Abstract：
:We measured the magnitude and time course of the increase in palpebral fissure width in ten normal volunteers in response to direct-acting (2.5% phenylephrine, 1% apraclonidine) and indirect-acting (10% cocaine, 1% hydroxyamphetamine) topical adrenergic drugs given in one eye. The increase in the palpebral fissure width of the treated eye was compared to the width of the untreated, control eye during a period of 60 minutes after each drug was administered. The difference in fissure width (asymmetry) between the treated and untreated eyes increased significantly for all drugs during the three- to 60-minute time period after treatment. There was no significant difference in the maximum eyelid effect among the adrenergic drugs tested. The drugs exerted their maximum effect by 30 minutes in 39 of the 40 trials (97.5%). The direct-acting drugs tended to exert their effect more quickly than the indirect-acting drugs. Our results demonstrate the expected increase in palpebral fissure width in response to topical adrenergic drugs in normal eyes. This information will provide a basis for evaluating Müller's muscle and its sympathetic innervation in patients with blepharoptosis.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Munden PM,Kardon RH,Denison CE,Carter KDdoi
10.1016/s0002-9394(14)76775-3subject
Has Abstractpub_date
1991-06-15 00:00:00pages
706-10issue
6eissn
0002-9394issn
1879-1891pii
S0002-9394(14)76775-3journal_volume
111pub_type
杂志文章abstract：:We reviewed the histories of three patients with sebaceous carcinoma (two of the eyelid and one of the caruncle) who had had their tumors excised by surgeons experienced in the Mohs' technique. In each patient the tumor was considered totally excised. In one patient, residual intraepithelial pagetoid sebaceous carcino...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74400-9
更新日期：1987-06-15 00:00:00
abstract：PURPOSE:To report color vision abnormalities associated with diabetic retinopathy. METHODS:Color vision function was measured at baseline in 2,701 patients enrolled in the Early Treatment Diabetic Retinopathy Study, a randomized trial investigating photocoagulation and aspirin in the treatment of diabetic retinopathy....
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(99)00227-5
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:Patients with idiopathic nystagmus syndrome often develop an abnormal head position. A horizontal face turn can be treated with the augmented Kestenbaum procedure, while patients with a chin up or chin down position can be treated with surgery on the vertical recti and/or oblique muscles. Although rare, some pa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.04.034
更新日期：2020-09-01 00:00:00
abstract：:To evaluate the ability of the Friedmann visual field analyzer to determine visual threshold and the depth of visual field defects, we correlated the visual threshold determined kinetically (Goldmann perimeter) with the static threshold (Friedmann analyzer) in various parts of the central field. We found the following...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90390-2
更新日期：1983-05-01 00:00:00
abstract：PURPOSE:A defect in the visual field is one of the serious complications of macular hole surgery. We investigated the relationship between the occurrence of visual field defect and the location of infusion cannula and air pressure during fluid-air exchange. METHODS:We studied 100 eyes from 90 patients with macular hol...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00597-3
更新日期：2000-11-01 00:00:00
abstract：PURPOSE:To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency. DESIGN:Interventional case report. METHODS:A 92-year-old African American woman was diagnosed with C...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.10.048
更新日期：2004-05-01 00:00:00
abstract：:Two patients had ocular myasthenia gravis coexistent with Hashimoto's thyroiditis. A 37-year-old woman presented with diplopia and displayed a head tremor and thyroid enlargement. Thyroid function tests showed an elevated thyroid stimulating hormone (TSH). A quantitative Tensilon test yeilded a "perverse" response and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90691-1
更新日期：1975-06-01 00:00:00
abstract：PURPOSE:To study the effect of commonly used preservative free artificial tear, carboxymethylcellulose (CMC) 0.5% (Refresh Plus, Allergan, Irvine, California) on visual acuity in symptomatic dry eye (SDE) and asymptomatic dry eye (ADE) patients. DESIGN:Nonrandomized prospective clinical trial. METHODS:Prospective stu...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2005.05.001
更新日期：2005-11-01 00:00:00
abstract：:The noninvasive laser Doppler technique was used to study retinal circulatory characteristics in five patients who underwent uncomplicated scleral buckling procedures. In each patient, the systolic/diastolic variation of the red blood cell speed in the retinal arteries (flow pulsatility ratio) was lower in the eye tha...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90012-0
更新日期：1983-02-01 00:00:00
abstract：PURPOSE:To report the formation of pigmented membranes on acrylic intraocular lenses (IOLs) after phacoemulsification and to determine the clinical characteristics of these pigmented membranes. DESIGN:Observational case series. METHODS:Four eyes of three patients were found to have pigmented membranes on their acryli...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.10.020
更新日期：2005-05-01 00:00:00
abstract：:We used wide-field color specular microscopy of the human corneal surface to study the morphologic changes that occur under extended-wear contact lenses. There was a shift in the frequency distribution of surface cells by size to larger cells, suggesting a prolonged residence time on the ocular surface. Other abnormal...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90818-4
更新日期：1986-03-15 00:00:00
abstract：PURPOSE:To report the clinical outcomes of penetrating keratoplasty (PK) after autologous cultivated limbal epithelial transplantation in eyes with limbal stem cell deficiency (LSCD) after ocular surface burns. DESIGN:Retrospective case series. METHODS:This study included 47 patients with unilateral LSCD treated by a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.05.019
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To describe the clinical manifestation and course of disseminated acute lymphoblastic leukemia in an adult. METHODS:Case report. Recurrence of disseminated disease was heralded by "salmon patch" involvement of the conjunctiva. The ocular tumor was treated successfully with external beam radiotherapy. RESULTS:...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71651-4
更新日期：1997-07-01 00:00:00
