The effect of active vitamin D administration on muscle mass in hemodialysis patients.

abstract：BACKGROUND AND OBJECTIVES:Ramucirumab is a fully immunoglobulin G (lgG) monoclonal antibody targeting vascular endothelial growth factor receptor type 2 (VEGFR2). Previous clinical trials suggested ramucirumab could improve the survival and increase the risk of adverse effects. Here, we aimed to assess the efficacy and...

journal_title：Clinical drug investigation

authors： Wang K,Qu X,Wang Y,Dong W,Shen H,Zhang T,Ni Y,Liu Q,Du J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The use of transdermal fentanyl for opioid-naïve patients is restricted, however, transdermal fentanyl is a useful opioid analgesic for patients in whom oral administration is difficult or for those with renal failure. In this study, the efficacy and safety of fentanyl citrate patches was evalu...

journal_title：Clinical drug investigation

authors： Yamaguchi S,Uchida E,Terahara T,Okawa K,Hashimoto F,Tanaka Y

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The use of budesonide/formoterol as both maintenance and reliever therapy in asthma is recommended in many countries; however, there are limited data available for the Asian patient population. OBJECTIVE:This study aimed to evaluate the short-term safety and tolerability of a fixed high-dose combination of ...

journal_title：Clinical drug investigation

authors： Saito T,Hasunuma T

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:This paper aimed to provide an overview from published randomised clinical trials of the efficacy and tolerability of lamotrigine monotherapy compared with carbamazepine and phenytoin when initiated in adult patients with newly diagnosed epilepsy. DESIGN:The review included two double-blind, randomised tria...

journal_title：Clinical drug investigation

authors： Mullens EL

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Sleep architecture changes with age, both in terms of efficiency and total duration of sleep. Hypnotic benzodiazepines promote rapid onset of sleep, uninterrupted sleep and longer duration of sleep in the absence of carryover sedation the following morning; therefore, these may be appropriate f...

journal_title：Clinical drug investigation

authors： De Vanna M,Rubiera M,Onor ML,Aguglia E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:This study was performed in healthy Chinese subjects to evaluate the safety and pharmacokinetic/pharmacodynamic characteristics of a novel injection formulation of dexlansoprazole in the context of single and multiple administration, compared with the original lansoprazole injection. METHODS:H...

journal_title：Clinical drug investigation

authors： Wu L,Liu J,Zheng Y,Zhai Y,Lin M,Wu G,Lv D,Shentu J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Inhaled corticosteroid (ICS)/long-acting beta(2)-agonist (LABA) combinations are the preferred maintenance therapy for adult asthma patients uncontrolled by ICS alone. Supporting data are largely from mixed populations of adolescents and adults, although ICS/LABA combinations are not approved f...

journal_title：Clinical drug investigation

authors： Aalbers R

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Tendon rupture can result from fluoroquinolone exposure. The objective of this study was to quantify relative and absolute risk and determine how risk is affected by timing of exposure. METHODS:The UK Health Improvement Network primary care database was used to perform a nested case-control st...

journal_title：Clinical drug investigation

authors： Morales DR,Slattery J,Pacurariu A,Pinheiro L,McGettigan P,Kurz X

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recently the PatenT (Prevalence, awareness, treatment and control of hypertension in Turkey) study showed that while the prevalence of hypertension in Turkey is high, effective control of BP is infrequently achieved. This study investigated the efficacy and safety of quinapril (as monotherapy o...

journal_title：Clinical drug investigation

authors： Yener G,Aran S,Bahceci M,Ozdemir K,Gultekin F,Lowe W

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:European guidelines do not recommend the use of carbamazepine, levetiracetam, phenobarbital, phenytoin, topiramate and valproic acid in patients taking direct oral anticoagulants (DOACs). Little is known regarding the clinical relevance of the interaction between DOACs and antiepileptic drugs. OBJECTIVES:To...

journal_title：Clinical drug investigation

authors： Giustozzi M,Mazzetti M,Paciaroni M,Agnelli G,Becattini C,Vedovati MC

更新日期：2021-01-01 00:00:00

abstract：:Lung infections caused by invasive filamentous fungi are very rare conditions in AIDS, but must be considered in patients with profound immune suppression especially in the presence of additional risk factors, such as hematologic malignancies, corticosteroid therapy, neutropenia, and chemotherapy. The authors report a...

