pediatric surgery international

    pub_type: 杂志文章


    authors: Sumida W,Uchida H,Tainaka T,Shirota C,Hinoki A,Kato T,Yokota K,Oshima K,Shirotuki R,Chiba K,Tanaka Y

    更新日期:2018-10-01 00:00:00