Abstract：
:Children with chronic idiopathic constipation (CIC) often end up at the surgeon when medical treatments have failed. This opinion piece discusses a recently described pattern of CIC called 'Rapid transit constipation (RTC)' first identified in 2011 as part of surgical workup. RTC was identified using a nuclear medicine gastrointestinal transit study (NMGIT or nuclear transit study) to determine the site of slowing within the bowel and to inform surgical treatment. Unexpectedly, we found that RTC occured in 29% of 1000 transit studies in a retrospective audit. Irritable bowel syndrome (IBS) occurs in 7-21% of the population, with a higher prevalence in young children and with constipation type dominating in the young. While 60% improve with time, 40% continue with symptoms. First-line therapy for IBS in adults is a diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols which reduces symptoms in > 70% of patients. In children with functional gastrointestinal disorders, fructose intolerance occurs in 35-55%. Reducing fructose produced significant improvement in 77-82% of intolerant patients. In children with RTC and a positive breath test upon fructose challenge, we found that exclusion of fructose significantly improved constipation, abdominal pain, stool consistency and decreased laxative use. We hypothesise that positive breath tests and improvement of pain and bowel frequency with sugar exclusion diets in RTC suggest these children have IBS-C. These observations raise the possibility that many children with CIC could be treated by reducing fructose early in their diet and this might prevent the development of IBS in later life.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Hutson JM,Hynes MC,Kearsey I,Yik YI,Veysey DM,Tudball CF,Cain TM,King SK,Southwell BRdoi
10.1007/s00383-019-04587-xsubject
Has Abstractpub_date
2020-01-01 00:00:00pages
11-19issue
1eissn
0179-0358issn
1437-9813pii
10.1007/s00383-019-04587-xjournal_volume
36pub_type
杂志文章,评审abstract：:Complete transposition of the penis and scrotum, or prepenile scrotum, is an uncommon congenital malformation. Concomitant genitourinary abnormalities, often life-threatening in nature, are frequently seen, and major malformations involving other organ systems may also be present. We report a newborn in whom complete ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050650
更新日期：1999-01-01 00:00:00
abstract：:Eight children with Morgagni hernia were operated between January 2000 and May 2005. Medical records of the patients were evaluated retrospectively. Ages of the patients were between 3.5 months and 9 years. The diaphragmatic defect was on the right in all patients except one. One patient had bilateral diapragmatic her...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1750-4
更新日期：2006-10-01 00:00:00
abstract：:Multiple endocrine neoplasia (MEN) 2B is a hereditary syndrome including medullary thyroid carcinoma (MTC), pheochromocytoma, gastrointestinal (GI) disorders, marfanoid facies, and multiple ganglioneuromas. MTC is the major cause of mortality, and often appears during the 1st decade of life. RET proto-oncogene mutatio...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0824-1
更新日期：2002-09-01 00:00:00
abstract：:Recently, most studies reported magnesium as a N-methyl-D-aspartate receptor antagonist and its analgesic and perioperative anaesthetic effects have been discussed with central desensitization pathway. We investigated the effects of caudal ropivacaine plus magnesium and compared with ropivacaine alone on postoperative...
journal_title：Pediatric surgery international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00383-006-1779-4
更新日期：2007-02-01 00:00:00
abstract：PURPOSE:Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare and the most severe form of functional intestinal obstruction in the newborn. This congenital condition is associated with non-obstructed urinary bladder, microcolon and decreased or absent intestinal peristalsis. This study was designe...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-011-2954-9
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Postoperative anxiety symptoms are distressing for both family and child. The aim of this study was to examine the prevalence of postoperative anxiety symptoms in children. METHODS:60 children aged 6-12 undergoing surgery were included in the study group. The study group was assessed three times in terms of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4273-x
更新日期：2018-07-01 00:00:00
abstract：:Rhizomelic chondrodysplasia punctata (RCP), a rare autosomal recessive disease characterized by a disorder of peroxisome metabolism, has been shown to affect multiple organ systems. A neonate presenting with a colonic perforation in the first few hours of life was subsequently diagnosed with RCP. A literature search r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1426-5
更新日期：2005-08-01 00:00:00
abstract：:Pseudoexstrophy is a rare variant of the exstrophy/epispadias complex, comprised of the musculoskeletal defects of classic exstrophy but with an intact bladder and urethra. We present a case of a neonate with left-sided gastroschisis and pseudoexstrophy, the first reported combination of these two anomalies. The anoma...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1217-4
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is a gastrointestinal disease of complex etiology resulting in devastating systemic inflammation and often death in premature newborns. We previously demonstrated that formula feeding inhibits ileal expression of heat shock protein-70 (Hsp70), a critical stress protein within ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4211-3
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Although it is virtually impossible to formulate a scheme that can satisfactorily collect all different types of vaginal malformations, a simple classification would be of a considerable value and would permit logical operative decisions. Many classifications of anomalies of uterus and vagina have been propo...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3121-7
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:For International Neuroblastoma Staging System (INSS) stages III or IV neuroblastoma (intermediate or high risk), complete excision of the primary tumor is not always feasible. Most current studies on the treatment outcome of these patients have reported on the complete excision status. The aim of this study is...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2417-8
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:Surgery of the inguinal canal is very common in infancy. Occasionally, injury of the bladder may occur with severe consequences. The aim of this paper was to warn young surgeons of this serious complication. METHODS:During the last 2 years, we observed four cases of bladder injury following surgery on inguinal...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2707-1
更新日期：2010-12-01 00:00:00
