Bronchoalveolar lavage with diluted porcine surfactant in mechanically ventilated term infants with meconium aspiration syndrome.

abstract：:We performed a prospective, randomised, investigator-masked and parallel-group study to compare topical lomefloxacin 0.3% instilled twice daily with topical chloramphenicol instilled five times daily in the treatment of acute bacterial conjunctivitis. 191 patients (lomefloxacin 96, chloramphenicol 95) were enrolled in...

journal_title：Clinical drug investigation

authors： Agius-Fernandez A,Patterson A,Fsadni M,Jauch A,Raj PS

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Gemigliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor used in the treatment of type 2 diabetes mellitus. This study evaluated possible pharmacodynamic and pharmacokinetic interactions between gemigliptin and metformin and investigated their tolerability. METHODS:A randomized, open-la...

journal_title：Clinical drug investigation

authors： Shin D,Cho YM,Lee S,Lim KS,Kim JA,Ahn JY,Cho JY,Lee H,Jang IJ,Yu KS

更新日期：2014-06-01 00:00:00

abstract：:Mecapegfilgrastim (HHPG-19K) is a long-acting pegylated recombinant human granulocyte-colony stimulating factor (rhG-CSF) that is administered subcutaneously as prophylaxis once per chemotherapy cycle as a weight-adjusted dose of 100 µg/kg or as a 6 mg fixed dose. It is approved in China to reduce the incidence of inf...

journal_title：Clinical drug investigation

authors： Al-Salama ZT,Keam SJ

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND AIM:Gastro-oesophageal reflux disease is a common medical problem that places a significant financial burden on outpatient pharmaceutical expenditure. A substantial proportion of this expenditure can be attributed to the use of proton pump inhibitors (PPIs). The aim of this analysis was to evaluate the c...

journal_title：Clinical drug investigation

authors： Lucioni C,Mazzi S,Rossi C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Tendon rupture can result from fluoroquinolone exposure. The objective of this study was to quantify relative and absolute risk and determine how risk is affected by timing of exposure. METHODS:The UK Health Improvement Network primary care database was used to perform a nested case-control st...

journal_title：Clinical drug investigation

authors： Morales DR,Slattery J,Pacurariu A,Pinheiro L,McGettigan P,Kurz X

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Inhaled corticosteroid (ICS)/long-acting beta(2)-agonist (LABA) combinations are the preferred maintenance therapy for adult asthma patients uncontrolled by ICS alone. Supporting data are largely from mixed populations of adolescents and adults, although ICS/LABA combinations are not approved f...

journal_title：Clinical drug investigation

authors： Aalbers R

更新日期：2010-01-01 00:00:00

abstract：:Intramuscular 17 α-hydroxyprogesterone caproate (Makena(®)), a synthetic progestin, is indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of a singleton spontaneous preterm birth. Makena(®) reduces the risk of preterm birth in this patient population, and is associated...

journal_title：Clinical drug investigation

authors： Hines M,Lyseng-Williamson KA,Deeks ED

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of the natural platelet-activating factor receptor antagonist, BN 52021 (ginkgolide B) in the treatment of patients with severe sepsis related to Gram-negative and mixed bacterial infection. DESIGN AND SETTING:Prospective, randomised, double-blind, placebo-controlled, mult...

journal_title：Clinical drug investigation

authors： Albrecht DM,van Ackern K,Bender HJ,Hof H,Kox W,Victor N,Funk P,Kieser M,Köhler S,Krausch D,Marzi I,Menges T,Schmidt H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Baicalein, a flavonoid isolated from the root of Scutellaria baicalensis Georgi, is a neuroprotective agent under development to treat Parkinson's disease. This study investigated the pharmacokinetics, safety and tolerability of baicalein after a multiple-ascending-dose protocol in healthy Chi...

journal_title：Clinical drug investigation

authors： Pang H,Xue W,Shi A,Li M,Li Y,Cao G,Yan B,Dong F,Xiao W,He G,Du G,Hu X,Cheng G

