In vitro ovine articular chondrocyte proliferation: experiments and modelling.

abstract：OBJECTIVES:To investigate the function and regulatory mechanism of Krüppel-like factor 3 (KLF3) in lung cancer. MATERIALS AND METHODS:KLF3 expression was analysed by qRT-PCR and Western blot assays. The proliferation, migration, invasion, cycle and apoptosis were measured by CCK-8 and EdU, wound-healing and Transwell,...

journal_title：Cell proliferation

authors： Wang R,Xu J,Xu J,Zhu W,Qiu T,Li J,Zhang M,Wang Q,Xu T,Guo R,Lu K,Yin Y,Gu Y,Zhu L,Huang P,Liu P,Liu L,De W,Shu Y

更新日期：2019-03-01 00:00:00

abstract：:Proliferation and multidrug resistance status are key predictors of therapeutic outcome in acute myeloid leukaemia (AML). Anthracyclines such as daunorubicin (DNR) are typically used to treat AML and can induce drug resistance. The goal of the studies described here was to select a combination of fluorescent probes th...

journal_title：Cell proliferation

authors： Boutonnat J,Barbier M,Muirhead K,Mousseau M,Ronot X,Seigneurin D

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:We previously reported that Golgi phosphoprotein 3 (GOLPH3) promotes glioma progression by inhibiting EGFR endocytosis and degradation, leading to EGFR accumulation and PI3K-AKT pathway over-activation. In the current study, we examine whether GOLPH3 affects the response of glioma cells to gefitinib, an EGFR...

journal_title：Cell proliferation

authors： Wang X,Wang Z,Zhang Y,Wang Y,Zhang H,Xie S,Xie P,Yu R,Zhou X

更新日期：2019-07-01 00:00:00

abstract：:On 31 May 2010, 14 072 567 bone marrow/apheresis donors registered in 44 countries and 426 501 cord blood units banked in 26 countries for public use were available to treat candidates to haemopoietic stem cell transplant lacking a family related compatible donor. Despite these impressive numbers, additional efforts a...

journal_title：Cell proliferation

authors： Rebulla P,Lecchi L

更新日期：2011-04-01 00:00:00

abstract：:The human skin equivalent (HSE) is an in vitro reconstructed model that resembles skin morphologically and biochemically. The HSE is formed by overlaying a fibroblast-populated collagen matrix with a suspension of epidermal cells. Basal keratinocytes attach to the dermal equivalent via a newly formed basement membrane...

journal_title：Cell proliferation

authors： Graeter LJ,Hull BE

更新日期：1996-12-01 00:00:00

abstract：:Stem cell research is now a very broad field encompassing cells derived from all stages of life from the embryonic stem cells of the early blastocyst through to the adult stem cells of many tissues of the body. Adult stem cells from a variety of tissues are proving to be pluripotent and can differentiate into cell typ...

journal_title：Cell proliferation

authors： Mackay-Sim A,Silburn P

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Osteosarcoma is the most commonly diagnosed primary malignancy of bone and its overall survival rate is still very low. The molecular mechanisms underlying the progression of osteosarcoma have not been clearly illuminated. Heat shock transcription factor 1 (HSF1) is a key regulator of the heat shock response...

journal_title：Cell proliferation

authors： Zhou Z,Li Y,Jia Q,Wang Z,Wang X,Hu J,Xiao J

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Skin-derived precursors are recognized to be a potentially autologous and accessible source of neural precursor cells for drug screening or cell-based treatments, in many neurological disorders. Thus, it is necessary to investigate appropriate methods for cryopreservation of such human skin-derived precursor...

journal_title：Cell proliferation

authors： Bakhtiari M,Mansouri K,Sadeghi Y,Mostafaie A

更新日期：2012-04-01 00:00:00

abstract：:The relationship of cyclin-dependent kinase inhibitor 3 (CDKN3) with tumours has previously been presented in a number of publications. However, the molecular network and interpretation of CDKN3 through the cell cycle between non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) have remaine...

journal_title：Cell proliferation

authors： Wang L,Sun L,Huang J,Jiang M

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:MicroRNAs are powerful regulators in hepatocellular carcinoma (HCC) tumorigenesis. MicoRNA-191 (miR-191) has been reported to play an important role in HCC, However, the regulatory mechanism is still unclear. In this study, we investigated the role of miR-191 in HCC and studied its underlying mechanisms of a...

