Two cases of statin-induced rhabdomyolysis associated with mononeuropathy.

abstract：BACKGROUND AND OBJECTIVES:Oxycodone tamper resistant (OTR) is a new extended-release abuse-deterrent formulation providing improvements in the tamper resistant characteristics. This study aimed to investigate the pharmacokinetic properties of the new OTR tablets and evaluate the bioequivalence of oxycodone from OTR and...

journal_title：Clinical drug investigation

authors： Luo Z,Miao J,Shu S,Wang Y,Zhu X,Hu C,Shen Y

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Recent data suggest that P-glycoprotein may be involved in cellular transport of lacosamide. OBJECTIVE:To investigate potential drug-drug interactions (DDIs) between lacosamide and digoxin, this phase I, multiple-dose, randomised, double-blind, placebo-controlled, crossover trial assessed the pharmacokineti...

journal_title：Clinical drug investigation

authors： Cawello W,Mueller-Voessing C,Andreas JO

更新日期：2014-05-01 00:00:00

abstract：:Psychotropic medications and alcohol are potential risk factors for falls in older adults. However, there has been no appraisal of the literature on whether these medications, both singly and in combination with alcohol, are associated with falls in community dwelling older adults (those aged 60 years and older living...

journal_title：Clinical drug investigation

authors： Laberge S,Crizzle AM

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Sleep architecture changes with age, both in terms of efficiency and total duration of sleep. Hypnotic benzodiazepines promote rapid onset of sleep, uninterrupted sleep and longer duration of sleep in the absence of carryover sedation the following morning; therefore, these may be appropriate f...

journal_title：Clinical drug investigation

authors： De Vanna M,Rubiera M,Onor ML,Aguglia E

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to confirm randomized clinical trial results showing that a fixed timolol/travoprost combination (TT; DuoTrav) controls intraocular pressure (IOP) better than a fixed timolol/latanoprost combination (TL; Xalacom) in everyday ophthalmic practice, when measured in the morning and >24 h...

journal_title：Clinical drug investigation

authors： Denis P,Lafuma A,Jeanbat V,Laurendeau C,Berdeaux G

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Tegoprazan is one of the potassium-competitive acid blockers (P-CABs). It exhibits its anti-secretory effects by competitively and reversibly blocking the availability of K+ of the H+, K+-ATPase. This study was designed to investigate the safety and pharmacokinetics of tegoprazan in healthy Ch...

journal_title：Clinical drug investigation

authors： He J,Cao G,Yu J,Wang J,Cheng N,Wu J,Zhang J,Wu X,Zhang B,Lu J,Chen S

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Elderly patients are more susceptible to Clostridium difficile infections (CDIs). Despite existing guidelines, there is no specific treatment for CDI in geriatrics. Vancomycin is commonly used in the treatment of CDI. Teicoplanin is an alternative glycopeptide which recently received marketing authorization ...

journal_title：Clinical drug investigation

authors： Davido B,Leplay C,Bouchand F,Dinh A,Villart M,Le Quintrec JL,Teillet L,Salomon J,Michelon H

更新日期：2017-07-01 00:00:00

abstract：:Twenty-four patients with vascular disorders, randomly divided into 3 dosage groups of 8 patients, were treated with a single oral dose of sulodexide (50, 100 or 200mg) and placebo. Tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1) activity and antigen, euglobulin lysis time, α2-antiplasmin,...

journal_title：Clinical drug investigation

authors： Messa GL,La Placa G,Puccetti L,Acciavatti A,Provvedi T,Palazzini E,Di Perri T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Matrix metalloproteinases (MMPs) are proteases with different biological and pathological activities, and many have been linked to several diseases. Targeting individual MMPs may offer a safer therapeutic potential for several diseases. We assessed the safety, tolerability, and pharmacokinetic...

journal_title：Clinical drug investigation

authors： Abd-Elaziz K,Voors-Pette C,Wang KL,Pan S,Lee Y,Mao J,Li Y,Chien B,Lau D,Diamant Z

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hypertension remains a major global health problem, and evidence suggests that the majority of patients will require two or more antihypertensive agents in order to reach specified BP targets. Combining two drugs from different classes has the potential to target different aspects of hypertensi...

