Intraocular pressure control with latanoprost/timolol and travoprost/timolol fixed combinations : a retrospective, multicentre, cross-sectional study.


OBJECTIVE:The aim of this study was to confirm randomized clinical trial results showing that a fixed timolol/travoprost combination (TT; DuoTrav) controls intraocular pressure (IOP) better than a fixed timolol/latanoprost combination (TL; Xalacom) in everyday ophthalmic practice, when measured in the morning and >24 hours after instillation. METHODS:Patients with ocular hypertension or primary open angle glaucoma stabilized on TT or TL were included in this retrospective cross-sectional study. Data on demographics, medical history and previous treatments were extracted from the patients' medical records. Last treatment instillation times and IOP values were recorded at clinic visits. Treatments were compared by analyses of variance, logistic regressions and propensity scores adjusted for confounding factors. RESULTS:Out of 316 patients included, 124 instilled TT, 192 instilled TL and 266 (84.2%) overall had instilled their eye drops within 24 hours. The patients' mean age was 64.5 years and 51.6% were female. Treatment groups were comparable except for longer disease and treatment durations in TL recipients. Worse eye mean IOPs were 25.8 mmHg at diagnosis and 21.9 mmHg on starting their designated fixed combination treatment. The best IOP control was provided by TT instillations (mean IOP 17.1 and 19.0 mmHg in the TT and TL groups, respectively; p < 0.001). This difference was reinforced by results in the subgroup of patients who instilled treatment >24 hours prior to IOP measurement (mean IOP 17.0 and 20.3 mmHg in the TT and TL groups, respectively; p < 0.004). Also, 82.6% of TT patients satisfied their ophthalmologists' IOP targets versus 51.1% of TL patients (p < 0.001). All significant differences persisted after adjustment for confounding factors. CONCLUSION:This study, conducted in routine ophthalmic practice, confirmed published clinical trial results showing that TT provides better IOP control than TL when measured in the morning, and that travoprost has longer-lasting residual effects than latanoprost when IOP is measured >24 hours after instillation. However, readers should interpret these findings in the context of a cross-sectional observational study conducted in a naturalistic setting.


Clin Drug Investig


Denis P,Lafuma A,Jeanbat V,Laurendeau C,Berdeaux G




Has Abstract


2008-01-01 00:00:00














  • Signals of Adverse Drug Reactions of Paliperidone Compared to Other Atypical Antipsychotics Using the Korean Adverse Event Reporting System Database.

    abstract:BACKGROUND AND OBJECTIVES:Schizophrenia is a severe public health problem and one of the top ten causes of disability, affecting about 1.1% of the world's population. Paliperidone is a new atypical antipsychotic used to treat schizophrenia. Several case reports about unexpected adverse drug reactions of paliperidone ha...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Seo DE,Kim S,Park BJ

    更新日期:2020-09-01 00:00:00

  • The Challenge of Pharmacotherapy in Children and Adolescents with Epilepsy-ADHD Comorbidity.

    abstract::Epilepsy is common in children and adolescents where its prevalence is 3.2-5.5/1000. About one-third of patients also have attention deficit hyperactivity/impulsivity disorder (ADHD). The possible relationship between epilepsy and ADHD is still unclear, and ADHD symptoms (such as inattention, hyperactivity, behavioral...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,评审


    authors: Verrotti A,Moavero R,Panzarino G,Di Paolantonio C,Rizzo R,Curatolo P

    更新日期:2018-01-01 00:00:00

  • Pharmacokinetics, safety and tolerability of single and multiple oral doses of aliskiren in healthy Chinese subjects: a randomized, single-blind, parallel-group, placebo-controlled study.

    abstract:BACKGROUND:Aliskiren is the first oral direct renin inhibitor to be approved for the treatment of hypertension. The pharmacokinetic and pharmacodynamic profile of aliskiren has been extensively characterized in Caucasian individuals; however, drug disposition, treatment response and tolerability can vary among ethnic g...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,随机对照试验


    authors: Hu P,Bartlett M,Karan RS,Jiang J,Zhang S,Zhang J,Howard D,Yeh CM,Al-Fayoumi S,Jarugula V,Dole WP

    更新日期:2010-01-01 00:00:00

  • Post-marketing surveillance of acarbose treatment in patients with type 2 diabetes mellitus and subjects with impaired glucose tolerance in China.

    abstract:OBJECTIVE:This open, prospective, non-interventional, non-randomised, multi-centre postmarketing surveillance study was conducted over a mean period of 13.9 weeks to assess the efficacy, safety and acceptance of acarbose in Chinese patients with type 2 diabetes mellitus and subjects with impaired glucose tolerance (IGT...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,多中心研究


    authors: Pan CY,Landen H

    更新日期:2007-01-01 00:00:00

  • Lack of bioequivalence between two aciclovir tablets in healthy subjects.

