当前位置： SCI文献检索 > CLINICAL DRUG INVESTIGATION期刊下所有文献 > Comparison of Serology and Reactogenicity between Influenza Subunit Vaccines and Whole Virus or Split Vaccines: A Review and Meta-Analysis of the Literature.

Comparison of Serology and Reactogenicity between Influenza Subunit Vaccines and Whole Virus or Split Vaccines: A Review and Meta-Analysis of the Literature.

Abstract：

:Currently three different inactivated influenza vaccine types are available: whole virus (WV), split (SPL) and subunit (SU) vaccines. Physicians and patients at risk for influenza complications may wonder whether there are important differences between the vaccine types with respect to antibody induction (serology) and adverse effects (reactogenicity). A literature review (1975 to 1995) was performed to evaluate the serology and reactogenicity of SU vaccines in comparison with either split or whole virus vaccines. 22 publications with randomised allocation were identified describing a total of 5416 serological observations, 2858 observations of local reactions, and 2990 observations of systemic reactions. Subjects included those from all age groups from children to the elderly. Absolute protection and reaction rate differences (RD) were calculated for the comparisons SU vs SPL or SU vs WV vaccine. These were subjected to a method of meta-analysis, resulting in pooled rate differences and their 95% confidence intervals. With the exception of the comparison SU vs WV vaccine in subjects born after 1957 and unexposed to the reappearing H1N1 subtype after 1977, no evidence was found to suggest relevant differences in seroresponse among the three currently available inactivated influenza vaccine types. Although insufficient data were available in the meta-analysis for vaccines in children for whom specific recommendations concerning these vaccines exist, adverse events after administration of any of the three vaccine types were generally mild and transitory; however, SU vaccines were associated with a lower frequency of local and systemic reactions.

journal_name

Clin Drug Investig

journal_title

Clinical drug investigation

authors

Beyer WE,Palache AM,Osterhaus AD

doi

10.2165/00044011-199815010-00001

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

1-12

issue

1

eissn

1173-2563

issn

1179-1918

pii

150101

journal_volume

15

pub_type

杂志文章

相关文献

CLINICAL DRUG INVESTIGATION文献大全
  • Effectiveness and satisfaction with zolmitriptan 5 mg nasal spray for treatment of migraine in real-life practice: results of a postmarketing surveillance study.

    abstract：OBJECTIVE:Addressing the needs of migraineurs by actively seeking patient feedback on disease-related disability and treatment satisfaction may lead to improved management and treatment outcomes. Patient feedback can be collected in postmarketing surveillance (PMS) studies. The objective of this PMS study was to evalua...

    journal_title：Clinical drug investigation

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.2165/00044011-200727010-00005

    authors： Diener HC,Evers S

    更新日期：2007-01-01 00:00:00

  • Intraocular pressure control with latanoprost/timolol and travoprost/timolol fixed combinations : a retrospective, multicentre, cross-sectional study.

    abstract：OBJECTIVE:The aim of this study was to confirm randomized clinical trial results showing that a fixed timolol/travoprost combination (TT; DuoTrav) controls intraocular pressure (IOP) better than a fixed timolol/latanoprost combination (TL; Xalacom) in everyday ophthalmic practice, when measured in the morning and >24 h...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/0044011-200828120-00004

    authors： Denis P,Lafuma A,Jeanbat V,Laurendeau C,Berdeaux G

    更新日期：2008-01-01 00:00:00

  • Amlexanox for the treatment of recurrent aphthous ulcers.

    abstract：:Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. The minor manifestation of the condition is the most common and is characterised by small, shallow, round or oval lesions that are surrounded by a raised erythematous h...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200525090-00001

    authors： Bell J

    更新日期：2005-01-01 00:00:00

  • Oral Teicoplanin as an Alternative First-Line Regimen in Clostridium difficile Infection in Elderly Patients: A Case Series.

