Prescription Drug Price Paradox: Cost Analysis of Canadian Online Pharmacies versus US Medicare Beneficiaries for the Top 100 Drugs.

abstract：BACKGROUND AND OBJECTIVE:More than 30% of patients with epilepsy have inadequate control of seizures with drug therapy. The goal of this study is to determine the budget impact (BI) of the introduction of brivaracetam to the portfolio of approved drugs in Spain as adjunctive therapy for the treatment of partial-onset e...

journal_title：Clinical drug investigation

authors： Barrachina-Martínez I,Vivas-Consuelo D,Piera-Balbastre A

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recently the PatenT (Prevalence, awareness, treatment and control of hypertension in Turkey) study showed that while the prevalence of hypertension in Turkey is high, effective control of BP is infrequently achieved. This study investigated the efficacy and safety of quinapril (as monotherapy o...

journal_title：Clinical drug investigation

authors： Yener G,Aran S,Bahceci M,Ozdemir K,Gultekin F,Lowe W

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The use of fibrinogen concentrate to treat or prevent major bleeding with regard to potential adverse reactions has not been free of controversy. Our objective was to perform a post-authorization safety study to describe the use of Clottafact® (LFB Biomedicaments) fibrinogen concentrate in real...

journal_title：Clinical drug investigation

authors： Colin-Bracamontes I,Pérez-Calatayud ÁA,Carrillo-Esper R,Rodríguez-Ayala E,Padilla-Molina M,Posadas-Nava A,Olvera-Vázquez S,Hernández-Salgado L

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bisphosphonates are commonly used to treat and prevent osteoporosis. These compounds have unusual pharmacokinetic characteristics because they bind strongly to bone, and a portion becomes buried under newly formed bone. Once incorporated into bone tissue, the subsequent release during bone remo...

journal_title：Clinical drug investigation

authors： Lasseter KC,Porras AG,Denker A,Santhanagopal A,Daifotis A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Nonsteroidal anti-inflammatory drugs are effective analgesics but their use during tonsillectomy is controversial because of the risk of postoperative bleeding. The aim of this study was to compare the analgesic efficacy and safety of nimesulide, a preferential cyclo-oxygenase type-2 inhibitor,...

journal_title：Clinical drug investigation

authors： Aho M,Kokki H,Nikanne E

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:This real-world study assessed the prevalence, risk factors for, and incidence of seizures in patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS:Patients with mCRPC were selected from MarketScan Commercial and Medicare Supplemental Databases between 1 January 2009 a...

journal_title：Clinical drug investigation

authors： Dharmani C,Bonafede M,Krivoshik A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several cases of facial paralysis have been reported following influenza vaccination; however, recent surveillance studies have not shown an increased risk. In this study, we analyzed the vaccine adverse event reporting system (VAERS) data to determine whether the facial paralysis reporting rat...

journal_title：Clinical drug investigation

authors： Kamath A,Maity N,Nayak MA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Elderly patients are more susceptible to Clostridium difficile infections (CDIs). Despite existing guidelines, there is no specific treatment for CDI in geriatrics. Vancomycin is commonly used in the treatment of CDI. Teicoplanin is an alternative glycopeptide which recently received marketing authorization ...

journal_title：Clinical drug investigation

authors： Davido B,Leplay C,Bouchand F,Dinh A,Villart M,Le Quintrec JL,Teillet L,Salomon J,Michelon H

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Epidemiological studies and clinical trials have shown that prevention of cardiovascular disease, the ultimate goal of hypertension treatment, requires a sufficient reduction in blood pressure. OBJECTIVE:The primary objective of this study was to compare the mean decrease in systolic (SBP) and diastolic (DB...

journal_title：Clinical drug investigation

authors： Pareek A,Chandurkar NB,Sharma R,Tiwari D,Gupta BS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Warfarin-related nephropathy is an unexplained acute kidney injury, and may occur in patients with supratherapeutic INR, in the absence of overt bleeding. Similar findings have been observed in rats treated with dabigatran etexilate. We conducted a prospective study in dabigatran etexilate-tre...

