Abstract:
:Objectives: Alcohol abuse is known to result in behavioral impairments (such as increased impulsivity, aggressive, and suicidal behavior), but the neurobiological basis for these behavioral impairments remains unknown. The objective of this review is to propose a neurobiological basis for alcohol-induced aggression, impulsivity, and suicidal behavior. Methods: Search was done by accessing PubMed/Medline, EBSCO, and PsycINFO databases. The search string used was "(Alcohol OR Alcoholism* OR Alcohol Abuse) AND (Behavior* OR Behavioral Impairment or Disorder) AND (Oxidative Stress OR Reactive Oxygen Species)." The electronic databases were searched for titles or abstracts containing these terms in all published articles between January 1, 1960, and May 31, 2019. The search was limited to studies published in English and other languages involving both animal and human subjects. Articles selected included randomized clinical trials (RCTs), observational studies, meta-analyses, and both systemic and narrative reviews, providing both quantitative and qualitative information with a measure of alcohol abuse or alcoholism as an outcome. Exclusion criteria were unpublished data of any form, including conference proceedings and dissertation. New key terms were identified (new term included: "Antioxidants, Neurotransmitters, Dopamine, Serotonin, GABA, Glutamate. Aggression, Impulsivity, Suicidal Behavior, hippocampus, prefrontal cortex, limbic system, psychiatric disorders, PTSD, Anxiety, Depression. These new terms were searched with Alcohol or Alcoholism or Alcohol Abuse and Oxidative Stress separately resulting in the identification of over 3000 articles. 196 were included in this article. Results: Multiple lines of evidence indicate that oxidative stress (OS) plays a critical underlying role in alcohol toxicity and behavioral impairments. Conclusions/Importance: People diagnosed with PTSD, anxiety disorder, depression, and those with a personality high in psychoticism as measured by the P Scale of the Eysenck Personality Questionnaire, with comorbid alcohol abuse or alcohol use disorder (AUD), may display increased impulsivity, aggression, and suicidal behavior because of the potentiating effect of alcohol-induced OS on their elevated brain oxidative status. Antioxidant therapy should be an integral part of acute alcohol intoxication and AUD treatment. Further research is necessary to fully understand the relationship between OS and alcohol-induced behavioral impairments.
journal_name
Subst Use Misusejournal_title
Substance use & misuseauthors
Tobore TOdoi
10.1080/10826084.2019.1645179subject
Has Abstractpub_date
2019-01-01 00:00:00pages
2290-2303issue
14eissn
1082-6084issn
1532-2491journal_volume
54pub_type
杂志文章,评审abstract::Background: Methamphetamine (MA) use among gay, bisexual, and other men who have sex with men (gbMSM) is a pervasive issue, associated with detrimental health outcomes. We identified factors associated with discontinuation or reduction in MA among a subset of gbMSM reporting frequent (at least weekly) use, with a spec...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2020.1756854
更新日期:2020-01-01 00:00:00
abstract::Registered and advanced practice nurses are employed in substance user treatment facilities across the US and in most industrialized countries. Patterns of employment and job descriptions for nurses, however, are highly inconsistent and seriously flawed. Many regulatory system, legislative and government agency factor...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2015.1007681
更新日期:2015-01-01 00:00:00
abstract::While marijuana and cocaine are the two most prevalent drugs used among arrestee populations, benzodiazepine use has surpassed that of opiates in several jurisdictions across the United States. Despite this proliferation, few scholarly works have focused on benzodiazepine use among individuals under criminal justice s...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1081/ja-120016569
更新日期:2003-01-01 00:00:00
abstract::This study was designed to provide reliability testing and validity information of the Drug Attitude Scale (DAS). One hundred twenty-eight subjects were drawn from a residential substance abuse(1) treatment program within a community mental health center. Seventy-five percent of the subjects were males and 25% were fe...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826080500411452
更新日期:2006-01-01 00:00:00
abstract::Federal and state funding agencies are encouraging or mandating the use of empirically supported treatments in addiction programs, yet many programs have not moved in this direction (Forman, Bovasso, and Woody, 2001 ; Roman and Johnson, 2002 ; Willenbring et al., 2004 ). To improve the skills of counselors in communit...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826080903534467
更新日期:2010-05-01 00:00:00
