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Aberrant expression of interferon regulatory factor 3 in human lung cancer.

Abstract：

:We analyzed the subcellular distributions and gene structures of interferon regulatory factor 3 (IRF3) transcription factor in 50 cases of human primary lung cancer. The immunohistochemical analyses revealed substantially aberrant IRF3 expression specific to the cancer lesions (2 and 6 tumors with nuclear staining, and 4 and 5 tumors with negative staining, in adenocarcinoma and squamous cell carcinoma, respectively), while the morphologically normal region around the tumors exhibited only cytoplasmic staining. In addition, we determined the sequence of the entire IRF3 coding region, and found two novel variants with the amino acid changes (S(175)(AGC)-->R(175)(CGC) and A(208)(GCC)-->D(208)(GAC)). The R(175) variant was also detected in a morphologically normal region around the nuclear staining squamous cell carcinoma, and exhibited almost the same functions as the wild type IRF3. On the other hand, the D(208) variant, found in the negative staining squamous cell carcinoma cases, reduced the nuclear translocation in response to IkappaB kinase epsilon stimulation, as compared to the wild type IRF3, but the same variant was detected in the surrounding morphologically normal region. The aberrant expression of IRF3 and the novel D(208) variant may provide clues to elucidate the etiology of primary lung cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tokunaga T,Naruke Y,Shigematsu S,Kohno T,Yasui K,Ma Y,Chua KJ,Katayama I,Nakamura T,Hishikawa Y,Koji T,Yatabe Y,Nagayasu T,Fujita T,Matsuyama T,Hayashi H

doi

10.1016/j.bbrc.2010.05.085

subject

Has Abstract

pub_date

2010-06-25 00:00:00

pages

202-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00985-X

journal_volume

397

pub_type

杂志文章

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