更新日期：2016-09-01 00:00:00

abstract：:Currently three different inactivated influenza vaccine types are available: whole virus (WV), split (SPL) and subunit (SU) vaccines. Physicians and patients at risk for influenza complications may wonder whether there are important differences between the vaccine types with respect to antibody induction (serology) an...

journal_title：Clinical drug investigation

authors： Beyer WE,Palache AM,Osterhaus AD

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to compare the systemic bioavailability of two aciclovir tablets, Rouz-Aciclovir (test) and Zovirax (reference), in 12 healthy volunteers. METHODS:In a crossover design, each subject received a single oral dose of aciclovir 400 mg followed by a 7-day washout period. Plasma concentrations of ...

journal_title：Clinical drug investigation

authors： Amini H,Javan M,Gazerani P,Ghaffari A,Ahmadiani A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Dutasteride is a dual inhibitor of type I and type II 5α-reductases and provides nearly complete suppression of dihydrotestosterone, which plays a key role in the aetiology and development of benign prostatic hyperplasia (BPH). Most knowledge about the efficacy and safety of dutasteride in BPH derives from t...

journal_title：Clinical drug investigation

authors： Na Y,Ye Z,Zhang S,Chinese Dutasteride Phase III Trial (ARIA108898) Study Group.

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of single doses of quinfamide and secnidazole in the treatment of amoebic non-dysenteric colitis in children. DESIGN:This was a prospective, longitudinal, double-blind, randomised, comparative study. SETTING:The participants were students or relatives of students at two ur...

journal_title：Clinical drug investigation

authors： Padilla N,Díaz R,Muñoz M

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The degree of cycle control achieved with a hormonal contraceptive method is an important determinant of its acceptance and continuation. This study set out to compare the cycle control and bleeding profile of drospirenone (DRSP) 3 mg/ethinylestradiol (EE) 20 μg in a 24-active pill/4-inert pill...

journal_title：Clinical drug investigation

authors： Anttila L,Neunteufel W,Petraglia F,Marr J,Kunz M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of d...

journal_title：Clinical drug investigation

authors： Wändell P,Carlsson AC,Sundquist J,Sundquist K

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:NSAIDs are widely used for patients presenting with low back pain. A quick-release formulation of lornoxicam, a potent NSAID from the chemical class of oxicams, offers a faster onset of pain relief compared with the standard tablet formulation. METHODS:Time to onset of pain relief with lornoxicam was compar...

journal_title：Clinical drug investigation

authors： Yakhno N,Guekht A,Skoromets A,Spirin N,Strachunskaya E,Ternavsky A,Olsen KJ,Moller PL

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Golimumab is a fully human anti-tumor necrosis factor monoclonal antibody approved for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). This study estimated rates of prespecified outcomes in patients with RA, PsA or AS initiating golimumab ...

journal_title：Clinical drug investigation

authors： Ziyadeh NJ,Geldhof A,Noël W,Otero-Lobato M,Esslinger S,Chakravarty SD,Wang Y,Seeger JD

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To compare changes in lipid levels (total cholesterol [total-C], low-density lipoprotein cholesterol [LDL-C], triglycerides [TG], and high-density lipoprotein cholesterol [HDL-C]) for patients who switched from standard fenofibrate 160 mg (requiring dosing with food) to fenofibrate 145 mg with no food effect ...

journal_title：Clinical drug investigation

authors： Davidson MH,Jones PH

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several systematic reviews and meta-analyses have been conducted including an analysis to investigate the difference between ethnic groups in the glucose-lowering efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors. This study assessed the factors related to the glucose-lowering efficacy and ...

journal_title：Clinical drug investigation

authors： Fujita K,Kaneko M,Narukawa M

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To characterise the pharmacokinetics of indinavir during different phases of the menstrual cycle in HIV-infected women. DESIGN:Open-label study. SETTING:The immunodeficiency clinic at Erie County Medical Center, Buffalo, New York. PATIENTS:Ten HIV-infected women were enrolled in the study. Eligibility crit...

