Pharmacokinetics and Exposure-Response Relationships of Dasotraline in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults.

abstract：:Epilepsy is common in children and adolescents where its prevalence is 3.2-5.5/1000. About one-third of patients also have attention deficit hyperactivity/impulsivity disorder (ADHD). The possible relationship between epilepsy and ADHD is still unclear, and ADHD symptoms (such as inattention, hyperactivity, behavioral...

journal_title：Clinical drug investigation

authors： Verrotti A,Moavero R,Panzarino G,Di Paolantonio C,Rizzo R,Curatolo P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Dobutamine causes an increase in cardiac output (CO) by augmenting stroke volume (SV) through enhanced left ventricular contractility and by decreasing systemic vascular resistance. However, in some patients, the dominant mechanism by which dobutamine improves left ventricular performance is an...

journal_title：Clinical drug investigation

authors： Ahonen J,Aranko K,Iivanainen A,Maunuksela EL,Paloheimo M,Olkkola KT

更新日期：2008-01-01 00:00:00

abstract：:None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade of one receptor. There is a possibility that a combination of antiemetics with different sites of activity would be more effective than one drug alone for prophylaxis against postoperative nausea and vomiting...

journal_title：Clinical drug investigation

authors： Fujii Y

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The management of patients on vitamin K antagonist therapy who require an invasive procedure is problematic. A randomised, controlled, double-blind clinical trial was designed to compare the efficacy and safety of bemiparin, a low molecular weight heparin (LMWH), with unfractionated heparin (UF...

journal_title：Clinical drug investigation

authors： Santamaría A,Ugarriza A,Muñoz C,De Diego I,López-Chulia F,Benet C,Martínez-González J,Gómez N,Pina E,Ortín X,Marco P,Roncalés FJ,Fontcuberta J

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:α(1)-Antitrypsin deficiency (α-ATD) is a disorder inherited in an autosomal recessive pattern, with co-dominant alleles known as the protease inhibitor system (Pi). The main function of α(1)-antitrypsin (α-AT) is to protect the lungs against a powerful elastase released from neutrophil leucocytes. α-ATD typi...

journal_title：Clinical drug investigation

authors： Sclar DA,Evans MA,Robison LM,Skaer TL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Congestion is the main cause of morbidity in patients with heart failure. Treatment of fluid overload is often challenging in everyday clinical practice. OBJECTIVE:The aim of this study was to determine the diuretic effect of acetazolamide in patients with exacerbations of chronic heart failure, in addition...

journal_title：Clinical drug investigation

authors： Imiela T,Budaj A

更新日期：2017-12-01 00:00:00

abstract：:Positron emission tomographic brain imaging and pathological examination have revealed that a chronic, intracerebral neuroinflammatory response lasting for years after a single brain injury may occur in humans. Evidence suggests the immune signaling molecule, tumor necrosis factor (TNF), is centrally involved in this ...

journal_title：Clinical drug investigation

authors： Tobinick E,Rodriguez-Romanacce H,Levine A,Ignatowski TA,Spengler RN

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The hematological side effects associated with mycophenolic acid (MPA) are relatively common and have severe consequences. The majority of literature data have not shown clear consistency in the MPA exposure-neutropenia relationship. We hypothesized that (i) adult de novo kidney transplant rec...

journal_title：Clinical drug investigation

authors： Kiang TKL,Partovi N,Shapiro RJ,Berman JM,Collier AC,Ensom MHH

更新日期：2018-11-01 00:00:00

abstract：:We performed a prospective, randomised, investigator-masked and parallel-group study to compare topical lomefloxacin 0.3% instilled twice daily with topical chloramphenicol instilled five times daily in the treatment of acute bacterial conjunctivitis. 191 patients (lomefloxacin 96, chloramphenicol 95) were enrolled in...

journal_title：Clinical drug investigation

authors： Agius-Fernandez A,Patterson A,Fsadni M,Jauch A,Raj PS

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mirabegron, a selective β3-adrenoceptor agonist for the treatment of overactive bladder (OAB), is eliminated by renal and metabolic routes. The potential influence of renal or hepatic impairment on the pharmacokinetics of mirabegron was evaluated. METHODS:Two separate open-label, single-dose,...