    abstract：BACKGROUND:Elderly patients are more susceptible to Clostridium difficile infections (CDIs). Despite existing guidelines, there is no specific treatment for CDI in geriatrics. Vancomycin is commonly used in the treatment of CDI. Teicoplanin is an alternative glycopeptide which recently received marketing authorization ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-017-0524-1

    authors： Davido B,Leplay C,Bouchand F,Dinh A,Villart M,Le Quintrec JL,Teillet L,Salomon J,Michelon H

    更新日期：2017-07-01 00:00:00

  • Manidipine for hypertension not controlled by dual therapy in patients with diabetes mellitus: a non-comparative, open-label study.

    abstract：BACKGROUND AND OBJECTIVE:Little is known about the effects of the calcium channel antagonist manidipine when it is added as a third drug in non-controlled hypertensive patients with diabetes mellitus receiving dual antihypertensive therapy. The aim of this study was to evaluate the response in terms of blood pressure (...

    journal_title：Clinical drug investigation

    pub_type： 临床试验,杂志文章

    doi：10.2165/11587400-000000000-00000

    authors： Martell-Claros N,de la Cruz JJ

    更新日期：2011-01-01 00:00:00

  • Reduction in opioid-related adverse events and improvement in function with parecoxib followed by valdecoxib treatment after non-cardiac surgery: a randomized, double-blind, placebo-controlled, parallel-group trial.

    abstract：BACKGROUND:Multimodal pain therapy including cyclo-oxygenase-2 inhibitors can result in optimal pain management with decreased opioid use and fewer opioid-related adverse events. Patient reported outcomes (PROs) help identify benefits in reduced opioid use and increased pain control. METHODS:In this randomized, double...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/11317570-000000000-00000

    authors： Langford RM,Joshi GP,Gan TJ,Mattera MS,Chen WH,Revicki DA,Chen C,Zlateva G

    更新日期：2009-01-01 00:00:00

  • Budget Impact Analysis of Brivaracetam Adjunctive Therapy for Partial-Onset Epileptic Seizures in Valencia Community, Spain.

    abstract：BACKGROUND AND OBJECTIVE:More than 30% of patients with epilepsy have inadequate control of seizures with drug therapy. The goal of this study is to determine the budget impact (BI) of the introduction of brivaracetam to the portfolio of approved drugs in Spain as adjunctive therapy for the treatment of partial-onset e...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-017-0615-z

    authors： Barrachina-Martínez I,Vivas-Consuelo D,Piera-Balbastre A

    更新日期：2018-04-01 00:00:00

  • Intravenous misuse of buprenorphine: characteristics and extent among patients undergoing drug maintenance therapy.

    abstract：:Sublingual buprenorphine [Subutex(R)] is used to treat opioid dependence. However, illicit intravenous (IV) injection of buprenorphine is a widespread problem. This survey investigated the IV misuse of buprenorphine among patients receiving drug replacement therapy at the Drug Addiction Centre in Udine, Italy. All pat...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/11536020-000000000-00000

    authors： Moratti E,Kashanpour H,Lombardelli T,Maisto M

    更新日期：2010-01-01 00:00:00

  • Effectiveness and tolerability of a trandolapril-based antihypertensive treatment regimen over 12 months in actual clinical care across Canada.

    abstract：BACKGROUND AND OBJECTIVES:There is little information on the effects of trandolapril on renal function when used in Canadian general practice. We evaluated the use and blood pressure (BP) lowering effectiveness of trandolapril-based therapies in Canadian conditions of actual care and attempted to capture assessments of...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s40261-013-0092-y

    authors： Tytus R,Burgess E,Maurer J,Vanjaka A

    更新日期：2013-08-01 00:00:00

  • Topical Lomefloxacin versus Topical Chloramphenicol in the Treatment of Acute Bacterial Conjunctivitis.