    abstract:OBJECTIVE:This study aimed to compare the systemic bioavailability of two aciclovir tablets, Rouz-Aciclovir (test) and Zovirax (reference), in 12 healthy volunteers. METHODS:In a crossover design, each subject received a single oral dose of aciclovir 400 mg followed by a 7-day washout period. Plasma concentrations of ...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,随机对照试验


    authors: Amini H,Javan M,Gazerani P,Ghaffari A,Ahmadiani A

    更新日期:2008-01-01 00:00:00

  • Role of lormetazepam in the treatment of insomnia in the elderly.

    abstract:BACKGROUND AND OBJECTIVE:Sleep architecture changes with age, both in terms of efficiency and total duration of sleep. Hypnotic benzodiazepines promote rapid onset of sleep, uninterrupted sleep and longer duration of sleep in the absence of carryover sedation the following morning; therefore, these may be appropriate f...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,随机对照试验


    authors: De Vanna M,Rubiera M,Onor ML,Aguglia E

    更新日期:2007-01-01 00:00:00

  • Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product.

    abstract:BACKGROUND AND OBJECTIVE:The enigmatic etiology of neurodegenerative diseases poses a challenge for the development of novel and efficient drugs. The objective of the present study was to evaluate the efficacy of a polyherbal (test) formulation on cognitive functions, inflammatory markers and oxidative stress in health...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,随机对照试验


    authors: Sadhu A,Upadhyay P,Agrawal A,Ilango K,Karmakar D,Singh GP,Dubey GP

    更新日期:2014-12-01 00:00:00

  • Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts.

    abstract:BACKGROUND:Cutaneous warts are caused by human papilloma virus (HPV) infection. FIT039, a specific inhibitor of CDK9, suppresses the proliferation of DNA viruses in vitro. PURPOSE:We evaluated the safety, plasma concentrations, and efficacy of FIT039 delivered by single application of an adhesive skin patch on normal ...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Sumi E,Nomura T,Asada R,Uozumi R,Tada H,Amino Y,Sawada T,Yonezawa A,Hagiwara M,Kabashima K

    更新日期:2019-01-01 00:00:00

  • Type 2 Diabetes Patients Reach Target Glycemic Control Faster Using IDegLira than Either Insulin Degludec or Liraglutide Given Alone.

    abstract:BACKGROUND AND OBJECTIVES:The time-course when changes in glycemic control and body weight were first manifest in patients with type 2 diabetes mellitus (T2DM) treated with a combination of insulin degludec and liraglutide (IDegLira) was assessed, comparing IDegLira to its individual components. METHODS:Data from week...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Vilsbøll T,Vora J,Jarlov H,Kvist K,Blonde L

    更新日期:2016-04-01 00:00:00

  • Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index.

    abstract:OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Raslová K,Tamer SC,Clauson P,Karl D

    更新日期:2007-01-01 00:00:00

  • Effectiveness and tolerability of a trandolapril-based antihypertensive treatment regimen over 12 months in actual clinical care across Canada.

    abstract:BACKGROUND AND OBJECTIVES:There is little information on the effects of trandolapril on renal function when used in Canadian general practice. We evaluated the use and blood pressure (BP) lowering effectiveness of trandolapril-based therapies in Canadian conditions of actual care and attempted to capture assessments of...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,多中心研究


    authors: Tytus R,Burgess E,Maurer J,Vanjaka A

    更新日期:2013-08-01 00:00:00

  • Pharmacokinetics, safety and tolerability of DA-6034, an anti-inflammatory agent, after single and multiple oral administrations in healthy volunteers.

    abstract:BACKGROUND AND OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. DA-6034 has been shown to be effective in an IBD model and has demonstrated a good toxicological profile in preclinical studies. This study evaluated the tolerability, safety and pharmacokinetics...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,随机对照试验


    authors: Lee J,Shin KH,Kim JR,Lim KS,Jang IJ,Chung JY

    更新日期:2014-01-01 00:00:00

  • Randomised, double-blind study of the effects of oxybutynin, tolterodine, trospium chloride and placebo on sleep in healthy young volunteers.

    abstract:OBJECTIVE:Central nervous effects of oral anticholinergics may limit the success of incontinence therapy and patient compliance. Only a few studies investigating this topic are available. This study was conducted to determine whether oral anticholinergics alter sleep and psychometric test parameters. DESIGN:Randomised...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Diefenbach K,Donath F,Maurer A,Quispe Bravo S,Wernecke KD,Schwantes U,Haselmann J,Roots I

    更新日期:2003-01-01 00:00:00

  • Hospitalization for severe bacterial infections in children after exposure to NSAIDs: a prospective adverse drug reaction reporting study.

