Dosing nucleoside reverse transcriptase inhibitors in adults receiving continuous veno-venous hemofiltration.

abstract：BACKGROUND AND OBJECTIVES:Dutasteride is currently marketed by GlaxoSmithKline (GSK), either as monotherapy or as a fixed-dose combination with tamsulosin. As part of the project to develop the fixed-dose combination product, alternative formulations of dutasteride were prepared by GSK, and their pharmacokinetic proper...

journal_title：Clinical drug investigation

authors： Fossler M,Zhu J,Roehrborn C,McAleese P,Manyak M

更新日期：2016-09-01 00:00:00

abstract：:None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade of one receptor. There is a possibility that a combination of antiemetics with different sites of activity would be more effective than one drug alone for prophylaxis against postoperative nausea and vomiting...

journal_title：Clinical drug investigation

authors： Fujii Y

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:The efficacy and tolerability of acarbose were examined in a postmarketing surveillance study of 27 803 patients with diabetes mellitus (26 044 were diagnosed as having type 2 diabetes) over a 12-week treatment period. PATIENTS AND M ethods: Overall efficacy data were reported for type 1 and type 2 diabetes, ...

journal_title：Clinical drug investigation

authors： Spengler M,Schmitz H,Landen H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recurrent aphthous ulceration is the most common oral mucosal disease known. It presents as three types: minor (most prevalent), major and herpetiform. However, there are no well established effective and reliable treatments of this condition. Alchemilla vulgaris (Lady's Mantle) has traditional...

journal_title：Clinical drug investigation

authors： Shrivastava R,John GW

更新日期：2006-01-01 00:00:00

abstract：:Intramuscular 17 α-hydroxyprogesterone caproate (Makena(®)), a synthetic progestin, is indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of a singleton spontaneous preterm birth. Makena(®) reduces the risk of preterm birth in this patient population, and is associated...

journal_title：Clinical drug investigation

authors： Hines M,Lyseng-Williamson KA,Deeks ED

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:This paper aimed to provide an overview from published randomised clinical trials of the efficacy and tolerability of lamotrigine monotherapy compared with carbamazepine and phenytoin when initiated in adult patients with newly diagnosed epilepsy. DESIGN:The review included two double-blind, randomised tria...

journal_title：Clinical drug investigation

authors： Mullens EL

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mirabegron, a selective β3-adrenoceptor agonist for the treatment of overactive bladder (OAB), is eliminated by renal and metabolic routes. The potential influence of renal or hepatic impairment on the pharmacokinetics of mirabegron was evaluated. METHODS:Two separate open-label, single-dose,...

journal_title：Clinical drug investigation

authors： Dickinson J,Lewand M,Sawamoto T,Krauwinkel W,Schaddelee M,Keirns J,Kerbusch V,Moy S,Meijer J,Kowalski D,Morton R,Lasseter K,Riff D,Kupčová V,van Gelderen M

更新日期：2013-01-01 00:00:00

abstract：:Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. The minor manifestation of the condition is the most common and is characterised by small, shallow, round or oval lesions that are surrounded by a raised erythematous h...

journal_title：Clinical drug investigation

authors： Bell J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cancer pain affects patients at all stages of the disease and there are clear guidelines for its management. Morphine is considered the first-choice strong opioid in the treatment of moderate-to-severe pain; however, numerous studies have shown that oxycodone controlled-release (CR) has a simi...

journal_title：Clinical drug investigation

authors： Silvestri B,Bandieri E,Del Prete S,Ianniello GP,Micheletto G,Dambrosio M,Sabbatini G,Endrizzi L,Marra A,Aitini E,Calorio A,Garetto F,Nastasi G,Piantedosi F,Sidoti V,Spanu P

更新日期：2008-01-01 00:00:00

abstract：:The role of postprandial hyperglycaemia in contributing to the risk of both micro- and macrovascular complications in patients with diabetes mellitus is being increasingly recognized. In type 2 diabetes, there is a progressive shift in the relative contributions of postprandial and fasting hyperglycaemia to the overal...

