Effect of adverse drug reactions on length of stay in intensive care units.

abstract：BACKGROUND AND OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. DA-6034 has been shown to be effective in an IBD model and has demonstrated a good toxicological profile in preclinical studies. This study evaluated the tolerability, safety and pharmacokinetics...

journal_title：Clinical drug investigation

authors： Lee J,Shin KH,Kim JR,Lim KS,Jang IJ,Chung JY

更新日期：2014-01-01 00:00:00

abstract：:A liquid formulation of sodium oxybate (Alcover(®)), the sodium salt of γ-hydroxybutyric acid (GHB), is approved in Italy and Austria for use in alcohol withdrawal syndrome and for the maintenance of abstinence in alcohol dependence. This article reviews the efficacy and tolerability of sodium oxybate in alcohol withd...

journal_title：Clinical drug investigation

authors： Keating GM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Bilastine is a novel second-generation antihistamine for the symptomatic treatment of allergic rhinitis and urticaria. The objective of this study was to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of bilastine following single and multiple oral doses in healthy Japanese ...

journal_title：Clinical drug investigation

authors： Togawa M,Yamaya H,Rodríguez M,Nagashima H

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:This paper aimed to provide an overview from published randomised clinical trials of the efficacy and tolerability of lamotrigine monotherapy compared with carbamazepine and phenytoin when initiated in adult patients with newly diagnosed epilepsy. DESIGN:The review included two double-blind, randomised tria...

journal_title：Clinical drug investigation

authors： Mullens EL

更新日期：1998-01-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The corresponding author was incorrect. ...

journal_title：Clinical drug investigation

authors： Song GG,Lee YH

更新日期：2019-07-01 00:00:00

abstract：:Elbasvir/grazoprevir demonstrated high sustained virologic response rates 12 weeks after the end of treatment (SVR12) across five clinical trials in subjects infected with chronic hepatitis C virus (HCV) genotype 1, including those with advanced chronic kidney disease (CKD), and GT4. Despite favorable results overall,...

journal_title：Clinical drug investigation

authors： Boyd SD,Tracy L,Komatsu TE,Harrington PR,Viswanathan P,Murray J,Sherwat A

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Warfarin is a commonly used oral anticoagulant and its interaction with other drugs can result in serious thrombotic or bleeding events. Currently, there is no definitive evidence on the possibility of an interaction between warfarin and oseltamivir. OBJECTIVE:The objective of this study was to investigate ...

journal_title：Clinical drug investigation

authors： Lee SH,Kang HR,Jung JW,Kwon JW,Hong KS,Yu KS,Cho SH

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Propofol is approved both for anaesthesia and sedation during intensive care. Serious adverse reactions with propofol have recently been reported, but patient exposure to the drug is unknown. OBJECTIVE:To investigate the consumption of propofol in Finnish hospitals and to develop a denominator to estimate p...

journal_title：Clinical drug investigation

authors： Kokki H,Närhi U

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the long-term cost effectiveness of exenatide once weekly (ExQW) versus insulin glargine (IG) or liraglutide 1.2 mg (Lira1.2mg) for the treatment of adult patients with type 2 diabetes mellitus (T2DM) not adequately controlled on oral antidiabetic drug (OAD) therapy...

journal_title：Clinical drug investigation

authors： Tzanetakos C,Bargiota A,Kourlaba G,Gourzoulidis G,Maniadakis N

更新日期：2018-01-01 00:00:00

abstract：:Intramuscular 17 α-hydroxyprogesterone caproate (Makena(®)), a synthetic progestin, is indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of a singleton spontaneous preterm birth. Makena(®) reduces the risk of preterm birth in this patient population, and is associated...

journal_title：Clinical drug investigation

authors： Hines M,Lyseng-Williamson KA,Deeks ED

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pegylated interferon (peg-IFN)-α2a and -α2b show different pharmacokinetic properties but are used interchangeably for hepatitis C treatment in traditional dual combinations and with newer agents. We assessed whether peg-IFN antiviral effects vary with peg-IFN subtype, affecting viral response...

