当前位置： SCI文献检索 > CLINICAL DRUG INVESTIGATION期刊下所有文献 > Changes in Cardiac Function After a Single Intravenous Administration of CKD-712 in Healthy Male Volunteers.

Changes in Cardiac Function After a Single Intravenous Administration of CKD-712 in Healthy Male Volunteers.

Abstract：

BACKGROUND AND OBJECTIVES:CKD-712, a candidate treatment for septic shock, acts by increasing cardiac output. This study investigated changes in the pharmacodynamics, pharmacokinetics, and tolerability of CKD-712 after a single intravenous administration. METHODS:A dose-block-randomized, double-blind, placebo-controlled, single-dose escalation study was conducted in 44 healthy subjects receiving 20, 40, 80, 160, 240, or 320 μg/kg CKD-712 or placebo. Pharmacodynamics were evaluated using computerized impedance cardiography, vital signs, platelet aggregation, and bleeding time. Serial blood and urine samples for pharmacokinetic analysis were collected up to 12 and 24 h, respectively, after the initiation of intravenous drug infusion. Tolerability assessments were performed throughout the study. RESULTS:The area under the effect-time curve of the cardiac index (AUECCI) and systolic blood pressure (AUECSBP) changed significantly with the 160 and 320 µg/kg doses of CKD-712 compared with placebo. Furthermore, the AUECCI and AUECSBP tended to increase as the systemic exposure of CKD-712 increased from 20 to 240 µg/kg. The frequency of drug-related adverse events (AEs), including cardiovascular symptoms, was higher with the 320 µg/kg dose. CONCLUSION:The pharmacological effects and on-target AEs of CKD-712 increased relative to the dose increments. The results of this study suggest that potentially therapeutic doses of CKD-712 could range from 160 to 240 μg/kg.

journal_name

Clin Drug Investig

journal_title

Clinical drug investigation

authors

Park SI,Kim J,Yu KS,Jang IJ,Lee S

doi

10.1007/s40261-017-0494-3

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

393-403

issue

4

eissn

1173-2563

issn

1179-1918

pii

10.1007/s40261-017-0494-3

journal_volume

37

pub_type

杂志文章,随机对照试验

相关文献

CLINICAL DRUG INVESTIGATION文献大全
  • Retraction Note to: Efficacy of Menatetrenone (Vitamin K2) against Non-Vertebral and Hip Fractures in Patients with Neurological Diseases : Meta-Analysis of Three Randomized, Controlled Trials.

    abstract：:The Editor-in-Chief has retracted this article because two of the three studies [1, 2] included in the meta-analysis (cited as references 11 and 12) have been retracted due to fabrication of the data, which has rendered the results of this meta-analysis invalid. ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,撤回出版物

    doi：10.1007/s40261-018-0643-3

    authors： Iwamoto J,Matsumoto H,Takeda T

    更新日期：2018-05-01 00:00:00

  • Cost-utility of treatments for pulmonary arterial hypertension: a Markov state-transition decision analysis model.

    abstract：BACKGROUND AND OBJECTIVE:Clinicians must choose between an increasing number of medications for the treatment of pulmonary arterial hypertension (PAH) with different routes of administration, adverse effects, costs and efficacies. We constructed a decision analysis to help inform treatment choices in PAH. METHODS:We c...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/11317820-000000000-00000

    authors： Garin MC,Clark L,Chumney EC,Simpson KN,Highland KB

    更新日期：2009-01-01 00:00:00

  • Pharmacokinetics of Repeated Melatonin Drug Administrations Prior to and After Surgery.

    abstract：BACKGROUND:Recent clinical studies have documented the analgesic, anti-inflammatory, antioxidative and anxiolytic effects of exogenous melatonin. The pharmacokinetic properties of melatonin have primarily been investigated in experimental studies. OBJECTIVE:The aim of this study was to estimate the pharmacokinetics of...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-016-0452-5

    authors： Harpsøe NG,Andersen LP,Mielke LV,Jønsson B,Jenstrup MT,Gögenur I,Rosenberg J