journal_title：Clinical drug investigation

authors： Pacheco P,Ventura AS,Branco T,Gonçalves L,Carvalho C

更新日期：2013-02-01 00:00:00

abstract：:Doravirine (MK-1439) is a novel non-nucleoside reverse transcriptase inhibitor indicated for the combination treatment of human immunodeficiency virus type-1 (HIV-1) infection. The recommended dose is 100 mg once daily. This review summarizes the pharmacokinetics of doravirine, the influence of intrinsic factors, and ...

journal_title：Clinical drug investigation

authors： Khalilieh S,Yee KL,Sanchez R,Stoch SA,Wenning L,Iwamoto M

更新日期：2020-10-01 00:00:00

abstract：:Heart rate is an established prognostic marker for longevity and is an important contributor in the pathophysiology of various cardiovascular diseases, including ischemic heart disease and heart failure. Most ischemic episodes are triggered by an increase in heart rate, which causes an imbalance between myocardial oxy...

journal_title：Clinical drug investigation

authors： Godino C,Colombo A,Margonato A

更新日期：2017-02-01 00:00:00

abstract：:Mecapegfilgrastim (HHPG-19K) is a long-acting pegylated recombinant human granulocyte-colony stimulating factor (rhG-CSF) that is administered subcutaneously as prophylaxis once per chemotherapy cycle as a weight-adjusted dose of 100 µg/kg or as a 6 mg fixed dose. It is approved in China to reduce the incidence of inf...

journal_title：Clinical drug investigation

authors： Al-Salama ZT,Keam SJ

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:In this study, we evaluated the effectiveness of amlodipine in patients with severe ischaemic left ventricular dysfunction (LVD) and mild to moderate heart failure, but not current angina, assessing the effects of the drug on symptoms, left ventricular function and exercise capacity. PATIENTS AND METHODS:We ...

journal_title：Clinical drug investigation

authors： Perna GP,Valle G,Cianfrone N,Luca GD,Amico C,Coli C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Clinicians must choose between an increasing number of medications for the treatment of pulmonary arterial hypertension (PAH) with different routes of administration, adverse effects, costs and efficacies. We constructed a decision analysis to help inform treatment choices in PAH. METHODS:We c...

journal_title：Clinical drug investigation

authors： Garin MC,Clark L,Chumney EC,Simpson KN,Highland KB

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Propofol is approved both for anaesthesia and sedation during intensive care. Serious adverse reactions with propofol have recently been reported, but patient exposure to the drug is unknown. OBJECTIVE:To investigate the consumption of propofol in Finnish hospitals and to develop a denominator to estimate p...

journal_title：Clinical drug investigation

authors： Kokki H,Närhi U

更新日期：2003-01-01 00:00:00

abstract：:The objective of the present study was to determine the frequency of adverse drug reactions (ADRs) in intensive care units (ICUs) and to evaluate their effect on the length of stay. We performed a prospective study to detect ADRs in 420 patients hospitalised in 10 predetermined beds in the ICU of our hospital between ...

journal_title：Clinical drug investigation

authors： Vargas E,Simón J,Martin JC,Puerro M,Gonzalez-Callejo MA,Jaime M,Gomez-Mayoral B,Duque F,Gomez-Delgado A,Moreno A

更新日期：1998-01-01 00:00:00

abstract：:The role of postprandial hyperglycaemia in contributing to the risk of both micro- and macrovascular complications in patients with diabetes mellitus is being increasingly recognized. In type 2 diabetes, there is a progressive shift in the relative contributions of postprandial and fasting hyperglycaemia to the overal...

journal_title：Clinical drug investigation

authors： Giugliano D,Ceriello A,Razzoli E,Esposito K

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the long-term cost effectiveness of exenatide once weekly (ExQW) versus insulin glargine (IG) or liraglutide 1.2 mg (Lira1.2mg) for the treatment of adult patients with type 2 diabetes mellitus (T2DM) not adequately controlled on oral antidiabetic drug (OAD) therapy...

journal_title：Clinical drug investigation

authors： Tzanetakos C,Bargiota A,Kourlaba G,Gourzoulidis G,Maniadakis N

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Golimumab is a fully human anti-tumor necrosis factor monoclonal antibody approved for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). This study estimated rates of prespecified outcomes in patients with RA, PsA or AS initiating golimumab ...

