Correction to: Comparison of the Efficacy and Safety of Tofacitinib and Apremilast in Patients with Active Psoriatic Arthritis: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.

abstract：:This review focuses on previously unpublished clinical and pharmacokinetic data with the diclofenac epolamine (diclofenac hydroxyethylpyrrolidine) patch supporting the hypothesis of a topical effect of this formulation. Previous studies have shown that 1 or 2 weeks of treatment with diclofenac epolamine provides pain ...

journal_title：Clinical drug investigation

authors： Petersen B,Rovati S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and tolerability of alendronic acid 70mg once weekly for the treatment of male osteoporosis. PATIENTS AND METHODS:This randomised, double-blind, placebo-controlled, 12-month trial compared the effect of alendronic acid 70mg once weekly or placebo (randomised 2 : 1) on bone mineral de...

journal_title：Clinical drug investigation

authors： Miller PD,Schnitzer T,Emkey R,Orwoll E,Rosen C,Ettinger M,Vandormael K,Daifotis A

更新日期：2004-01-01 00:00:00

abstract：:Cytochrome P450 (CYP) 3A4 has been considered to be the most important enzyme system for metabolism of lopinavir/ritonavir (LPV/r), a widely used HIV protease inhibitor (PI) recommended during pregnancy. Herein we present a clinical case of a pregnant HIV-infected woman who was taking standard doses of LPV/r, 400/100 ...

journal_title：Clinical drug investigation

authors： López Aspiroz E,Cabrera Figueroa SE,Iglesias Gómez A,Valverde Merino MP,Domínguez-Gil Hurlé A

更新日期：2015-01-01 00:00:00

abstract：:Despite the availability of effective pain treatments, there are numerous barriers to effective management resulting in a large proportion of patients not achieving optimal pain control. Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraint...

journal_title：Clinical drug investigation

authors： Zuccaro SM,Vellucci R,Sarzi-Puttini P,Cherubino P,Labianca R,Fornasari D

更新日期：2012-02-22 00:00:00

abstract：:Lung infections caused by invasive filamentous fungi are very rare conditions in AIDS, but must be considered in patients with profound immune suppression especially in the presence of additional risk factors, such as hematologic malignancies, corticosteroid therapy, neutropenia, and chemotherapy. The authors report a...

journal_title：Clinical drug investigation

authors： Pacheco P,Ventura AS,Branco T,Gonçalves L,Carvalho C

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dyslipidaemia is a major cardiovascular risk factor associated with type 2 diabetes mellitus. Saroglitazar (ZYH1) is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity. It has been developed for the treatment of dyslipidaemia an...

journal_title：Clinical drug investigation

authors： Jani RH,Kansagra K,Jain MR,Patel H

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fentanyl buccal soluble film (FBSF) is a small, bilayered, water-soluble polymer film (BioErodible MucoAdhesive; BEMA™) that adheres to the buccal mucosa and rapidly delivers fentanyl into the systemic circulation. It is approved for the treatment of cancer breakthrough pain in adult opioid-to...

journal_title：Clinical drug investigation

authors： Finn AL,Vasisht N,Stark JG,Gever LN,Tagarro I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dutasteride is currently marketed by GlaxoSmithKline (GSK), either as monotherapy or as a fixed-dose combination with tamsulosin. As part of the project to develop the fixed-dose combination product, alternative formulations of dutasteride were prepared by GSK, and their pharmacokinetic proper...

journal_title：Clinical drug investigation

authors： Fossler M,Zhu J,Roehrborn C,McAleese P,Manyak M

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Icosapent ethyl is a high-purity prescription form of eicosapentaenoic acid ethyl ester approved as an adjunct to diet to reduce triglyceride levels in adult patients with triglyceride levels ≥500 mg/dL (≥5.65 mmol/L). The objective of this open-label, drug-drug interaction study was to examine...

journal_title：Clinical drug investigation

authors： Braeckman RA,Stirtan WG,Soni PN

更新日期：2015-01-01 00:00:00

abstract：:Early initiation of rational and effective combination therapy consisting of antihypertensive drugs with two different and complementary mechanisms of actions is increasingly becoming accepted in clinical practice and by guidelines as a first-line approach to control blood pressure (BP) and prevent cardiovascular outc...

