Abstract：
:In animal studies, tetrahydrocannabinol (THC) has been found to affect brain morphology, particularly within areas rich in cannabinoid receptors (e.g., hippocampus, cerebral cortex). While cannabis remains the most widely used illicit drug worldwide, there has been limited work investigating its effects on human brain tissue. In this paper, we conducted a systematic review of existing structural magnetic resonance imaging studies to examine whether cannabis use is associated with significant changes in brain anatomy. We identified only 13 structural neuroimaging studies, which were diverse in terms of sample characteristics (e.g., age of participants, duration and frequency of use) and methodology (e.g., image analysis). No study found global structural changes in cannabis users, although six studies reported regional alterations. While changes in the hippocampus and parahippocampus were frequently identified, the findings were inconsistent across studies. The available literature also provides some evidence that regional structural changes are associated with cannabis use patterns (particularly cumulative dosage and frequency of use), as well as measures of psychopathology (e.g., measures of depressive and psychotic symptoms). Together, these structural imaging findings suggest that THC exposure does affect brain morphology, especially in medial-temporal regions. Given the small literature available and the limitations of studies to date, further research is clearly required, particularly given the prevalence of cannabis use worldwide.
journal_name
Subst Use Misusejournal_title
Substance use & misuseauthors
Lorenzetti V,Lubman DI,Whittle S,Solowij N,Yücel Mdoi
10.3109/10826084.2010.482443subject
Has Abstractpub_date
2010-09-01 00:00:00pages
1787-808issue
11eissn
1082-6084issn
1532-2491journal_volume
45pub_type
杂志文章,评审abstract：:This article recommends a longitudinal, national study of the outcomes of substance user treatment, plus a cohort of users who do not enter treatment. Viewing addiction primarily as a brain disease has provided interesting descriptive information but dismisses the psychological, social, political, economic, and legal ...
journal_title：Substance use & misuse
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journal_title：Substance use & misuse
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abstract：:This study examines patterns of alcohol consumption among the Hispanic immigrant population in Valencia (Spain), and also whether the length of immigrants' residence in our country and perceived degree of discrimination have any influence on such patterns. A total of 610 Spanish-speaking immigrants (314 women, 296 men...
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abstract：:Tobacco involvement among US youth was investigated in a national survey conducted in 2005-2007 of 2,274 respondents aged 14-21, including those not in school. Logistic regressions predicted tobacco involvement. Males had higher rates of tobacco use than females, but males and females had equal rates of heavy use and ...
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journal_title：Substance use & misuse
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journal_title：Substance use & misuse
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journal_title：Substance use & misuse
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journal_title：Substance use & misuse
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journal_title：Substance use & misuse
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