    abstract：:We performed a prospective, randomised, investigator-masked and parallel-group study to compare topical lomefloxacin 0.3% instilled twice daily with topical chloramphenicol instilled five times daily in the treatment of acute bacterial conjunctivitis. 191 patients (lomefloxacin 96, chloramphenicol 95) were enrolled in...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-199815040-00001

    authors： Agius-Fernandez A,Patterson A,Fsadni M,Jauch A,Raj PS

    更新日期：1998-01-01 00:00:00

  • The Impact of Ramucirumab on Survival in Patients with Advanced Solid Tumors: A Systematic Review and Meta-Analysis of Randomized II/III Controlled Trials.

    abstract：BACKGROUND AND OBJECTIVES:Ramucirumab is a fully immunoglobulin G (lgG) monoclonal antibody targeting vascular endothelial growth factor receptor type 2 (VEGFR2). Previous clinical trials suggested ramucirumab could improve the survival and increase the risk of adverse effects. Here, we aimed to assess the efficacy and...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s40261-015-0355-x

    authors： Wang K,Qu X,Wang Y,Dong W,Shen H,Zhang T,Ni Y,Liu Q,Du J

    更新日期：2016-01-01 00:00:00

  • Treatment of Major Depressive Disorder in Japanese Patients with Cancer: A Matched Cohort Study Using Employer-Based Health Insurance Claims Data.

    abstract：BACKGROUND AND OBJECTIVE:Patients with cancer are at high risk of major depressive disorder (MDD), but little is known about their MDD treatment. We investigated the use of antidepressants and other drugs for MDD after cancer diagnosis, and patient characteristics associated with their use. METHODS:Adults with a new c...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-020-00976-6

    authors： Akechi T,Fujimoto S,Mishiro I,Murase K

    更新日期：2020-12-01 00:00:00

  • Cost-utility of treatments for pulmonary arterial hypertension: a Markov state-transition decision analysis model.

    abstract：BACKGROUND AND OBJECTIVE:Clinicians must choose between an increasing number of medications for the treatment of pulmonary arterial hypertension (PAH) with different routes of administration, adverse effects, costs and efficacies. We constructed a decision analysis to help inform treatment choices in PAH. METHODS:We c...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/11317820-000000000-00000

    authors： Garin MC,Clark L,Chumney EC,Simpson KN,Highland KB

    更新日期：2009-01-01 00:00:00

  • Cost effectiveness of venlafaxine compared with generic fluoxetine or generic amitriptyline in major depressive disorder in the UK.

    abstract：OBJECTIVE:To estimate the cost effectiveness of venlafaxine compared with generic fluoxetine and generic amitriptyline used in major depressive disorder in primary care in the UK. METHODS:A decision-tree model for the treatment of major depressive disorder was constructed using a Delphi panel. The tree was populated w...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200929030-00004

    authors： Lenox-Smith A,Greenstreet L,Burslem K,Knight C

    更新日期：2009-01-01 00:00:00

  • Relative and Absolute Risk of Tendon Rupture with Fluoroquinolone and Concomitant Fluoroquinolone/Corticosteroid Therapy: Population-Based Nested Case-Control Study.

    abstract：BACKGROUND AND OBJECTIVE:Tendon rupture can result from fluoroquinolone exposure. The objective of this study was to quantify relative and absolute risk and determine how risk is affected by timing of exposure. METHODS:The UK Health Improvement Network primary care database was used to perform a nested case-control st...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-018-0729-y

    authors： Morales DR,Slattery J,Pacurariu A,Pinheiro L,McGettigan P,Kurz X

    更新日期：2019-02-01 00:00:00

  • The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in Coronary Artery Disease Patients with Type 2 Diabetes Mellitus: Rationale and Design of RosCal Study.

    abstract：INTRODUCTION:More and more evidence suggests that the density of calcification plays an important role in the plaque stability. However, few studies have investigated the statin treatment on the density of plaque calcification in patients with both coronary artery disease (CAD) and type 2 diabetes mellitus. METHODS:On...

    journal_title：Clinical drug investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/s40261-016-0445-4

    authors： Zhang W,Luan Y,Jin C,Xu S,Bi X,Zhao Y,Qiu F,Fu G,Wang M

    更新日期：2016-12-01 00:00:00

  • Acid-Suppressive Therapy and Risk of Infections: Pros and Cons.

