Levetiracetam in idiopathic generalised epilepsy and porphyria cutanea tarda.

abstract：BACKGROUND AND OBJECTIVE:The enigmatic etiology of neurodegenerative diseases poses a challenge for the development of novel and efficient drugs. The objective of the present study was to evaluate the efficacy of a polyherbal (test) formulation on cognitive functions, inflammatory markers and oxidative stress in health...

journal_title：Clinical drug investigation

authors： Sadhu A,Upadhyay P,Agrawal A,Ilango K,Karmakar D,Singh GP,Dubey GP

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:More than 30% of patients with epilepsy have inadequate control of seizures with drug therapy. The goal of this study is to determine the budget impact (BI) of the introduction of brivaracetam to the portfolio of approved drugs in Spain as adjunctive therapy for the treatment of partial-onset e...

journal_title：Clinical drug investigation

authors： Barrachina-Martínez I,Vivas-Consuelo D,Piera-Balbastre A

更新日期：2018-04-01 00:00:00

abstract：:None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade of one receptor. There is a possibility that a combination of antiemetics with different sites of activity would be more effective than one drug alone for prophylaxis against postoperative nausea and vomiting...

journal_title：Clinical drug investigation

authors： Fujii Y

更新日期：2002-09-01 00:00:00

abstract：:The efficacy and tolerability of fluticasone aqueous nasal spray, 200µg once daily for 21 days, was compared with cetirizine, 10mg once daily for 21 days, in a multicentre, randomised, double-blind, double-dummy, parallel group study. 237 evaluable patients aged 12 years and above, with seasonal allergic rhinitis (def...

journal_title：Clinical drug investigation

authors： Vervloet D,Charpin D,Desfougeres JL

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Injectable collagenase Clostridium histolyticum is efficacious in correcting Dupuytren's contracture as assessed by changes in the angle of contracture and range of motion (ROM). However, clinically important changes in ROM have not been evaluated in depth. The objective of this secondary analy...

journal_title：Clinical drug investigation

authors： Witthaut J,Bushmakin AG,Gerber RA,Cappelleri JC,Le Graverand-Gastineau MP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The use of transdermal fentanyl for opioid-naïve patients is restricted, however, transdermal fentanyl is a useful opioid analgesic for patients in whom oral administration is difficult or for those with renal failure. In this study, the efficacy and safety of fentanyl citrate patches was evalu...

journal_title：Clinical drug investigation

authors： Yamaguchi S,Uchida E,Terahara T,Okawa K,Hashimoto F,Tanaka Y

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Propofol is approved both for anaesthesia and sedation during intensive care. Serious adverse reactions with propofol have recently been reported, but patient exposure to the drug is unknown. OBJECTIVE:To investigate the consumption of propofol in Finnish hospitals and to develop a denominator to estimate p...

journal_title：Clinical drug investigation

authors： Kokki H,Närhi U

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dasotraline is a novel inhibitor of dopamine and norepinephrine reuptake currently being investigated in clinical studies for the treatment of attention-deficit/hyperactivity disorder (ADHD). Uniquely, relative to current ADHD medications, dasotraline has a slow absorption and long elimination...

journal_title：Clinical drug investigation

authors： Hopkins SC,Sunkaraneni S,Skende E,Hing J,Passarell JA,Loebel A,Koblan KS

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To estimate the cost effectiveness of venlafaxine compared with generic fluoxetine and generic amitriptyline used in major depressive disorder in primary care in the UK. METHODS:A decision-tree model for the treatment of major depressive disorder was constructed using a Delphi panel. The tree was populated w...

journal_title：Clinical drug investigation

authors： Lenox-Smith A,Greenstreet L,Burslem K,Knight C

更新日期：2009-01-01 00:00:00

abstract：:The Editor-in-Chief has retracted this article because two of the three studies [1, 2] included in the meta-analysis (cited as references 11 and 12) have been retracted due to fabrication of the data, which has rendered the results of this meta-analysis invalid. ...

