Abstract：
:The NaCl content of the culture medium of human fibroblasts (WI-38) was elevated from 0.12 M to 0.23 M. Previously it had been shown that exposure of fibroblasts to such high NaCl conditions resulted in a rise of both glycolysis and respiration ("energetic stress"), mainly due to increased demands of energy for active ion transport ("sodium pump"). While "young" (Phase II) and "senescent" (Phase III) cells did not show a significant increase of apoptosis over the basal rate (ca. 4%) under treatment with either a high-NaCl medium or TNF-alpha (10 nM) alone, combined treatment resulted in a strong increase in Phase II cells and a significantly lesser rise in the case of "senescent" Phase III cells. We conclude, therefore, that energetic stress stimulates sensitivity to apoptosis by (in the presence of) TNF-alpha, especially pronounced in potentially replicating "young" as compared with irreversible postmitotic ("senescent") fibroblasts. Possible causes of this differential responsiveness and implications for the in vivo situation (in the organism) were discussed.
journal_name
Z Gerontol Geriatrjournal_title
Zeitschrift fur Gerontologie und Geriatrieauthors
Steinkamp M,Schachtschabel DOdoi
10.1007/s003910170014subject
Has Abstractpub_date
2001-12-01 00:00:00pages
437-40issue
6eissn
0948-6704issn
1435-1269journal_volume
34pub_type
杂志文章abstract：BACKGROUND:Early discharge from a rehabilitation center is only possible, if patients are able to do basic transfers independently (e.g., get up from bed and walk to the toilet). Against this background, the Lie-to-Sit-to-Stand-to-Walk Transfer (LSSWT) test was developed in order to quantify complex transfer abilities ...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-011-0169-2
更新日期：2011-08-01 00:00:00
abstract：:The causes of pain must always be clarified, as long as it can be justified. In dementia the placebo effect can be lacking. A treatment on demand is difficult to implement. Correctly applied nonmedicinal treatment has few unwanted effects but mostly needs constant support by personnel. Medications with anticholinergic...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-019-01578-4
更新日期：2019-10-01 00:00:00
abstract：:Chronic or repeated stress can induce a damage of neurons, especially in hippocampus, by which the degree of damage differs in various species. Sapolski has reported that there is a correlation between hippocampal degeneration, disturbed feedback reaction, and hypersecretion of glucocorticoids. The aim of this study w...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s003910050087
更新日期：1999-04-01 00:00:00
abstract：:Due to the excellent efficacy of antiretroviral treatment increasingly more people with human immunodeficiency virus (HIV) infections survive to old age. The national and international definition of older people with HIV infections comprises those aged 50 years and older. Practitioners caring for these patients have t...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-019-01669-2
更新日期：2020-03-01 00:00:00
abstract：:Sheltered living groups are enjoying great popularity in Germany. They represent an alternative to home care on the one hand and to nursing homes on the other hand. Under German law they face a conflict situation and must fulfil many legal requirements, which confront the foundation and operation with legal barriers. ...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章,评审
doi：10.1007/s00391-019-01649-6
更新日期：2020-10-01 00:00:00
abstract：:After a pilot study in 2010 in segregated wards for patients with dementia in nursing homes (DWB) and in community-based living communities for older people with dementia (DWG), major differences in the proportion of mentally stressed employees were found (DWB: 57%, DWG: 26%) as well as in the proportion of employees ...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章,评审
doi：10.1007/s00391-020-01709-2
更新日期：2020-10-01 00:00:00
abstract：:The obvious increase of human age even up to above one hundred years in nearly all civilised countries leeds the autor to discuss the following actual gerontologic problems: the needs for further splitting of categories of high age, the reasons for the rapid increase of the oldest-old group and the predicted "mushroom...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The existence of a so-called "vitauct process" is discussed by means of the glucocorticoid-induced stimulation of tyrosine aminotransferase activity. Own experiments show that the highest possible stimulation of the enzyme by cortisol and stress in the liver of old Wistar rats is not lower than in young-adult animals....