abstract::In Brazil, the medicinal misuse of trihexyphenidyl (Artane) has been observed among several segments of society. The present study was conducted in the city of São Paulo during 2002 to characterize this abuse. A sample of 21 users and 16 ex-users was interviewed using qualitative methodology; the subjects were single,...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1081/ja-200052423
更新日期:2005-01-01 00:00:00
abstract::Background: Maternal depression has been linked to substance use in adolescents, but the mechanisms of the relationship between maternal depression and adolescent substance use are less clear. Specifically, previous literature has overlooked the role of fathers as a potential protective or exacerbating factor in buffe...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2019.1610446
更新日期:2019-01-01 00:00:00
abstract::The study examined a representative sample of the 1,060,000 individuals discharged from drug user treatment in the United States in the 12 months before September 1990, and compared self-reports of behavior 5 years before to 5 years after treatment. Self-reports about recent drug use were compared with urine samples, ...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826080009148243
更新日期:2000-10-01 00:00:00
abstract::This study examined the neurobehavioral functioning of neonates prenatally exposed to methadone (n = 11) or buprenorphine (n = 10), who underwent the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) examinations on days 3, 5, 7, 10, and 14 post-delivery. Linear mixed model analyses revealed that NNNS ...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2010.484474
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Incarcerated populations have high rates of childhood adversities and substance use problems. Moreover, childhood adversities are well-documented predictors of substance misuse. OBJECTIVE:To investigate the impact of childhood sexual and physical abuse, caregiver abuse of drugs or alcohol, and time spent in...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2016.1261899
更新日期:2017-05-12 00:00:00
abstract::Background: Substances that can be vaped include nicotine, marijuana, cocaine, heroin, and a range of synthetic drugs called new psychoactive substances (NPS). Due to the rising popularity of vaping among adolescents, it is crucial to understand the relationships between vaping and illicit drug use. Objectives: This p...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2020.1849305
更新日期:2021-01-01 00:00:00
abstract::In the mid-20th century, Selvararajan Yesudian (1916-1998), who was born in India to a Christian father, a physician, and spent most of his life in Switzerland, coauthored (with Elisabeth Haich) a book entitled Yoga and Health; since then, the coupling of these two words has largely defined the meaning of yoga in the ...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2013.803878
更新日期:2013-09-01 00:00:00
abstract::Background: Little is known about heterogeneity in developmental trajectories of alcohol and marijuana use among at-risk youth. Objective: This study aims to examine how child maltreatment and father structural factors at different stages in the life course are associated with different patterns of alcohol and marijua...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2019.1701033
更新日期:2020-01-01 00:00:00
abstract::Adolescents frequently state health as a broad-ranging reason for wanting to quit smoking. Much less is known regarding performance-related reasons. We hypothesized that more male than female smokers want to quit for performance-related reasons (e.g., to improve athletic performance). As part of a telephone screen to ...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1081/ja-120017652
更新日期:2003-06-01 00:00:00
abstract::Objective and method: Betel (areca) nut has recently received interest from researchers and policy makers for its role as a psychoactive substance. It was historically limited to Asia-pacific region, but with the advent of globalization, it has become an equally challenging public health problem across the globe. Prev...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2019.1660677
更新日期:2020-01-01 00:00:00
abstract::Few studies have focused on cannabis dependence as compared to other drugs more commonly acknowledged as presenting a substantial need for treatment. This paper presents findings from a 2004-2005 study of drug user treatment clients in Southern Ontario, Canada. Clients with cannabis (n = 128) or cocaine (n = 300) as t...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826080802494875
更新日期:2009-01-01 00:00:00
abstract::This article poses questions about the meaning of retention in substance user treatment. Retention has become a "gold standard" for substance user-treatment programs, suggesting it has become more than an indicator of positive outcomes, but a positive treatment outcome in its own right. Retention has been studied in n...
