Abstract：
OBJECTIVE:To investigate prescribing trends of selective serotonin reuptake inhibitors (SSRIs) during the course of the Defeat Depression Campaign (1992 to 1996). METHODS:This study utilised cross-sectional data on the prescribing of SSRIs for the treatment of depression from a large primary care database for the 5 consecutive years of the Defeat Depression Campaign, producing the largest study of SSRI use to date. RESULTS:A total of 93 600 prescriptions were issued for fluoxetine, paroxetine and sertraline, in 27 210 treatment episodes. Over the 5-year period, there was a five-fold increase in the number of prescriptions issued, and a four-fold increase in the number of patients treated, reflecting a trend for longer periods of treatment. Patients initiating treatment with fluoxetine were most likely and those initiating treatment with sertraline were least likely to complete 60, 90 and 120 consecutive days of treatment. Differences in dose patterns also emerged and were consistent throughout the study. Fluoxetine-treated patients were most likely to remain on the starting dose of 20mg daily, while large numbers of sertraline-treated patients received doses above the recommended dose of 50mg daily. These differences were not apparent from clinical trials, and this may be an artefact of trial design. CONCLUSION:Differences in the doses prescribed may explain why sertraline-treated patients are less likely to complete an adequate course of antidepressant therapy. Longitudinal studies are required to evaluate fully the clinical significance of these findings.
journal_name
Clin Drug Investigjournal_title
Clinical drug investigationauthors
Donoghue Jdoi
10.2165/00044011-199816060-00005subject
Has Abstractpub_date
1998-01-01 00:00:00pages
453-62issue
6eissn
1173-2563issn
1179-1918pii
160605journal_volume
16pub_type
杂志文章abstract：OBJECTIVE:In this study, we evaluated the effectiveness of amlodipine in patients with severe ischaemic left ventricular dysfunction (LVD) and mild to moderate heart failure, but not current angina, assessing the effects of the drug on symptoms, left ventricular function and exercise capacity. PATIENTS AND METHODS:We ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-199816040-00003
更新日期：1998-01-01 00:00:00
abstract：:Early initiation of rational and effective combination therapy consisting of antihypertensive drugs with two different and complementary mechanisms of actions is increasingly becoming accepted in clinical practice and by guidelines as a first-line approach to control blood pressure (BP) and prevent cardiovascular outc...
journal_title：Clinical drug investigation
pub_type： 杂志文章,评审
doi：10.2165/11538440-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：:The efficacy and tolerability of fluticasone aqueous nasal spray, 200µg once daily for 21 days, was compared with cetirizine, 10mg once daily for 21 days, in a multicentre, randomised, double-blind, double-dummy, parallel group study. 237 evaluable patients aged 12 years and above, with seasonal allergic rhinitis (def...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-199713060-00001
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Several drugs may interact with levothyroxine and reduce its bioavailability. The aim of this study was to analyse the Italian general practice patients with hypothyroidism from 2002-2011, in terms of variation of thyroid-stimulating hormone (TSH) levels, number of levothyroxine prescriptions ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-015-0271-0
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Despite the introduction of Medicare Part D (MPD) and 2012 Affordable Care Act (ACA), patients have a cost burden due to increases in drug prices. To overcome cost barriers, some patients purchase their medications from Canadian online pharmacies as Canadian prescription drug prices are believ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-017-0556-6
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:CKD-712, a candidate treatment for septic shock, acts by increasing cardiac output. This study investigated changes in the pharmacodynamics, pharmacokinetics, and tolerability of CKD-712 after a single intravenous administration. METHODS:A dose-block-randomized, double-blind, placebo-controll...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-017-0494-3
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Status epilepticus (SE) is an important emergency situation associated with high morbidity and mortality. The goal of pharmacological therapy-rapid seizure termination-is only achieved in just over half of patients with first-line anti-epileptic drug (AED) therapy and many patients require sec...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-015-0295-5
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:The efficacy and tolerability of a new combination inhaler containing both salmeterol 50mg and fluticasone 100mg in a single device was compared with the delivery of the two drugs via two separate inhalers in a multicentre, double-blind, double-dummy study. PATIENTS:244 symptomatic asthma patients (age range...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-199816030-00003
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Icosapent ethyl is a high-purity prescription form of eicosapentaenoic acid ethyl ester approved as an adjunct to diet to reduce triglyceride levels in adult patients with triglyceride levels ≥500 mg/dL (≥5.65 mmol/L). The objective of this open-label, drug-drug interaction study was to examine...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-014-0252-8
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy and tolerability of alendronic acid 70mg once weekly for the treatment of male osteoporosis. PATIENTS AND METHODS:This randomised, double-blind, placebo-controlled, 12-month trial compared the effect of alendronic acid 70mg once weekly or placebo (randomised 2 : 1) on bone mineral de...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-200424060-00003
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of d...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-018-0740-3
更新日期：2019-02-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. The corresponding author was incorrect. ...
