How I treat elderly patients with myeloma.

abstract：:Advances in fluorescence-activated cell sorter technology have brought about multicolor analysis of cell phenotypes. To clarify the phenotypes of human hematopoietic stem cells (HSCs), we initially prepared novel antibodies against CD34 and labeled one of them (4A1) with allophycocyanin (APC). With this, we analyzed t...

journal_title：Blood

authors： Gunji Y,Nakamura M,Hagiwara T,Hayakawa K,Matsushita H,Osawa H,Nagayoshi K,Nakauchi H,Yanagisawa M,Miura Y

更新日期：1992-07-15 00:00:00

abstract：:We analyzed mutations of 7 vitamin K-dependent protein and cytochrome P450 2C9 genes in 45 patients and investigated whether any contribute to the large interpatient variability in the warfarin dose-effect relationship. Total clearance and daily dose, INR and INR/Cp, were used as pharmacokinetic and pharmacodynamic in...

journal_title：Blood

authors： Shikata E,Ieiri I,Ishiguro S,Aono H,Inoue K,Koide T,Ohgi S,Otsubo K

更新日期：2004-04-01 00:00:00

abstract：:Patients aged ≥60 years with treatment-naive Hodgkin lymphoma (HL) have few treatment options and inferior survival due to treatment-related toxicities and comorbidities. This phase 2, nonrandomized, open-label study evaluated brentuximab vedotin (BV) monotherapy (results previously reported), BV plus dacarbazine (DTI...

journal_title：Blood

authors： Friedberg JW,Forero-Torres A,Bordoni RE,Cline VJM,Patel Donnelly D,Flynn PJ,Olsen G,Chen R,Fong A,Wang Y,Yasenchak CA

更新日期：2017-12-28 00:00:00

abstract：:Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a powerful karyotyping tool in numerous translational cancer studies. SNP-A complements traditional metaphase cytogenetics with the unique ability to delineate a previously hidden chromosomal defect, copy neutral loss of heterozygosity ...

journal_title：Blood

authors： O'Keefe C,McDevitt MA,Maciejewski JP

更新日期：2010-04-08 00:00:00

abstract：:Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease of immune hyperactivation. Unlike pediatric HLH, adult HLH is rarely driven by germline genetic variants. Although numerous precipitating etiologies have been identified, the reason that HLH occurs in only a subset of individuals ...

journal_title：Blood

authors： Miller PG,Sperling AS,Gibson CJ,Viswanathan K,Castellano C,McConkey M,Ceremsak J,Taylor MS,Birndt S,Perner F,Arnason J,Agrawal M,Schram AM,Nikiforow S,Pihan G,Hasserjian RP,Aster JC,La Rosée P,Morgan EA,Berliner N,

更新日期：2020-12-24 00:00:00

abstract：:Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic c...

journal_title：Blood

authors： Melemed AS,Ryder JW,Vik TA

更新日期：1997-11-01 00:00:00

abstract：:Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.5...

journal_title：Blood

authors： Lijfering WM,Brouwer JL,Veeger NJ,Bank I,Coppens M,Middeldorp S,Hamulyák K,Prins MH,Büller HR,van der Meer J

更新日期：2009-05-21 00:00:00

abstract：:We compared the ability of aspirin to suppress platelet aggregation and thromboxane synthesis in ten normal subjects and ten patients with diabetic angiopathy and high rate of entry of new platelets into the circulation. When single doses of 100 to 1,000 mg aspirin were ingested daily for 1 month, there were time gaps...

journal_title：Blood

authors： DiMinno G,Silver MJ,Cerbone AM,Murphy S

更新日期：1986-10-01 00:00:00

abstract：:For many in vivo gene therapy clinical applications, it is desirable to control the expression of the transferred transgene using pharmacologic agents. To evaluate the feasibility of accomplishing this using corticosteroids, pharmacologic agents widely used in clinical medicine, we constructed replication deficient ad...

journal_title：Blood

authors： Narumi K,Suzuki M,Song W,Moore MA,Crystal RG

更新日期：1998-08-01 00:00:00

abstract：:To obtain information relevant to the question of bone marrow transplantation, we examined the prognostic significance of disease features recorded at the time of diagnosis among 625 patients, aged 5 to 45, with Philadelphia chromosome-positive, nonblastic chronic granulocytic leukemia. The actuarial death rate for th...

journal_title：Blood

authors： Sokal JE,Baccarani M,Tura S,Fiacchini M,Cervantes F,Rozman C,Gomez GA,Galton DA,Canellos GP,Braun TJ