journal_title:Substance use & misuse
pub_type: 杂志文章,评审
doi:10.1080/10826080802525967
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Although a good deal of research has assessed the positive effects that involvement in religion has on alcohol use, there is relatively little research on the negative aspects of religious life and alcohol problems. OBJECTIVES:This study has two objectives. The first is to see if spiritual struggles are ass...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2017.1387567
更新日期:2018-04-16 00:00:00
abstract::Background: Alcohol harm is a major contributor to the burden of disease in South Africa. This study aimed to identify the extent of heavy drinking and symptoms of alcohol problems among adult drinkers and associated demographic and other risk factors in the Tshwane Metropole of South Africa. Methods: A household surv...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2019.1609987
更新日期:2019-01-01 00:00:00
abstract::This paper reviews findings from 58 prospective studies of illicit substance use (ISU) among adolescents. It arranges 384 findings according to three types of influence (viz., social, attitudinal, and intrapersonal) and four levels of influence (viz., ultimate, distal, proximal, and immediate). The bulk of evidence re...
journal_title:Substance use & misuse
pub_type: 杂志文章,评审
doi:10.3109/10826089809059341
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Living in neighborhoods with a high density of alcohol outlets and socioeconomic disadvantage may increase residents' alcohol use. Few researchers have studied these exposures in relation to multiple types of alcohol use, including beverage-specific consumption, and how individual demographic factors influen...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2015.1027927
更新日期:2015-01-01 00:00:00
abstract::Recent research has suggested that depression causes teens to begin smoking to elevate their mood. Other studies, however, have suggested the reverse causal direction: smoking causes depression. To gain a more complete understanding of the relationship between smoking and depression, potential mediators should be expl...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1081/ja-200030505
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The rise in opioid use and overdose has increased the importance of improving data collection methods for the purpose of targeting resources to high-need populations and responding rapidly to emerging trends. OBJECTIVE:To determine whether Twitter data could be used to identify geographic differences in opi...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2018.1458319
更新日期:2018-11-10 00:00:00
abstract::This commentary is a discussion of primary socialization theory emphasizing the centrality of family processes on adolescents' affiliation with deviant peers and subsequent deviant behaviors. The focus of the discussion is the persistent influence of family processes well into adolescence. An empirical model illustrat...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826089909039394
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:HIV infection is problematic among all drug users, not only injection drug users. Drug users are at risk for contracting HIV by engaging in risky sexual behaviors. OBJECTIVE:The present study sought to determine whether inhibitory processes moderate the relationship between problematic drug use and HIV-risk...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2014.912230
更新日期:2014-09-01 00:00:00
abstract::Epidemiological studies among migrant ethnic groups are potentially important as a way to provide insight into the relative importance of genetic, cultural, and socioeconomic factors in the etiology of substance use disorders. This paper summarizes prior United Kingdom studies of the prevalence of substance-use-associ...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826089709055862
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Communal online folk pharmacology fuels the drive for short cuts in attaining muscle enhancement, fat loss, and youthful skin. OBJECTIVES:The study used "netnography" to explore female use of CJC-1295, a synthetic growth hormone analogue from the perspectives contained in Internet forum activity. METHODS:A...
journal_title:Substance use & misuse
pub_type: 杂志文章,评审
doi:10.3109/10826084.2015.1082595
更新日期:2016-01-02 00:00:00
abstract::Despite some skepticism about the existence of sexual addiction, the addiction model has proven very useful for treating compulsive sexual behaviors. Addictive sexual disorders often coexist with chemical dependency and are a frequently unrecognized cause of chemical dependency relapse. Sex addiction also contributes ...
journal_title:Substance use & misuse
pub_type: 杂志文章,评审
doi:10.1081/ja-100108428
更新日期:2001-12-01 00:00:00
abstract::Alcohol and alcohol expectancies relate to sexual victimization. The present study examined these links in a sample of 407 predominantly Hispanic male and female college students, along the Mexico-US border. The study also examined the independent contribution of sexual sensation seeking to the prediction of victimiza...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826081003694854
更新日期:2010-11-01 00:00:00
abstract::We examined the influence of religious denomination (RD) and religiosity/spirituality on licit and illicit substance use beyond the potential impact of parental variables. Data from a representative sample of Swiss men (n = 5,387) approximately 20 years old were collected between August 2010 and November 2011. We aske...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2013.799017
更新日期:2013-09-01 00:00:00