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Steroid compounds and the dilatation of ovarian and uterine veins in the mouse.

Abstract：

:The possible role of reproductive steroids in the vascular changes o f the estrous and menstrual cycles and of pregnancy has prompted both clinical observations and animal experiments on the influence of sex hormones on the physiology of blood vessels. Research was carried out to develop a method for exposing blood vessels of the ovariectomized mouse to the continous influence of steroids, for quantitating resulting changes in blood vessel diameter, and for evaluatin the results. The method was used for direct comparison of the effects of 10 steroid compounds. Small pellets of each of 10 steroids, or glass pellets as controls, were tied to the right uterine horns of groups of 10 ovariectomized adult virgin mice. After 7 or 21 days, the mice were killed, and the diameters of the right and left ovarian and uterine veins were measured. The largest significant increases in diameter, particularly after 21 days, were observed in mice treated with testosterone, dihydrotestosterone, estrone, estradiol-17beta, and progesterone. Lesser or no significant increases were seen in mice that had received 20-alpha-dihydroprogesterone, 20-beta-dihydroprogesterone, cholesterol, 16-alpha-hydroxyprogesterone, and 17-alpha-hydroxyprogesetrone.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Forbes TR,Glassen G

doi

10.1016/0002-9378(72)90637-0

subject

Has Abstract

pub_date

1972-07-01 00:00:00

pages

678-80

issue

5

eissn

0002-9378

issn

1097-6868

pii

0002-9378(72)90637-0

journal_volume

113

pub_type

杂志文章

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