更新日期：1985-12-01 00:00:00

abstract：:The incidence of chronic lymphocytic leukemia (CLL) in Taiwan is markedly lower than that in Western countries, but we have seen a drastically increasing trend. We explored this distinct incidence trend of CLL for Taiwanese. The epidemiologic data of CLL for Taiwanese and Caucasian Americans during 1986 to 2005 were o...

journal_title：Blood

authors： Wu SJ,Huang SY,Lin CT,Lin YJ,Chang CJ,Tien HF

更新日期：2010-11-25 00:00:00

abstract：:Screening for hereditary hemochromatosis (HHC) by means of transferrin saturation (TS) levels has been advocated and will identify many patients who are asymptomatic. The purposes of this study were (1) to determine HFE genotypes among asymptomatic HHC patients and correlate this profile with the degree of iron overlo...

journal_title：Blood

authors： Sham RL,Raubertas RF,Braggins C,Cappuccio J,Gallagher M,Phatak PD

更新日期：2000-12-01 00:00:00

abstract：:Hematopoiesis is tightly controlled by transcription regulatory networks, but how and when specific transcription factors control lineage commitment are still largely unknown. Within the hematopoietic stem cell (Lin(-)Sca-1(+)c-Kit(+)) compartment these lineage-specific transcription factors are expressed at low level...

journal_title：Blood

authors： Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP

更新日期：2010-11-18 00:00:00

abstract：:Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to nitrosourea-induced cytotoxicity and the development of secondary leukemia after nitrosourea treatment. Isolated CD34+ myeloid progenitors were also found to have l...

journal_title：Blood

authors： Gerson SL,Phillips W,Kastan M,Dumenco LL,Donovan C

更新日期：1996-09-01 00:00:00

abstract：:Cord plasma contains colony-stimulating activity (CSA) which stimulates the in vitro clonal growth of neutrophils, eosinophils, macrophages, erythrocytes, and persisting mast cells in semisolid cultures. Analysis of day 35 colonies in agar cultures was found to be a suitable means of demonstrating this activity and di...

journal_title：Blood

authors： Brown RD,Yuen E,Kronenberg H,Rickard KA

更新日期：1986-07-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is characterized by delayed senescence and slow accumulation of monoclonal, small lymphocytes. Basic fibroblast growth factor (bFGF) is a pleiotropic cytokine that plays a role in hematopoiesis and apoptosis. Elevated bFGF levels have been detected in urine from patients with a varie...

journal_title：Blood

authors： Menzel T,Rahman Z,Calleja E,White K,Wilson EL,Wieder R,Gabrilove J

更新日期：1996-02-01 00:00:00

abstract：:Men1 is a tumor suppressor gene mutated in endocrine neoplasms. Besides its endocrine role, the Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysine 4 methyltransferase. Although menin and MLL fusion proteins cooperate to activate Homeobox (Hox) gene expression during tr...

journal_title：Blood

authors： Maillard I,Chen YX,Friedman A,Yang Y,Tubbs AT,Shestova O,Pear WS,Hua X

更新日期：2009-02-19 00:00:00

abstract：:The mechanism of lymphomagenesis of hepatitis C virus (HCV)-related B-cell lymphoma is unknown. Recently, it has been suggested that HCV may induce B-cell clonal proliferation and t(14;18) translocation in patients chronically infected with the virus. Thus, this study investigated the effect of antiviral treatment on ...

journal_title：Blood

authors： Zuckerman E,Zuckerman T,Sahar D,Streichman S,Attias D,Sabo E,Yeshurun D,Rowe JM

更新日期：2001-03-15 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is curative for hemophagocytic lymphohistiocytosis (HLH). However, patients frequently have significant morbidity before transplantation and there is high transplant-related mortality (TRM). Because first-degree HLH is caused by immune dysregulation, a reduced-intensity condi...

journal_title：Blood

authors： Cooper N,Rao K,Gilmour K,Hadad L,Adams S,Cale C,Davies G,Webb D,Veys P,Amrolia P

更新日期：2006-02-01 00:00:00

abstract：:The large granular lymphocyte (LGL) population, which effects a natural killer (NK) function, consists of cells whose lineage derivation has not been clearly established on the basis of phenotypic and functional properties. To clarify the relationship of LGL/NK cells to T cells we studied patterns of rearrangement and...

journal_title：Blood

authors： Pelicci PG,Allavena P,Subar M,Rambaldi A,Pirelli A,Di Bello M,Barbui T,Knowles DM 2nd,Dalla-Favera R,Mantovani A

更新日期：1987-11-01 00:00:00

abstract：:While studying patient plasma containing an unusual pattern of von Willebrand factor (VWF) multimers, we discovered a previously unreported phenomenon: heavy predominance of dimeric VWF. Genomic analysis revealed a new congenital mutation (Tyr87Ser) that altered the final stages of VWF biosynthesis. This mutation in t...

