Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study.

Abstract:

:It is hypothesized that ampicillin may treat subclinical deciduitis and prolong the "effective" latent period in patients with preterm premature rupture of the membranes. We studied 82 patients with preterm rupture of membranes who were managed expectantly and were randomly assigned either to receive ampicillin prophylaxis (n = 43) or not to receive ampicillin prophylaxis (n = 39). Patients were excluded from study entry on admission if they had suspected or frank chorioamnionitis, active preterm labor, a history of penicillin allergy, multiple gestation, or cervical cerclage. There were no significant differences between the groups in duration of membrane rupture prior to admission, gestational age at membrane rupture, use of steroids and tocolysis, and demographic factors. Life-table analysis showed that the risk of delivery was significantly lower for the group of patients receiving prophylactic ampicillin. The incidence of neonatal infection was significantly lower in the ampicillin group, 1 (2%) versus 6 (17%), p less than 0.04.

journal_name

Am J Obstet Gynecol

authors

Amon E,Lewis SV,Sibai BM,Villar MA,Arheart KL

doi

10.1016/s0002-9378(88)80002-4

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

539-43

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(88)80002-4

journal_volume

159

pub_type

临床试验,杂志文章,随机对照试验
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