Interleukin-6 receptor superantagonist Sant7 inhibits TGF-beta-induced proliferation of human lung fibroblasts.

abstract：:Cell proliferation was investigated in human tumour xenografts using bromodeoxyuridine (BrdUrd) labelling, evaluated either by flow cytometry or in tissue sections, and also using the proliferation marker Ki-67. BrdUrd labelling was found to increase when cryostat tumour sections were digested with an enzymic solution...

journal_title：Cell proliferation

authors： Parkins CS,Bush C,Price P,Steel GG

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the rapid repair potential of adipose-derived stem cells (ADSCs) co-overexpressing VEGF and GDNF on bilateral cavernous nerve injury (BCNI) in rat models. Progressive fibrosis of the penis that occurs shortly after BCNI is a key cause of clinical treatment difficulty of erectile dysfunction (ED)....

journal_title：Cell proliferation

authors： Yang W,Chen Z,Ma X,Ouyang X,Fang J,Wei H

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:The bone tissue engineering primarily focuses on three-dimensional co-culture systems, which physical and biological properties resemble the cell matrix of actual tissues. The complex dialogue between bone-forming and endothelial cells (ECs) in a tissue-engineered construct will directly regulate angiogenesi...

journal_title：Cell proliferation

authors： Li L,Li J,Zou Q,Zuo Y,Cai B,Li Y

更新日期：2019-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection in vitro causes transformation of B cells and generates B lymphoblastoid cell lines (LCLs). These LCLs have been widely used for the diagnostic of several genetic metabolic disorders. However, up to now, efficiency of LCL generation has been based on misleading subjective analysis. I...

journal_title：Cell proliferation

authors： Mello AS,Burin MG,Michellin K,Viapiana M,Giugliani R,Coelho JC,Bauer ME

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to obtain antitumour molecules targeting to activate PKM2 through adequate computational methods combined with biological activity experiments. METHODS:The structure-based virtual screening was utilized to screen effective activator targeting PKM2 from ZINC database. Molecular dyna...

journal_title：Cell proliferation

authors： Li Y,Bao M,Yang C,Chen J,Zhou S,Sun R,Wu C,Li X,Bao J

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Small aromatic compounds like flavonoids can intercalate with DNA molecules bringing about conformational changes leading to reduced replication and transcription. Here, we have examined one dietary flavonoid, quercetin (found in many fruit and vegetables), for possible anti-cancer effects, on HeLa cells ori...

journal_title：Cell proliferation

authors： Bishayee K,Ghosh S,Mukherjee A,Sadhukhan R,Mondal J,Khuda-Bukhsh AR

更新日期：2013-04-01 00:00:00

abstract：:RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. To study the possibility of a novel system of cell ablation mediated by RAIDD, a preadipocyte cell line (3T3L1) was stably transfected with a plasmid containi...

journal_title：Cell proliferation

authors： Felmer R,Horvat S,Clinton M,Clark AJ

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:Mitophagy is considered to be a key mechanism in the pathogenesis of intestinal ischaemic reperfusion (IR) injury. NOD-like receptor X1 (NLRX1) is located in the mitochondria and is highly expressed in the intestine, and is known to modulate ROS production, mitochondrial damage, autophagy and apoptosis. Howe...

journal_title：Cell proliferation

authors： Li S,Zhou Y,Gu X,Zhang X,Jia Z

更新日期：2021-01-11 00:00:00

abstract：:A number of techniques, including autoradiography after in vivo administration of tritiated thymidine ([3H]dT), immunohistochemistry after in vivo administration of bromodeoxyuridine (BrdUrd), and flow cytometry (FCM) with and without BrdUrd detection were compared in the epithelium of ventral mouse tongue. Investigat...

journal_title：Cell proliferation

authors： Dörr W,Arui J,Beisker W,Schultz-Hector S

更新日期：1994-06-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a severe health problem worldwide, and vascular calcification (VC) contributes substantially to the cardiovascular morbidity and high mortality of CKD. CKD is often accompanied by a variety of pathophysiological states, such as inflammation, oxidative stress, hyperglycaemia, hyperparath...

journal_title：Cell proliferation

authors： Zhang YX,Tang RN,Wang LT,Liu BC

更新日期：2021-01-27 00:00:00

abstract：:Studies on growth regulation in vitro to a large extent rely on comparison of growth curves. However, these do not discriminate between the relative contributions of the mitotic rate and the apoptotic rate to the net growth rate. In the present study, differential effects of 17beta-oestradiol (E2, 10(-8) M) and/or tam...

