Abstract:
:Chronic or repeated stress can induce a damage of neurons, especially in hippocampus, by which the degree of damage differs in various species. Sapolski has reported that there is a correlation between hippocampal degeneration, disturbed feedback reaction, and hypersecretion of glucocorticoids. The aim of this study was to investigate if the signal transmission via glucocorticoid receptors (GR) in the brain of male wistar rats of two age groups (5-6 and 17-24 months, respectively) is changed in aging and which cytoplasmic factors/modulators participate in this process. The binding of 3H-dexamethasone to cytosolic GR, the transformation, translocation, and nuclear binding of GR complexes (GRC) were studied before and after physiological stress. The influence of cytoplasmic modulators ASTP1) and HSP 70(1)), isolated from brain cytosol and purified, and of exogenous PK C1) was also tested in parallel incubation systems. Whereas old control animals showed a higher cytosolic concentration of unoccupied GR than young ones, this was significantly reduced only in old stressed rats 60 min after stress compared to old controls. The part of transformed GRC, bound to isolated nuclei, was somewhat lower in old than in young rats before and after stress. The nuclear GRC binding could be slightly elevated by addition of ASTP and HSP 70, resp., at the heat transformation of GRC; however, by simultaneous addition of PK C it was significantly increased in both age groups. The GRC binding also rose significantly in stressed animals compared to controls, after simultaneous addition of PK C to more than double of initial assays in young animals. Purified ASTP, isolated from brain cytosol of young animals, showed a higher 32P-incorporation after phosphorylation in vitro than that from old animals. The reduced phosphorylation of ASTP could be one possible cause of the retarded transformation/translocation and the reduced nuclear binding of GRC together with the restricted expression of HSP 70 and decreased PK C activity in the old rat brain.
journal_name
Z Gerontol Geriatrjournal_title
Zeitschrift fur Gerontologie und Geriatrieauthors
Martin R,al-Scheibani AH,Martin Hdoi
10.1007/s003910050087subject
Has Abstractpub_date
1999-04-01 00:00:00pages
76-82issue
2eissn
0948-6704issn
1435-1269journal_volume
32pub_type
杂志文章abstract:BACKGROUND:Ambulatory geriatric rehabilitation (AGR) is a prevention program for multimorbid patients with the contractual agreement to prevent the need for care and hospital admissions and to promote self-sufficiency. It provides an opportunity to reduce the prevalence of polypharmacy and to discontinue potentially in...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-019-01589-1
更新日期:2020-08-01 00:00:00
abstract::Although viewed critically in geriatrics, benzodiazepine use is still common among old people. Before reducing the dosage the following questions must be considered: 1. Are there indications for benzodiazepine treatment and will discontinuation cause relevant rebound symptoms of the initial disorder treated? 2. To wha...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-016-1171-5
更新日期:2017-02-01 00:00:00
abstract::Symptoms presented by patients with Alzheimer-type dementia do not only reflect organic disturbances only but require a holistic and person-oriented view. Affective and behavioral disturbances are not necessarily secondary to cognitive impairment. Guidelines are presented for a multidimensional treatment involving the...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s003910170072
更新日期:2001-04-01 00:00:00
abstract::"Rehabilitation instead of nursing care" is one of the most important entitlements of the social welfare legislation to long-term care. In Germany 1.2 million evaluations per year are done by the experts of the medical review boards of the health insurance funds. As a part of those evaluations the experts also have to...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Over the course of the demographic transition with an aging and shrinking work force, work participation of older employees becomes more and more important. Earlier investigations found social groups to be different in work-related and individual aspects, which were shown to be associated with motivation for...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-018-1450-4
更新日期:2019-02-01 00:00:00
abstract::The purpose of the study was to measure the prevalence of difficulties in elderly inpatients in opening a range of common commercial drug packagings, in breaking a bar-scored tablet, and in reading medication instructions. Sixty-seven patients (female: 47; male: 20, mean age: 81.6 +/- 6.1) who reported that they had m...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:In all, 39 % of people living in Swiss nursing homes suffer from dementia. Detailed data about type and course of symptoms displayed by these patients in their terminal phase are lacking. METHODS:This descriptive, retrospective study analysed 65 nursing documents from deceased people with dementia in four n...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0668-z
更新日期:2015-02-01 00:00:00
abstract::The purpose of this study was to validate the German translation of the originally English Fullerton Advanced Balance Scale (FAB-D). The 10-item test battery is a performance-based measure that addresses the multiple dimensions of balance. The German FAB-D using a forward-backward procedure was examined by a sample of...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-011-0236-8
更新日期:2011-12-01 00:00:00
abstract::The results of the determination of hematologic values from 262 men and 242 women, participants of an aging study and half of each group 44.4 +/- 0.9 and 63.0 +/- 0.9 (men) and 44.4 +/- 0.9 and 62.8 +/- 0.8 years old (women), respectively, are compared. In men, one analyte (hemoglobin decreasing) and four indices show...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910170062
更新日期:2001-06-01 00:00:00
abstract::Heating of food induces the formation of Maillard reaction products (MRPs) caused by the reaction of reducing sugars with proteins or amino acids. Analogous reactions occur in the human body, eventually forming "Advanced Glycation Endproducts" (AGEs). AGEs accumulate in aging tissues accelerating degenerative-inflamma...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-005-0263-4
更新日期:2005-10-01 00:00:00
abstract::Programmes containing health-enhancing physical exercise should be evaluated using standards that are just as rigorous as those required for drug development. In contrast to new medicines, exercise programmes are highly complex. This has to be taken into account when designing the research plan. In order to illustrate...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 临床试验,杂志文章
doi:10.1007/s00391-012-0329-z
更新日期:2013-01-01 00:00:00
abstract::Sheltered living groups are enjoying great popularity in Germany. They represent an alternative to home care on the one hand and to nursing homes on the other hand. Under German law they face a conflict situation and must fulfil many legal requirements, which confront the foundation and operation with legal barriers. ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-019-01649-6
更新日期:2020-10-01 00:00:00