    更新日期：2016-12-01 00:00:00

  • Manidipine for hypertension not controlled by dual therapy in patients with diabetes mellitus: a non-comparative, open-label study.

    abstract：BACKGROUND AND OBJECTIVE:Little is known about the effects of the calcium channel antagonist manidipine when it is added as a third drug in non-controlled hypertensive patients with diabetes mellitus receiving dual antihypertensive therapy. The aim of this study was to evaluate the response in terms of blood pressure (...

    journal_title：Clinical drug investigation

    pub_type： 临床试验,杂志文章

    doi：10.2165/11587400-000000000-00000

    authors： Martell-Claros N,de la Cruz JJ

    更新日期：2011-01-01 00:00:00

  • Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index.

    abstract：OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/00044011-200727040-00007

    authors： Raslová K,Tamer SC,Clauson P,Karl D

    更新日期：2007-01-01 00:00:00

  • Combination therapy with milrinone and esmolol for heart protection in patients with severe sepsis: a prospective, randomized trial.

    abstract：BACKGROUND AND OBJECTIVE:As a β-adrenoceptor antagonist (β-blocker), esmolol can reduce cardiac output and the phosphodiesterase III inhibitor milrinone has been shown to improve heart contractility in patients with septic shock. This study was performed to assess the effects of esmolol combined with milrinone in patie...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40261-015-0325-3

    authors： Wang Z,Wu Q,Nie X,Guo J,Yang C

    更新日期：2015-11-01 00:00:00

  • Oral Contraceptives and Neutropenia: A Population-Based Cohort Study.

    abstract：BACKGROUND:Oral contraceptives (OCs) are one of the most commonly used classes of drugs worldwide. A case of neutropenia and associated infections in a young woman using OCs that settled after discontinuation and reappeared upon re-challenge, has led us to investigate a potential association between oral contraceptives...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-019-00818-0

    authors： Rosenthal YS,Chodick G,Rosenthal A,Shalev V,Ram HS,Koren G

    更新日期：2019-10-01 00:00:00

  • Correction to: Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes: Their Use and Differential Features.

    abstract：:Page 806, column 1, line 3: The text, which previously read. ...

    journal_title：Clinical drug investigation

    pub_type： 已发布勘误

    doi：10.1007/s40261-020-00892-9

    authors： Lyseng-Williamson KA

    更新日期：2020-03-01 00:00:00

  • Effectiveness and satisfaction with zolmitriptan 5 mg nasal spray for treatment of migraine in real-life practice: results of a postmarketing surveillance study.

    abstract：OBJECTIVE:Addressing the needs of migraineurs by actively seeking patient feedback on disease-related disability and treatment satisfaction may lead to improved management and treatment outcomes. Patient feedback can be collected in postmarketing surveillance (PMS) studies. The objective of this PMS study was to evalua...

    journal_title：Clinical drug investigation

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.2165/00044011-200727010-00005

    authors： Diener HC,Evers S

    更新日期：2007-01-01 00:00:00

  • Clinical experience in invasive fungal infections.

    abstract：:Lung infections caused by invasive filamentous fungi are very rare conditions in AIDS, but must be considered in patients with profound immune suppression especially in the presence of additional risk factors, such as hematologic malignancies, corticosteroid therapy, neutropenia, and chemotherapy. The authors report a...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-012-0017-1

    authors： Pacheco P,Ventura AS,Branco T,Gonçalves L,Carvalho C

    更新日期：2013-02-01 00:00:00

  • Gadobutrol: a review of its use for contrast-enhanced magnetic resonance imaging in adults and children.

    abstract：:Since the introduction of the first gadolinium-based contrast agent (GBCA) approximately 25 years ago, magnetic resonance imaging (MRI) using GBCAs has revolutionized diagnostic and follow-up imaging of pathological lesions, with clinical applications expanded to encompass almost all fields of medicine. Intravenous ga...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40261-013-0066-0

    authors： Scott LJ

    更新日期：2013-04-01 00:00:00

  • Pharmacoeconomic impact of adverse events of long-term opioid treatment for the management of persistent pain.