journal_title：Clinical drug investigation

authors： da Silva PM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hypertension, one of the major treatable cardiovascular (CV) risk factors, usually occurs in association with other major risk factors. As well as providing rapid blood pressure (BP) goal attainment, antihypertensive therapy should also provide reductions in CV events and mortality in a wide r...

journal_title：Clinical drug investigation

authors： Ogilvie RI,Anand S,Roy P,De Souza S,PEACH investigators.

更新日期：2008-01-01 00:00:00

abstract：:Psychotropic medications and alcohol are potential risk factors for falls in older adults. However, there has been no appraisal of the literature on whether these medications, both singly and in combination with alcohol, are associated with falls in community dwelling older adults (those aged 60 years and older living...

journal_title：Clinical drug investigation

authors： Laberge S,Crizzle AM

更新日期：2019-02-01 00:00:00

abstract：:This narrative review summarises the benefits, risks and appropriate use of acid-suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists, advocating a rationale balanced and individualised approach aimed to minimise any serious adverse consequences. It focuses on current controversies on ...

journal_title：Clinical drug investigation

authors： Fisher L,Fisher A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recurrent aphthous ulceration is the most common oral mucosal disease known. It presents as three types: minor (most prevalent), major and herpetiform. However, there are no well established effective and reliable treatments of this condition. Alchemilla vulgaris (Lady's Mantle) has traditional...

journal_title：Clinical drug investigation

authors： Shrivastava R,John GW

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Vedolizumab, a humanized monoclonal antibody against the α4β7 integrin, is indicated for treatment of moderately to severely active ulcerative colitis or Crohn's disease. In this placebo-controlled, double-blind, randomized, single ascending-dose study, the pharmacokinetics, pharmacodynamics, ...

journal_title：Clinical drug investigation

authors： Rosario M,Wyant T,Leach T,Sankoh S,Scholz C,Parikh A,Fox I,Feagan BG

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor under clinical investigation in solid tumours. This study evaluated the influence of P-glycoprotein (P-gp) inhibition (single-dose rifampicin) and simultaneous cytochrome P450 3A4 (CYP3A4)/P-gp induction (multiple-dose rifampicin) ...

journal_title：Clinical drug investigation

authors： Shumaker RC,Aluri J,Fan J,Martinez G,Thompson GA,Ren M

更新日期：2014-09-01 00:00:00

abstract：:Appropriate and successful management of pain with opioid analgesics is based on tailoring pharmacologic treatment to the individual and identifying the minimal effective dose at which pain is controlled with minimal adverse effects. Morphine and morphine-like-agonists exhibit similar pharmacodynamic profiles, but sub...

journal_title：Clinical drug investigation

authors： Geppetti P,Benemei S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Overactive bladder is a prevalent condition worldwide that is associated with a considerable burden, both on the patient and on society. OBJECTIVE:Our objective was to assess the economic value of fesoterodine compared with tolterodine extended release (ER) for the treatment of overactive bladder (OAB) with...

journal_title：Clinical drug investigation

authors： Angulo JC,Valpas A,Rejas J,Linden K,Kvasz M,Snedecor SJ

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:This study was performed in healthy Chinese subjects to evaluate the safety and pharmacokinetic/pharmacodynamic characteristics of a novel injection formulation of dexlansoprazole in the context of single and multiple administration, compared with the original lansoprazole injection. METHODS:H...

journal_title：Clinical drug investigation

authors： Wu L,Liu J,Zheng Y,Zhai Y,Lin M,Wu G,Lv D,Shentu J

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To estimate the cost effectiveness of venlafaxine compared with generic fluoxetine and generic amitriptyline used in major depressive disorder in primary care in the UK. METHODS:A decision-tree model for the treatment of major depressive disorder was constructed using a Delphi panel. The tree was populated w...