journal_title：Clinical drug investigation

authors： Iwamoto J,Matsumoto H,Takeda T

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The hematological side effects associated with mycophenolic acid (MPA) are relatively common and have severe consequences. The majority of literature data have not shown clear consistency in the MPA exposure-neutropenia relationship. We hypothesized that (i) adult de novo kidney transplant rec...

journal_title：Clinical drug investigation

authors： Kiang TKL,Partovi N,Shapiro RJ,Berman JM,Collier AC,Ensom MHH

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Characteristics of nucleoside reverse transcriptase inhibitors (NRTIs) make the drug class susceptible to elimination via continuous veno-venous hemofiltration (CVVH), potentially leading to suboptimal drug concentrations if given at the recommended anephric doses during CVVH. The objective of ...

journal_title：Clinical drug investigation

authors： McLaughlin MM,Ammar AT,Gerzenshtein L,Scarsi KK

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Interferon-alpha treatment is associated with a large number of adverse effects. Depressive symptoms are not unexpected, and potentially dangerous psychiatric adverse effects can induce life-threatening conditions. We compared the incidence of depressive symptoms in patients with chronic hepati...

journal_title：Clinical drug investigation

authors： Neri S,Pulvirenti D,Bertino G

更新日期：2006-01-01 00:00:00

abstract：:Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. The minor manifestation of the condition is the most common and is characterised by small, shallow, round or oval lesions that are surrounded by a raised erythematous h...

journal_title：Clinical drug investigation

authors： Bell J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:To evaluate the efficacy and safety of bronchoalveolar lavage (BAL) with diluted porcine surfactant in mechanically ventilated term infants with severe acute respiratory distress syndrome (ARDS) due to meconium aspiration syndrome (MAS). METHODS:Eight consecutive mechanically ventilated term infants with se...

journal_title：Clinical drug investigation

authors： Lista G,Bianchi S,Castoldi F,Fontana P,Cavigioli F

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Schizophrenia is a severe public health problem and one of the top ten causes of disability, affecting about 1.1% of the world's population. Paliperidone is a new atypical antipsychotic used to treat schizophrenia. Several case reports about unexpected adverse drug reactions of paliperidone ha...

journal_title：Clinical drug investigation

authors： Seo DE,Kim S,Park BJ

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dutasteride is currently marketed by GlaxoSmithKline (GSK), either as monotherapy or as a fixed-dose combination with tamsulosin. As part of the project to develop the fixed-dose combination product, alternative formulations of dutasteride were prepared by GSK, and their pharmacokinetic proper...

journal_title：Clinical drug investigation

authors： Fossler M,Zhu J,Roehrborn C,McAleese P,Manyak M

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE AND DESIGN:There is comparatively little information on asthma management in China. A multicentre, randomised, open-label, parallel-group, 6-week treatment study was conducted to evaluate the efficacy and safety of salmeterol/fluticasone propionate combination treatment in Chinese adult asthmatic patients. S...

journal_title：Clinical drug investigation

authors： Zhong NS,Ping ZJ,Humphries MJ,Xin D

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Elderly patients are more susceptible to Clostridium difficile infections (CDIs). Despite existing guidelines, there is no specific treatment for CDI in geriatrics. Vancomycin is commonly used in the treatment of CDI. Teicoplanin is an alternative glycopeptide which recently received marketing authorization ...

journal_title：Clinical drug investigation

authors： Davido B,Leplay C,Bouchand F,Dinh A,Villart M,Le Quintrec JL,Teillet L,Salomon J,Michelon H

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hypertension remains a major global health problem, and evidence suggests that the majority of patients will require two or more antihypertensive agents in order to reach specified BP targets. Combining two drugs from different classes has the potential to target different aspects of hypertensi...

