Challenges and opportunities in the design of age-appropriate drug products.

Abstract:

:The age appropriateness of a pharmaceutical product for older patient populations is most important in achieving ease of use, administration, and adherence as well as the therapeutic benefit of the drug. Drug development is a lengthy and risky investment accompanied by extensive regulatory requirements to meet all the safety, efficacy, and quality criteria of a pharmaceutical product. Older adults represent a very heterogeneous patient population with different needs compared to younger adults. Major areas that should be considered in the design of age-appropriate products (AAP) are age- and disease-related aspects such as (a) different dose strengths, (b) issues in handling, administering, and managing the drug product, (c) and complex medication regimens. The application of different technologies can meet these specific needs and should be considered at the very beginning of product development when setting the targeted quality product profile (TQPP) or later on during the product life-cycle management.

journal_name

Z Gerontol Geriatr

authors

Stegemann S

doi

10.1007/s00391-012-0361-z

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

479-84

issue

6

eissn

0948-6704

issn

1435-1269

journal_volume

45

pub_type

杂志文章
  • [Traffic accidents of senior citizen car drivers].

    abstract::The number of accidents caused by older car drivers increases annually in Germany. Typical errors of older drivers concern the right of way, changes of direction and conflicts with pedestrians at cross walks. These errors are attributed to deficient information gathering and processing caused by old age and illness. I...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s003910050123

    authors: Emsbach M,Friedel B

    更新日期:1999-10-01 00:00:00

  • [Retirement as crisis or good fortune? Results of a quantitative-qualitative longitudinal study].

    abstract::Results of a longitudinal study about the transition to retirement are presented. 329 persons were interviewed three times (quantitative study) and 20 persons conducted a semi-structured diary (qualitative study), covering in both groups a two-year period (from half a year before retirement to one and a half years aft...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s003910050168

    authors: Mayring P

    更新日期:2000-04-01 00:00:00

  • [Neurobiology of posttraumatic and somatoform disorders in the elderly].

    abstract:BACKGROUND:Clinically relevant posttraumatic stress disorders are almost always associated with physical symptoms, which are, on the one hand, classified as somatoform and, on the other hand, may also present as somatic comorbidities. The psychological, neurobiological, endocrinological and immunological correlations a...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-014-0629-6

    authors: Noll-Hussong M

    更新日期:2014-04-01 00:00:00

  • [Duodenal ulcers, gastric ulcers and Helicobacter pylori].

    abstract::The mortality in elderly patients over the age of 80 years with peptic ulcers in the case of complications, such as bleeding and perforation is higher than in the general population. Duodenal ulcers are associated with Helicobacter pylori infections in 90% of cases and in 70% of gastric ulcers. The treatment of elderl...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章,评审

    doi:10.1007/s00391-017-1190-x

    authors: Dovjak P

    更新日期:2017-02-01 00:00:00

  • [Active life expectancy in Germany and in the United States. A cohort analysis based on the "German Socio-Economic Panel" (GSOEP) and the "Panel Study of Income Dynamics" (PSID)].

    abstract::Using the method of multistate life-tables, the article presents results on active life expectancy on the basis of the German Socio-Economic Panel (GSOEP) and the Panel Study of Income Dynamics (PSID). The transitions into and out of active life are based on event-history analysis and are calculated for different coho...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-002-0127-0

    authors: Klein T,Unger R

    更新日期:2002-12-01 00:00:00

  • [Images and discourses of ageing--annotations to the state of research].

    abstract::Up to now, images of ageing are considered unilaterally from an individualising perspective in which the cause for negative images as well as the starting point for potential change is localised in cognitive attitude patterns. In this contribution we plead for a conceptual extension of the research on images of ageing...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章,评审

    doi:10.1007/s00391-007-0445-3

    authors: Amrhein L,Backes GM

    更新日期:2007-04-01 00:00:00

  • [Decline in renal function in old age : Part of physiological aging versus age-related disease].

    abstract::The incidence and prevalence of chronic renal disease (CKD) in elderly patients are continuously increasing worldwide. Loss of renal function is not only considered to be part of the aging process itself but also reflects the multimorbidity of many geriatric patients. Calculating the glomerular filtration rate using s...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-016-1109-y

    authors: Braun F,Brinkkötter PT

    更新日期:2016-08-01 00:00:00

  • [Interventional gerontology in German-speaking countries: a social and behavioral science assessment].

    abstract::This work is aimed at reviewing 20 years of gerontological intervention research within the social and behavioral domain in German speaking countries. Only controlled studies based on adequate measurement instruments are considered. Literature analyses reveal that the issue of cognitive intervention research is well-c...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章,评审

    doi:10.1007/s003910050022

    authors: Wahl HW,Tesch-Römer C

    更新日期:1998-04-01 00:00:00

  • [Education and graduate education in geriatrics and gerontology: current status in Austria].