    abstract：:Opioids are the most powerful analgesic drugs currently available and consequently form an essential part of the treatment options for malignant and non-malignant chronic pain. However, the benefits of these medications can be offset by gastrointestinal adverse events such as nausea, vomiting and constipation, as well...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03256935

    authors： Annemans L

    更新日期：2011-01-01 00:00:00

  • Effectiveness of an Intervention to Improve Management of COPD using the AUDIT Methodology: Results of the Neumo-Advance Study.

    abstract：BACKGROUND AND OBJECTIVE:The implementation of chronic obstructive pulmonary disease (COPD) guidelines in the real-world setting remains low. Pulmonologists should participate in the new paradigms of chronicity of COPD, by providing their knowledge, expertise, innovation and research. The objective of this study was to...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-019-00787-4

    authors： de Miguel-Díez J,Jiménez-García R,López de Andrés A,Zaragoza Arnáez F

    更新日期：2019-07-01 00:00:00

  • Barriers to pain management: focus on opioid therapy.

    abstract：:Despite the availability of effective pain treatments, there are numerous barriers to effective management resulting in a large proportion of patients not achieving optimal pain control. Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraint...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,评审

    doi：10.2165/11630040-000000000-00000

    authors： Zuccaro SM,Vellucci R,Sarzi-Puttini P,Cherubino P,Labianca R,Fornasari D

    更新日期：2012-02-22 00:00:00

  • Type 2 Diabetes Patients Reach Target Glycemic Control Faster Using IDegLira than Either Insulin Degludec or Liraglutide Given Alone.

    abstract：BACKGROUND AND OBJECTIVES:The time-course when changes in glycemic control and body weight were first manifest in patients with type 2 diabetes mellitus (T2DM) treated with a combination of insulin degludec and liraglutide (IDegLira) was assessed, comparing IDegLira to its individual components. METHODS:Data from week...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-016-0376-0

    authors： Vilsbøll T,Vora J,Jarlov H,Kvist K,Blonde L

    更新日期：2016-04-01 00:00:00

  • Amlodipine in ischaemic left ventricular dysfunction with mild to moderate heart failure.

    abstract：OBJECTIVE:In this study, we evaluated the effectiveness of amlodipine in patients with severe ischaemic left ventricular dysfunction (LVD) and mild to moderate heart failure, but not current angina, assessing the effects of the drug on symptoms, left ventricular function and exercise capacity. PATIENTS AND METHODS:We ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-199816040-00003

    authors： Perna GP,Valle G,Cianfrone N,Luca GD,Amico C,Coli C

    更新日期：1998-01-01 00:00:00

  • Prescription Drug Price Paradox: Cost Analysis of Canadian Online Pharmacies versus US Medicare Beneficiaries for the Top 100 Drugs.

    abstract：BACKGROUND AND OBJECTIVES:Despite the introduction of Medicare Part D (MPD) and 2012 Affordable Care Act (ACA), patients have a cost burden due to increases in drug prices. To overcome cost barriers, some patients purchase their medications from Canadian online pharmacies as Canadian prescription drug prices are believ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-017-0556-6

    authors： Kim SH,Ryu YJ,Cho NE,Kim AE,Chang J

    更新日期：2017-10-01 00:00:00

  • Bronchoalveolar lavage with diluted porcine surfactant in mechanically ventilated term infants with meconium aspiration syndrome.

    abstract：BACKGROUND:To evaluate the efficacy and safety of bronchoalveolar lavage (BAL) with diluted porcine surfactant in mechanically ventilated term infants with severe acute respiratory distress syndrome (ARDS) due to meconium aspiration syndrome (MAS). METHODS:Eight consecutive mechanically ventilated term infants with se...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200626010-00002

    authors： Lista G,Bianchi S,Castoldi F,Fontana P,Cavigioli F

    更新日期：2006-01-01 00:00:00

  • Effects of a Novel Aldose Reductase Inhibitor, Fidarestat (SNK-860), on Vibration Perception Threshold and Subjective Symptoms in Patients with Diabetic Polyneuropathy : An Open-Label Pilot Study.