journal_title：Clinical drug investigation

authors： Molteni M,Crippa M,Orenti A,Polo Friz H,Menghini A,Tramacere P,Marano G,Cimminiello C,Boracchi P

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Characteristics of nucleoside reverse transcriptase inhibitors (NRTIs) make the drug class susceptible to elimination via continuous veno-venous hemofiltration (CVVH), potentially leading to suboptimal drug concentrations if given at the recommended anephric doses during CVVH. The objective of ...

journal_title：Clinical drug investigation

authors： McLaughlin MM,Ammar AT,Gerzenshtein L,Scarsi KK

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIM:Gastro-oesophageal reflux disease is a common medical problem that places a significant financial burden on outpatient pharmaceutical expenditure. A substantial proportion of this expenditure can be attributed to the use of proton pump inhibitors (PPIs). The aim of this analysis was to evaluate the c...

journal_title：Clinical drug investigation

authors： Lucioni C,Mazzi S,Rossi C

更新日期：2005-01-01 00:00:00

abstract：:Cytochrome P450 (CYP) 3A4 has been considered to be the most important enzyme system for metabolism of lopinavir/ritonavir (LPV/r), a widely used HIV protease inhibitor (PI) recommended during pregnancy. Herein we present a clinical case of a pregnant HIV-infected woman who was taking standard doses of LPV/r, 400/100 ...

journal_title：Clinical drug investigation

authors： López Aspiroz E,Cabrera Figueroa SE,Iglesias Gómez A,Valverde Merino MP,Domínguez-Gil Hurlé A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hypertension remains a major global health problem, and evidence suggests that the majority of patients will require two or more antihypertensive agents in order to reach specified BP targets. Combining two drugs from different classes has the potential to target different aspects of hypertensi...

journal_title：Clinical drug investigation

authors： Barrios V,Brommer P,Haag U,Calderón A,Escobar C

更新日期：2009-01-01 00:00:00

abstract：:This review focuses on previously unpublished clinical and pharmacokinetic data with the diclofenac epolamine (diclofenac hydroxyethylpyrrolidine) patch supporting the hypothesis of a topical effect of this formulation. Previous studies have shown that 1 or 2 weeks of treatment with diclofenac epolamine provides pain ...

journal_title：Clinical drug investigation

authors： Petersen B,Rovati S

更新日期：2009-01-01 00:00:00

abstract：:Twenty-four patients with vascular disorders, randomly divided into 3 dosage groups of 8 patients, were treated with a single oral dose of sulodexide (50, 100 or 200mg) and placebo. Tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1) activity and antigen, euglobulin lysis time, α2-antiplasmin,...

journal_title：Clinical drug investigation

authors： Messa GL,La Placa G,Puccetti L,Acciavatti A,Provvedi T,Palazzini E,Di Perri T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Rates and impacts of worsening symptoms in patients with psoriasis have not been well characterized. OBJECTIVES:To assess the risk of clinically relevant worsening of psoriasis symptoms in patients treated with adalimumab versus placebo and to determine the health-related quality-of-life (HRQOL) impacts of ...

journal_title：Clinical drug investigation

authors： Papp KA,Signorovitch J,Ramakrishnan K,Yu AP,Gupta SR,Bao Y,Mulani PM

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The efficacy and tolerability of acarbose were examined in a postmarketing surveillance study of 27 803 patients with diabetes mellitus (26 044 were diagnosed as having type 2 diabetes) over a 12-week treatment period. PATIENTS AND M ethods: Overall efficacy data were reported for type 1 and type 2 diabetes, ...

journal_title：Clinical drug investigation

authors： Spengler M,Schmitz H,Landen H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients with cancer are at high risk of major depressive disorder (MDD), but little is known about their MDD treatment. We investigated the use of antidepressants and other drugs for MDD after cancer diagnosis, and patient characteristics associated with their use. METHODS:Adults with a new c...

journal_title：Clinical drug investigation

authors： Akechi T,Fujimoto S,Mishiro I,Murase K

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Multimodal pain therapy including cyclo-oxygenase-2 inhibitors can result in optimal pain management with decreased opioid use and fewer opioid-related adverse events. Patient reported outcomes (PROs) help identify benefits in reduced opioid use and increased pain control. METHODS:In this randomized, double...

