Abstract：
BACKGROUND AND AIMS:The etiology of atherosclerosis is multifactorial. Genetic and environmental factors are involved in the development of atherosclerosis. Human arylamine N-acetyltransferase 2 (NAT2) is an important metabolizing enzyme that exhibits genetic polymorphisms and modifies individual response and/or toxicity to many xenobiotics. We undertook this study to investigate the NAT2 polymorphisms in patients with atherosclerosis. METHODS:Genotyping for NAT2 alleles was performed using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) in 285 Algerian patients with atherosclerosis and 286 controls. RESULTS:There was no association between NAT2 polymorphisms and atherosclerosis risk. However, the haplotype NAT2(*)5F decreased susceptibility to the disease (p = 0.005, OR = 0.55, 95% CI = 0.37-0.84). The frequency of the slow acetylator phenotype was approximately 50% in both cases and controls. CONCLUSIONS:These results suggest that NAT2 polymorphisms may not be involved in the pathogenesis of atherosclerosis.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Khelil M,Zenati A,Makrelouf M,Otmane A,Tayebi Bdoi
10.1016/j.arcmed.2010.03.008subject
Has Abstractpub_date
2010-04-01 00:00:00pages
215-20issue
3eissn
0188-4409issn
1873-5487pii
S0188-4409(10)00051-2journal_volume
41pub_type
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