Abstract:
:The cholinesterase inhibitor tacrine exerts a marked therapeutic effect only at a dose which is not tolerated by many patients because of the gastrointestinal side effects and hepatotoxicity of the drug. In patients who tolerate a high dose of tacrine the mean increase in cognitive abilities is roughly equivalent to the decline which occurs within 1 year in an untreated group. At a high dose tacrine may also temporarily delay the progression of symptoms of Alzheimer's disease. Only a minority of patients with mild to moderate Alzheimer's disease can be treated with tacrine. For them, however, tacrine is the most promising treatment option presently available.
journal_name
Z Gerontol Geriatrjournal_title
Zeitschrift fur Gerontologie und Geriatrieauthors
Kurz A,Marquard R,Mösch Dsubject
Has Abstractpub_date
1995-05-01 00:00:00pages
163-8issue
3eissn
0948-6704issn
1435-1269journal_volume
28pub_type
杂志文章,评审abstract::Prolonged suboptimal intake of micronutrients leads via a series of mechanisms to impairment of cognitive performance. Supplementation can correct these deficits. Malnutrition impairs cognitive performance only when micronutrient levels fall below certain critical thresholds. Malnutrition in the elderly is commonly th...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-01 00:00:00
abstract::In the following contribution the under-proportional participation rate of older workers in vocational training is analyzed. Regarding the changes concerning the organization of vocational training to more job-integrated, self-directed and computer-based learning the consequences for training opportunities, motivation...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910070048
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:In all, 39 % of people living in Swiss nursing homes suffer from dementia. Detailed data about type and course of symptoms displayed by these patients in their terminal phase are lacking. METHODS:This descriptive, retrospective study analysed 65 nursing documents from deceased people with dementia in four n...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0668-z
更新日期:2015-02-01 00:00:00
abstract::Insects can serve as excellent models to show that the genetically determined life span of organisms as well as that of other traits is characterized by high phenotypic plasticity. Depending on different environmental conditions the life cycle strategy can therefore be highly variable. Thus developmental and aging pro...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-004-0231-4
更新日期:2004-06-01 00:00:00
abstract::A large number of published overview and original articles provide evidence and declare the need for immediate, appropriate preventive lifestyle measures to prevent the development of dementia and Alzheimer's disease (AD). However, despite this, there are great difficulties in drafting effective guidelines in this fie...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-011-0263-5
更新日期:2012-01-01 00:00:00
abstract:AIM:The goal of this study was to perform a structured analysis of the treatment quality and acute complications of geriatric patients with diabetes mellitus (DM) cared for by nursing services and nursing home facilities. Secondly, structural problems and potentials for improvement in the care of multimorbid older peop...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-014-0626-9
更新日期:2015-04-01 00:00:00
abstract::Scabies is a frequent ectoparasitosis the prevalence of which also seems to increase in older patients. Correct and timely diagnosis of scabies in older age is hampered by atypical clinical manifestations, the potential lack of pruritus and a variety of differential diagnoses. Scabies crustosa, a highly contagious sub...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-019-01650-z
更新日期:2019-12-01 00:00:00
abstract::Symptoms presented by patients with Alzheimer-type dementia do not only reflect organic disturbances only but require a holistic and person-oriented view. Affective and behavioral disturbances are not necessarily secondary to cognitive impairment. Guidelines are presented for a multidimensional treatment involving the...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s003910170072
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Over the last 10 years the German pension system has undergone several reforms including the abandonment of early retirement policies and an increase in the statutory retirement age. Consequently, the average retirement age has increased and future retiree cohorts have adjusted the retirement expectations an...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-016-1053-x
更新日期:2018-01-01 00:00:00
abstract::The quantifying of care needed is an important issue of the long-term care insurance act in Germany. In the last three decades limits of self-sufficiency have been defined in the context of law, medicine, social science and nursing science. Following these approaches this study distinguishes between determining the li...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract::Chronic or repeated stress can induce a damage of neurons, especially in hippocampus, by which the degree of damage differs in various species. Sapolski has reported that there is a correlation between hippocampal degeneration, disturbed feedback reaction, and hypersecretion of glucocorticoids. The aim of this study w...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910050087
更新日期:1999-04-01 00:00:00
abstract::The NaCl content of the culture medium of human fibroblasts (WI-38) was elevated from 0.12 M to 0.23 M. Previously it had been shown that exposure of fibroblasts to such high NaCl conditions resulted in a rise of both glycolysis and respiration ("energetic stress"), mainly due to increased demands of energy for active...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910170014