journal_title：Clinical drug investigation

authors： Barrios V,Brommer P,Haag U,Calderón A,Escobar C

更新日期：2009-01-01 00:00:00

abstract：:Opioids are the most powerful analgesic drugs currently available and consequently form an essential part of the treatment options for malignant and non-malignant chronic pain. However, the benefits of these medications can be offset by gastrointestinal adverse events such as nausea, vomiting and constipation, as well...

journal_title：Clinical drug investigation

authors： Annemans L

更新日期：2011-01-01 00:00:00

abstract：:Appropriate and successful management of pain with opioid analgesics is based on tailoring pharmacologic treatment to the individual and identifying the minimal effective dose at which pain is controlled with minimal adverse effects. Morphine and morphine-like-agonists exhibit similar pharmacodynamic profiles, but sub...

journal_title：Clinical drug investigation

authors： Geppetti P,Benemei S

更新日期：2009-01-01 00:00:00

abstract：:Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. The minor manifestation of the condition is the most common and is characterised by small, shallow, round or oval lesions that are surrounded by a raised erythematous h...

journal_title：Clinical drug investigation

authors： Bell J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Schizophrenia is a severe public health problem and one of the top ten causes of disability, affecting about 1.1% of the world's population. Paliperidone is a new atypical antipsychotic used to treat schizophrenia. Several case reports about unexpected adverse drug reactions of paliperidone ha...

journal_title：Clinical drug investigation

authors： Seo DE,Kim S,Park BJ

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Warfarin-related nephropathy is an unexplained acute kidney injury, and may occur in patients with supratherapeutic INR, in the absence of overt bleeding. Similar findings have been observed in rats treated with dabigatran etexilate. We conducted a prospective study in dabigatran etexilate-tre...

journal_title：Clinical drug investigation

authors： Molteni M,Crippa M,Orenti A,Polo Friz H,Menghini A,Tramacere P,Marano G,Cimminiello C,Boracchi P

更新日期：2019-04-01 00:00:00

abstract：:Intramuscular 17 α-hydroxyprogesterone caproate (Makena(®)), a synthetic progestin, is indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of a singleton spontaneous preterm birth. Makena(®) reduces the risk of preterm birth in this patient population, and is associated...

journal_title：Clinical drug investigation

authors： Hines M,Lyseng-Williamson KA,Deeks ED

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several antiviral therapies are now available for patients with chronic hepatitis B (CHB), but the most cost-effective strategy for Chinese patients is unclear. The aim of this study was to estimate the long-term cost effectiveness of the antiviral treatments (lamivudine, adefovir, telbivudine ...

journal_title：Clinical drug investigation

authors： Zhang C,Ke W,Gao Y,Zhou S,Liu L,Ye X,Yao Z,Yang Y

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Congestion is the main cause of morbidity in patients with heart failure. Treatment of fluid overload is often challenging in everyday clinical practice. OBJECTIVE:The aim of this study was to determine the diuretic effect of acetazolamide in patients with exacerbations of chronic heart failure, in addition...

journal_title：Clinical drug investigation

authors： Imiela T,Budaj A

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Deferiprone (DFP), deferasirox (DFX) and deferoxamine (DFO) are used in thalassaemia major (TM) patients to treat chronic iron overload. We evaluated the cost-effectiveness of DFP, compared with DFX and DFO monotherapy, from an Italian healthcare system perspective. METHODS:A Markov model was used over a time ...

journal_title：Clinical drug investigation

authors： Pepe A,Rossi G,Bentley A,Putti MC,Frizziero L,D'Ascola DG,Cuccia L,Spasiano A,Filosa A,Caruso V,Hanif A,Meloni A

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Patients with schizophrenia or related disorders often switch antipsychotic therapy, most commonly due to lack of efficacy and side effects. The differences in anticipated efficacy and tolerability among atypical antipsychotics may drive switching behaviours. Switching to long-acting antipsychotics may impro...