    abstract：:This narrative review summarises the benefits, risks and appropriate use of acid-suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists, advocating a rationale balanced and individualised approach aimed to minimise any serious adverse consequences. It focuses on current controversies on ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40261-017-0519-y

    authors： Fisher L,Fisher A

    更新日期：2017-07-01 00:00:00

  • Indinavir Pharmacokinetics during Different Phases of the Menstrual Cycle in HIV-Infected Women.

    abstract：OBJECTIVE:To characterise the pharmacokinetics of indinavir during different phases of the menstrual cycle in HIV-infected women. DESIGN:Open-label study. SETTING:The immunodeficiency clinic at Erie County Medical Center, Buffalo, New York. PATIENTS:Ten HIV-infected women were enrolled in the study. Eligibility crit...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200222020-00007

    authors： Frost CE,Adams J,Shelton M,Ebid AH,Gugino LJ,Hewitt R,Difrancesco R,Ingalls E,Cousins S,Hu J,Morse GD

    更新日期：2002-01-01 00:00:00

  • Pharmacokinetic and pharmacodynamic profiles of a fixed-dose combination of olmesartan medoxomil and amlodipine in healthy Chinese males and females.

    abstract：OBJECTIVES:This study investigated the pharmacokinetics and pharmacodynamics of a fixed-dose combination (FDC) tablet of olmesartan medoxomil 20 mg and amlodipine 5 mg (CS-8663) in healthy Chinese subjects. METHODS:This single-centre, open-label study was conducted in five healthy males and five females aged 18-45 yea...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-012-0026-0

    authors： Chen X,Hu P,Jiang J,Liu T,Zhong W,Liu H,Zhao Q

    更新日期：2012-12-01 00:00:00

  • Quinapril for treatment of hypertension in Turkey: dose titration and diuretic combination treatment strategies.

    abstract：BACKGROUND AND OBJECTIVE:Recently the PatenT (Prevalence, awareness, treatment and control of hypertension in Turkey) study showed that while the prevalence of hypertension in Turkey is high, effective control of BP is infrequently achieved. This study investigated the efficacy and safety of quinapril (as monotherapy o...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/00044011-200727090-00003

    authors： Yener G,Aran S,Bahceci M,Ozdemir K,Gultekin F,Lowe W

    更新日期：2007-01-01 00:00:00

  • Safety, Tolerability and Pharmacokinetics of Single Ascending and Multiple Oral Doses of Tegoprazan in Healthy Chinese Subjects.

    abstract：BACKGROUND AND OBJECTIVES:Tegoprazan is one of the potassium-competitive acid blockers (P-CABs). It exhibits its anti-secretory effects by competitively and reversibly blocking the availability of K+ of the H+, K+-ATPase. This study was designed to investigate the safety and pharmacokinetics of tegoprazan in healthy Ch...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-020-00986-4

    authors： He J,Cao G,Yu J,Wang J,Cheng N,Wu J,Zhang J,Wu X,Zhang B,Lu J,Chen S

    更新日期：2021-01-01 00:00:00

  • Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data.

    abstract：BACKGROUND AND OBJECTIVE:Schizophrenia treatment has been shifting to resocialization by efficacious antipsychotic drugs. However, even some of the pivotal studies of approved new antipsychotic drugs with proven efficacy had failed due to high placebo response. The aim of this study was to identify the potential factor...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,meta分析

    doi：10.1007/s40261-018-0661-1

    authors： Matsusaki A,Kaneko M,Narukawa M

    更新日期：2018-08-01 00:00:00

  • Efficacy and safety of dutasteride in Chinese adults with symptomatic benign prostatic hyperplasia: a randomized, double-blind, parallel-group, placebo-controlled study with an open-label extension.

    abstract：BACKGROUND:Dutasteride is a dual inhibitor of type I and type II 5α-reductases and provides nearly complete suppression of dihydrotestosterone, which plays a key role in the aetiology and development of benign prostatic hyperplasia (BPH). Most knowledge about the efficacy and safety of dutasteride in BPH derives from t...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/11593750-000000000-00000

    authors： Na Y,Ye Z,Zhang S,Chinese Dutasteride Phase III Trial (ARIA108898) Study Group.

