Abstract:
:Alzheimer's disease (AD) is the most frequent form of dementia worldwide. The increasing incidence of AD is due to the dramatic rise in life expectancy. Generally, AD shows a multifactorial etiology and manifests itself only at an older age. However, a small percentage of cases have a monogenic cause, are inherited as an autosomal dominant trait, and begin much earlier. In these cases, molecular analysis and genetic consultation may make sense.
journal_name
Z Gerontol Geriatrjournal_title
Zeitschrift fur Gerontologie und Geriatrieauthors
Honneth J,Nehen HG,Haseke Jdoi
10.1007/s00391-010-0101-1subject
Has Abstractpub_date
2010-06-01 00:00:00pages
177-9issue
3eissn
0948-6704issn
1435-1269journal_volume
43pub_type
杂志文章abstract::The number of elderly patients with non-Hodgkin's lymphomas (NHL) is continuously increasing. The diagnostic and staging procedures should be carried out in elderly patients as careful as in younger patients. Furthermore, for treatment decisions geriatric assessment and the patient's preferences concerning therapy are...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910170049
更新日期:2001-08-01 00:00:00
abstract::The existence of a so-called "vitauct process" is discussed by means of the glucocorticoid-induced stimulation of tyrosine aminotransferase activity. Own experiments show that the highest possible stimulation of the enzyme by cortisol and stress in the liver of old Wistar rats is not lower than in young-adult animals....
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Patients with dementia (PD) are a special challenge for the healthcare system. They are responsible for 5% of the expenditure in the German healthcare service. The disease-related deficits and the associated need for care leads to the fact that patients are not able to live in their own residence and rely on...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-020-01715-4
更新日期:2020-03-18 00:00:00
abstract::Programmes containing health-enhancing physical exercise should be evaluated using standards that are just as rigorous as those required for drug development. In contrast to new medicines, exercise programmes are highly complex. This has to be taken into account when designing the research plan. In order to illustrate...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 临床试验,杂志文章
doi:10.1007/s00391-012-0329-z
更新日期:2013-01-01 00:00:00
abstract::The age appropriateness of a pharmaceutical product for older patient populations is most important in achieving ease of use, administration, and adherence as well as the therapeutic benefit of the drug. Drug development is a lengthy and risky investment accompanied by extensive regulatory requirements to meet all the...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-012-0361-z
更新日期:2012-08-01 00:00:00
abstract::Heating of food induces the formation of Maillard reaction products (MRPs) caused by the reaction of reducing sugars with proteins or amino acids. Analogous reactions occur in the human body, eventually forming "Advanced Glycation Endproducts" (AGEs). AGEs accumulate in aging tissues accelerating degenerative-inflamma...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-005-0263-4
更新日期:2005-10-01 00:00:00
abstract::From its origin to its death the human organism is submitted to functional, material, and morphological changes that are perceptible. These changes permit classifying an individual as young, adult, old, active or infirm. But this estimation is not always correct. Some appear younger, some older than expected from thei...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s003910070011
更新日期:2000-01-01 00:00:00
abstract::The HILDE project proceeds from a theoretical conception of quality of life which considers both the significance of objective living conditions claimed in the Swedish level of living approach and the significance of processes of subjective perceptions and judgements accentuated in the American quality of life approac...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-006-0408-0
更新日期:2006-10-01 00:00:00
abstract::In Germany, there clearly appears to be a gap between care carried out at home and in in-patient settings (residential nursing care). Numerous innovative projects of alternatively structured care, like for instance shared flats or group care units for people with dementia are placed in between the traditional, either ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-005-0298-6
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Anemia and hypoalbuminemia (HA) are acknowledged independent risk factors for morbidity and mortality in geriatric patients and are associated with nutritional status and frailty. Data exist regarding the association between albumin and frailty, anemia and frailty as well as frailty and nutritional status; h...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-015-0872-5
更新日期:2015-10-01 00:00:00
abstract::In 25 patients (10 male, 15 female) with systemic sclerosis aged between 28 and 79 years the biological age was determined. Alterations in the sense of "premature aging" were observed in the mean and developed stronger in male patients. They have to be counted in a greater part on the real process of disease. Compared...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::The Northern Germany Nursing Research Network (Pflegeforschungsverbund Nord) has dedicated itself to developing management instruments intended to optimize the nursing process. It is coordinated by the administrative office of the Institute of Public Health and Nursing Research (Institut für Public Health und Pflegefo...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-006-0382-6
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:In the course of demographic developments, an increase of vascular surgical procedures including major amputations in very elderly, multimorbid geriatric patients is expected. Due to the high vulnerability of these patients, geriatric rehabilitation directly following the acute inpatient treatment is likely ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0848-x
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Clinically relevant posttraumatic stress disorders are almost always associated with physical symptoms, which are, on the one hand, classified as somatoform and, on the other hand, may also present as somatic comorbidities. The psychological, neurobiological, endocrinological and immunological correlations a...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0629-6
更新日期:2014-04-01 00:00:00
