Abstract：
BACKGROUND:Among the many consequences of loss of CFTR protein function, a significant reduction of the secretion of bicarbonate (HCO3-) in cystic fibrosis (CF) is a major pathogenic feature. Loss of HCO3- leads to abnormally low pH and impaired mucus clearance in airways and other exocrine organs, which suggests that NaHCO3 inhalation may be a low-cost, easily accessible therapy for CF. OBJECTIVE:To evaluate the safety, tolerability, and effects of inhaled aerosols of NaHCO3 solutions (4.2% and 8.4%). METHODS:An experimental, prospective, open-label, pilot, clinical study was conducted with 12 CF volunteer participants over 18 years of age with bronchiectasis and pulmonary functions classified as mildly to severely depressed. Sputum rheology, pH, and microbiology were examined as well as spirometry, exercise performance, quality-of-life assessments, dyspnea, blood count, and venous blood gas levels. RESULTS:Sputum pH increased immediately after inhalation of NaHCO3 at each clinical visit and was inversely correlated with rheology when all parameters were evaluated: [G' (elasticity of the mucus) = - 0.241; G″ (viscosity of the mucus) = - 0.287; G* (viscoelasticity of the mucus) = - 0.275]. G* and G' were slightly correlated with peak flow, forced expiratory volume in 1 s (FEV1), and quality of life; G″ was correlated with quality of life; sputum pH was correlated with oxygen consumption (VO2) and vitality score in quality of life. No changes were observed in blood count, venous blood gas, respiratory rate, heart rate, peripheral oxygen saturation of hemoglobin (SpO2), body temperature, or incidence of dyspnea. No adverse events associated with the study were observed. CONCLUSION:Nebulized NaHCO3 inhalation appears to be a safe and well tolerated potential therapeutic agent in the management of CF. Nebulized NaHCO3 inhalation temporarily elevates airway liquid pH and reduces sputum viscosity and viscoelasticity.
journal_name
Clin Drug Investigjournal_title
Clinical drug investigationauthors
Gomez CCS,Parazzi PLF,Clinckspoor KJ,Mauch RM,Pessine FBT,Levy CE,Peixoto AO,Ribeiro MÂGO,Ribeiro AF,Conrad D,Quinton PM,Marson FAL,Ribeiro JDdoi
10.1007/s40261-019-00861-xsubject
Has Abstractpub_date
2020-02-01 00:00:00pages
105-117issue
2eissn
1173-2563issn
1179-1918pii
10.1007/s40261-019-00861-xjournal_volume
40pub_type
杂志文章abstract：:Page 806, column 1, line 3: The text, which previously read. ...
journal_title：Clinical drug investigation
pub_type： 已发布勘误
doi：10.1007/s40261-020-00892-9
更新日期：2020-03-01 00:00:00
abstract：:The objective of the present study was to determine the frequency of adverse drug reactions (ADRs) in intensive care units (ICUs) and to evaluate their effect on the length of stay. We performed a prospective study to detect ADRs in 420 patients hospitalised in 10 predetermined beds in the ICU of our hospital between ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-199815040-00011
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Vedolizumab, a humanized monoclonal antibody against the α4β7 integrin, is indicated for treatment of moderately to severely active ulcerative colitis or Crohn's disease. In this placebo-controlled, double-blind, randomized, single ascending-dose study, the pharmacokinetics, pharmacodynamics, ...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-016-0437-4
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The management of patients on vitamin K antagonist therapy who require an invasive procedure is problematic. A randomised, controlled, double-blind clinical trial was designed to compare the efficacy and safety of bemiparin, a low molecular weight heparin (LMWH), with unfractionated heparin (UF...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-013-0141-6
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abstract：:This article discusses current practice in the treatment of conjunctivitis and how the use of topical moxifloxacin can increase therapeutic effectiveness, reduce treatment failures and, consequently, be cost effective and reduce the societal burden of the disorder. Current practice and effectiveness data were derived ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/11589020-000000000-00000
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abstract：OBJECTIVE:To estimate the cost effectiveness of venlafaxine compared with generic fluoxetine and generic amitriptyline used in major depressive disorder in primary care in the UK. METHODS:A decision-tree model for the treatment of major depressive disorder was constructed using a Delphi panel. The tree was populated w...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-200929030-00004
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Indacaterol is a novel, inhaled, once-daily, ultra-long-acting β2-adrenoceptor agonist that has been approved in the EU for the treatment of chronic obstructive pulmonary disease (COPD). Ethnic differences may influence the pharmacokinetics and pharmacodynamics of a drug, and it is therefore important to com...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.2165/11586520-000000000-00000
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abstract：BACKGROUND AND OBJECTIVES:CKD-712, a candidate treatment for septic shock, acts by increasing cardiac output. This study investigated changes in the pharmacodynamics, pharmacokinetics, and tolerability of CKD-712 after a single intravenous administration. METHODS:A dose-block-randomized, double-blind, placebo-controll...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-017-0494-3
更新日期：2017-04-01 00:00:00
abstract：:The Editor-in-Chief has retracted this article because two of the three studies [1, 2] included in the meta-analysis (cited as references 11 and 12) have been retracted due to fabrication of the data, which has rendered the results of this meta-analysis invalid. ...