    更新日期：2012-01-01 00:00:00

  • Sodium oxybate: a review of its use in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence.

    abstract：:A liquid formulation of sodium oxybate (Alcover(®)), the sodium salt of γ-hydroxybutyric acid (GHB), is approved in Italy and Austria for use in alcohol withdrawal syndrome and for the maintenance of abstinence in alcohol dependence. This article reviews the efficacy and tolerability of sodium oxybate in alcohol withd...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40261-013-0158-x

    authors： Keating GM

    更新日期：2014-01-01 00:00:00

  • Randomised, double-blind study of the effects of oxybutynin, tolterodine, trospium chloride and placebo on sleep in healthy young volunteers.

    abstract：OBJECTIVE:Central nervous effects of oral anticholinergics may limit the success of incontinence therapy and patient compliance. Only a few studies investigating this topic are available. This study was conducted to determine whether oral anticholinergics alter sleep and psychometric test parameters. DESIGN:Randomised...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200323060-00003

    authors： Diefenbach K,Donath F,Maurer A,Quispe Bravo S,Wernecke KD,Schwantes U,Haselmann J,Roots I

    更新日期：2003-01-01 00:00:00

  • An economic perspective on urinary tract infection: the "costs of resignation".

    abstract：BACKGROUND:Urinary tract infection (UTI) is a leading cause of morbidity in the female population, with high levels of prevalence and recurrence within 6 months. OBJECTIVES:Our objective was to estimate annual costs and health resource utilization by women with UTIs, and the impact on quality of life (QoL) due to lowe...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-013-0069-x

    authors： Ciani O,Grassi D,Tarricone R

    更新日期：2013-04-01 00:00:00

  • The role of topical moxifloxacin, a new antibacterial in Europe, in the treatment of bacterial conjunctivitis.

    abstract：:This article discusses current practice in the treatment of conjunctivitis and how the use of topical moxifloxacin can increase therapeutic effectiveness, reduce treatment failures and, consequently, be cost effective and reduce the societal burden of the disorder. Current practice and effectiveness data were derived ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/11589020-000000000-00000

    authors： Benitez-Del-Castillo J,Verboven Y,Stroman D,Kodjikian L

    更新日期：2011-01-01 00:00:00

  • Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium: randomised, double-blind trial in acute low back pain.

    abstract：BACKGROUND:NSAIDs are widely used for patients presenting with low back pain. A quick-release formulation of lornoxicam, a potent NSAID from the chemical class of oxicams, offers a faster onset of pain relief compared with the standard tablet formulation. METHODS:Time to onset of pain relief with lornoxicam was compar...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/00044011-200626050-00004

    authors： Yakhno N,Guekht A,Skoromets A,Spirin N,Strachunskaya E,Ternavsky A,Olsen KJ,Moller PL

    更新日期：2006-01-01 00:00:00

  • Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index.

    abstract：OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/00044011-200727040-00007

    authors： Raslová K,Tamer SC,Clauson P,Karl D

    更新日期：2007-01-01 00:00:00

  • Pharmacokinetics, Pharmacodynamics and Population Pharmacokinetic/Pharmacodynamic Modelling of Bilastine, a Second-Generation Antihistamine, in Healthy Japanese Subjects.

    abstract：BACKGROUND AND OBJECTIVES:Bilastine is a novel second-generation antihistamine for the symptomatic treatment of allergic rhinitis and urticaria. The objective of this study was to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of bilastine following single and multiple oral doses in healthy Japanese ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40261-016-0447-2

    authors： Togawa M,Yamaya H,Rodríguez M,Nagashima H

    更新日期：2016-12-01 00:00:00