journal_title：Clinical drug investigation

authors： Dickinson J,Lewand M,Sawamoto T,Krauwinkel W,Schaddelee M,Keirns J,Kerbusch V,Moy S,Meijer J,Kowalski D,Morton R,Lasseter K,Riff D,Kupčová V,van Gelderen M

更新日期：2013-01-01 00:00:00

abstract：:The objective of the present study was to determine the frequency of adverse drug reactions (ADRs) in intensive care units (ICUs) and to evaluate their effect on the length of stay. We performed a prospective study to detect ADRs in 420 patients hospitalised in 10 predetermined beds in the ICU of our hospital between ...

journal_title：Clinical drug investigation

authors： Vargas E,Simón J,Martin JC,Puerro M,Gonzalez-Callejo MA,Jaime M,Gomez-Mayoral B,Duque F,Gomez-Delgado A,Moreno A

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Indacaterol is a novel, inhaled, once-daily, ultra-long-acting β2-adrenoceptor agonist that has been approved in the EU for the treatment of chronic obstructive pulmonary disease (COPD). Ethnic differences may influence the pharmacokinetics and pharmacodynamics of a drug, and it is therefore important to com...

journal_title：Clinical drug investigation

authors： Hosoe M,Woessner R,Matsushima S,Lawrence D,Kramer B

更新日期：2011-01-01 00:00:00

abstract：:Despite the availability of effective pain treatments, there are numerous barriers to effective management resulting in a large proportion of patients not achieving optimal pain control. Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraint...

journal_title：Clinical drug investigation

authors： Zuccaro SM,Vellucci R,Sarzi-Puttini P,Cherubino P,Labianca R,Fornasari D

更新日期：2012-02-22 00:00:00

abstract：:Iobitridol is a water-soluble, non-ionic, monomeric, low-osmolar, iodine-based contrast medium in which the potential for interaction with membrane proteins in the body has been minimized by stable masking of the molecule's lipophilic tri-iodinated benzene ring. It is approved in various countries worldwide for use as...

journal_title：Clinical drug investigation

authors： McCormack PL

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To compare the real-life treatment of acute exacerbations of chronic bronchitis (AECBs) using moxifloxacin tablets or one of the oral macrolides azithromycin, clarithromycin or roxithromycin in terms of symptom relief, time until improvement and cure, overall efficacy and tolerability. METHODS:This prospecti...

journal_title：Clinical drug investigation

authors： Schaberg T,Möller M,File T,Stauch K,Landen H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In England, the uptake of direct oral anticoagulants (DOACs) for stroke prevention in atrial fibrillation has been slow and varied across different Clinical Commissioning Groups (CCGs). This study aimed to profile the prescribing of oral anticoagulants for stroke prevention in patients with atr...

journal_title：Clinical drug investigation

authors： Medlinskiene K,Fay M,Petty D

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy and tolerability of high-dose N-acetylcysteine (NAC) in the treatment of patients with exacerbations of chronic obstructive pulmonary disease (COPD). DESIGN AND PATIENTS:Randomised, double-blind, double-dummy, placebo-controlled study in 123 patients experiencing an acute exacerba...

journal_title：Clinical drug investigation

authors： Zuin R,Palamidese A,Negrin R,Catozzo L,Scarda A,Balbinot M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients with cancer are at high risk of major depressive disorder (MDD), but little is known about their MDD treatment. We investigated the use of antidepressants and other drugs for MDD after cancer diagnosis, and patient characteristics associated with their use. METHODS:Adults with a new c...

journal_title：Clinical drug investigation

authors： Akechi T,Fujimoto S,Mishiro I,Murase K

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:For patients with hypertension, effective 24-hour blood pressure (BP) control is vital to ensure protection against the early morning surge in BP and the associated increased risk of cardiovascular events. The aim of this analysis was to assess the 24-hour antihypertensive efficacy of olmesartan medoxomil (2...

journal_title：Clinical drug investigation

authors： Brunner HR,Arakawa K

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:NSAIDs are widely used for patients presenting with low back pain. A quick-release formulation of lornoxicam, a potent NSAID from the chemical class of oxicams, offers a faster onset of pain relief compared with the standard tablet formulation. METHODS:Time to onset of pain relief with lornoxicam was compar...

