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Consumption and distribution of propofol in anaesthesia and intensive care use in Finland.

Abstract：

BACKGROUND:Propofol is approved both for anaesthesia and sedation during intensive care. Serious adverse reactions with propofol have recently been reported, but patient exposure to the drug is unknown. OBJECTIVE:To investigate the consumption of propofol in Finnish hospitals and to develop a denominator to estimate patient exposure. METHODS:The consumption of propofol was investigated using the drug consumption database for 1990-2001. Distribution between anaesthesia and intensive care use in Finnish hospitals was investigated by a survey covering the period 2000-2001. We based the estimate of patient exposure on doses commonly described in the literature on propofol use in different indications. RESULTS:Total consumption of propofol increased more than 4-fold from 1990-2001. Most of the propofol consumed was the 10 mg/mL strength. In 2001, one-third of the total sales consisted of the 20 mg/mL strength. In 2000 and 2001, a little more than half of the total consumption of propofol was used for sedation in intensive care. CONCLUSION:The use of propofol is increasing in Finland. Half of the propofol was used in anaesthesia units and half in intensive care units. We propose the following defined daily doses: 175mg for anaesthesia induction; 750 mg/patient-hour for anaesthesia maintenance; and 4200 mg/patient-day for sedation in intensive care.M.

journal_name

Clin Drug Investig

journal_title

Clinical drug investigation

authors

Kokki H,Närhi U

doi

10.2165/00044011-200323010-00003

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

21-6

issue

1

eissn

1173-2563

issn

1179-1918

journal_volume

23

pub_type

杂志文章

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