journal_title：Clinical drug investigation
pub_type： 已发布勘误
doi：10.1007/s40261-019-00817-1
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Concerns that antiepileptic brand-to-generic interchange results in disruption of seizure control are widespread. The objective of this study was to evaluate the safety and tolerability of the brand-to-generic levetiracetam switch in patients with focal or generalized epilepsy. METHODS:A prosp...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-015-0351-1
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Characteristics of nucleoside reverse transcriptase inhibitors (NRTIs) make the drug class susceptible to elimination via continuous veno-venous hemofiltration (CVVH), potentially leading to suboptimal drug concentrations if given at the recommended anephric doses during CVVH. The objective of ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-015-0275-9
更新日期：2015-04-01 00:00:00
abstract：:Elbasvir/grazoprevir demonstrated high sustained virologic response rates 12 weeks after the end of treatment (SVR12) across five clinical trials in subjects infected with chronic hepatitis C virus (HCV) genotype 1, including those with advanced chronic kidney disease (CKD), and GT4. Despite favorable results overall,...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-017-0492-5
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. DA-6034 has been shown to be effective in an IBD model and has demonstrated a good toxicological profile in preclinical studies. This study evaluated the tolerability, safety and pharmacokinetics...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-013-0147-0
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:This study aimed to compare the systemic bioavailability of two aciclovir tablets, Rouz-Aciclovir (test) and Zovirax (reference), in 12 healthy volunteers. METHODS:In a crossover design, each subject received a single oral dose of aciclovir 400 mg followed by a 7-day washout period. Plasma concentrations of ...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.2165/00044011-200828010-00006
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:First-line bevacizumab-based therapy has been shown to improve outcomes in patients with advanced non-squamous non-small-cell lung cancer (NSCLC). The recent international phase IV SAiL study (a Study of Avastin [bevacizumab] in combination with platinum-containing chemotherapy in patients with...
journal_title：Clinical drug investigation
pub_type： 杂志文章,多中心研究
doi：10.1007/s40261-012-0001-9
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy and safety of single doses of quinfamide and secnidazole in the treatment of amoebic non-dysenteric colitis in children. DESIGN:This was a prospective, longitudinal, double-blind, randomised, comparative study. SETTING:The participants were students or relatives of students at two ur...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-200020020-00003
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Post-marketing surveillance studies can provide supplemental data on the safety of medications in the general population. OBJECTIVE:This study aimed to evaluate the safety of analgesic regimens including the NSAID lornoxicam in the short-term treatment of postoperative pain in a clinically relevant populati...
journal_title：Clinical drug investigation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2165/11538860-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To compare the bioavailability of two 15mg ambroxol lozenges with a commercial 30mg ambroxol tablet. DESIGN:Open-label, two-way crossover study. METHOD:Each formulation was randomly administered to 20 healthy Thai volunteers (ten male and ten female) with a 1-week washout period between formulations. After ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-200323040-00007
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Congestion is the main cause of morbidity in patients with heart failure. Treatment of fluid overload is often challenging in everyday clinical practice. OBJECTIVE:The aim of this study was to determine the diuretic effect of acetazolamide in patients with exacerbations of chronic heart failure, in addition...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-017-0577-1
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine do not affect the pharmacokinetics of lithium or valproate; therefore, concomitant...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-019-00860-y
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...
journal_title：Clinical drug investigation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2165/00044011-200727040-00007
更新日期：2007-01-01 00:00:00
abstract：:This review focuses on previously unpublished clinical and pharmacokinetic data with the diclofenac epolamine (diclofenac hydroxyethylpyrrolidine) patch supporting the hypothesis of a topical effect of this formulation. Previous studies have shown that 1 or 2 weeks of treatment with diclofenac epolamine provides pain ...
journal_title：Clinical drug investigation
pub_type： 杂志文章,评审
doi：10.2165/0044011-200929010-00001
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Herpes zoster (HZ) and its most frequent complication, post-herpetic neuralgia (PHN), have been shown to considerably impact quality of life (QoL). This has not yet been demonstrated in Japan. METHODS:QoL in HZ and PHN patients was evaluated using the Zoster Brief Pain Inventory (ZBPI), EuroQ...
journal_title：Clinical drug investigation
pub_type： 杂志文章,多中心研究
doi：10.1007/s40261-017-0581-5
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To investigate the efficacy and tolerability of high-dose N-acetylcysteine (NAC) in the treatment of patients with exacerbations of chronic obstructive pulmonary disease (COPD). DESIGN AND PATIENTS:Randomised, double-blind, double-dummy, placebo-controlled study in 123 patients experiencing an acute exacerba...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-200525060-00005
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Matrix metalloproteinases (MMPs) are proteases with different biological and pathological activities, and many have been linked to several diseases. Targeting individual MMPs may offer a safer therapeutic potential for several diseases. We assessed the safety, tolerability, and pharmacokinetic...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-020-00981-9
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The degree of cycle control achieved with a hormonal contraceptive method is an important determinant of its acceptance and continuation. This study set out to compare the cycle control and bleeding profile of drospirenone (DRSP) 3 mg/ethinylestradiol (EE) 20 μg in a 24-active pill/4-inert pill...
journal_title：Clinical drug investigation
pub_type： 临床试验,杂志文章,meta分析,多中心研究
doi：10.2165/11590260-000000000-00000
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Recent data suggest that P-glycoprotein may be involved in cellular transport of lacosamide. OBJECTIVE:To investigate potential drug-drug interactions (DDIs) between lacosamide and digoxin, this phase I, multiple-dose, randomised, double-blind, placebo-controlled, crossover trial assessed the pharmacokineti...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-014-0180-7
更新日期：2014-05-01 00:00:00
