Abstract:
OBJECTIVE:To compare the efficacy and safety of single doses of quinfamide and secnidazole in the treatment of amoebic non-dysenteric colitis in children. DESIGN:This was a prospective, longitudinal, double-blind, randomised, comparative study. SETTING:The participants were students or relatives of students at two urban elementary schools in Celaya, Guanajuato, Mexico. PARTICIPANTS:Patients aged between 2 and 15 years of age with cysts of Entamoeba histolytica in stool samples for 3 consecutive days as detected by Faust's concentration method were enrolled in this study. INTERVENTIONS AND OUTCOME MEASURES:Single doses of quinfamide 4.3 mg/kg or secnidazole 30 mg/kg were administered. Patients were asked about the acceptability of the flavour of the drugs. Efficacy was evaluated by the presence or absence of E. histolytica cysts in stool samples on the fifth, sixth and seventh days after administration of the drugs. Adverse events were evaluated by direct questioning of patients. RESULTS:734 patients were evaluated by coproparasitoscopy, of whom 239 (32.6%) had E. histolytica cysts. 112 patients were randomised to receive quinfamide and 127 to receive secnidazole. Differences in age, bodyweight, size and gender distribution were not statistically significant between the groups. 108 patients (96%) in the quinfamide group and 15 patients (12%) in the secnidazole group reported the flavour as good (p < 0.0001). 95 patients (85%) in the quinfamide group and 93 patients (73%) in the secnidazole group had negative stool samples at the end of treatment (p = 0.04). Nausea (p < 0.0001), abdominal pain (p < 0.05) and unpleasant taste (i.e. metallic taste 3 to 5 days after administration of secnidazole) in mouth (p < 0.0001) were more common in the secnidazole group than in the quinfamide group. CONCLUSIONS:Quinfamide is an excellent option for amoebic non-dysenteric colitis because of its high parasitoscopic efficacy, minimum adverse effects and good acceptance by children. The single-dose schedule guarantees completion of treatment.
journal_name
Clin Drug Investigjournal_title
Clinical drug investigationauthors
Padilla N,Díaz R,Muñoz Mdoi
10.2165/00044011-200020020-00003subject
Has Abstractpub_date
2000-01-01 00:00:00pages
89-93issue
2eissn
1173-2563issn
1179-1918journal_volume
20pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Mirabegron, a selective β3-adrenoceptor agonist for the treatment of overactive bladder (OAB), is eliminated by renal and metabolic routes. The potential influence of renal or hepatic impairment on the pharmacokinetics of mirabegron was evaluated. METHODS:Two separate open-label, single-dose,...
journal_title:Clinical drug investigation
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abstract:OBJECTIVES:This paper aimed to provide an overview from published randomised clinical trials of the efficacy and tolerability of lamotrigine monotherapy compared with carbamazepine and phenytoin when initiated in adult patients with newly diagnosed epilepsy. DESIGN:The review included two double-blind, randomised tria...
journal_title:Clinical drug investigation
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journal_title:Clinical drug investigation
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abstract:BACKGROUND AND OBJECTIVE:Dobutamine causes an increase in cardiac output (CO) by augmenting stroke volume (SV) through enhanced left ventricular contractility and by decreasing systemic vascular resistance. However, in some patients, the dominant mechanism by which dobutamine improves left ventricular performance is an...
journal_title:Clinical drug investigation
pub_type: 杂志文章,随机对照试验
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abstract::Cytochrome P450 (CYP) 3A4 has been considered to be the most important enzyme system for metabolism of lopinavir/ritonavir (LPV/r), a widely used HIV protease inhibitor (PI) recommended during pregnancy. Herein we present a clinical case of a pregnant HIV-infected woman who was taking standard doses of LPV/r, 400/100 ...
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journal_title:Clinical drug investigation
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更新日期:2010-01-01 00:00:00
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更新日期:2014-09-01 00:00:00
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doi:10.2165/00044011-199815040-00001
更新日期:1998-01-01 00:00:00
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更新日期:2013-12-01 00:00:00
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更新日期:2017-12-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章,多中心研究
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更新日期:2007-01-01 00:00:00
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journal_title:Clinical drug investigation
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更新日期:2007-01-01 00:00:00
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更新日期:2013-02-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Clinical drug investigation
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doi:10.2165/00044011-199815060-00009
更新日期:1998-01-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:Clinical drug investigation
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更新日期:2005-01-01 00:00:00
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更新日期:2015-11-01 00:00:00
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journal_title:Clinical drug investigation
pub_type: 杂志文章,随机对照试验
doi:10.2165/11533050-000000000-00000
更新日期:2010-01-01 00:00:00
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更新日期:2019-10-01 00:00:00
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更新日期:2012-02-01 00:00:00