journal_title：Clinical drug investigation

authors： Giugliano D,Ceriello A,Razzoli E,Esposito K

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost effectiveness of subcutaneous interferon-beta-1a (IFNbeta-1a) 44mug three times weekly in relapsing-remitting multiple sclerosis (RRMS) using an econometric model. METHODS:Data on RRMS patients treated with IFNbeta-1a 22 or 44mug subcutaneously three times weekly or placebo for up to 4 y...

journal_title：Clinical drug investigation

authors： Lepen C,Coyle P,Vollmer T,Blumhardt L,Lilliu H,Beresniak A

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Despite the introduction of Medicare Part D (MPD) and 2012 Affordable Care Act (ACA), patients have a cost burden due to increases in drug prices. To overcome cost barriers, some patients purchase their medications from Canadian online pharmacies as Canadian prescription drug prices are believ...

journal_title：Clinical drug investigation

authors： Kim SH,Ryu YJ,Cho NE,Kim AE,Chang J

更新日期：2017-10-01 00:00:00

abstract：:We report the case of a 50-year-old male patient with idiopathic generalised epilepsy and porphyria cutanea tarda. Valproic acid and phenobarbital monotherapy controlled seizures but exacerbated porphyric symptomatology, while clobazam, clonazepam and lamotrigine monotherapy were well tolerated as regards porphyric di...

journal_title：Clinical drug investigation

authors： Bilo L,Meo R,Fulvia de Leva M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The degree of cycle control achieved with a hormonal contraceptive method is an important determinant of its acceptance and continuation. This study set out to compare the cycle control and bleeding profile of drospirenone (DRSP) 3 mg/ethinylestradiol (EE) 20 μg in a 24-active pill/4-inert pill...

journal_title：Clinical drug investigation

authors： Anttila L,Neunteufel W,Petraglia F,Marr J,Kunz M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The skeletal muscle relaxant tizanidine is approved by the US FDA and the European Medicines Agency for treating spasticity and is supplied as tablets for oral administration. However, tizanidine has a poor bioavailability, due to extensive first-pass metabolism. Therefore, the nasal route of a...

journal_title：Clinical drug investigation

authors： Vitale DC,Piazza C,Sinagra T,Urso V,Cardì F,Drago F,Salomone S

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to compare the systemic bioavailability of two aciclovir tablets, Rouz-Aciclovir (test) and Zovirax (reference), in 12 healthy volunteers. METHODS:In a crossover design, each subject received a single oral dose of aciclovir 400 mg followed by a 7-day washout period. Plasma concentrations of ...

journal_title：Clinical drug investigation

authors： Amini H,Javan M,Gazerani P,Ghaffari A,Ahmadiani A

更新日期：2008-01-01 00:00:00

abstract：:Opioids are the most powerful analgesic drugs currently available and consequently form an essential part of the treatment options for malignant and non-malignant chronic pain. However, the benefits of these medications can be offset by gastrointestinal adverse events such as nausea, vomiting and constipation, as well...

journal_title：Clinical drug investigation

authors： Annemans L

更新日期：2011-01-01 00:00:00

abstract：:In an in vivo rat model of myocardial infarction, opioid receptor stimulation has been observed to result in a reduction in infarct size similar to that produced by ischaemic preconditioning. The ability of glibenclamide to abolish this effect suggests an involvement of the myocardial ATP-sensitive potassium (K(ATP)) ...

journal_title：Clinical drug investigation

authors： McCormack KJ,Chapleo CB

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of fidarestat (SNK-860) on vibration perception threshold, as measured by C64 quantitative tuning fork (64Hz) analysis, as well as its effects on subjective symptoms in patients with diabetic polyneuro-pathy. DESIGN AND SETTING:Open-label, prospective study conducted at 12 hospitals i...

journal_title：Clinical drug investigation

authors： Hotta N,Yasuda K,Sumita Y,Sano T,Kakuta H,Nagashima M,Hayashi Y,Yamamoto M,Wakao T,Okuyama M,Kobayashi M,Mori K

更新日期：2004-01-01 00:00:00

abstract：:The efficacy and tolerability of fluticasone aqueous nasal spray, 200µg once daily for 21 days, was compared with cetirizine, 10mg once daily for 21 days, in a multicentre, randomised, double-blind, double-dummy, parallel group study. 237 evaluable patients aged 12 years and above, with seasonal allergic rhinitis (def...