journal_title：Clinical drug investigation

authors： Barrios V,Brommer P,Haag U,Calderón A,Escobar C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Status epilepticus (SE) is an important emergency situation associated with high morbidity and mortality. The goal of pharmacological therapy-rapid seizure termination-is only achieved in just over half of patients with first-line anti-epileptic drug (AED) therapy and many patients require sec...

journal_title：Clinical drug investigation

authors： Moreno Morales EY,Fernandez Peleteiro M,Bondy Peña EC,Domínguez Lorenzo JM,Pardellas Santiago E,Fernández A

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recently the PatenT (Prevalence, awareness, treatment and control of hypertension in Turkey) study showed that while the prevalence of hypertension in Turkey is high, effective control of BP is infrequently achieved. This study investigated the efficacy and safety of quinapril (as monotherapy o...

journal_title：Clinical drug investigation

authors： Yener G,Aran S,Bahceci M,Ozdemir K,Gultekin F,Lowe W

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...

journal_title：Clinical drug investigation

authors： Raslová K,Tamer SC,Clauson P,Karl D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:α(1)-Antitrypsin deficiency (α-ATD) is a disorder inherited in an autosomal recessive pattern, with co-dominant alleles known as the protease inhibitor system (Pi). The main function of α(1)-antitrypsin (α-AT) is to protect the lungs against a powerful elastase released from neutrophil leucocytes. α-ATD typi...

journal_title：Clinical drug investigation

authors： Sclar DA,Evans MA,Robison LM,Skaer TL

更新日期：2012-05-01 00:00:00

abstract：:Despite the availability of effective pain treatments, there are numerous barriers to effective management resulting in a large proportion of patients not achieving optimal pain control. Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraint...

journal_title：Clinical drug investigation

authors： Zuccaro SM,Vellucci R,Sarzi-Puttini P,Cherubino P,Labianca R,Fornasari D

更新日期：2012-02-22 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Phenylephrine HCl 10 mg has been used as a nasal decongestant for over 50 years, yet only limited pharmacokinetic and metabolic data are available. The purpose of this study was to evaluate single-dose pharmacokinetics and safety of phenylephrine HCl 10, 20, and 30 mg and to assess cardiovascu...

journal_title：Clinical drug investigation

authors： Gelotte CK,Zimmerman BA

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Clinicians must choose between an increasing number of medications for the treatment of pulmonary arterial hypertension (PAH) with different routes of administration, adverse effects, costs and efficacies. We constructed a decision analysis to help inform treatment choices in PAH. METHODS:We c...

journal_title：Clinical drug investigation

authors： Garin MC,Clark L,Chumney EC,Simpson KN,Highland KB

更新日期：2009-01-01 00:00:00

abstract：:We performed a prospective, randomised, investigator-masked and parallel-group study to compare topical lomefloxacin 0.3% instilled twice daily with topical chloramphenicol instilled five times daily in the treatment of acute bacterial conjunctivitis. 191 patients (lomefloxacin 96, chloramphenicol 95) were enrolled in...

journal_title：Clinical drug investigation

authors： Agius-Fernandez A,Patterson A,Fsadni M,Jauch A,Raj PS

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:This paper aimed to provide an overview from published randomised clinical trials of the efficacy and tolerability of lamotrigine monotherapy compared with carbamazepine and phenytoin when initiated in adult patients with newly diagnosed epilepsy. DESIGN:The review included two double-blind, randomised tria...

journal_title：Clinical drug investigation

authors： Mullens EL

更新日期：1998-01-01 00:00:00

abstract：:We report the long-term effects of deferasirox 10-30 mg/kg/day on cardiac iron overload in a case series of five patients with transfusion-dependent beta-thalassaemia major who underwent up to 5 years of chelation therapy. Iron overload was monitored by multislice multi-echo T2* magnetic resonance imaging (MRI). Overa...

journal_title：Clinical drug investigation

authors： Ruffo GB,Borsellino Z,Cuccia L,Marocco MR,Gagliardotto F,Tarantino R

更新日期：2010-01-01 00:00:00