    abstract:BACKGROUND:NSAIDs are widely used to treat fever and pain in children, but their possible role in the progression of some bacterial infections is controversial. OBJECTIVE:This study was performed to analyse reported cases of severe bacterial infection associated with NSAID exposure in children admitted for this reason...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Leroy S,Marc E,Bavoux F,Tréluyer JM,Gendrel D,Bréart G,Pons G,Chalumeau M

    更新日期:2010-01-01 00:00:00

  • The Impact of Ramucirumab on Survival in Patients with Advanced Solid Tumors: A Systematic Review and Meta-Analysis of Randomized II/III Controlled Trials.

    abstract:BACKGROUND AND OBJECTIVES:Ramucirumab is a fully immunoglobulin G (lgG) monoclonal antibody targeting vascular endothelial growth factor receptor type 2 (VEGFR2). Previous clinical trials suggested ramucirumab could improve the survival and increase the risk of adverse effects. Here, we aimed to assess the efficacy and...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,meta分析,评审


    authors: Wang K,Qu X,Wang Y,Dong W,Shen H,Zhang T,Ni Y,Liu Q,Du J

    更新日期:2016-01-01 00:00:00

  • Effect of hyaluronidase on the pharmacokinetics of free and total platinum species after intra-arterial Cisplatin in refractory patients with colorectal liver metastases.

    abstract::A pharmacokinetic study was carried out in patients with unresectable colorectal liver metastases who had primarily been included in a phase II trial of intra-arterial cisplatin (DDP) plus intravenous fluorouracil. Ten patients of those accrued for the clinical study underwent the pharmacokinetic investigation upon li...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Civalleri D,Esposito M,De Cain F,Balletto N,Mondini G,Gogioso L,Viale M,Vannozzi MO

    更新日期:1996-08-01 00:00:00

  • Cost-effectiveness analysis of antiviral therapies for hepatitis B e antigen-positive chronic hepatitis B patients in China.

    abstract:BACKGROUND AND OBJECTIVE:Several antiviral therapies are now available for patients with chronic hepatitis B (CHB), but the most cost-effective strategy for Chinese patients is unclear. The aim of this study was to estimate the long-term cost effectiveness of the antiviral treatments (lamivudine, adefovir, telbivudine ...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Zhang C,Ke W,Gao Y,Zhou S,Liu L,Ye X,Yao Z,Yang Y

    更新日期:2015-03-01 00:00:00

  • Cost-utility of treatments for pulmonary arterial hypertension: a Markov state-transition decision analysis model.

    abstract:BACKGROUND AND OBJECTIVE:Clinicians must choose between an increasing number of medications for the treatment of pulmonary arterial hypertension (PAH) with different routes of administration, adverse effects, costs and efficacies. We constructed a decision analysis to help inform treatment choices in PAH. METHODS:We c...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Garin MC,Clark L,Chumney EC,Simpson KN,Highland KB

    更新日期:2009-01-01 00:00:00

  • Drug interactions with levothyroxine therapy in patients with hypothyroidism: observational study in general practice.

    abstract:BACKGROUND AND OBJECTIVES:Several drugs may interact with levothyroxine and reduce its bioavailability. The aim of this study was to analyse the Italian general practice patients with hypothyroidism from 2002-2011, in terms of variation of thyroid-stimulating hormone (TSH) levels, number of levothyroxine prescriptions ...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Trifirò G,Parrino F,Sultana J,Giorgianni F,Ferrajolo C,Bianchini E,Medea G,Benvenga S,Cricelli I,Cricelli C,Lapi F

    更新日期:2015-03-01 00:00:00

  • Efficacy and Safety of Fentanyl Citrate Patch, Including a Low-Dose 0.5 mg Formulation, in Opioid-Naïve Patients with Cancer Pain.

    abstract:BACKGROUND AND OBJECTIVE:The use of transdermal fentanyl for opioid-naïve patients is restricted, however, transdermal fentanyl is a useful opioid analgesic for patients in whom oral administration is difficult or for those with renal failure. In this study, the efficacy and safety of fentanyl citrate patches was evalu...

    journal_title:Clinical drug investigation

    pub_type: 临床试验,杂志文章


    authors: Yamaguchi S,Uchida E,Terahara T,Okawa K,Hashimoto F,Tanaka Y

    更新日期:2020-11-01 00:00:00

  • Basal and Bolus Insulin Dose Changes after Switching Basal Insulin to Insulin Degludec in Patients with Type 1 Diabetes Mellitus: A Pilot Study.

    abstract:BACKGROUND AND OBJECTIVES:Ultra-long-acting insulin degludec (DEG) has a longer duration of action and less daily variability relative to other basal insulin (BI), and thus may benefit patients with type 1 diabetes mellitus (T1DM). We examined the impact of switching BI to DEG on glycemic control and insulin dose in T1...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Hamamoto Y,Honjo S,Fujimoto K,Tokumoto S,Ikeda H,Wada Y,Koshiyama H