journal_title：Cell proliferation

authors： Budtz PE

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:Pre-eclampsia is a leading cause of morbidity and mortality during pregnancy. Although the two forms of this disorder, early- (EOPE) and late-onset of pre-eclampsia (LOPE) are different, the underlying pathology remains elusive. We aim to unravel the difference and to identify novel biomarkers for EOPE and L...

journal_title：Cell proliferation

authors： Guo F,Zhang B,Yang H,Fu Y,Wang Y,Huang J,Cheng M,Li X,Shen Z,Li L,He P,Xiang AP,Wang S,Zhang H

更新日期：2020-12-17 00:00:00

abstract：OBJECTIVES:The main objective of this paper was to investigate whether the oxygen consumption rate (OCR) of cells entrapped in alginate hydrogels depends on presence of soluble factors present in foetal bovine serum (FBS). MATERIALS AND METHODS:Pericellular oxygen concentrations were measured using a photochemical oxy...

journal_title：Cell proliferation

authors： Larsen BE,Pettersen EO,Tønnesen HH,Melvik JE

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Stiffness of bone tissue differs response to its physiological or pathological status, such as osteoporosis or osteosclerosis. Consequently, the function of cells residing in bone tissue including osteoblasts (OBs), osteoclasts and osteocytes will be affected. However, to the best of our knowledge, the detai...

journal_title：Cell proliferation

authors： Zhang T,Lin S,Shao X,Zhang Q,Xue C,Zhang S,Lin Y,Zhu B,Cai X

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:Limbal stem cells (LSC) are self-renewing, highly proliferative cells in vitro, which express a set of specific markers and in vivo have the capacity to reconstruct the entire corneal epithelium in cases of ocular surface injury. Currently, LSC transplantation is a commonly used procedure in patients with ei...

journal_title：Cell proliferation

authors： Monteiro BG,Serafim RC,Melo GB,Silva MC,Lizier NF,Maranduba CM,Smith RL,Kerkis A,Cerruti H,Gomes JA,Kerkis I

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:Accumulating evidence demonstrated that the long noncoding RNA (lncRNA) HOTAIR (Hox transcript antisense intergenic RNA) plays key role in renal cell carcinoma (RCC) malignancy, while microRNA-124 (miR-124) is a tumour suppressor in RCC. The aim of this work was to assess the biological function of HOTAIR an...

journal_title：Cell proliferation

authors： Pan Y,Wu Y,Hu J,Shan Y,Ma J,Ma H,Qi X,Jia L

更新日期：2018-12-01 00:00:00

abstract：:Electromagnetic ultra-wideband pulses (UWB) or nanopulses, are generated by a wide range of electronic devices used in communications and radar technology. However, the specific effects of nanopulse exposure on cell growth and function have not been extensively investigated. Here, studies have been conducted to determ...

journal_title：Cell proliferation

authors： Sylvester PW,Shah SJ,Haynie DT,Briski KP

更新日期：2005-06-01 00:00:00

abstract：:The effect of various GnRH analogues, and their conjugates on proliferation, clonogenicity and cell cycle phase distribution of MCF-7 and Ishikawa human cancer cell lines was studied. GnRH-III, a sea lamprey GnRH analogue reduced cell proliferation by 35% and clonogenicity by 55%. Structural modifications either decre...

journal_title：Cell proliferation

authors： Kálnay A,Pályi I,Vincze B,Mihalik R,Mezõ I,Pató J,Seprõdi J,Lovas S,Murphy RF

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVES:To understand if there exists a functional interaction between arsenic trioxide and paclitaxel in vitro. MATERIALS AND METHODS:HeLa and HCT116 (rho53(+/+) and rho53(-/-)) cells were treated with As2O3 and/or paclitaxel for various times. Treated cells were collected for analyses using a combination of flow ...

journal_title：Cell proliferation

authors： Duan Q,Komissarova E,Dai W

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:This study focuses on experimental analysis and corresponding mathematical simulation of in vitro HUVECs (human umbilical vein endothelial cells) proliferation in the presence of various types of drugs. MATERIALS AND METHODS:HUVECs, once seeded in Petri dishes, were expanded to confluence. Temporal profiles...