journal_title：Clinical drug investigation

authors： Lenox-Smith A,Greenstreet L,Burslem K,Knight C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several cases of facial paralysis have been reported following influenza vaccination; however, recent surveillance studies have not shown an increased risk. In this study, we analyzed the vaccine adverse event reporting system (VAERS) data to determine whether the facial paralysis reporting rat...

journal_title：Clinical drug investigation

authors： Kamath A,Maity N,Nayak MA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The skeletal muscle relaxant tizanidine is approved by the US FDA and the European Medicines Agency for treating spasticity and is supplied as tablets for oral administration. However, tizanidine has a poor bioavailability, due to extensive first-pass metabolism. Therefore, the nasal route of a...

journal_title：Clinical drug investigation

authors： Vitale DC,Piazza C,Sinagra T,Urso V,Cardì F,Drago F,Salomone S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:α(1)-Antitrypsin deficiency (α-ATD) is a disorder inherited in an autosomal recessive pattern, with co-dominant alleles known as the protease inhibitor system (Pi). The main function of α(1)-antitrypsin (α-AT) is to protect the lungs against a powerful elastase released from neutrophil leucocytes. α-ATD typi...

journal_title：Clinical drug investigation

authors： Sclar DA,Evans MA,Robison LM,Skaer TL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Polypharmacy, regarded as an indicator of potentially inappropriate medications (PIMs), may lead to a higher risk of serious health consequences in elderly patients with osteoporosis. Thus, this study aimed to analyze the association between polypharmacy and hip fracture in patients with osteop...

journal_title：Clinical drug investigation

authors： Park HY,Kim S,Sohn HS,Kwon JW

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Oxycodone tamper resistant (OTR) is a new extended-release abuse-deterrent formulation providing improvements in the tamper resistant characteristics. This study aimed to investigate the pharmacokinetic properties of the new OTR tablets and evaluate the bioequivalence of oxycodone from OTR and...

journal_title：Clinical drug investigation

authors： Luo Z,Miao J,Shu S,Wang Y,Zhu X,Hu C,Shen Y

更新日期：2020-02-01 00:00:00

abstract：:A specific beta(2)-adrenoceptor-mediated effect, hypokalaemia, was studied in healthy volunteers after single as well as multiple dosages of the long-acting agonist formoterol and the short-acting agent salbutamol. The purpose of the study was to test with simple methodologies if rapidly induced tachyphylaxis for this...

journal_title：Clinical drug investigation

authors： van den Berg BT,Louwerse RT,Luiken GJ,Jonkers RE,van Boxtel CJ

更新日期：1998-01-01 00:00:00

abstract：:Mecapegfilgrastim (HHPG-19K) is a long-acting pegylated recombinant human granulocyte-colony stimulating factor (rhG-CSF) that is administered subcutaneously as prophylaxis once per chemotherapy cycle as a weight-adjusted dose of 100 µg/kg or as a 6 mg fixed dose. It is approved in China to reduce the incidence of inf...

journal_title：Clinical drug investigation

authors： Al-Salama ZT,Keam SJ

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Bilastine is a novel second-generation antihistamine for the symptomatic treatment of allergic rhinitis and urticaria. The objective of this study was to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of bilastine following single and multiple oral doses in healthy Japanese ...

journal_title：Clinical drug investigation

authors： Togawa M,Yamaya H,Rodríguez M,Nagashima H

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To investigate prescribing trends of selective serotonin reuptake inhibitors (SSRIs) during the course of the Defeat Depression Campaign (1992 to 1996). METHODS:This study utilised cross-sectional data on the prescribing of SSRIs for the treatment of depression from a large primary care database for the 5 co...

journal_title：Clinical drug investigation

authors： Donoghue J

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Oral contraceptives (OCs) are one of the most commonly used classes of drugs worldwide. A case of neutropenia and associated infections in a young woman using OCs that settled after discontinuation and reappeared upon re-challenge, has led us to investigate a potential association between oral contraceptives...

journal_title：Clinical drug investigation

authors： Rosenthal YS,Chodick G,Rosenthal A,Shalev V,Ram HS,Koren G

更新日期：2019-10-01 00:00:00