Abstract:
:We report the long-term effects of deferasirox 10-30 mg/kg/day on cardiac iron overload in a case series of five patients with transfusion-dependent beta-thalassaemia major who underwent up to 5 years of chelation therapy. Iron overload was monitored by multislice multi-echo T2* magnetic resonance imaging (MRI). Overall, T2* MRI showed a decrease from baseline in cardiac iron levels in all patients during treatment with deferasirox (baseline T2* levels 13-24 ms; final T2* levels 21-41 ms). The improvement in T2* values correlated with maintenance of left ventricular ejection fraction (LVEF) [baseline LVEF values 56-61%; final LVEF values 57-70%]. Deferasirox chelation treatment regimen was well tolerated and adherence to the regimen was good. In conclusion, this case series suggests that deferasirox may decrease cardiac iron overload and maintain stable LVEF over the long term. Moreover, it emphasizes the importance of T2* multislice multi-echo MRI in the monitoring of cardiac iron overload.
journal_name
Clin Drug Investigjournal_title
Clinical drug investigationauthors
Ruffo GB,Borsellino Z,Cuccia L,Marocco MR,Gagliardotto F,Tarantino Rdoi
10.2165/11534480-000000000-00000subject
Has Abstractpub_date
2010-01-01 00:00:00pages
267-73issue
4eissn
1173-2563issn
1179-1918pii
6journal_volume
30pub_type
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journal_title:Clinical drug investigation
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-05-01 00:00:00
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00
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更新日期:2005-01-01 00:00:00