journal_title：Cell proliferation

authors： Tian F,Yu C,Wu M,Wu X,Wan L,Zhu X

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the rapid repair potential of adipose-derived stem cells (ADSCs) co-overexpressing VEGF and GDNF on bilateral cavernous nerve injury (BCNI) in rat models. Progressive fibrosis of the penis that occurs shortly after BCNI is a key cause of clinical treatment difficulty of erectile dysfunction (ED)....

journal_title：Cell proliferation

authors： Yang W,Chen Z,Ma X,Ouyang X,Fang J,Wei H

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Vascular disorders are associated with phenotypical switching of vascular smooth muscle cells (VSMCs). We investigated the effect of bone morphogenetic protein (BMP)-2 in controlling VSMC phenotype and vascular disorder progression. Lysine (K)-specific demethylase 1A (KDM1A) has been identified to target BMP...

journal_title：Cell proliferation

authors： Zhang X,Huang T,Zhai H,Peng W,Zhou Y,Li Q,Yang H

更新日期：2020-01-01 00:00:00

abstract：:We previously found that the stable overexpression of oestrogen receptor-alpha in the human endothelial cell line ECV304* inhibits its growth in vitro, and that this inhibition is possibly mediated through a down-regulation of the vasoactive agents endothelin-1 and vascular endothelial growth factor. Here we show an i...

journal_title：Cell proliferation

authors： Ali SH,O'Donnell AL,Balu D,Pohl MB,Seyler MJ,Mohamed S,Mousa S,Dandona P

更新日期：2001-08-01 00:00:00

abstract：:Two groups of male rats were treated orally for 60 days with ebrotidine and cimetidine, used as reference standard, respectively. The dose used of both drugs was 500 mg/kg. A third group, used as control, received 10 ml/kg of an aqueous agar suspension. After receiving the last dose, the animals were killed by inhalat...

journal_title：Cell proliferation

authors： Romero A,Gómez F,Villamayor F,Sacristán A,Ortíz JA

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVES:The main objective of this paper was to investigate whether the oxygen consumption rate (OCR) of cells entrapped in alginate hydrogels depends on presence of soluble factors present in foetal bovine serum (FBS). MATERIALS AND METHODS:Pericellular oxygen concentrations were measured using a photochemical oxy...

journal_title：Cell proliferation

authors： Larsen BE,Pettersen EO,Tønnesen HH,Melvik JE

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Embryo implantation needs a reciprocal interaction between competent embryo and receptive endometrium. Adenosine triphosphate (ATP) produced by stressed or injured cells acts as an important signalling molecule. This study aims to investigate whether adenosine triphosphate (ATP) plays an important role in the...

journal_title：Cell proliferation

authors： Gu XW,Yang Y,Li T,Chen ZC,Fu T,Pan JM,Ou JP,Yang ZM

更新日期：2020-02-01 00:00:00

abstract：:In order to determine the role of micromilieu in tumour spheroid growth, a mathematical model was developed to predict EMT6/Ro spheroid growth and microenvironment based upon numerical solution of the diffusion/reaction equation for oxygen, glucose, lactate ion, carbon dioxide, bicarbonate ion, chlorine ion and hydrog...

journal_title：Cell proliferation

authors： Casciari JJ,Sotirchos SV,Sutherland RM

更新日期：1992-01-01 00:00:00

abstract：:Extracellular vesicles (EVs), a heterogeneous group of vesicles differing in size and shape, cargo content and function, are membrane-bound and nano-sized vesicles that could be released by nearly all variations of cells. EVs have gained considerable attention in the past decades for their functions in modulating inte...

journal_title：Cell proliferation

authors： Wu Z,Zhang Z,Xia W,Cai J,Li Y,Wu S

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Secondary bacterial pneumonia is common following influenza infection. However, it remains unclear about the underlying molecular mechanisms. MATERIALS AND METHODS:We established a mouse model of post-influenza S aureus pneumonia using conditional Shp2 knockout mice (LysMCre/+ :Shp2flox/flox ). The survival...

journal_title：Cell proliferation

authors： Ouyang W,Liu C,Pan Y,Han Y,Yang L,Xia J,Xu F

更新日期：2020-01-01 00:00:00

abstract：:The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This review will focus on these mechanisms, i.e. regulation of cyclin-dependent kinases (CDK) by cyclins, CDK inhibitors and phosphorylating events. The quality checkpoints activated after DNA damage are also discussed. The complexity ...