journal_title：Clinical drug investigation

authors： Vervloet D,Charpin D,Desfougeres JL

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:As a β-adrenoceptor antagonist (β-blocker), esmolol can reduce cardiac output and the phosphodiesterase III inhibitor milrinone has been shown to improve heart contractility in patients with septic shock. This study was performed to assess the effects of esmolol combined with milrinone in patie...

journal_title：Clinical drug investigation

authors： Wang Z,Wu Q,Nie X,Guo J,Yang C

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:This study investigated the pharmacokinetics and pharmacodynamics of a fixed-dose combination (FDC) tablet of olmesartan medoxomil 20 mg and amlodipine 5 mg (CS-8663) in healthy Chinese subjects. METHODS:This single-centre, open-label study was conducted in five healthy males and five females aged 18-45 yea...

journal_title：Clinical drug investigation

authors： Chen X,Hu P,Jiang J,Liu T,Zhong W,Liu H,Zhao Q

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:TZP-101 is a selective, small molecule ghrelin receptor agonist in clinical development for the treatment of gastric motility disorders. The objectives of this study was to assess pharmacokinetic parameters of TZP-101 after multiple- and single-dose administration to healthy subjects and patien...

journal_title：Clinical drug investigation

authors： Wargin W,Thomas H,Clohs L,St-Louis C,Ejskjaer N,Gutierrez M,Shaughnessy L,Kosutic G

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to confirm randomized clinical trial results showing that a fixed timolol/travoprost combination (TT; DuoTrav) controls intraocular pressure (IOP) better than a fixed timolol/latanoprost combination (TL; Xalacom) in everyday ophthalmic practice, when measured in the morning and >24 h...

journal_title：Clinical drug investigation

authors： Denis P,Lafuma A,Jeanbat V,Laurendeau C,Berdeaux G

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor under clinical investigation in solid tumours. This study evaluated the influence of P-glycoprotein (P-gp) inhibition (single-dose rifampicin) and simultaneous cytochrome P450 3A4 (CYP3A4)/P-gp induction (multiple-dose rifampicin) ...

journal_title：Clinical drug investigation

authors： Shumaker RC,Aluri J,Fan J,Martinez G,Thompson GA,Ren M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A new oral antidiabetic drug class, sodium-glucose co-transporter-2 inhibitors (SGLT-2 inhibitors), has been covered by national health insurance in Taiwan since May 2016. This study estimated the impacts of insurance coverage for SGLT-2 inhibitors on the replacement effects of antidiabetic dr...

journal_title：Clinical drug investigation

authors： Chen HY,Chiu PY,Chang CJ,Tsai LL,Huang YL,Hsu JC

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cerebral vasospasm is a common and serious complication of aneurysmal subarachnoid haemorrhage (SAH). Many studies have revealed a role of inflammation in the development of cerebral vasospasm. This study aimed to investigate whether topically administered dexamethasone could attenuate vasospas...

journal_title：Clinical drug investigation

authors： Fei L,Golwa F

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and tolerability of alendronic acid 70mg once weekly for the treatment of male osteoporosis. PATIENTS AND METHODS:This randomised, double-blind, placebo-controlled, 12-month trial compared the effect of alendronic acid 70mg once weekly or placebo (randomised 2 : 1) on bone mineral de...

journal_title：Clinical drug investigation

authors： Miller PD,Schnitzer T,Emkey R,Orwoll E,Rosen C,Ettinger M,Vandormael K,Daifotis A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fentanyl buccal soluble film (FBSF) is a small, bilayered, water-soluble polymer film (BioErodible MucoAdhesive; BEMA™) that adheres to the buccal mucosa and rapidly delivers fentanyl into the systemic circulation. It is approved for the treatment of cancer breakthrough pain in adult opioid-to...

journal_title：Clinical drug investigation

authors： Finn AL,Vasisht N,Stark JG,Gever LN,Tagarro I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Phenylephrine HCl 10 mg has been used as a nasal decongestant for over 50 years, yet only limited pharmacokinetic and metabolic data are available. The purpose of this study was to evaluate single-dose pharmacokinetics and safety of phenylephrine HCl 10, 20, and 30 mg and to assess cardiovascu...

journal_title：Clinical drug investigation

authors： Gelotte CK,Zimmerman BA

更新日期：2015-09-01 00:00:00