abstract：:The need for contralateral inguinal exploration in children during unilateral inguinal hernia repair remains controversial. We questioned whether an elective preoperative sonographic examination of the contralateral inguinal canal was accurate enough to prevent unnecessary exploration of the asymptotic side. Sonograph...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00180090
更新日期：1996-08-01 00:00:00
abstract：:Congenital anterior penile urethral fistula is a rare anomaly; only seven cases have been reported to date. This report outlines the clinical presentation and the embryologic mechanism of a case associated with urethral duplication. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1063-9
更新日期：2003-12-01 00:00:00
abstract：:Between 1993-2002 we used both diagnostic and operative laparoscopy in the management of five cases of persistent müllerian duct syndrome (BMDS). Two siblings from two different families accounted for four of the cases. They presented with cryptorchidism and inguinal hernias. The diagnosis was established during diagn...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-0984-7
更新日期：2003-09-01 00:00:00
abstract：:An infant born in the 34th week of gestation weighing 5,355 g with a massive sacrococcygeal (SC) tumor was delivered by elective cesarean section. An ultrasonographic examination showed solid and cystic components in the tumor. Resection was successfully undertaken with insertion of a Nélaton catheter into the rectum ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000451
更新日期：2001-03-01 00:00:00
abstract：:An unrecognised right aortic arch (RAA) found at thoracotomy may complicate the repair of oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF). This paper analyses the patient characteristics, peri-operative management, and outcome of 16 infants with a RAA, and proposes management guidelines. Between 1948 an...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050505
更新日期：1999-01-01 00:00:00
abstract：:Oesophageal atresia (OA) is often associated with anomalies of other systems. The genetic contribution to the formation of the VACTERL association is not clear. The objective of this study was to evaluate the incidence of associated anomalies in two different racial populations. The associated anomalies in neonates wi...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830100692
更新日期：2002-05-01 00:00:00
abstract：:Hirschsprung disease (HSCR) is a fairly well understood congenital, genetically based functional obstruction due to the congenital absence of ganglion cells in the distal bowel. However, although over 90% of Hirschsprung cases conform to the normally accepted histological diagnostic criteria, it has become increasingl...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-016-4038-3
更新日期：2017-03-01 00:00:00
abstract：AIM:The aim of this study was to examine the relationship between birth weight, pulmonary artery (PA) size, and outcome in congenital diaphragmatic hernia (CDH) to establish if PA size has prognostic value. METHODS:The subjects for this study were 39 consecutive left-sided CDH patients treated at our institution accor...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-011-2899-z
更新日期：2011-08-01 00:00:00
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journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2187-8
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:Fetal extraperitoneal rectal perforation (FERP) is an extremely rare entity. The objective of this report is to review the available literature on this condition and to add our experience with four additional cases managed at our institution. METHODS:A literature search was performed for journal articles addre...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-019-04514-0
更新日期：2019-09-01 00:00:00
abstract：:Extensive loss of small bowel in all age groups has significant morbidity and mortality consequences. Despite the astonishing ability of the small bowel to compensate for an extensive loss, long-term parenteral nutrition and enteral nutrition, tailored to the need of the patients in relation to the missing intestinal ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-016-4043-6
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:Haemolytic uraemic syndrome (HUS) is the commonest childhood cause of acute renal failure. Peritoneal dialysis peritonitis (PDP) is a well-recognised complication, with some children requiring surgical intervention (SI). The aim of this study is to determine whether the presence of enteric organisms in cases of...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3833-6
更新日期：2016-03-01 00:00:00
abstract：:Polyorchidism is defined as the presence of more than two testes. We report the case of a 3-year-old boy and review the embryology and surgical management of the condition. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050247
更新日期：1998-01-01 00:00:00
abstract：:A congenital diaphragmatic hernia (CDH) model was induced in pregnant rats following administration of 100 mg nitrofen. The fetuses were stored and fixed in Bouin's solution for 24 h after caesarean section at term. After fixation, the lungs were dissected out. Immunostaining of the CDH lungs and controls with rabbit ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00180080
更新日期：1996-08-01 00:00:00
abstract：:Gastroesophageal reflux (GER) is common after repair of esophageal atresia with a distal tracheoesophageal fistula (EATOF). In a retrospective study we assessed whether early 18-h pH monitoring can predict the development of EATOF-associated gastroesophageal reflux. During 1980-1997, 90 consecutive patients had primar...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1270-z
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Pediatric surgeons and patient organisations agree that fewer centers for anorectal malformations with larger patient numbers are essential to reach better treatment. The European Union transacts a political process which aims to realize such centers of expertise for a multitude of rare diseases. All the cen...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3752-6
更新日期：2015-08-01 00:00:00
abstract：AIM:The objective of the present study was to evaluate the diagnostic methods, concomitant organ injuries, factors affecting mortality and morbidity, treatment methods, and outcomes of patients treated for traumatic gastrointestinal (GI) perforation. MATERIALS AND METHODS:We conducted a retrospective review of the med...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3963-5
更新日期：2016-11-01 00:00:00
abstract：:Primary hydatid disease of the pancreas is rare. The authors report a 3-year-old girl who had a cystic mass in the head of the pancreas with no other viscera involved. At laparatomy the entire endocyst was totally extracted from the surrounding pancreatic parenchyma. The postoperative course was uneventful. She is cur...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050677
更新日期：1999-01-01 00:00:00