journal_title：Clinical drug investigation
pub_type： 杂志文章,撤回出版物
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更新日期：2018-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Dasotraline is a novel inhibitor of dopamine and norepinephrine reuptake currently being investigated in clinical studies for the treatment of attention-deficit/hyperactivity disorder (ADHD). Uniquely, relative to current ADHD medications, dasotraline has a slow absorption and long elimination...
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abstract：BACKGROUND AND OBJECTIVES:Status epilepticus (SE) is an important emergency situation associated with high morbidity and mortality. The goal of pharmacological therapy-rapid seizure termination-is only achieved in just over half of patients with first-line anti-epileptic drug (AED) therapy and many patients require sec...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-015-0295-5
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abstract：BACKGROUND AND OBJECTIVES:The hematological side effects associated with mycophenolic acid (MPA) are relatively common and have severe consequences. The majority of literature data have not shown clear consistency in the MPA exposure-neutropenia relationship. We hypothesized that (i) adult de novo kidney transplant rec...
journal_title：Clinical drug investigation
pub_type： 杂志文章
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abstract：BACKGROUND AND OBJECTIVE:Polypharmacy, regarded as an indicator of potentially inappropriate medications (PIMs), may lead to a higher risk of serious health consequences in elderly patients with osteoporosis. Thus, this study aimed to analyze the association between polypharmacy and hip fracture in patients with osteop...
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abstract：BACKGROUND AND OBJECTIVES:Matrix metalloproteinases (MMPs) are proteases with different biological and pathological activities, and many have been linked to several diseases. Targeting individual MMPs may offer a safer therapeutic potential for several diseases. We assessed the safety, tolerability, and pharmacokinetic...
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pub_type： 杂志文章
doi：10.1007/s40261-020-00981-9
更新日期：2021-01-01 00:00:00
abstract：:Lung infections caused by invasive filamentous fungi are very rare conditions in AIDS, but must be considered in patients with profound immune suppression especially in the presence of additional risk factors, such as hematologic malignancies, corticosteroid therapy, neutropenia, and chemotherapy. The authors report a...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-012-0017-1
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Clinical studies have reported that zonisamide is effective for a wide range of seizure types, including refractory partial-onset seizures. However, there have been no reported studies of the efficacy of zonisamide in the Chinese population to date. The aim of the present study was to evaluate ...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.2165/11539750-000000000-00000
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Several systematic reviews and meta-analyses have been conducted including an analysis to investigate the difference between ethnic groups in the glucose-lowering efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors. This study assessed the factors related to the glucose-lowering efficacy and ...
journal_title：Clinical drug investigation
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s40261-016-0478-8
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The degree of cycle control achieved with a hormonal contraceptive method is an important determinant of its acceptance and continuation. This study set out to compare the cycle control and bleeding profile of drospirenone (DRSP) 3 mg/ethinylestradiol (EE) 20 μg in a 24-active pill/4-inert pill...
