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Urogenital disorders in women with adjuvant endocrine therapy after early breast cancer.

Abstract：

OBJECTIVE:To investigate the prevalence of urogenital symptoms and vaginal atrophy in postmenopausal breast cancer patients on adjuvant endocrine therapy. STUDY DESIGN:A population-based, cross-sectional study on postmenopausal breast cancer patients on adjuvant endocrine treatment and age-matched control subjects. Vaginal atrophy was assessed by gynecologic examination and atrophy-related symptoms by validated questionnaires. RESULTS:In all, 57.6% of aromatase inhibitor-treated and 32.4% of tamoxifen-treated breast cancer patients rated at least 1 vaginal atrophy symptom as moderate/severe, which was significantly more common than in control subjects (P < .01). Aromatase inhibitor-treated patients more often had moderate or severe vaginal atrophy (P < .05), a more atrophic cytohormonal evaluation, and significantly higher vaginal pH (P < .05) than all control subjects, irrespective of hormonal use. CONCLUSION:Our findings indicate that the frequency of vaginal atrophy symptoms, particularly in aromatase inhibitor-treated women, might have been underestimated in previous clinical trials.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Baumgart J,Nilsson K,Stavreus-Evers A,Kask K,Villman K,Lindman H,Kallak T,Sundström-Poromaa I

doi

10.1016/j.ajog.2010.08.035

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

26.e1-7

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(10)01038-0

journal_volume

204

pub_type

杂志文章

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