    更新日期:2017-09-01 00:00:00

  • Cost Effectiveness of Exenatide Once Weekly Versus Insulin Glargine and Liraglutide for the Treatment of Type 2 Diabetes Mellitus in Greece.

    abstract:OBJECTIVE:The objective of this study was to evaluate the long-term cost effectiveness of exenatide once weekly (ExQW) versus insulin glargine (IG) or liraglutide 1.2 mg (Lira1.2mg) for the treatment of adult patients with type 2 diabetes mellitus (T2DM) not adequately controlled on oral antidiabetic drug (OAD) therapy...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,随机对照试验


    authors: Tzanetakos C,Bargiota A,Kourlaba G,Gourzoulidis G,Maniadakis N

    更新日期:2018-01-01 00:00:00

  • Evaluation of the efficacy and tolerability of acarbose in patients with diabetes mellitus : a postmarketing surveillance study.

    abstract:OBJECTIVE:The efficacy and tolerability of acarbose were examined in a postmarketing surveillance study of 27 803 patients with diabetes mellitus (26 044 were diagnosed as having type 2 diabetes) over a 12-week treatment period. PATIENTS AND M ethods: Overall efficacy data were reported for type 1 and type 2 diabetes, ...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Spengler M,Schmitz H,Landen H

    更新日期:2005-01-01 00:00:00

  • RETRACTED ARTICLE: Combination Antiemetic Regimens for Prevention of Postoperative Nausea and Vomiting : Focus on High-Risk Patients.

    abstract::None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade of one receptor. There is a possibility that a combination of antiemetics with different sites of activity would be more effective than one drug alone for prophylaxis against postoperative nausea and vomiting...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章,收录出版,评审


    authors: Fujii Y

    更新日期:2002-09-01 00:00:00

  • Safety and Feasibility of Treatment with Rivaroxaban for Non-Canonical Indications: A Case Series Analysis.

    abstract:BACKGROUND AND OBJECTIVES:The new oral anticoagulants (NOACs) are used for the prevention of thromboembolic complications in patients with non-valvular atrial fibrillation (AF) and those at risk of deep venous thrombosis. Their rapid onset of action and predictable pharmacokinetic and pharmacodynamic profiles make them...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Acanfora D,Acanfora C,Scicchitano P,Longobardi M,Furgi G,Casucci G,Lanzillo B,Dentamaro I,Zito A,Incalzi RA,Ciccone MM

    更新日期:2016-10-01 00:00:00

  • Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism.

    abstract:BACKGROUND AND OBJECTIVE:The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of d...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Wändell P,Carlsson AC,Sundquist J,Sundquist K

    更新日期:2019-02-01 00:00:00

  • Dosing nucleoside reverse transcriptase inhibitors in adults receiving continuous veno-venous hemofiltration.

    abstract:BACKGROUND AND OBJECTIVE:Characteristics of nucleoside reverse transcriptase inhibitors (NRTIs) make the drug class susceptible to elimination via continuous veno-venous hemofiltration (CVVH), potentially leading to suboptimal drug concentrations if given at the recommended anephric doses during CVVH. The objective of ...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: McLaughlin MM,Ammar AT,Gerzenshtein L,Scarsi KK

    更新日期:2015-04-01 00:00:00

  • Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate.

    abstract:BACKGROUND AND OBJECTIVE:Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine do not affect the pharmacokinetics of lithium or valproate; therefore, concomitant...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Sun L,Yagoda S,Yao B,Graham C,von Moltke L

    更新日期:2020-01-01 00:00:00

  • The role of topical moxifloxacin, a new antibacterial in Europe, in the treatment of bacterial conjunctivitis.

    abstract::This article discusses current practice in the treatment of conjunctivitis and how the use of topical moxifloxacin can increase therapeutic effectiveness, reduce treatment failures and, consequently, be cost effective and reduce the societal burden of the disorder. Current practice and effectiveness data were derived ...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Benitez-Del-Castillo J,Verboven Y,Stroman D,Kodjikian L

    更新日期:2011-01-01 00:00:00

  • α1-Proteinase inhibitor (human) in the treatment of hereditary emphysema secondary to α1-antitrypsin deficiency: number and costs of years of life gained.

    abstract:BACKGROUND:α(1)-Antitrypsin deficiency (α-ATD) is a disorder inherited in an autosomal recessive pattern, with co-dominant alleles known as the protease inhibitor system (Pi). The main function of α(1)-antitrypsin (α-AT) is to protect the lungs against a powerful elastase released from neutrophil leucocytes. α-ATD typi...

    journal_title:Clinical drug investigation

    pub_type: 杂志文章


    authors: Sclar DA,Evans MA,Robison LM,Skaer TL

    更新日期:2012-05-01 00:00:00