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:This contribution refers to the 2009 Council of Experts Report on health system development and discusses the special care requirements of old people. This includes the geriatric phenomenon of multimorbidity, polypharmacy in old people with multiple diseases, and the need for care. The probability and complexity of mu...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-009-0072-2
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Over the last 10 years the German pension system has undergone several reforms including the abandonment of early retirement policies and an increase in the statutory retirement age. Consequently, the average retirement age has increased and future retiree cohorts have adjusted the retirement expectations an...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-016-1053-x
更新日期：2018-01-01 00:00:00
abstract：:Scabies is a frequent ectoparasitosis the prevalence of which also seems to increase in older patients. Correct and timely diagnosis of scabies in older age is hampered by atypical clinical manifestations, the potential lack of pruritus and a variety of differential diagnoses. Scabies crustosa, a highly contagious sub...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章,评审
doi：10.1007/s00391-019-01650-z
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Ambulatory geriatric rehabilitation (AGR) is a prevention program for multimorbid patients with the contractual agreement to prevent the need for care and hospital admissions and to promote self-sufficiency. It provides an opportunity to reduce the prevalence of polypharmacy and to discontinue potentially in...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-019-01589-1
更新日期：2020-08-01 00:00:00
abstract：:Nonpharmacological treatments can improve the quality of life of people with dementia. The objective of this review is to evaluate the effects of nonpharmacological treatments on quality of life and to analyze corresponding instruments by performing a systematic review of the literature. Candidate studies were first i...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00391-012-0341-3
更新日期：2013-02-01 00:00:00
abstract：:While hemiendoprothesis has been established in the treatment of hip fractures of aged people because of less operative trauma, better effectiveness and satisfying functionality, surgical management of trochanteric fractures is still in discussion. In our study, we found no severe difference of living conditions or mo...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The BRD social security system contains numerous regulations concerning the smoothness of regulating social security benefits between unemployment benefit to pension benefit. Raising the retirement age for unemployed will lead to long-term unemployment or to a decreasing pension payment in the case of early retirement...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：BACKROUND:Until recently public health and health services research has not been concerned with people suffering from dementia with a Turkish migration background as a priority. There is little evidence about the situation of this population; however, it is known that these individuals almost always live with their fam...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-014-0802-y
更新日期：2015-07-01 00:00:00
abstract：:Decubitus is one appropriate quality indicator in health care. Quality- or risk-management in the field of decubitus prevention is of interest for all involved professions. Nursing, medical and administrative staff are equally responsible. Data collection, evaluation and feedback aiming at the highest achievable benef...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-004-0219-0
更新日期：2004-04-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most frequent form of dementia worldwide. The increasing incidence of AD is due to the dramatic rise in life expectancy. Generally, AD shows a multifactorial etiology and manifests itself only at an older age. However, a small percentage of cases have a monogenic cause, are inherited as...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-010-0101-1
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Patients with dementia (PD) are a special challenge for the healthcare system. They are responsible for 5% of the expenditure in the German healthcare service. The disease-related deficits and the associated need for care leads to the fact that patients are not able to live in their own residence and rely on...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-020-01715-4
更新日期：2020-03-18 00:00:00
abstract：:This work is aimed at reviewing 20 years of gerontological intervention research within the social and behavioral domain in German speaking countries. Only controlled studies based on adequate measurement instruments are considered. Literature analyses reveal that the issue of cognitive intervention research is well-c...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章,评审
doi：10.1007/s003910050022
更新日期：1998-04-01 00:00:00
abstract：:The first chapter gives a brief overview of dominant perspectives on reminiscence and life review in aging research since the 60s. The scepticism of most age researchers against personal history as a dominant concern of the aged in the late 60s was replaced by a more optimistic view which corresponded with a new Zeitg...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:The treatment and care of individuals with dementia, who are admitted to general hospitals due to somatic diseases, often leads to crisis situations which not only compromise the therapeutic benefit, but also can be followed by avoidable institutionalization in nursing homes or psychiatric hospitals. With the model pr...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-008-0021-5
更新日期：2008-12-01 00:00:00
abstract：:Selected activities of daily living are used to describe the micro-area (dwelling), mezzo-area (quarter) and exo-area (outside the quarter). In a survey of 115 elderly people, the five-year-changes from 1985/86 to 1990/91 in their areas of mobility in a working class district are documented. Special interest is given ...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：PURPOSE OF THE STUDY:In this study the relevance of sense of coherence (SOC) for coping with an illness was examined in subjects with Parkinson's disease. According to Antonovsky's model (1997) the sense of coherence is an important resource when it comes to dealing with stressors. To take into consideration the integr...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-008-0009-1
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Dementia may influence as a co-morbid condition the management of chronic obstructive airway disease. However, the frequency and the consequences of dementia in older people with chronic obstructive airway disease are largely unknown. PATIENTS AND METHODS:The frequency and the severity of dementia in geriat...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-011-0223-0
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:The aim of this project was to obtain information about drug therapy in geriatric units. PATIENTS AND METHODS:Members of the geriatrics in Bavaria database (GiB-DAT) collected data on discharge medication and transferred them to the database. A total of 88,840 data sets of geriatric rehabilitation clinics a...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-012-0382-7
更新日期：2012-08-01 00:00:00
abstract：:From its origin to its death the human organism is submitted to functional, material, and morphological changes that are perceptible. These changes permit classifying an individual as young, adult, old, active or infirm. But this estimation is not always correct. Some appear younger, some older than expected from thei...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章,评审
doi：10.1007/s003910070011
更新日期：2000-01-01 00:00:00
abstract：:Experience and behavior of dying people are on a lot of variables. Age, cultural background, human relations, personality and environment are some of these determinants. For an appropriate care for the dying it is necessary to perceive and realize the expectations and requirements of the dying person. The human relati...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:The use of technological innovations can play a significant role in healthy aging and social participation in old age; however, it is not well understood how social contexts can influence or support older adults' use of technology. This study explored the associations between technology use, perceived techno...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-019-01529-z
更新日期：2020-05-01 00:00:00
abstract：:In the following article, two of the increasingly important public health scientific disciplines of care for the elderly are compared under systematic aspects - gerontopsychiatry and nursing science - with the aim of determining the similarities and differences of both disciplines. There follows a discussion of social...
journal_title：Zeitschrift fur Gerontologie und Geriatrie
pub_type： 杂志文章
doi：10.1007/s00391-004-0247-9
更新日期：2004-08-01 00:00:00
