Influence of terbutaline on ovine uterine response to prostaglandin E2 challenge.

Abstract:

OBJECTIVE:Our purpose was to test the effects of terbutaline on uterine electric and contractile responses to prostaglandin E2. STUDY DESIGN:In five late-gestation ewes, prostaglandin E2 (22.9 +/- 2.3 micrograms/min for 3 minutes) was given twice at 30-minute intervals during control. Terbutaline sulfate (2 micrograms/min) was then infused for 30 minutes. Prostaglandin E2 challenge was repeated 10 minutes after the onset of terbutaline infusion and thereafter at 30-minute intervals. Two-way analysis of variance for repeated measures revealed a significant main effect for time (p less than or equal to 0.0001) and between time and response (p less than or equal to 0.05). RESULTS:Both electric (p less than or equal to 0.0001) and intrauterine pressure (p less than or equal to 0.0001) responses were suppressed during terbutaline. The influence on intrauterine pressure persisted 10 minutes after terbutaline (p less than or equal to 0.01) while the electric response was not different from control. CONCLUSIONS:Terbutaline initially diminishes both uterine contractile and electric activity, but electric recovery precedes contractile recovery.

journal_name

Am J Obstet Gynecol

authors

Reid DL,Davidson SR,Phernetton TM,Rankin JH

doi

10.1016/0002-9378(92)91864-7

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

231-5

issue

1 Pt 1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(92)91864-7

journal_volume

166

pub_type

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