    abstract：OBJECTIVE:To evaluate the effects of fidarestat (SNK-860) on vibration perception threshold, as measured by C64 quantitative tuning fork (64Hz) analysis, as well as its effects on subjective symptoms in patients with diabetic polyneuro-pathy. DESIGN AND SETTING:Open-label, prospective study conducted at 12 hospitals i...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200424110-00006

    authors： Hotta N,Yasuda K,Sumita Y,Sano T,Kakuta H,Nagashima M,Hayashi Y,Yamamoto M,Wakao T,Okuyama M,Kobayashi M,Mori K

    更新日期：2004-01-01 00:00:00

  • Bemiparin versus unfractionated heparin as bridging therapy in the perioperative management of patients on vitamin K antagonists: the BERTA study.

    abstract：BACKGROUND AND OBJECTIVE:The management of patients on vitamin K antagonist therapy who require an invasive procedure is problematic. A randomised, controlled, double-blind clinical trial was designed to compare the efficacy and safety of bemiparin, a low molecular weight heparin (LMWH), with unfractionated heparin (UF...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40261-013-0141-6

    authors： Santamaría A,Ugarriza A,Muñoz C,De Diego I,López-Chulia F,Benet C,Martínez-González J,Gómez N,Pina E,Ortín X,Marco P,Roncalés FJ,Fontcuberta J

    更新日期：2013-12-01 00:00:00

  • Salmeterol/Fluticasone Propionate in a Single Inhaler is Superior to Budesonide Alone in Control of Chinese Asthmatic Adults : An Open-Label, Randomised, 6-Week Study.

    abstract：OBJECTIVE AND DESIGN:There is comparatively little information on asthma management in China. A multicentre, randomised, open-label, parallel-group, 6-week treatment study was conducted to evaluate the efficacy and safety of salmeterol/fluticasone propionate combination treatment in Chinese adult asthmatic patients. S...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200424100-00004

    authors： Zhong NS,Ping ZJ,Humphries MJ,Xin D

    更新日期：2004-01-01 00:00:00

  • Retrospective comparison of the effectiveness of a fenofibrate 145 mg formulation compared with the standard 160 mg tablet.

    abstract：OBJECTIVE:To compare changes in lipid levels (total cholesterol [total-C], low-density lipoprotein cholesterol [LDL-C], triglycerides [TG], and high-density lipoprotein cholesterol [HDL-C]) for patients who switched from standard fenofibrate 160 mg (requiring dosing with food) to fenofibrate 145 mg with no food effect ...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.2165/00044011-200828100-00002

    authors： Davidson MH,Jones PH

    更新日期：2008-01-01 00:00:00

  • Regression and Genomic Analyses on the Association Between Dose-Normalized Mycophenolic Acid Exposure and Absolute Neutrophil Count in Steroid-Free, De Novo Kidney Transplant Recipients.

    abstract：BACKGROUND AND OBJECTIVES:The hematological side effects associated with mycophenolic acid (MPA) are relatively common and have severe consequences. The majority of literature data have not shown clear consistency in the MPA exposure-neutropenia relationship. We hypothesized that (i) adult de novo kidney transplant rec...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-018-0694-5

    authors： Kiang TKL,Partovi N,Shapiro RJ,Berman JM,Collier AC,Ensom MHH

    更新日期：2018-11-01 00:00:00

  • Perindopril for control of blood pressure in patients with hypertension and other cardiovascular risk factors: an open-label, observational, multicentre, general practice-based study.

    abstract：BACKGROUND AND OBJECTIVES:Hypertension, one of the major treatable cardiovascular (CV) risk factors, usually occurs in association with other major risk factors. As well as providing rapid blood pressure (BP) goal attainment, antihypertensive therapy should also provide reductions in CV events and mortality in a wide r...

    journal_title：Clinical drug investigation

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.2165/00044011-200828110-00001

    authors： Ogilvie RI,Anand S,Roy P,De Souza S,PEACH investigators.