abstract::The number of accidents caused by older car drivers increases annually in Germany. Typical errors of older drivers concern the right of way, changes of direction and conflicts with pedestrians at cross walks. These errors are attributed to deficient information gathering and processing caused by old age and illness. I...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910050123
更新日期:1999-10-01 00:00:00
abstract::The NaCl content of the culture medium of human fibroblasts (WI-38) was elevated from 0.12 M to 0.23 M. Previously it had been shown that exposure of fibroblasts to such high NaCl conditions resulted in a rise of both glycolysis and respiration ("energetic stress"), mainly due to increased demands of energy for active...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910170014
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Geriatric medicine in Germany is faced with an increasing demand for continuous documentation and evaluation of its effectiveness and efficiency. Hence, the Federal Association (FA) of Clinical Geriatric Departments (Bundesarbeitsgemeinschaft der Klinisch-Geriatrischen Einrichtungen e.V.) has funded a workin...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910050076
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:The N‑terminal pro-brain natriuretic peptide (NT-proBNP) has an important prognostic value in chronic renal insufficiency; however, most studies have been conducted in patients with end-stage renal disease (ESRD). In this study we evaluated the prognostic significance of NT-proBNP in very old patients with s...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-017-1327-y
更新日期:2018-12-01 00:00:00
abstract::Functional deficits of elderly patients are often not recognized during routine treatment in acute hospital care. In Germany, there are only limited experiences with the use of standardized assessment-scales in this health care setting. In this study, 112 patients were recruited for a very broad geriatric assessment f...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Ambulatory geriatric rehabilitation (AGR) is a prevention program for multimorbid patients with the contractual agreement to prevent the need for care and hospital admissions and to promote self-sufficiency. It provides an opportunity to reduce the prevalence of polypharmacy and to discontinue potentially in...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-019-01589-1
更新日期:2020-08-01 00:00:00
abstract::The trial "Outpatient Geriatric Rehabilitation (AMBRA)" has been launched to compare two outpatient rehabilitation models close to their place of residence or at home: a mobile rehabilitation team based at a geriatric hospital department and a community-based outpatient rehabilitation center run by GPs. Primary analys...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-002-0065-x
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:The use of technological innovations can play a significant role in healthy aging and social participation in old age; however, it is not well understood how social contexts can influence or support older adults' use of technology. This study explored the associations between technology use, perceived techno...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-019-01529-z
更新日期:2020-05-01 00:00:00
abstract::The incidence of diabetes has increased in the recent years. Diabetes is characterized by increased sugar concentrations in the blood. Due to this dysregulation, more carbohydrate-induced modification of proteins - so-called advanced glycation end products (AGEs) - are formed endogenously by non-enzymatic reactions. T...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-011-0282-2
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:In all, 39 % of people living in Swiss nursing homes suffer from dementia. Detailed data about type and course of symptoms displayed by these patients in their terminal phase are lacking. METHODS:This descriptive, retrospective study analysed 65 nursing documents from deceased people with dementia in four n...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0668-z
更新日期:2015-02-01 00:00:00
abstract::The aim of the present study was to describe the course and outcome of rehabilitation using a national recommended assessment program (AGAST). In our study 162 patients with stroke were included. Nearly all patients had improvement of activities of daily living (Barthel Index) and mobility (Tinetti Gait and Balance Sc...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910050105
更新日期:1999-06-01 00:00:00
abstract::Results of a longitudinal study about the transition to retirement are presented. 329 persons were interviewed three times (quantitative study) and 20 persons conducted a semi-structured diary (qualitative study), covering in both groups a two-year period (from half a year before retirement to one and a half years aft...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910050168
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:A large number of older acutely ill patients with cognitive impairment are treated in geriatric care units. Since 1990 some geriatric departments in Germany have established special care units (SCU) for this patient population. In 2010 the first inventory of SCUs in Germany was carried out, which was not bas...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-018-1439-z
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Demographic changes result in a higher prevalence of patients suffering from dementia in hospital. In Germany, epidemiological data of this target group are scarce and prevalence rates from university hospitals (UH) are not available. The prevalence rates and distribution were analyzed on the basis of ICD-10...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-018-1433-5
更新日期:2019-10-01 00:00:00
abstract::Efforts to improve the quality of care mainly depend on sufficient capacities of staff qualifications. Professional training is of primary importance to prepare for new tasks and to reduce educational deficits. The results of an empirical study carried out by the Federal Department of Family Affairs and the Kuratorium...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::National and international data networks for data transfer and communication are playing an increasingly important role in science and medicine. These networks already exist on a regional, national and international scale. The biggest international network, the Internet, offers more than 300 sites referring to "aging"...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00