abstract：:We developed a method to quantify the surface contour of the peripapillary nerve fiber layer from simultaneous stereoscopic videographic images. Parameters that describe this contour are defined and compared to standard optic nerve structural parameters (cup/disk ratio, disk rim area, cup volume) in three age-matched ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73308-2
更新日期：1989-10-15 00:00:00
abstract：:A 53-year-old woman had a spontaneous nontraumatic rupture of the globe secondary to severely increased orbital pressure from an orbital cellulitis. To our knowledge this is the first such case reported. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90477-x
更新日期：1979-08-01 00:00:00
abstract：PURPOSE:Descemet membrane endothelial keratoplasty is a new technique for the replacement of diseased corneal endothelium with healthy donor endothelium. During this procedure, manipulation of the donor endothelium-Descemet membrane layer within the recipient anterior chamber can be associated with loss of the correct ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.01.005
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To examine whether indocyanine green (ICG) dye induces apoptosis in human retinal pigment epithelial (RPE) cells. DESIGN:Laboratory investigation. METHODS:Pure cultures of human RPE cells were isolated. Retinal pigment epithelial cells were incubated with different concentrations of ICG dye (1 mg/ml, 5 mg/ml,...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.11.016
更新日期：2004-05-01 00:00:00
abstract：:We evaluated whether the rate of occurrence of glaucomatous disk damage in eyes with an optic disk hemorrhage differed from the rate of occurrence in control eyes. We compared 24 patients with a disk hemorrhage to 24 control patients, who had been matched for diagnosis, disk appearance, and visual fields. Cup volume a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74272-2
更新日期：1987-04-15 00:00:00
abstract：PURPOSE:To compare the demographics and ocular characteristics, including anterior segment optical coherence tomography images and zonular instability, in eyes with a history of acute angle closure (AAC) attack and subsequent cataract surgery. DESIGN:Retrospective case-control study. METHODS:A total of 68 eyes of 56 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.09.003
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:To provide evidence-based recommendations for diabetic macular edema (DME) management based on updated information from publications on DME treatment modalities. DESIGN:Perspective. METHODS:A literature search for "diabetic macular edema" or "diabetic maculopathy" was performed using the PubMed, Cochrane Libr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,实务指引
doi：10.1016/j.ajo.2013.11.012
更新日期：2014-03-01 00:00:00
abstract：:We investigated albumin and IgG concentrations in the aqueous humor of 41 patients before intracapsular cataract extraction (primary samples) and at the end of surgery (secondary samples). Albumin and IgG concentrations were determined in all samples by means of a quantitative fluoroimmunoassay. A short-term topical a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71914-2
更新日期：1983-12-01 00:00:00
abstract：PURPOSE:To report a patient with ocular ischemic syndrome due to an internal carotid artery stenosis in whom we confirmed improved retinal blood flow noninvasively after carotid endarterectomy. DESIGN:Observational case report. METHODS:Retinal flowmetry. RESULTS:In a 72-year-old hypertensive man with a transient isc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01531-3
更新日期：2002-08-01 00:00:00
abstract：PURPOSE:To evaluate the ocular hypotensive effect and safety of carteolol hydrochloride 1% vs timolol maleate 0.5%. METHODS:One hundred seventy-six patients with ocular hypertension or primary open-angle glaucoma were randomly assigned to receive either carteolol 1% twice a day or timolol maleate 0.5% solution twice a...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0002-9394(14)70865-7
更新日期：1997-10-01 00:00:00
abstract：PURPOSE:To measure the changes in optic disk morphology after unilateral disk hemorrhage and to compare the changes between eyes. DESIGN:Observational case series. METHODS:Ten glaucoma patients who had a unilateral disk hemorrhage were enrolled. The baseline measurements obtained by Heidelberg Retina Tomograph (HRT) ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01791-9
更新日期：2002-12-01 00:00:00
abstract：:In five cases choroidal malignant melanoma spontaneously converted from epitheloid to spindle cell and vice versa. The cultured epitheloid cells divided more frequently and grew faster than the spindle cells. Cells from one tumor were cloned and developed into a cell line. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90528-0
更新日期：1975-09-01 00:00:00
abstract：:We analyzed 34 sets of optic disk photographs from 19 patients with glaucoma who had been followed up for ten years to evaluate changes in the position of the vasculature of the optic disks over time. Each photograph was analyzed by an image analyzer's edge-defining program for optic disk analysis and by three experie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74101-7
更新日期：1987-11-15 00:00:00
abstract：PURPOSE:To determine the incidence of outer foveal defects after macular hole surgery and to evaluate the relationship between the defect and visual outcome. DESIGN:Retrospective, observational case series. METHODS:A retrospective analysis was performed on 50 eyes from 50 patients who underwent macular hole surgery w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.08.034
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:To evaluate the outcome of intravitreal injection of aflibercept in cases with exudative age-related macular degeneration, (AMD) resistant to injections of bevacizumab or ranibizumab. DESIGN:Retrospective observational case series. METHODS:A retrospective chart review at a single institution was conducted to ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.02.017
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:Although the association of cystoid macular edema with peripheral choroidal melanoma has been studied previously, the pathogenesis of cystoid macular edema as evaluated by light and electron microscopy remains controversial. We evaluated the cause of cystoid macular edema at the retinal capillary level. METHOD...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73867-x
更新日期：1995-02-01 00:00:00
abstract：PURPOSE:To correlate visual acuity measured with the Optec 800 to the gold-standard Early Treatment Diabetic Retinopathy Study (ETDRS) chart. DESIGN:Prospective, cross-sectional study. METHODS:Forty patients of the Vanderbilt Eye Institute agreed to undergo visual acuity testing. Five patients were excluded because o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2006.09.053
更新日期：2007-03-01 00:00:00