    更新日期：2008-01-01 00:00:00

  • RETRACTED ARTICLE: Combination Antiemetic Regimens for Prevention of Postoperative Nausea and Vomiting : Focus on High-Risk Patients.

    abstract：:None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade of one receptor. There is a possibility that a combination of antiemetics with different sites of activity would be more effective than one drug alone for prophylaxis against postoperative nausea and vomiting...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,收录出版,评审

    doi：10.2165/00044011-200222090-00001

    authors： Fujii Y

    更新日期：2002-09-01 00:00:00

  • Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium: randomised, double-blind trial in acute low back pain.

    abstract：BACKGROUND:NSAIDs are widely used for patients presenting with low back pain. A quick-release formulation of lornoxicam, a potent NSAID from the chemical class of oxicams, offers a faster onset of pain relief compared with the standard tablet formulation. METHODS:Time to onset of pain relief with lornoxicam was compar...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2165/00044011-200626050-00004

    authors： Yakhno N,Guekht A,Skoromets A,Spirin N,Strachunskaya E,Ternavsky A,Olsen KJ,Moller PL

    更新日期：2006-01-01 00:00:00

  • Differential antiviral effects of pegylated interferon-α2a and pegylated interferon-α2b in chronic hepatitis C.

    abstract：BACKGROUND AND OBJECTIVES:Pegylated interferon (peg-IFN)-α2a and -α2b show different pharmacokinetic properties but are used interchangeably for hepatitis C treatment in traditional dual combinations and with newer agents. We assessed whether peg-IFN antiviral effects vary with peg-IFN subtype, affecting viral response...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-014-0241-y

    authors： Durante-Mangoni E,Parrella A,Iossa D,Andini R,Molaro R,Battimelli C,Sodano G,Utili R

    更新日期：2014-12-01 00:00:00

  • Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers.

    abstract：BACKGROUND AND OBJECTIVES:Baicalein, a flavonoid isolated from the root of Scutellaria baicalensis Georgi, is a neuroprotective agent under development to treat Parkinson's disease. This study investigated the pharmacokinetics, safety and tolerability of baicalein after a multiple-ascending-dose protocol in healthy Chi...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40261-016-0418-7

    authors： Pang H,Xue W,Shi A,Li M,Li Y,Cao G,Yan B,Dong F,Xiao W,He G,Du G,Hu X,Cheng G

    更新日期：2016-09-01 00:00:00

  • Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism.

    abstract：BACKGROUND AND OBJECTIVE:The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of d...

    journal_title：Clinical drug investigation

    pub_type： 杂志文章

    doi：10.1007/s40261-018-0740-3

    authors： Wändell P,Carlsson AC,Sundquist J,Sundquist K

    更新日期：2019-02-01 00:00:00

  • Oxycodone controlled-release as first-choice therapy for moderate-to-severe cancer pain in Italian patients: results of an open-label, multicentre, observational study.

    abstract：BACKGROUND AND OBJECTIVES:Cancer pain affects patients at all stages of the disease and there are clear guidelines for its management. Morphine is considered the first-choice strong opioid in the treatment of moderate-to-severe pain; however, numerous studies have shown that oxycodone controlled-release (CR) has a simi...

    journal_title：Clinical drug investigation

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.2165/00044011-200828070-00001

    authors： Silvestri B,Bandieri E,Del Prete S,Ianniello GP,Micheletto G,Dambrosio M,Sabbatini G,Endrizzi L,Marra A,Aitini E,Calorio A,Garetto F,Nastasi G,Piantedosi F,Sidoti V,Spanu P

    更新日期：2008-01-01 00:00:00