Abstract:
BACKGROUND:The N‑terminal pro-brain natriuretic peptide (NT-proBNP) has an important prognostic value in chronic renal insufficiency; however, most studies have been conducted in patients with end-stage renal disease (ESRD). In this study we evaluated the prognostic significance of NT-proBNP in very old patients with stage 3 chronic kidney disease (CKD) and compared its prognostic value in CKD3a versus CKD3b patients. METHODS:Patients (age ≥80 years old) hospitalized with stage 3 CKD from 2007 to 2010 who were eligible for this prospective study underwent follow-up examinations in 2015. The examinations included measurements of anthropometric characteristics, blood pressure, plasma NT-proBNP, creatinine, and lipids. End-point events were all-cause death and major adverse cardiac events (MACEs). RESULTS:A total of 168 patients (mean age 87.4 ± 2.9 years, range 80-99 years) were included in the analysis (CKD3a, n = 117; CKD3b, n = 51). The results showed that CKD3b was associated with lower hemoglobin levels, higher NT-proBNP levels and a higher rate of hypertension compared with CKD3a. After a median follow-up of 3.8 years (interquartile range 1.5-6.1 years), a higher NT-proBNP level was associated with a higher risk of all-cause death (hazard ratio HR 1.986, 95% confidence interval CI 1.276-2.819, p = 0.028) and MACEs (HR 2.872, 95% CI 1.241-6.644, p = 0.014) after adjusting for age, sex, and traditional risk factors; however, a subgroup comparison showed that elevated NT-proBNP levels were associated with a higher risk of all-cause death (HR 2.350, 95% CI 1.906-6.091, p = 0.039) and MACEs (HR 3.025, 95% CI 1.024-8.940, p = 0.045) in CKD3a but not CKD3b. CONCLUSION:Levels of NT-proBNP increased with decreased renal function in very old patients with stage 3 CKD; therefore, NT-proBNP is an independent predictor for all-cause death and MACEs in these patients but has a greater prognostic value in CKD3a than in CKD3b.
journal_name
Z Gerontol Geriatrjournal_title
Zeitschrift fur Gerontologie und Geriatrieauthors
Gao P,Zhu Q,Bian S,Liu H,Xie Hdoi
10.1007/s00391-017-1327-ysubject
Has Abstractpub_date
2018-12-01 00:00:00pages
889-896issue
8eissn
0948-6704issn
1435-1269pii
10.1007/s00391-017-1327-yjournal_volume
51pub_type
杂志文章abstract:BACKGROUND:Early discharge from a rehabilitation center is only possible, if patients are able to do basic transfers independently (e.g., get up from bed and walk to the toilet). Against this background, the Lie-to-Sit-to-Stand-to-Walk Transfer (LSSWT) test was developed in order to quantify complex transfer abilities ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-011-0169-2
更新日期:2011-08-01 00:00:00
abstract::The German version of the Falls Efficacy Scale-International Version (FES-I), which is presented, was developed for the documentation of fall-related selfefficacy in older persons by a EU-funded expert network (Prevention of Falls Network Europe ProFaNE). The FES-I represents a modification of the original Falls Effic...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-006-0400-8
更新日期:2006-08-01 00:00:00
abstract::The interdisciplinary symposium of the working group "anemia in the aged" on the occasion of the annual conference of the German Society of Geriatrics focused this year on vitamin B12 deficiency in aged patients. Experts from hematopathology, clinical geriatrics and geriatric hematology presented the case of a 78-year...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-018-1410-z
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Dry mouth is a frequently occurrence in elderly people and causes numerous clinical and social problems. OBJECTIVE:To investigate the quality of life in geriatric patients living in nursing homes depending on the subjective sensation of dry mouth and associated oral parameters. MATERIAL AND METHODS:A total...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-015-0968-y
更新日期:2017-02-01 00:00:00
abstract::Patients with Graves' or Plummer's disease have usually definitively been treated by surgery or radioiodine. If, however, the patient does not accept either form of treatment or the risk of surgery or the inconveniences of the radioiodine treatment by far out-weight the expected benefit for the patient, alternative th...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::Heating of food induces the formation of Maillard reaction products (MRPs) caused by the reaction of reducing sugars with proteins or amino acids. Analogous reactions occur in the human body, eventually forming "Advanced Glycation Endproducts" (AGEs). AGEs accumulate in aging tissues accelerating degenerative-inflamma...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-005-0263-4
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Although internet usage among older adults is steadily increasing, there is still a digital divide between generations. Younger internet users seem to be more open towards new media. Recent studies showed the negative influence of computer anxiety on internet usage. It is not known how older adults deal with...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0838-z
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Little is known about the prevalence of falls and the related risk factors in the general population of community-living older people in Germany. OBJECTIVES:To assess the prevalence and related predictors of different types of falls in a sample of community-dwelling 65 years and older people in Germany livi...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-008-0506-2
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Current Swiss politics concerning age and ageing are orientated towards the principle "out-patient before in-patient". As part of new regulations, in 2011 all communities were required to set up information offices to answer questions about out-patient and in-patient care. OBJECTIVES:The aim of this qualita...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-015-0948-2
更新日期:2016-08-01 00:00:00
abstract::The global shift in demographics towards aging populations is leading to a commensurate increase in age-related disease and frailty. It is essential to optimise health services to meet current needs and prepare for anticipated future demands. This paper explores issues impacting on people living with cognitive impairm...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-017-1224-4
更新日期:2017-05-01 00:00:00
abstract::The concept of active ageing comprises the maintenance of societal participation throughout the life span into old age. "Good" ageing in line with this activity paradigm develops into a starting point of social inequality rather than being its result. Based on the German Ageing Survey (DEAS) we investigated access to ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-013-0498-4
更新日期:2013-07-01 00:00:00
abstract::Functional deficits of elderly patients are often not recognized during routine treatment in acute hospital care. In Germany, there are only limited experiences with the use of standardized assessment-scales in this health care setting. In this study, 112 patients were recruited for a very broad geriatric assessment f...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Dementia may influence as a co-morbid condition the management of chronic obstructive airway disease. However, the frequency and the consequences of dementia in older people with chronic obstructive airway disease are largely unknown. PATIENTS AND METHODS:The frequency and the severity of dementia in geriat...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-011-0223-0