    abstract::Further education in practical, clinical and scientific-theoretical gerontology is of great importance either for the global care of the elderly or to increase the knowledge concerning the problems of aging. In this paper we try to evaluate critically activities referring to this, to furthermore develop in internation...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:

    authors: Niedermüller H

    更新日期:1997-03-01 00:00:00

  • [Wife against advance directive: a case-inspired legal and ethical clarification].

    abstract::Advance directives and durable powers of attorney are two increasingly used tools for patients' precedent autonomy; however, their combined use, as recommended by major institutions in Germany, might in reality result in various discrepancies between the wording and interpretation of the directive and the surrogate's ...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-019-01634-z

    authors: Schöne-Seifert B,Gutmann T,Klother K,Kolb G

    更新日期:2019-12-01 00:00:00

  • [Treatment of pain in people with dementia].

    abstract::The causes of pain must always be clarified, as long as it can be justified. In dementia the placebo effect can be lacking. A treatment on demand is difficult to implement. Correctly applied nonmedicinal treatment has few unwanted effects but mostly needs constant support by personnel. Medications with anticholinergic...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-019-01578-4

    authors: Schuler M

    更新日期:2019-10-01 00:00:00

  • [The last year of life: a representative study of deceased patients. Living arrangement, place of death and utilization of health resources].

    abstract::The aim of the present study was to describe the pattern of service use (hospitals, homes, ambulatory services) in the year before death. The results are based on administrative data for the elderly inhabitants of the city of Mannheim, who died during one year (n = 2507), as well as on a survey of the next of kin of a...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s003910050034

    authors: Bickel H

    更新日期:1998-06-01 00:00:00

  • [Kidney transplantation in old age].

    abstract::Older patients clearly benefit from a kidney transplantation despite multiple comorbidities and complications, particularly with respect to life expectancy. Older patients remaining on dialysis on average die earlier compared to patients who underwent a kidney transplantation. In addition, patients experience a signif...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章,评审

    doi:10.1007/s00391-016-1118-x

    authors: Kurschat C

    更新日期:2016-08-01 00:00:00

  • [Associations between cognitive performance in a dementia screening test (SKT) and an intelligence test (WAIS IV) : Which deficits in cognitive performance in old age indicate a possible pathological deterioration process?]

    abstract:BACKGROUND:Which deficits in cognitive performance indicate the onset of a pathological deterioration process in older persons? AIM AND OBJECTIVES:Based on an established dementia screening test in elderly adults, a differentiation can be made between healthy cognitive performance and the onset of pathological deficit...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-017-1263-x

    authors: Pauli L,Daseking M,Petermann F,Stemmler M

    更新日期:2018-04-01 00:00:00

  • [Ideal types of interaction patterns of psychosomatic patients in geriatric inpatient treatment].

    abstract:BACKGROUND:Cooperation between psychosomatic and geriatric medicine is still sporadic and rarely institutionally integrated. At the same time, however, nearly half of geriatric inpatients suffer from psychopathological symptoms of clinical relevance. The patterns of interactions between patients and professionals of th...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-012-0381-8

    authors: Lindner R,Foerster R,von Renteln-Kruse W

    更新日期:2013-07-01 00:00:00

  • An exercise programme for community-dwelling, mobility-restricted and chronically ill older adults with structured support by the general practitioner's practice (HOMEfit). From feasibility to evaluation.

    abstract::Programmes containing health-enhancing physical exercise should be evaluated using standards that are just as rigorous as those required for drug development. In contrast to new medicines, exercise programmes are highly complex. This has to be taken into account when designing the research plan. In order to illustrate...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00391-012-0329-z

    authors: Hinrichs T,Brach M,Bucchi C,Moschny A,Wilm S,Thiem U,Platen P

    更新日期:2013-01-01 00:00:00

  • [Special care units for patients with cognitive impairment : Results of a nationwide survey in geriatric hospitals in Germany].

    abstract:BACKGROUND:A large number of older acutely ill patients with cognitive impairment are treated in geriatric care units. Since 1990 some geriatric departments in Germany have established special care units (SCU) for this patient population. In 2010 the first inventory of SCUs in Germany was carried out, which was not bas...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-018-1439-z

    authors: Zieschang T,Bauer J,Kopf D,Rösler A

    更新日期:2019-10-01 00:00:00

  • [Traumatic experiences in elderly Germans. Importance for mental and physical health at a population level].

    abstract:BACKGROUND:World War II (WWII) is probably the most distressing and fatal historical event in Europe's recent past. Research on mental and physical health sequelae of these traumatic experiences from WWII has only started recently. OBJECTIVES:An overview on the findings from several population-based studies investigat...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-014-0624-y

    authors: Glaesmer H

    更新日期:2014-04-01 00:00:00

  • [Cognitive dysfunction after abdominal surgery in elderly patients].

    abstract::Elderly patients often suffer from postoperative cognitive deficits (POCD) after serious surgical operations. The reasons for this are not well understood. We investigated the influence of the invasiveness of the operation and the duration of the operation as well as the patient's preoperative physical status on measu...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-004-0212-7

    authors: Müller SV,Krause N,Schmidt M,Münte TF,Münte S

    更新日期:2004-12-01 00:00:00

  • [Vertical and horizontal social inequality and motivation for early retirement].