journal_title：Blood

authors： Rosenberg JB,Haberichter SL,Jozwiak MA,Vokac EA,Kroner PA,Fahs SA,Kawai Y,Montgomery RR

更新日期：2002-09-01 00:00:00

abstract：:We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype and mutations occurring at the exon-12 of the NPM gene. In this paper, we have elu...

journal_title：Blood

authors： Falini B,Bolli N,Shan J,Martelli MP,Liso A,Pucciarini A,Bigerna B,Pasqualucci L,Mannucci R,Rosati R,Gorello P,Diverio D,Roti G,Tiacci E,Cazzaniga G,Biondi A,Schnittger S,Haferlach T,Hiddemann W,Martelli MF,Gu W,

更新日期：2006-06-01 00:00:00

abstract：:Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like...

journal_title：Blood

authors： Yi H,Yu X,Gao P,Wang Y,Baek SH,Chen X,Kim HL,Subjeck JR,Wang XY

更新日期：2009-06-04 00:00:00

abstract：:Autologous T cells targeting Epstein-Barr virus (EBV) latent membrane proteins (LMPs) have shown safety and efficacy in the treatment of patients with type 2 latency EBV-associated lymphomas for whom standard therapies have failed, including high-dose chemotherapy followed by autologous stem-cell rescue. However, the ...

journal_title：Blood

authors： McLaughlin LP,Rouce R,Gottschalk S,Torrano V,Carrum G,Wu MF,Hoq F,Grilley B,Marcogliese AM,Hanley PJ,Gee AP,Brenner MK,Rooney CM,Heslop HE,Bollard CM

更新日期：2018-11-29 00:00:00

abstract：:Oncogenic RAS alleles encode proteins that accumulate in the guanosine triphosphate (GTP)-bound state. Because post-translational processing of Ras by farnesyltransferase is essential for biologic function, inhibitors of this enzyme have been developed as rational cancer therapeutics. We have investigated farnesyltran...

journal_title：Blood

authors： Mahgoub N,Taylor BR,Gratiot M,Kohl NE,Gibbs JB,Jacks T,Shannon KM

更新日期：1999-10-01 00:00:00

abstract：:The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given...

journal_title：Blood

authors： D'Souza A,Hayman SR,Buadi F,Mauermann M,Lacy MQ,Gertz MA,Kyle RA,Kumar S,Greipp PR,Lust JA,Russell SJ,Zeldenrust S,Dingli D,Witzig TE,Rajkumar SV,Dispenzieri A

更新日期：2011-10-27 00:00:00

abstract：:Investigators in the United Kingdom have shown that hereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history is an ineffective screen, and tissue staining used to type amyloid is unreliable. Misdiagnosis of AL can lead to inappropriate use of chemotherapy and failure to diag...

journal_title：Blood

authors： Comenzo RL,Zhou P,Fleisher M,Clark B,Teruya-Feldstein J

更新日期：2006-05-01 00:00:00

abstract：:Donor-derived T cells have been proposed to play a role in pathogenesis of chronic graft-versus-host disease (cGVHD). The impact of ex vivo T-cell depletion (TCD) on cGVHD was analyzed in a randomized multicenter trial involving unrelated donor marrow transplants. A total of 404 patients diagnosed with hematologic mal...

journal_title：Blood

authors： Pavletic SZ,Carter SL,Kernan NA,Henslee-Downey J,Mendizabal AM,Papadopoulos E,Gingrich R,Casper J,Yanovich S,Weisdorf D,National Heart, Lung, and Blood Institute Unrelated Donor Marrow Transplantation Trial.

更新日期：2005-11-01 00:00:00

abstract：:In a randomized multicenter study the influence of hydroxyurea versus busulfan on the duration of the chronic phase and on survival of chronic myelogenous leukemia (CML) was determined. In addition cross resistance and adverse reactions of the drugs were analyzed. From July 1983 to January 1991, 441 CML patients were ...

journal_title：Blood

authors： Hehlmann R,Heimpel H,Hasford J,Kolb HJ,Pralle H,Hossfeld DK,Queisser W,Löffler H,Heinze B,Georgii A

更新日期：1993-07-15 00:00:00

abstract：:The incidence and severity of acute graft-versus-host disease (GVHD) after allogeneic transplantation using peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor (G-CSF) appear to be no worse than those after bone marrow transplantation, despite the presence of large numbers of T cells i...

journal_title：Blood

authors： Pan L,Delmonte J Jr,Jalonen CK,Ferrara JL

更新日期：1995-12-15 00:00:00