当前位置： SCI文献检索 > CLINICAL DRUG INVESTIGATION期刊下所有文献 > Quinapril for treatment of hypertension in Turkey: dose titration and diuretic combination treatment strategies.

Quinapril for treatment of hypertension in Turkey: dose titration and diuretic combination treatment strategies.

Abstract：

BACKGROUND AND OBJECTIVE:Recently the PatenT (Prevalence, awareness, treatment and control of hypertension in Turkey) study showed that while the prevalence of hypertension in Turkey is high, effective control of BP is infrequently achieved. This study investigated the efficacy and safety of quinapril (as monotherapy or in combination with hydrochlorothiazide [HCTZ]) for achieving BP control (target <140/90 mm Hg) in Turkish subjects with mild to moderate hypertension. METHODS:Two-hundred male and female outpatients aged 19-65 years with mild to moderate hypertension (stage I or II, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure 7 guidelines) entered this 12-week, open-label study. All subjects received quinapril 20 mg/day for 6 weeks. If BP targets were achieved at week 6, responders were maintained on 20 mg/day; if BP targets were not achieved, non-responders were randomised to quinapril 40 mg/day or quinapril 20 mg/day + HCTZ 12.5 mg/day for the remainder of the study. RESULTS:After 6 weeks, 63% of subjects achieved BP targets, and 82% of week-6 responders who continued on quinapril 20 mg/day maintained BP targets at week 12. Of the non-responders, 50% and 52% randomised to quinapril 40 mg/day or quinapril 20 mg/day + HCTZ 12.5 mg/day, respectively, went on to achieve BP targets by week 12. Safety was not compromised with increased dosages or use of combination therapy. CONCLUSION:Quinapril was an effective and safe treatment for achieving and maintaining recommended BP targets in this sample population. These findings will provide clinicians in Turkey with valuable data on the use of quinapril for effective control and management of hypertension.

journal_name

Clin Drug Investig

journal_title

Clinical drug investigation

authors

Yener G,Aran S,Bahceci M,Ozdemir K,Gultekin F,Lowe W

doi

10.2165/00044011-200727090-00003

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

613-22

issue

9

eissn

1173-2563

issn

1179-1918

pii

2793

journal_volume

27

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

CLINICAL DRUG INVESTIGATION文献大全