    abstract:BACKGROUND:Over the course of the demographic transition with an aging and shrinking work force, work participation of older employees becomes more and more important. Earlier investigations found social groups to be different in work-related and individual aspects, which were shown to be associated with motivation for...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-018-1450-4

    authors: du Prel JB,Schrettenbrunner C,Hasselhorn HM

    更新日期:2019-02-01 00:00:00

  • [Diastolic heart failure: heart failure with preserved ejection fraction].

    abstract::The prognosis for patients with diastolic heart failure--heart failure with preserved ejection fraction--has not improved in the last few decades despite improvement of prognosis for all patients with heart failure. Diastolic dysfunction is a typical finding in elderly patients with heart failure. The diagnostic proce...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-012-0345-z

    authors: Dovjak P

    更新日期:2013-01-01 00:00:00

  • [Enzyme adaptation and "vitauct" process].

    abstract::The existence of a so-called "vitauct process" is discussed by means of the glucocorticoid-induced stimulation of tyrosine aminotransferase activity. Own experiments show that the highest possible stimulation of the enzyme by cortisol and stress in the liver of old Wistar rats is not lower than in young-adult animals....

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:

    authors: Martin H,Benedix M,Dörfelt G,Martin R

    更新日期:1996-07-01 00:00:00

  • [Care situation for hospitalized patients with cognitive disorders].

    abstract:BACKGROUND:The number of patients with a cognitive disorder will increase significantly in the coming years due to demographic changes. The number of patients from this group requiring stationary treatment will inevitably increase in all medical specialties. The aim of our survey was to examine how hospitals are prepar...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-013-0482-z

    authors: Schütz D,Füsgen I

    更新日期:2013-04-01 00:00:00

  • [The impact of different reference groups for the assessment of quality of life in people suffering from dementia-determination of competence groups with HILDE].

    abstract::The HILDE project proceeds from a theoretical conception of quality of life which considers both the significance of objective living conditions claimed in the Swedish level of living approach and the significance of processes of subjective perceptions and judgements accentuated in the American quality of life approac...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-006-0408-0

    authors: Becker S,Kaspar R,Kruse A

    更新日期:2006-10-01 00:00:00

  • [Possibilities and chances for using the internet by the elderly].

    abstract::More and more older people interested in continuing education recognise the many possibilities for information, communication and co-operation which Internet offers to them. Institutes of continuing education and other institutions serving older people are required to provide training for this target group in order to...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s003910070059

    authors: Stadelhofer C

    更新日期:2000-06-01 00:00:00

  • [Recognizing pain in geriatric patients by an interdisciplinary team. Reliability of judgment and factors of influence].

    abstract::The prevalence of chronic pain increases with age. The awareness of pain in geriatric patients is more difficult than in younger people because of various reasons. The occupational groups of the geriatric team might be different in respect of discerning symptoms of pain. 126 geriatric patients were enrolled in this st...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s003910170039

    authors: Schuler M,Neuhauser T,Hauer K,Oster P,Razus D,Hacker M

    更新日期:2001-10-01 00:00:00

  • Professional caregivers' knowledge in dermatology : Improving knowledge and communication to dermatologists in geriatric facilities.

    abstract:BACKGROUND:Research regarding effective collaboration and communication between professional caregivers and dermatologists and the need for further education and training for caregivers in the field of geriatric dermatology still remains relatively scarce. OBJECTIVE:To document the state of knowledge of professional c...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-016-1132-z

    authors: Meyer-Kühling I,Eckardt R,Makrantonaki E

    更新日期:2018-01-01 00:00:00

  • [Relocation decisions to nursing homes for older persons with intellectual disability].

    abstract:BACKGROUND AND OBJECTIVE:A relevant number of older persons with intellectual disability (ID) moves from residential settings in the disability sector to nursing homes. The study analyzes from the perspective of self-determination, which factors lead to moves to nursing homes and to what extent older persons with ID an...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-019-01536-0

    authors: Dieckmann F,Rodekohr B,Mätze C

    更新日期:2019-05-01 00:00:00

  • [Perspectives for professionally sufficient and adequate care of ageing patients].

    abstract::This contribution deals with the question of how existing health care systems can be sufficiently and adequately adapted to ageing patients in general, and to patients with special needs for nursing care and assistance. Simultaneously, it advocates explicit consideration of the dimensions of social inequality and heal...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-009-0070-4

    authors: Naegele G

    更新日期:2009-12-01 00:00:00

  • [Tacrine: progress in treatment of Alzheimer's disease?].

    abstract::The cholinesterase inhibitor tacrine exerts a marked therapeutic effect only at a dose which is not tolerated by many patients because of the gastrointestinal side effects and hepatotoxicity of the drug. In patients who tolerate a high dose of tacrine the mean increase in cognitive abilities is roughly equivalent to t...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章,评审

    doi:

    authors: Kurz A,Marquard R,Mösch D

    更新日期:1995-05-01 00:00:00