journal_title：Clinical drug investigation

authors： Yakhno N,Guekht A,Skoromets A,Spirin N,Strachunskaya E,Ternavsky A,Olsen KJ,Moller PL

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Golimumab is a fully human anti-tumor necrosis factor monoclonal antibody approved for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). This study estimated rates of prespecified outcomes in patients with RA, PsA or AS initiating golimumab ...

journal_title：Clinical drug investigation

authors： Ziyadeh NJ,Geldhof A,Noël W,Otero-Lobato M,Esslinger S,Chakravarty SD,Wang Y,Seeger JD

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Recent clinical studies have documented the analgesic, anti-inflammatory, antioxidative and anxiolytic effects of exogenous melatonin. The pharmacokinetic properties of melatonin have primarily been investigated in experimental studies. OBJECTIVE:The aim of this study was to estimate the pharmacokinetics of...

journal_title：Clinical drug investigation

authors： Harpsøe NG,Andersen LP,Mielke LV,Jønsson B,Jenstrup MT,Gögenur I,Rosenberg J

更新日期：2016-12-01 00:00:00

abstract：:Doravirine (MK-1439) is a novel non-nucleoside reverse transcriptase inhibitor indicated for the combination treatment of human immunodeficiency virus type-1 (HIV-1) infection. The recommended dose is 100 mg once daily. This review summarizes the pharmacokinetics of doravirine, the influence of intrinsic factors, and ...

journal_title：Clinical drug investigation

authors： Khalilieh S,Yee KL,Sanchez R,Stoch SA,Wenning L,Iwamoto M

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness and safety of amlodipine in two cohorts of hypertensive patients, one newly diagnosed and the other previously diagnosed but not controlled with drug therapy, and to assess the risk factors for the entire sample at the outset of the study. PATIENTS AND DESIGN:We designed a postm...

journal_title：Clinical drug investigation

authors： Valcárcel Y,Jiménez R,Arístegui R,Gil A,Nota Study Group.

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Patients with schizophrenia or related disorders often switch antipsychotic therapy, most commonly due to lack of efficacy and side effects. The differences in anticipated efficacy and tolerability among atypical antipsychotics may drive switching behaviours. Switching to long-acting antipsychotics may impro...

journal_title：Clinical drug investigation

authors： Rosa F,Schreiner A,Thomas P,Sherif T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIM:Gastro-oesophageal reflux disease is a common medical problem that places a significant financial burden on outpatient pharmaceutical expenditure. A substantial proportion of this expenditure can be attributed to the use of proton pump inhibitors (PPIs). The aim of this analysis was to evaluate the c...

journal_title：Clinical drug investigation

authors： Lucioni C,Mazzi S,Rossi C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A new oral antidiabetic drug class, sodium-glucose co-transporter-2 inhibitors (SGLT-2 inhibitors), has been covered by national health insurance in Taiwan since May 2016. This study estimated the impacts of insurance coverage for SGLT-2 inhibitors on the replacement effects of antidiabetic dr...

journal_title：Clinical drug investigation

authors： Chen HY,Chiu PY,Chang CJ,Tsai LL,Huang YL,Hsu JC

更新日期：2018-12-01 00:00:00

abstract：:Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. The minor manifestation of the condition is the most common and is characterised by small, shallow, round or oval lesions that are surrounded by a raised erythematous h...

journal_title：Clinical drug investigation

authors： Bell J

更新日期：2005-01-01 00:00:00

abstract：:In an in vivo rat model of myocardial infarction, opioid receptor stimulation has been observed to result in a reduction in infarct size similar to that produced by ischaemic preconditioning. The ability of glibenclamide to abolish this effect suggests an involvement of the myocardial ATP-sensitive potassium (K(ATP)) ...

journal_title：Clinical drug investigation

authors： McCormack KJ,Chapleo CB

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of single doses of quinfamide and secnidazole in the treatment of amoebic non-dysenteric colitis in children. DESIGN:This was a prospective, longitudinal, double-blind, randomised, comparative study. SETTING:The participants were students or relatives of students at two ur...

journal_title：Clinical drug investigation

authors： Padilla N,Díaz R,Muñoz M

更新日期：2000-01-01 00:00:00