更新日期:2011-08-01 00:00:00
abstract::Depression in old age is common and also dangerous due to somatic comorbidity and suicide; however, it is often not recognized and not adequately treated. Psychotherapy is almost never offered to the elderly. However, clinical experience, single-case studies and some controlled trials show effectiveness--at least to t...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-012-0469-1
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Ambulatory geriatric rehabilitation (AGR) is a prevention program for multimorbid patients with the contractual agreement to prevent the need for care and hospital admissions and to promote self-sufficiency. It provides an opportunity to reduce the prevalence of polypharmacy and to discontinue potentially in...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-019-01589-1
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Aged skin is the sum of chronological und UV-induced aging. Light-exposed skin is unattractive, with irregular pigmentation, roughness und scaliness. The skin is often dry and itches. METHODS:The present paper provides an overview of diseases of aging skin and describes how to prevent or reduce disease by p...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-014-0670-5
更新日期:2015-06-01 00:00:00
abstract::The existence of a so-called "vitauct process" is discussed by means of the glucocorticoid-induced stimulation of tyrosine aminotransferase activity. Own experiments show that the highest possible stimulation of the enzyme by cortisol and stress in the liver of old Wistar rats is not lower than in young-adult animals....
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Due to the combined effects of a persistent low birth rate, the forthcoming retirement of the "baby-boom generation" and an increasing life expectancy, the German system of "social security" will face severe challenges in the coming decades. The foreseeable doubling of the ratio between pensioners and employees by 205...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-003-0136-7
更新日期:2003-04-01 00:00:00
abstract::After a pilot study in 2010 in segregated wards for patients with dementia in nursing homes (DWB) and in community-based living communities for older people with dementia (DWG), major differences in the proportion of mentally stressed employees were found (DWB: 57%, DWG: 26%) as well as in the proportion of employees ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-020-01709-2
更新日期:2020-10-01 00:00:00
abstract::In this review, studies on number processing and calculation in demented patients are summarized. Single cases, group studies and our own examinations all show that acalculia is a frequent symptom of dementia and correlates with severity of dementia. While calculation and numeral transcoding deficits are often promine...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s003910200013
更新日期:2002-04-01 00:00:00
abstract::Three strategies are followed in handling the key issue within the field of action of care an services for the elderly: securing the material needs of those requiring care, creating appropriate care structures, and providing an effective counselling back-up to alleviate interface problems. Those latter, process-orient...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s003910050055
更新日期:1998-10-01 00:00:00
abstract::During recent years, a discussion on work activity of retirees has commenced also in Germany. First, this contribution presents a survey of the North American phenomenon of bridge employment and, second, complements leadoff empirical results on individual motives and favored basic conditions in Germany. Individual and...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-009-0047-3
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:The number of multiple chronically ill older people is increasing and multimorbidity is associated with high utilization of health services. Integrated care management is increasingly used to address this problem; however, there is a substantial lack of reliable data on its effectiveness in this target group...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-020-01796-1
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Strengthening cognitive resources of residents in nursing homes is an important goal of preventive activities. The aim of this systematic review was to answer the question which intervention is most effective for nursing home residents to strengthen their cognitive resources. METHOD:A systematic literature ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,meta分析
doi:10.1007/s00391-019-01654-9
更新日期:2020-12-01 00:00:00
abstract::The Northern Germany Nursing Research Network (Pflegeforschungsverbund Nord) has dedicated itself to developing management instruments intended to optimize the nursing process. It is coordinated by the administrative office of the Institute of Public Health and Nursing Research (Institut für Public Health und Pflegefo...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-006-0382-6
更新日期:2006-06-01 00:00:00
abstract::In China, fundamental changes in population development have occurred during the past 50 years. The demographic transition in China required only a few years, while in most European countries this process took several decades. The fertility and mortality rates have declined very quickly, like in Japan and South Korea....
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-012-0401-8
更新日期:2013-07-01 00:00:00
abstract::The geriatric screening according to AGAST (Arbeitsgruppe Geriatrisches Basisassessment) contains functional and diagnosis related items, and risk indicators of prognostic relevance, particularly in hospitalized patients. In a retrospective, cohort study, we compared the screening results in 250 consecutive patients o...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-003-0098-9
更新日期:2003-06-01 00:00:00
abstract::The paper reviews the present state of gerontological research in South Africa and provides examples of relevant studies. So far, most of the research has focused on socioeconomic conditions, e.g, financial status, living arrangements, and intergeneration family relations. During recent years another topic has gained ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s003910050014
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Which deficits in cognitive performance indicate the onset of a pathological deterioration process in older persons? AIM AND OBJECTIVES:Based on an established dementia screening test in elderly adults, a differentiation can be made between healthy cognitive performance and the onset of pathological deficit...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-017-1263-x
更新日期:2018-04-01 00:00:00
abstract::Geriatric patients with non-valvular atrial fibrillation (AF) are increasingly being treated with novel oral anticoagulants (NOAC) to prevent ischemic stroke. This article highlights the outcome of an expert meeting on the practical use of NOAC in elderly patients. An interdisciplinary group of experts discussed the c...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-016-1027-z
更新日期:2016-04-01 00:00:00