journal_title：Clinical drug investigation

authors： Durante-Mangoni E,Parrella A,Iossa D,Andini R,Molaro R,Battimelli C,Sodano G,Utili R

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Deferiprone (DFP), deferasirox (DFX) and deferoxamine (DFO) are used in thalassaemia major (TM) patients to treat chronic iron overload. We evaluated the cost-effectiveness of DFP, compared with DFX and DFO monotherapy, from an Italian healthcare system perspective. METHODS:A Markov model was used over a time ...

journal_title：Clinical drug investigation

authors： Pepe A,Rossi G,Bentley A,Putti MC,Frizziero L,D'Ascola DG,Cuccia L,Spasiano A,Filosa A,Caruso V,Hanif A,Meloni A

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In England, the uptake of direct oral anticoagulants (DOACs) for stroke prevention in atrial fibrillation has been slow and varied across different Clinical Commissioning Groups (CCGs). This study aimed to profile the prescribing of oral anticoagulants for stroke prevention in patients with atr...

journal_title：Clinical drug investigation

authors： Medlinskiene K,Fay M,Petty D

更新日期：2019-04-01 00:00:00

abstract：:Iobitridol is a water-soluble, non-ionic, monomeric, low-osmolar, iodine-based contrast medium in which the potential for interaction with membrane proteins in the body has been minimized by stable masking of the molecule's lipophilic tri-iodinated benzene ring. It is approved in various countries worldwide for use as...

journal_title：Clinical drug investigation

authors： McCormack PL

更新日期：2013-02-01 00:00:00

abstract：:Androgenetic alopecia (AGA) is characterized by non-scarring follicle miniaturization. Despite the success of approved therapies, commonly reported side effects and the need for continual use has led to the investigation of alternative therapies. The aim of this paper is to critically review the success of off-label, ...

journal_title：Clinical drug investigation

authors： Gupta AK,Mays RR,Versteeg SG,Shear NH,Piguet V,Piraccini BM

更新日期：2019-03-01 00:00:00

abstract：:A pharmacokinetic study was carried out in patients with unresectable colorectal liver metastases who had primarily been included in a phase II trial of intra-arterial cisplatin (DDP) plus intravenous fluorouracil. Ten patients of those accrued for the clinical study underwent the pharmacokinetic investigation upon li...

journal_title：Clinical drug investigation

authors： Civalleri D,Esposito M,De Cain F,Balletto N,Mondini G,Gogioso L,Viale M,Vannozzi MO

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Aliskiren is the first oral direct renin inhibitor to be approved for the treatment of hypertension. The pharmacokinetic and pharmacodynamic profile of aliskiren has been extensively characterized in Caucasian individuals; however, drug disposition, treatment response and tolerability can vary among ethnic g...

journal_title：Clinical drug investigation

authors： Hu P,Bartlett M,Karan RS,Jiang J,Zhang S,Zhang J,Howard D,Yeh CM,Al-Fayoumi S,Jarugula V,Dole WP

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bisphosphonates are commonly used to treat and prevent osteoporosis. These compounds have unusual pharmacokinetic characteristics because they bind strongly to bone, and a portion becomes buried under newly formed bone. Once incorporated into bone tissue, the subsequent release during bone remo...

journal_title：Clinical drug investigation

authors： Lasseter KC,Porras AG,Denker A,Santhanagopal A,Daifotis A

更新日期：2005-01-01 00:00:00

abstract：:Early initiation of rational and effective combination therapy consisting of antihypertensive drugs with two different and complementary mechanisms of actions is increasingly becoming accepted in clinical practice and by guidelines as a first-line approach to control blood pressure (BP) and prevent cardiovascular outc...

journal_title：Clinical drug investigation

authors： da Silva PM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cerebral vasospasm is a common and serious complication of aneurysmal subarachnoid haemorrhage (SAH). Many studies have revealed a role of inflammation in the development of cerebral vasospasm. This study aimed to investigate whether topically administered dexamethasone could attenuate vasospas...