journal_title：Clinical drug investigation

authors： Langford RM,Joshi GP,Gan TJ,Mattera MS,Chen WH,Revicki DA,Chen C,Zlateva G

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The management of advanced gastrointestinal stromal tumors (GISTs) has been modified considerably by the availability of costly tyrosine kinase inhibitors (TKIs); however, the best therapeutic sequence in terms of cost and effectiveness remains unknown. OBJECTIVE:The aim of this study was to compare four ...

journal_title：Clinical drug investigation

authors： Nerich V,Fleck C,Chaigneau L,Isambert N,Borg C,Kalbacher E,Jary M,Simon P,Pivot X,Blay JY,Limat S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. DA-6034 has been shown to be effective in an IBD model and has demonstrated a good toxicological profile in preclinical studies. This study evaluated the tolerability, safety and pharmacokinetics...

journal_title：Clinical drug investigation

authors： Lee J,Shin KH,Kim JR,Lim KS,Jang IJ,Chung JY

更新日期：2014-01-01 00:00:00

abstract：:Currently three different inactivated influenza vaccine types are available: whole virus (WV), split (SPL) and subunit (SU) vaccines. Physicians and patients at risk for influenza complications may wonder whether there are important differences between the vaccine types with respect to antibody induction (serology) an...

journal_title：Clinical drug investigation

authors： Beyer WE,Palache AM,Osterhaus AD

更新日期：1998-01-01 00:00:00

abstract：:Page 806, column 1, line 3: The text, which previously read. ...

journal_title：Clinical drug investigation

authors： Lyseng-Williamson KA

更新日期：2020-03-01 00:00:00

abstract：:A liquid formulation of sodium oxybate (Alcover(®)), the sodium salt of γ-hydroxybutyric acid (GHB), is approved in Italy and Austria for use in alcohol withdrawal syndrome and for the maintenance of abstinence in alcohol dependence. This article reviews the efficacy and tolerability of sodium oxybate in alcohol withd...

journal_title：Clinical drug investigation

authors： Keating GM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost effectiveness of subcutaneous interferon-beta-1a (IFNbeta-1a) 44mug three times weekly in relapsing-remitting multiple sclerosis (RRMS) using an econometric model. METHODS:Data on RRMS patients treated with IFNbeta-1a 22 or 44mug subcutaneously three times weekly or placebo for up to 4 y...

journal_title：Clinical drug investigation

authors： Lepen C,Coyle P,Vollmer T,Blumhardt L,Lilliu H,Beresniak A

更新日期：2003-01-01 00:00:00

abstract：:Oral teneligliptin [Teneglucon® (Argentina)], a dipeptidyl peptidase-4 inhibitor, is indicated for the treatment of adults with type 2 diabetes (T2DM). This article reviews the pharmacology, therapeutic efficacy and tolerability of teneligliptin in the treatment of adults with T2DM. In 12- or 16-week, placebo-controll...

journal_title：Clinical drug investigation

authors： Scott LJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...

journal_title：Clinical drug investigation

authors： Raslová K,Tamer SC,Clauson P,Karl D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hypertension, one of the major treatable cardiovascular (CV) risk factors, usually occurs in association with other major risk factors. As well as providing rapid blood pressure (BP) goal attainment, antihypertensive therapy should also provide reductions in CV events and mortality in a wide r...

journal_title：Clinical drug investigation

authors： Ogilvie RI,Anand S,Roy P,De Souza S,PEACH investigators.

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Injectable collagenase Clostridium histolyticum is efficacious in correcting Dupuytren's contracture as assessed by changes in the angle of contracture and range of motion (ROM). However, clinically important changes in ROM have not been evaluated in depth. The objective of this secondary analy...

journal_title：Clinical drug investigation

authors： Witthaut J,Bushmakin AG,Gerber RA,Cappelleri JC,Le Graverand-Gastineau MP

更新日期：2011-11-01 00:00:00