Abstract:
BACKGROUND:To evaluate the efficacy and safety of bronchoalveolar lavage (BAL) with diluted porcine surfactant in mechanically ventilated term infants with severe acute respiratory distress syndrome (ARDS) due to meconium aspiration syndrome (MAS). METHODS:Eight consecutive mechanically ventilated term infants with severe ARDS due to MAS underwent BAL with 15 mL/kg of diluted (5.3mg phospholipid/mL) surfactant saline suspension (porcine surfactant [Curosurf]). Treatment was administered slowly in aliquots of 2.5 mL. The mean age of neonates at treatment was 3.5 (range 1-8) hours. Heart rate, systemic blood pressure and oxygen saturation were monitored continuously. Arterial blood gases were measured immediately before treatment, and again at 3 and 6 hours post-treatment. Chest x-rays were taken 6 and 24 hours after treatment. RESULTS:Radiological improvement was evident in all eight patients 6 hours post-treatment. Compared with pre-BAL values, significant improvements (p < 0.05) in mean values for partial pressure of oxygen in arterial blood, partial pressure of carbon dioxide in arterial blood, pH, arterial/alveolar O2 ratio and oxygenation index were documented at 3 and 6 hours after BAL. In all patients, tracheal fluids that had been meconium-stained prior to BAL were clear of meconium after BAL. Only one patient required nitric oxide therapy for transient pulmonary hypertension. No adverse sequelae of treatment occurred during the study. CONCLUSIONS:BAL with dilute porcine surfactant administered slowly in 2.5 mL aliquots improved oxygenation and chest x-ray findings, without causing major adverse effects, in mechanically ventilated term infants with ARDS due to MAS.
journal_name
Clin Drug Investigjournal_title
Clinical drug investigationauthors
Lista G,Bianchi S,Castoldi F,Fontana P,Cavigioli Fdoi
10.2165/00044011-200626010-00002subject
Has Abstractpub_date
2006-01-01 00:00:00pages
13-9issue
1eissn
1173-2563issn
1179-1918pii
2612journal_volume
26pub_type
杂志文章abstract::We report the case of a 50-year-old male patient with idiopathic generalised epilepsy and porphyria cutanea tarda. Valproic acid and phenobarbital monotherapy controlled seizures but exacerbated porphyric symptomatology, while clobazam, clonazepam and lamotrigine monotherapy were well tolerated as regards porphyric di...
journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.2165/00044011-200626060-00007
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journal_title:Clinical drug investigation
pub_type: 杂志文章,评审
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.1007/s40261-018-0740-3
更新日期:2019-02-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.2165/00044011-200424100-00004
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journal_title:Clinical drug investigation
pub_type: 杂志文章
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journal_title:Clinical drug investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03256935
更新日期:2011-01-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章,评审
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.2165/00044011-199612020-00005
更新日期:1996-08-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章,撤回出版物
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pub_type: 临床试验,杂志文章,多中心研究
doi:10.2165/11599080-000000000-00000
更新日期:2012-04-01 00:00:00
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journal_title:Clinical drug investigation
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journal_title:Clinical drug investigation
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doi:10.2165/00044011-199816020-00005
更新日期:1998-01-01 00:00:00
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journal_title:Clinical drug investigation
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doi:10.1007/s40261-015-0358-7
更新日期:2016-02-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.2165/00044011-199510030-00005
更新日期:1995-09-01 00:00:00
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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doi:10.2165/11539360-000000000-00000
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doi:10.2165/00044011-200626080-00006
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章,多中心研究
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更新日期:2018-01-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.2165/00044011-199816040-00003
更新日期:1998-01-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.2165/00044011-200323040-00007
更新日期:2003-01-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.1007/s40261-018-0689-2
更新日期:2018-12-01 00:00:00
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更新日期:2015-07-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40261-016-0418-7
更新日期:2016-09-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章
doi:10.1007/s40261-018-00744-7
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.2165/11630040-000000000-00000
更新日期:2012-02-22 00:00:00