Abstract：
:A strong immunoreactivity for ferritin was observed in the neuritic (senile) plaques in Alzheimer's disease hippocampus. The ferritin accumulation was almost exclusively associated with the microglia, which appeared to have proliferated greatly. These cells were also positive for HLA-DR, a putative marker for reactive microglia. In contrast, in the diffuse plaques, which were without neuritic pathology, the ferritin-stained microglia appeared to be normal. Microglia were seen frequently in contact with neurons undergoing neurofibrillary changes but only the tangles in the extracellular space were ferritin positive. No ferritin was detected, by Western blots, in paired helical filaments isolated from Alzheimer's disease brain, suggesting that ferritin was most likely weakly associated with and was not a constituent of these fibrils. No correlation between increased ferritin/microglia activity and blood-brain barrier leakage was detected. Ferritin, an iron-storage protein, might have a role in the formation of amyloid through the action of free radicals generated during the release of iron from the ferritin molecule. Alternatively, the ferritin/microglia system might be secondarily involved in the removal and processing of the amyloid.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Grundke-Iqbal I,Fleming J,Tung YC,Lassmann H,Iqbal K,Joshi JGdoi
10.1007/BF00334497subject
Has Abstractpub_date
1990-01-01 00:00:00pages
105-10issue
2eissn
0001-6322issn
1432-0533journal_volume
81pub_type
杂志文章abstract：:Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of intracellular lumina and pseudopsammoma bodies, expression of a distinct pattern of cytokeratins and clinically by pronounced perifocal brain edema. Here we descr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1093-x
更新日期：2013-03-01 00:00:00
abstract：:An in vivo method for positively staining dead neurons was developed and compared with an in vitro staining method using acid fuchsin. Neurons previously killed by intracerebral injections of kainic acid were selectively stained by trypan blue within 15 min of its injection in vivo into the central nervous system of r...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687254
更新日期：1989-01-01 00:00:00
abstract：:Neuregulins belong to a family of multipotent growth-promoting proteins, and have been shown to have a crucial role in accumulating acetylcholine receptor at neuromuscular junctions. A functional role of neuregulins in muscle regeneration has not yet been identified. Using reverse transcription (RT)-PCR, Western blot ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0198-5
更新日期：2007-04-01 00:00:00
abstract：:The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and ATF6 play a central role in the initiation and regulation of the UPR. The accumulation of misfolded and aggregated proteins is a common characte...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-015-1462-8
更新日期：2015-09-01 00:00:00
abstract：:Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor fro...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-014-1327-6
更新日期：2014-12-01 00:00:00
abstract：:Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294808
更新日期：1995-01-01 00:00:00
abstract：:Involvement of the choroid plexus by lymphoma (Hodgkin) is a hitherto undescribed complication. We report herein the case of a 49-year-old man who developed, shortly before death, neurologic symptoms seemingly related to extensive involvement of choroid plexus and surrounding ventricular structures by lymphoma (Hodgki...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00692063
更新日期：1977-02-28 00:00:00
abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687789
更新日期：1988-01-01 00:00:00
abstract：:In a previous study the occurrence of nerve fibre degeneration with a distribution as in dying-back neuropathies was described in young rats subjected to severe protein deprivation (Oldfors 1981). In this study the ultrastructural appearance of the degeneration of the nerve fibres at different levels of the longitudin...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688871
更新日期：1982-01-01 00:00:00
abstract：:We report a case of embryonal tumor with novel inclusion bodies occurring in the cerebellum of a 12-year-old girl. The tumor was histopathologically composed of small undifferentiated cells intermingled with a small number of rhabdoid cells, which had an ultrastructural feature of intermediate filament whorls. Immunoh...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1015-7
更新日期：2005-07-01 00:00:00
abstract：:The immunohistochemical distribution of alpha and beta subunits of S-100 protein (S-100 alpha, S-100 beta, respectively) in 138 cases of human brain tumors was investigated by the avidin-biotin immunoperoxidase method. Brain tumors can be divided into four groups: group 1 [S-100 alpha (+) and/or S-100 beta (+)]; astro...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296376
更新日期：1991-01-01 00:00:00
abstract：:A study was undertaken to determine the pathological significance of previously unrecognized intracytoplasmic eosinophilic inclusions (IEIs) in ependymoma. The study group consisted of 58 ependymomas, all of which were pathologically characterized and graded according to the 1993 WHO classification. Electron microscop...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007427
更新日期：2000-02-01 00:00:00
abstract：:Respiratory chain dysfunction leads to reactive oxygen species (ROS) generation with following oxidative stress and cellular damage. A histochemical and immunohistochemical study was performed on muscle biopsies from 17 patients with mitochondrial disease [chronic progressive external ophthalmoplegia (CPEO), mitochond...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100455
更新日期：2002-03-01 00:00:00
abstract：:We present a case of progressive supranuclear palsy (PSP) with palatal myoclonus occurred in a 64-year-old man. The nucleus olivaris of the medulla oblongata showed high signal intensity on T2-weighted MR images, indicating brainstem tegmental atrophy, which were confirmed as hypertrophy of the nucleus inferior olivar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050706