journal_title：Clinical drug investigation
pub_type： 临床试验,杂志文章,meta分析,多中心研究
doi：10.2165/11590260-000000000-00000
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abstract：BACKGROUND AND OBJECTIVES:Fentanyl buccal soluble film (FBSF) is a small, bilayered, water-soluble polymer film (BioErodible MucoAdhesive; BEMA™) that adheres to the buccal mucosa and rapidly delivers fentanyl into the systemic circulation. It is approved for the treatment of cancer breakthrough pain in adult opioid-to...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/11594670-000000000-00000
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Characteristics of nucleoside reverse transcriptase inhibitors (NRTIs) make the drug class susceptible to elimination via continuous veno-venous hemofiltration (CVVH), potentially leading to suboptimal drug concentrations if given at the recommended anephric doses during CVVH. The objective of ...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-015-0275-9
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...
journal_title：Clinical drug investigation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2165/00044011-200727040-00007
更新日期：2007-01-01 00:00:00
abstract：:We performed a prospective, randomised, investigator-masked and parallel-group study to compare topical lomefloxacin 0.3% instilled twice daily with topical chloramphenicol instilled five times daily in the treatment of acute bacterial conjunctivitis. 191 patients (lomefloxacin 96, chloramphenicol 95) were enrolled in...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/00044011-199815040-00001
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Dutasteride is a dual inhibitor of type I and type II 5α-reductases and provides nearly complete suppression of dihydrotestosterone, which plays a key role in the aetiology and development of benign prostatic hyperplasia (BPH). Most knowledge about the efficacy and safety of dutasteride in BPH derives from t...
journal_title：Clinical drug investigation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2165/11593750-000000000-00000
更新日期：2012-01-01 00:00:00
abstract：:Sublingual buprenorphine [Subutex(R)] is used to treat opioid dependence. However, illicit intravenous (IV) injection of buprenorphine is a widespread problem. This survey investigated the IV misuse of buprenorphine among patients receiving drug replacement therapy at the Drug Addiction Centre in Udine, Italy. All pat...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.2165/11536020-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Multimodal pain therapy including cyclo-oxygenase-2 inhibitors can result in optimal pain management with decreased opioid use and fewer opioid-related adverse events. Patient reported outcomes (PROs) help identify benefits in reduced opioid use and increased pain control. METHODS:In this randomized, double...
journal_title：Clinical drug investigation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2165/11317570-000000000-00000
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Oxycodone tamper resistant (OTR) is a new extended-release abuse-deterrent formulation providing improvements in the tamper resistant characteristics. This study aimed to investigate the pharmacokinetic properties of the new OTR tablets and evaluate the bioequivalence of oxycodone from OTR and...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-019-00870-w
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Gemigliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor used in the treatment of type 2 diabetes mellitus. This study evaluated possible pharmacodynamic and pharmacokinetic interactions between gemigliptin and metformin and investigated their tolerability. METHODS:A randomized, open-la...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40261-014-0184-3
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The use of transdermal fentanyl for opioid-naïve patients is restricted, however, transdermal fentanyl is a useful opioid analgesic for patients in whom oral administration is difficult or for those with renal failure. In this study, the efficacy and safety of fentanyl citrate patches was evalu...
journal_title：Clinical drug investigation
pub_type： 临床试验,杂志文章
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更新日期：2020-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Interferon-alpha treatment is associated with a large number of adverse effects. Depressive symptoms are not unexpected, and potentially dangerous psychiatric adverse effects can induce life-threatening conditions. We compared the incidence of depressive symptoms in patients with chronic hepati...
journal_title：Clinical drug investigation
pub_type： 杂志文章,随机对照试验
doi：10.2165/00044011-200626110-00005
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The new oral anticoagulants (NOACs) are used for the prevention of thromboembolic complications in patients with non-valvular atrial fibrillation (AF) and those at risk of deep venous thrombosis. Their rapid onset of action and predictable pharmacokinetic and pharmacodynamic profiles make them...
journal_title：Clinical drug investigation
pub_type： 杂志文章
doi：10.1007/s40261-016-0436-5
更新日期：2016-10-01 00:00:00