abstract::Geriatric patients with non-valvular atrial fibrillation (AF) are increasingly being treated with novel oral anticoagulants (NOAC) to prevent ischemic stroke. This article highlights the outcome of an expert meeting on the practical use of NOAC in elderly patients. An interdisciplinary group of experts discussed the c...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-016-1027-z
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:A correlation between asymmetry in electroencephalographs (EEG) and depression has been demonstrated in many studies. To the best of our knowledge there are no studies including oldest old geriatric patients. OBJECTIVE:The objective of this study was to evaluate whether frontal and parietal alpha asymmetry ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-016-1108-z
更新日期:2018-02-01 00:00:00
abstract::The European Academy for Medicine of Ageing was founded in 1995 by a nucleus group of European professors: Duursma (Utrecht, NL), Evans (Oxford, GB), Michel (Geneve, CH) and Stähelin (Basel, CH). The aim was to get an adequate postgraduate training under the auspices of an international faculty. A whole curriculum con...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-005-1113-0
更新日期:2005-09-01 00:00:00
abstract::Malignant wounds arise either primary or secondary in the context of a malignant transformation of already existing wounds. A plethora of skin tumors, such as basal cell carcinoma, squamous cell carcinoma, melanoma, lymphoma as well as cutaneous metastases of other malignancies can ulcerate and be the cause of maligna...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-019-01629-w
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Current Swiss politics concerning age and ageing are orientated towards the principle "out-patient before in-patient". As part of new regulations, in 2011 all communities were required to set up information offices to answer questions about out-patient and in-patient care. OBJECTIVES:The aim of this qualita...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-015-0948-2
更新日期:2016-08-01 00:00:00
abstract::During the past decades, the number of hip fractures has been increasing steadily. Perioperative thromboprophylaxis has become a routine aspect in the care of geriatric hip fracture patients. In addition, a large proportion of these patients are already anticoagulated because of internistic comorbidities before they s...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-013-0595-4
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The aim of palliative care is to help people with a progressive, probably fatal disease to achieve the highest possible quality of life. Any treatment is radically oriented towards the needs of the affected persons and their relatives. Although nursing institutions for seniors are the second most frequent pl...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-020-01803-5
更新日期:2021-02-01 00:00:00
abstract::The number of elderly patients with non-Hodgkin's lymphomas (NHL) is continuously increasing. The diagnostic and staging procedures should be carried out in elderly patients as careful as in younger patients. Furthermore, for treatment decisions geriatric assessment and the patient's preferences concerning therapy are...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910170049
更新日期:2001-08-01 00:00:00
abstract:AIM:The goal of this study was to perform a structured analysis of the treatment quality and acute complications of geriatric patients with diabetes mellitus (DM) cared for by nursing services and nursing home facilities. Secondly, structural problems and potentials for improvement in the care of multimorbid older peop...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0626-9
更新日期:2015-04-01 00:00:00
abstract::Efforts to improve the quality of care mainly depend on sufficient capacities of staff qualifications. Professional training is of primary importance to prepare for new tasks and to reduce educational deficits. The results of an empirical study carried out by the Federal Department of Family Affairs and the Kuratorium...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::Patients with Graves' or Plummer's disease have usually definitively been treated by surgery or radioiodine. If, however, the patient does not accept either form of treatment or the risk of surgery or the inconveniences of the radioiodine treatment by far out-weight the expected benefit for the patient, alternative th...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::The NaCl content of the culture medium of human fibroblasts (WI-38) was elevated from 0.12 M to 0.23 M. Previously it had been shown that exposure of fibroblasts to such high NaCl conditions resulted in a rise of both glycolysis and respiration ("energetic stress"), mainly due to increased demands of energy for active...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910170014
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:It has been questioned by researchers in robotics as well in the general public to what extent companion-type robots can support the elderly with the fulfillment of their psychological and social needs. Although these robots have already been used in care settings in Germany, research has referred little to ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-017-1346-8
更新日期:2018-01-01 00:00:00
abstract::Older people often report a decline in their cognitive functions - memory problems and difficulty finding words are frequently mentioned. In this context it is essential to differentiate between age-related cognitive decline and pathological processes as they occur in the context of dementia. Neuropsychological diagno...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-020-01800-8
更新日期:2020-12-01 00:00:00
abstract::For a period of 3 consecutive years, all fall events were prospectively recorded in geriatric hospital in-patients by using a standardized protocol. The incidence was 9.1 fall events/1000 hospital days in 5946 patients, and 41.0/1000 hospital days in 1015 patients (17.0%) who actually had falls. The fall rate varied b...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-004-0204-7
更新日期:2004-02-01 00:00:00
abstract::It is well known that problems with compliance rise exponentially when more that 4 drugs are prescribed. The rising use of prescription medicine forces the GP to balance the benefit of evidence group-based appropriate drug use against the problems arising when medication is given to older people and to consider differ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-005-1104-1
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Although internet usage among older adults is steadily increasing, there is still a digital divide between generations. Younger internet users seem to be more open towards new media. Recent studies showed the negative influence of computer anxiety on internet usage. It is not known how older adults deal with...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0838-z
更新日期:2015-12-01 00:00:00
abstract::Basic research on aging has moved well beyond describing the aging of physiological systems and developing theories of aging, to the pursuit of mechanistic answers to questions such as: Why do we age? Why do individuals within a population age differently? Why do different species have such different life spans? How d...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910170024
更新日期:2001-12-01 00:00:00