更新日期：1997-09-01 00:00:00
abstract：:By unknown mechanisms, the symptoms of amyotrophic lateral sclerosis (ALS) seem to spread along neuroanatomical pathways to engulf the motor nervous system. The rate at which symptoms spread is one of the primary drivers of disease progression. One mechanism by which ALS symptoms could spread is by a prion-like propag...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-014-1342-7
更新日期：2014-12-01 00:00:00
abstract：:The finding of novel fibroblastic onion bulb-like structures in peripheral nerves is reported for the first time in avian riboflavin deficiency. Day old broiler meat chickens were fed a riboflavin deficient diet (1.8 mg/kg) and were killed on postnatal days 6, 11, 16, 21 and 31, whereas control chickens were fed a con...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0215-8
更新日期：2007-08-01 00:00:00
abstract：:A case of secretory meningioma with numerous meningothelial rosettes is reported. A 66-year-old man with moyamoya disease gradually developed skull deformity, and underwent surgery for the skull tumor overlying the hemisphere. Histological examination disclosed numerous meningothelial rosettes quite similar to those i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227831
更新日期：1992-01-01 00:00:00
abstract：:Keratan sulphate proteoglycan (KSPG) is a developmentally regulated barrier molecule, directing axonal growth during central nervous system (CNS) formation. The possible re-expression and functional significance of KSPG in preventing axon regeneration following spinal cord injury (SCI) is poorly understood. In the pre...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0589-6
更新日期：2002-12-01 00:00:00
abstract：:Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but its role in the clinical management of diffuse low-grade gliomas (LGG) is still being defined. DNA hypermethylation of the O (6) -methylguanine-DNA methyltransferase (MGMT) promoter is associated with an improved response to TMZ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1403-6
更新日期：2015-04-01 00:00:00
abstract：:This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050426
更新日期：1996-01-01 00:00:00
abstract：:The paper describes the clinical and morphological features of a congenital neurological disease affecting two in-bred litter-mate kittens. The principal neurological features were ataxia and dysmetria. In one of the kittens light microscopy revealed widespread vacuolation of white and grey matter of the brain and spi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690561
更新日期：1976-06-15 00:00:00
abstract：:Extracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) represent pathological hallmark lesions of Alzheimer's disease (AD). Both lesions develop in parallel in the human brain throughout the pre...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-019-02053-5
更新日期：2019-12-01 00:00:00
abstract：:3-Nitropropionic acid (NPA), a toxin which irreversibly inhibits the Krebs cycle enzyme succinate dehydrogenase, causes severe neurologic disease and a specific pattern of morphologic brain damage when given subcutaneously to rats. To determine whether hypotension or hypoxemia were necessary for development of morphol...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688340
更新日期：1987-01-01 00:00:00
abstract：:The growth potential of 65 pituitary adenomas was determined by histochemical analysis with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine (BrdUdR) labeling, and counts of argyrophilic nucleolar organizer regions (Ag-NORs). The mean proliferating cell indices (PCIs) determined by Ki-67 an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00311392
更新日期：1992-01-01 00:00:00
abstract：:It has been suggested that delayed development in either the peripheral or central nervous system could underlie the sudden infant death syndrome (SIDS). We studied the phrenic nerve in an attempt to find if maturation in this nerve was delayed in SIDS, and to see if fiber size differences could explain the paucity of...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050445
更新日期：1996-01-01 00:00:00
abstract：:Axonal degeneration contributes to the transient and permanent neurological deficits seen in multiple sclerosis, an inflammatory disease of the central nervous system. To study the immunological mechanisms causing axonal degeneration, we induced experimental autoimmune encephalomyelitis (EAE) in wildtype Lewis rats an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0047-y
更新日期：2006-06-01 00:00:00
abstract：:To investigate the relationship between cerebral amyloid angiopathy and subcortical (lobar) hemorrhage, we examined the severity of amyloid deposition in the leptomeningeal, cortical and subcortical arteries in 28 autopsied elderly patients with cerebral amyloid angiopathy with subcortical hemorrhage, deep cerebral he...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00228574
更新日期：1993-01-01 00:00:00
abstract：:A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00697397
更新日期：1983-01-01 00:00:00
abstract：:A man of 75 years of age had had lightning pains in the legs for 8 years. Clinical examination demonstrated mild pyramidal signs and involvement of the posterior columns. A morphine pump was placed in the epidural space in the lumbar region to treat the pain. He died two weeks later from a massive pulmonary embolism. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00695497
更新日期：1987-01-01 00:00:00
abstract：:We have previously characterized three human leucine-rich repeats and immunoglobulin-like domains (LRIG) genes and proteins, named LRIG1-3 and proposed that they may act as suppressors of tumor growth. The LRIG1 transmembrane protein antagonizes the activity of epidermal growth factor receptor family receptor tyrosine...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0032-5
更新日期：2006-03-01 00:00:00