journal_title：Clinical drug investigation

authors： Frost CE,Adams J,Shelton M,Ebid AH,Gugino LJ,Hewitt R,Difrancesco R,Ingalls E,Cousins S,Hu J,Morse GD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A new oral antidiabetic drug class, sodium-glucose co-transporter-2 inhibitors (SGLT-2 inhibitors), has been covered by national health insurance in Taiwan since May 2016. This study estimated the impacts of insurance coverage for SGLT-2 inhibitors on the replacement effects of antidiabetic dr...

journal_title：Clinical drug investigation

authors： Chen HY,Chiu PY,Chang CJ,Tsai LL,Huang YL,Hsu JC

更新日期：2018-12-01 00:00:00

abstract：:The aim of this case study was to examine the efficacy of a dipeptidyl peptidase-4 inhibitor (anagliptin) and an α-glucosidase inhibitor (miglitol) when added to ongoing insulin treatment in patients with type 2 diabetes mellitus. Continuous glucose monitoring was performed in four Japanese insulin-treated inpatients ...

journal_title：Clinical drug investigation

authors： Kishimoto M,Noda M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Post-marketing surveillance studies can provide supplemental data on the safety of medications in the general population. OBJECTIVE:This study aimed to evaluate the safety of analgesic regimens including the NSAID lornoxicam in the short-term treatment of postoperative pain in a clinically relevant populati...

journal_title：Clinical drug investigation

authors： Rawal N,Krøner K,Simin-Geertsen M,Hejl C,Likar R

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pegylated interferon (peg-IFN)-α2a and -α2b show different pharmacokinetic properties but are used interchangeably for hepatitis C treatment in traditional dual combinations and with newer agents. We assessed whether peg-IFN antiviral effects vary with peg-IFN subtype, affecting viral response...

journal_title：Clinical drug investigation

authors： Durante-Mangoni E,Parrella A,Iossa D,Andini R,Molaro R,Battimelli C,Sodano G,Utili R

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Characteristics of nucleoside reverse transcriptase inhibitors (NRTIs) make the drug class susceptible to elimination via continuous veno-venous hemofiltration (CVVH), potentially leading to suboptimal drug concentrations if given at the recommended anephric doses during CVVH. The objective of ...

journal_title：Clinical drug investigation

authors： McLaughlin MM,Ammar AT,Gerzenshtein L,Scarsi KK

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The time-course when changes in glycemic control and body weight were first manifest in patients with type 2 diabetes mellitus (T2DM) treated with a combination of insulin degludec and liraglutide (IDegLira) was assessed, comparing IDegLira to its individual components. METHODS:Data from week...

journal_title：Clinical drug investigation

authors： Vilsbøll T,Vora J,Jarlov H,Kvist K,Blonde L

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is a general concern about the use of multisource (generic) antibacterials in the clinical setting with registration based solely on bioequivalence data. In order to address this concern, two modified-release formulations of clarithromycin (i.e. the originator Klacid XL and the generic Kl...

journal_title：Clinical drug investigation

authors： Snyman JR,Schoeman HS,Grobusch MP,Henning M,Rabie W,Hira M,Parshotam K,Mithal Y,Singh S,Ramdas Z

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Propofol is approved both for anaesthesia and sedation during intensive care. Serious adverse reactions with propofol have recently been reported, but patient exposure to the drug is unknown. OBJECTIVE:To investigate the consumption of propofol in Finnish hospitals and to develop a denominator to estimate p...

journal_title：Clinical drug investigation

authors： Kokki H,Närhi U

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Insulin degludec is a basal insulin with a slow and distinct absorption mechanism resulting in an ultra-long, flat, and stable pharmacokinetic profile in patients with diabetes mellitus. The aim of this study was to examine the effect of hepatic impairment on the single-dose pharmacokinetics of...

journal_title：Clinical drug investigation

authors： Kupčová V,Arold G,Roepstorff C,Højbjerre M,Klim S,Haahr H

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The optimal choice for first- and second-line antiseizure medications for pediatric patients with convulsive status epilepticus remains ambiguous. The present study aimed to estimate the comparative effect on the efficacy and safety of different antiseizure medications in pediatric patients wit...

journal_title：Clinical drug investigation

authors： Zhang Y,Liu Y,Liao Q,Liu Z

更新日期：2021-01-01 00:00:00