journal_title：Clinical drug investigation

authors： Ziyadeh NJ,Geldhof A,Noël W,Otero-Lobato M,Esslinger S,Chakravarty SD,Wang Y,Seeger JD

更新日期：2020-11-01 00:00:00

abstract：:The efficacy and tolerability of fluticasone aqueous nasal spray, 200µg once daily for 21 days, was compared with cetirizine, 10mg once daily for 21 days, in a multicentre, randomised, double-blind, double-dummy, parallel group study. 237 evaluable patients aged 12 years and above, with seasonal allergic rhinitis (def...

journal_title：Clinical drug investigation

authors： Vervloet D,Charpin D,Desfougeres JL

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Polypharmacy, regarded as an indicator of potentially inappropriate medications (PIMs), may lead to a higher risk of serious health consequences in elderly patients with osteoporosis. Thus, this study aimed to analyze the association between polypharmacy and hip fracture in patients with osteop...

journal_title：Clinical drug investigation

authors： Park HY,Kim S,Sohn HS,Kwon JW

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The new oral anticoagulants (NOACs) are used for the prevention of thromboembolic complications in patients with non-valvular atrial fibrillation (AF) and those at risk of deep venous thrombosis. Their rapid onset of action and predictable pharmacokinetic and pharmacodynamic profiles make them...

journal_title：Clinical drug investigation

authors： Acanfora D,Acanfora C,Scicchitano P,Longobardi M,Furgi G,Casucci G,Lanzillo B,Dentamaro I,Zito A,Incalzi RA,Ciccone MM

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Concerns that antiepileptic brand-to-generic interchange results in disruption of seizure control are widespread. The objective of this study was to evaluate the safety and tolerability of the brand-to-generic levetiracetam switch in patients with focal or generalized epilepsy. METHODS:A prosp...

journal_title：Clinical drug investigation

authors： Vari MS,Pinto F,Mencaroni E,Giudizioso G,Minetti C,La Neve A,Francavilla T,Piccioli M,Striano S,del Gaudio L,Tovo P,Striano P,Verrotti A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Despite the introduction of Medicare Part D (MPD) and 2012 Affordable Care Act (ACA), patients have a cost burden due to increases in drug prices. To overcome cost barriers, some patients purchase their medications from Canadian online pharmacies as Canadian prescription drug prices are believ...

journal_title：Clinical drug investigation

authors： Kim SH,Ryu YJ,Cho NE,Kim AE,Chang J

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several cases of facial paralysis have been reported following influenza vaccination; however, recent surveillance studies have not shown an increased risk. In this study, we analyzed the vaccine adverse event reporting system (VAERS) data to determine whether the facial paralysis reporting rat...

journal_title：Clinical drug investigation

authors： Kamath A,Maity N,Nayak MA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Dobutamine causes an increase in cardiac output (CO) by augmenting stroke volume (SV) through enhanced left ventricular contractility and by decreasing systemic vascular resistance. However, in some patients, the dominant mechanism by which dobutamine improves left ventricular performance is an...

journal_title：Clinical drug investigation

authors： Ahonen J,Aranko K,Iivanainen A,Maunuksela EL,Paloheimo M,Olkkola KT

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is a general concern about the use of multisource (generic) antibacterials in the clinical setting with registration based solely on bioequivalence data. In order to address this concern, two modified-release formulations of clarithromycin (i.e. the originator Klacid XL and the generic Kl...

journal_title：Clinical drug investigation

authors： Snyman JR,Schoeman HS,Grobusch MP,Henning M,Rabie W,Hira M,Parshotam K,Mithal Y,Singh S,Ramdas Z

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Tegoprazan is one of the potassium-competitive acid blockers (P-CABs). It exhibits its anti-secretory effects by competitively and reversibly blocking the availability of K+ of the H+, K+-ATPase. This study was designed to investigate the safety and pharmacokinetics of tegoprazan in healthy Ch...

journal_title：Clinical drug investigation

authors： He J,Cao G,Yu J,Wang J,Cheng N,Wu J,Zhang J,Wu X,Zhang B,Lu J,Chen S

更新日期：2021-01-01 00:00:00