journal_title：Clinical drug investigation

authors： Rosa F,Schreiner A,Thomas P,Sherif T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The standard of care for HIV treatment is a three-drug regimen consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) and either a non-nucleoside reverse transcriptase inhibitor, a protease inhibitor (PI) or an integrase strand transfer inhibitor. Darunavir boosted with ritonavi...

journal_title：Clinical drug investigation

authors： Lackey P,Mills A,Carpio F,Hsu R,DeJesus E,Pierone G,Henegar C,Fusco J,Fusco G,Wohlfeiler M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:For patients with hypertension, effective 24-hour blood pressure (BP) control is vital to ensure protection against the early morning surge in BP and the associated increased risk of cardiovascular events. The aim of this analysis was to assess the 24-hour antihypertensive efficacy of olmesartan medoxomil (2...

journal_title：Clinical drug investigation

authors： Brunner HR,Arakawa K

更新日期：2006-01-01 00:00:00

abstract：:Doravirine (MK-1439) is a novel non-nucleoside reverse transcriptase inhibitor indicated for the combination treatment of human immunodeficiency virus type-1 (HIV-1) infection. The recommended dose is 100 mg once daily. This review summarizes the pharmacokinetics of doravirine, the influence of intrinsic factors, and ...

journal_title：Clinical drug investigation

authors： Khalilieh S,Yee KL,Sanchez R,Stoch SA,Wenning L,Iwamoto M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Currently evidence about clinical and demographic predictors of response to newer antidepressants such as duloxetine is limited. This study aimed to investigate whether a number of predictors, particularly co-morbid anxiety disorders and anxious depression, are associated with clinical improve...

journal_title：Clinical drug investigation

authors： Nasso ED,Chiesa A,Serretti A,De Ronchi D,Mencacci C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Multimodal pain therapy including cyclo-oxygenase-2 inhibitors can result in optimal pain management with decreased opioid use and fewer opioid-related adverse events. Patient reported outcomes (PROs) help identify benefits in reduced opioid use and increased pain control. METHODS:In this randomized, double...

journal_title：Clinical drug investigation

authors： Langford RM,Joshi GP,Gan TJ,Mattera MS,Chen WH,Revicki DA,Chen C,Zlateva G

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients with cancer are at high risk of major depressive disorder (MDD), but little is known about their MDD treatment. We investigated the use of antidepressants and other drugs for MDD after cancer diagnosis, and patient characteristics associated with their use. METHODS:Adults with a new c...

journal_title：Clinical drug investigation

authors： Akechi T,Fujimoto S,Mishiro I,Murase K

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To compare changes in lipid levels (total cholesterol [total-C], low-density lipoprotein cholesterol [LDL-C], triglycerides [TG], and high-density lipoprotein cholesterol [HDL-C]) for patients who switched from standard fenofibrate 160 mg (requiring dosing with food) to fenofibrate 145 mg with no food effect ...

journal_title：Clinical drug investigation

authors： Davidson MH,Jones PH

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Following oral administration of abiraterone acetate, the parent compound abiraterone acetate is rapidly metabolized to abiraterone. To our knowledge, bioanalytical methods to date have not been able to detect the parent compound in human plasma, and bioassay was only performed on the metabolit...

journal_title：Clinical drug investigation

authors： Bouhajib M,Tayab Z

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Insulin degludec is a basal insulin with a slow and distinct absorption mechanism resulting in an ultra-long, flat, and stable pharmacokinetic profile in patients with diabetes mellitus. The aim of this study was to examine the effect of hepatic impairment on the single-dose pharmacokinetics of...

journal_title：Clinical drug investigation

authors： Kupčová V,Arold G,Roepstorff C,Højbjerre M,Klim S,Haahr H

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Vedolizumab, a humanized monoclonal antibody against the α4β7 integrin, is indicated for treatment of moderately to severely active ulcerative colitis or Crohn's disease. In this placebo-controlled, double-blind, randomized, single ascending-dose study, the pharmacokinetics, pharmacodynamics, ...

journal_title：Clinical drug investigation

authors： Rosario M,Wyant T,Leach T,Sankoh S,Scholz C,Parikh A,Fox I,Feagan BG

更新日期：2016-11-01 00:00:00