journal_title：Cell proliferation

authors： Vermeulen K,Van Bockstaele DR,Berneman ZN

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:It is not known whether or not epithelial progenitors of the pyloric antrum are involved in gastric carcinogenesis. Normally, these progenitors give rise to two main cell lineages: pit and gland mucous cells. This study was designed to examine the changes that occur in pyloric antral mucous cell lineages and ...

journal_title：Cell proliferation

authors： Karam SM,Tomasetto C,Rio MC

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:Glucagon-like peptide 2 (GLP2) is involved in the regulation of energy absorption and metabolism. Despite the importance of the GLP2 signalling mechanisms on osteoclast, little has been studied on how GLP2 works during osteoclastogenesis. MATERIALS AND METHODS:RAW264.7 cells were infected with rLV-Green-GLP...

journal_title：Cell proliferation

authors： Lu Y,Lu D,Hu Y

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to obtain antitumour molecules targeting to activate PKM2 through adequate computational methods combined with biological activity experiments. METHODS:The structure-based virtual screening was utilized to screen effective activator targeting PKM2 from ZINC database. Molecular dyna...

journal_title：Cell proliferation

authors： Li Y,Bao M,Yang C,Chen J,Zhou S,Sun R,Wu C,Li X,Bao J

更新日期：2018-12-01 00:00:00

abstract：:RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. To study the possibility of a novel system of cell ablation mediated by RAIDD, a preadipocyte cell line (3T3L1) was stably transfected with a plasmid containi...

journal_title：Cell proliferation

authors： Felmer R,Horvat S,Clinton M,Clark AJ

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:Temozolomide (TMZ) is one of the most commonly used clinical drugs for glioblastoma (GBM) treatment, but its drug sensitivity needs to be improved. Gamabufotalin (CS-6), the primary component of the traditional Chinese medicine "ChanSu," was shown to have strong anti-cancer activity. However, more efforts sh...

journal_title：Cell proliferation

authors： Lan YL,Chen C,Wang X,Lou JC,Xing JS,Zou S,Hu JL,Lyu W,Zhang B

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:It has been widely reported that maternal diabetes impairs oocyte quality. However, the responsible mechanisms remain to be explored. In the present study, we focused on whether SIRT3-GSK3β pathway mediates the meiotic defects in oocytes from diabetic mice. MATERIALS AND METHODS:GSK3β functions in mouse ooc...

journal_title：Cell proliferation

authors： Xin Y,Jin Y,Ge J,Huang Z,Han L,Li C,Wang D,Zhu S,Wang Q

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Five-year survival rate at early lung tumour was about 70%; however, its early diagnosis rate was still at a low level, so the enhancement of diagnosis level for early lung tumour is the key factor to increase the survival rate. Diagnosis and therapy of early lung tumour are still challenged. METHODS:The mag...

journal_title：Cell proliferation

authors： Yang Y,Huang Z,Pu X,Yin G,Wang L,Gao F

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Recent data show that Imatinib mesylate (IM) also affects haematopoietic stem cells (HSC), T lymphocytes and dendritic cells that do not harbour constitutively active tyrosine kinases. MATERIALS AND METHODS:We evaluated possible effects of IM on human bone marrow-derived mesenchymal stem cells (MSC) in vitr...

journal_title：Cell proliferation

authors： Fierro F,Illmer T,Jing D,Schleyer E,Ehninger G,Boxberger S,Bornhäuser M

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:Both interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) are crucially involved in fibrotic events that characterize interstitial lung diseases (ILD). Therefore, the aim of this study was to investigate in primary cultures of normal and fibrotic human lung fibroblasts (HLF), exposed to either...

journal_title：Cell proliferation

authors： Gallelli L,Falcone D,Pelaia G,Renda T,Terracciano R,Malara N,Vatrella A,Sanduzzi A,D'Agostino B,Rossi F,Vancheri C,Maselli R,Marsico SA,Savino R

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Nonylphenol (NP) is present ubiquitously in both aquatic and terrestrial environments. This compound is considered an important endocrine disruptor and its toxic/oestrogenic activity has been investigated in a number of in vitro and in vivo studies. Human exposure to NP may occur by cutaneous absorption, ing...

journal_title：Cell proliferation

authors： Manente L,Sellitti A,Lucariello A,Laforgia V,De Falco M,De Luca A

更新日期：2011-10-01 00:00:00