journal_title：Clinical drug investigation

authors： Fei L,Golwa F

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Inhaled corticosteroid (ICS)/long-acting beta(2)-agonist (LABA) combinations are the preferred maintenance therapy for adult asthma patients uncontrolled by ICS alone. Supporting data are largely from mixed populations of adolescents and adults, although ICS/LABA combinations are not approved f...

journal_title：Clinical drug investigation

authors： Aalbers R

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Congestion is the main cause of morbidity in patients with heart failure. Treatment of fluid overload is often challenging in everyday clinical practice. OBJECTIVE:The aim of this study was to determine the diuretic effect of acetazolamide in patients with exacerbations of chronic heart failure, in addition...

journal_title：Clinical drug investigation

authors： Imiela T,Budaj A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Post-marketing surveillance studies can provide supplemental data on the safety of medications in the general population. OBJECTIVE:This study aimed to evaluate the safety of analgesic regimens including the NSAID lornoxicam in the short-term treatment of postoperative pain in a clinically relevant populati...

journal_title：Clinical drug investigation

authors： Rawal N,Krøner K,Simin-Geertsen M,Hejl C,Likar R

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:This real-world study assessed the prevalence, risk factors for, and incidence of seizures in patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS:Patients with mCRPC were selected from MarketScan Commercial and Medicare Supplemental Databases between 1 January 2009 a...

journal_title：Clinical drug investigation

authors： Dharmani C,Bonafede M,Krivoshik A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Despite the introduction of Medicare Part D (MPD) and 2012 Affordable Care Act (ACA), patients have a cost burden due to increases in drug prices. To overcome cost barriers, some patients purchase their medications from Canadian online pharmacies as Canadian prescription drug prices are believ...

journal_title：Clinical drug investigation

authors： Kim SH,Ryu YJ,Cho NE,Kim AE,Chang J

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The use of budesonide/formoterol as both maintenance and reliever therapy in asthma is recommended in many countries; however, there are limited data available for the Asian patient population. OBJECTIVE:This study aimed to evaluate the short-term safety and tolerability of a fixed high-dose combination of ...

journal_title：Clinical drug investigation

authors： Saito T,Hasunuma T

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Concerns that antiepileptic brand-to-generic interchange results in disruption of seizure control are widespread. The objective of this study was to evaluate the safety and tolerability of the brand-to-generic levetiracetam switch in patients with focal or generalized epilepsy. METHODS:A prosp...

journal_title：Clinical drug investigation

authors： Vari MS,Pinto F,Mencaroni E,Giudizioso G,Minetti C,La Neve A,Francavilla T,Piccioli M,Striano S,del Gaudio L,Tovo P,Striano P,Verrotti A

更新日期：2016-01-01 00:00:00

abstract：:A specific beta(2)-adrenoceptor-mediated effect, hypokalaemia, was studied in healthy volunteers after single as well as multiple dosages of the long-acting agonist formoterol and the short-acting agent salbutamol. The purpose of the study was to test with simple methodologies if rapidly induced tachyphylaxis for this...

journal_title：Clinical drug investigation

authors： van den Berg BT,Louwerse RT,Luiken GJ,Jonkers RE,van Boxtel CJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several systematic reviews and meta-analyses have been conducted including an analysis to investigate the difference between ethnic groups in the glucose-lowering efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors. This study assessed the factors related to the glucose-lowering efficacy and ...

journal_title：Clinical drug investigation

authors： Fujita K,Kaneko M,Narukawa M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients with cancer are at high risk of major depressive disorder (MDD), but little is known about their MDD treatment. We investigated the use of antidepressants and other drugs for MDD after cancer diagnosis, and patient characteristics associated with their use. METHODS:Adults with a new c...

journal_title：Clinical drug investigation

authors： Akechi T,Fujimoto S,Mishiro I,Murase K

更新日期：2020-12-01 00:00:00