journal_title：Cell proliferation

authors： Mancuso L,Scanu M,Pisu M,Concas A,Cao G

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:This study was designed to investigate the role of circ_0078767/miR-330-3p/RASSF1A in non-small-cell lung cancer (NSCLC). Bioinformatic analysis was performed to screen for the differentially expressed genes in NSCLC tissues from adjacent lung tissues. MATERIALS AND METHODS:qRT-PCR was used to detect the RN...

journal_title：Cell proliferation

authors： Chen T,Yang Z,Liu C,Wang L,Yang J,Chen L,Li W

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Fibrotic cataract, including posterior capsule opacification (PCO) and anterior subcapsular cataract (ASC), renders millions of people visually impaired worldwide. However, the underlying mechanism remains poorly understood. Here, we report a miRNA-based regulatory pathway that controls pathological fibrosis...

journal_title：Cell proliferation

authors： Wang X,Wang L,Sun Y,Chen B,Xiong L,Chen J,Huang M,Wu J,Tan X,Zheng Y,Huang S,Liu Y

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:Translational research using adult stem cells derived from various tissues has been highlighted in cell-based therapy. However, there are many limitations to using conventional culture systems of adult stem cells for clinically applicability, including limited combinations of cytokines and use of nutrients d...

journal_title：Cell proliferation

authors： Shin KS,Lee HJ,Jung J,Cha DH,Kim GJ

更新日期：2010-10-01 00:00:00

abstract：:The present study was designed to analyse the effect of red blood cells on T-cell proliferation and expansion. A comparative study was done in peripheral blood cell cultures stimulated with phytohemagglutinin, with or without red blood cells. The presence of red blood cells had a consistent enhancing effect on T lymph...

journal_title：Cell proliferation

authors： Porto B,Fonseca AM,Godinho I,Arosa FA,Porto G

更新日期：2001-12-01 00:00:00

abstract：:Laminin-2 (LN-2, alpha2beta1gamma1) is a basement membrane-associated laminin isoform usually considered in the context of muscle and nerve tissues. To test the hypothesis that LN-2 can additionally modulate epithelial cell biology, an analysis of the role of LN-2 in cell adhesion, activation of signalling intermediat...

journal_title：Cell proliferation

authors： Dowgiert J,Sosne G,Kurpakus-Wheater M

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:Oestrogen is known to inhibit osteoclastogenesis, and numerous studies have identified it as an autophagic activator. To date, the role of oestrogen in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis remains unclear. This study aimed to determine the effect of autophagy regulated by t...

journal_title：Cell proliferation

authors： Cheng L,Zhu Y,Ke D,Xie D

更新日期：2020-04-01 00:00:00

abstract：:Telomere length plays an important role in regulating the proliferative capacity of cells, and serves as a marker for cell cycle history and also for their remaining replicative potential. Mesenchymal stromal cells (MSC) are known to be a significant cell source for therapeutic intervention and tissue engineering. To ...

journal_title：Cell proliferation

authors： Yanada S,Ochi M,Kojima K,Sharman P,Yasunaga Y,Hiyama E

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:Yes-associated protein (YAP) has been reported to regulate cell proliferation and differentiation. We aimed to characterize the role of YAP in angiotensin II (Ang II)-induced hypertensive vascular remodelling (HVR) and vascular smooth muscle cells (VSMCs) phenotypic modulation and to explore the underlying m...

journal_title：Cell proliferation

authors： Lin M,Yuan W,Su Z,Lin C,Huang T,Chen Y,Wang J

更新日期：2018-12-01 00:00:00

abstract：:Neural stem cells (NSCs) are early precursors of neuronal and glial cells. NSCs are capable of generating identical progeny through virtually unlimited numbers of cell divisions (cell proliferation), producing daughter cells committed to differentiation. Nuclear factor kappa B (NF-kappaB) is an inducible, ubiquitous t...

journal_title：Cell proliferation

authors： Piotrowska MJ,Widera D,Kaltschmidt B,an der Heiden U,Kaltschmidt C

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:Somatic stem cells can be obtained from a variety of adult human tissues. However, it was not clear whether human parathyroid glands, which secrete parathyroid hormones and are essential in maintaining homeostasis levels of calcium ions in the circulation, contained stem cells. We aimed to investigate the po...

journal_title：Cell proliferation

authors： Shih YR,Kuo TK,Yang AH,Lee OK,Lee CH

更新日期：2009-08-01 00:00:00