更新日期:2001-12-01 00:00:00
abstract::The aim of this study is to bring into focus the living conditions of the older adults in Turkey by using quality of life (QoL) criteria through which to highlight dimensions relating to their QoL status in comparison to other age cohorts. Are there specific QoL issues among older adults that would indicate that they ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-013-0502-z
更新日期:2013-12-01 00:00:00
abstract::The aging of the Italian population is an emerging public health priority. In 2025 Italy is expected to have the highest world median age with nearly half of the population over 50 years old. To avoid an unbearable burden of disease and disability on future generations, we must identify areas for intensive disease and...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910050139
更新日期:1999-12-01 00:00:00
abstract::Older people often report a decline in their cognitive functions - memory problems and difficulty finding words are frequently mentioned. In this context it is essential to differentiate between age-related cognitive decline and pathological processes as they occur in the context of dementia. Neuropsychological diagno...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-020-01800-8
更新日期:2020-12-01 00:00:00
abstract::Advance directives and durable powers of attorney are two increasingly used tools for patients' precedent autonomy; however, their combined use, as recommended by major institutions in Germany, might in reality result in various discrepancies between the wording and interpretation of the directive and the surrogate's ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-019-01634-z
更新日期:2019-12-01 00:00:00
abstract::Efforts to improve the quality of care mainly depend on sufficient capacities of staff qualifications. Professional training is of primary importance to prepare for new tasks and to reduce educational deficits. The results of an empirical study carried out by the Federal Department of Family Affairs and the Kuratorium...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Dementia may influence as a co-morbid condition the management of chronic obstructive airway disease. However, the frequency and the consequences of dementia in older people with chronic obstructive airway disease are largely unknown. PATIENTS AND METHODS:The frequency and the severity of dementia in geriat...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-011-0223-0
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:The study of housing and living spaces has always played a central role in sociogerontological research. For example, living environments are seen as essential influencing factors on the quality of life and personal well-being (or the lack of it) of older people. The study of the relationship between space a...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-020-01743-0
更新日期:2020-08-01 00:00:00
abstract::The existence of a so-called "vitauct process" is discussed by means of the glucocorticoid-induced stimulation of tyrosine aminotransferase activity. Own experiments show that the highest possible stimulation of the enzyme by cortisol and stress in the liver of old Wistar rats is not lower than in young-adult animals....
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::The mortality in elderly patients over the age of 80 years with peptic ulcers in the case of complications, such as bleeding and perforation is higher than in the general population. Duodenal ulcers are associated with Helicobacter pylori infections in 90% of cases and in 70% of gastric ulcers. The treatment of elderl...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s00391-017-1190-x
更新日期:2017-02-01 00:00:00
abstract::It is well known that problems with compliance rise exponentially when more that 4 drugs are prescribed. The rising use of prescription medicine forces the GP to balance the benefit of evidence group-based appropriate drug use against the problems arising when medication is given to older people and to consider differ...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-005-1104-1
更新日期:2005-09-01 00:00:00
abstract::This contribution refers to the 2009 Council of Experts Report on health system development and discusses the special care requirements of old people. This includes the geriatric phenomenon of multimorbidity, polypharmacy in old people with multiple diseases, and the need for care. The probability and complexity of mu...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-009-0072-2
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Little is known about the prevalence of falls and the related risk factors in the general population of community-living older people in Germany. OBJECTIVES:To assess the prevalence and related predictors of different types of falls in a sample of community-dwelling 65 years and older people in Germany livi...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-008-0506-2
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Research regarding effective collaboration and communication between professional caregivers and dermatologists and the need for further education and training for caregivers in the field of geriatric dermatology still remains relatively scarce. OBJECTIVE:To document the state of knowledge of professional c...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-016-1132-z
更新日期:2018-01-01 00:00:00
abstract::Functional deficits of elderly patients are often not recognized during routine treatment in acute hospital care. In Germany, there are only limited experiences with the use of standardized assessment-scales in this health care setting. In this study, 112 patients were recruited for a very broad geriatric assessment f...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The HILDE project proceeds from a theoretical conception of quality of life which considers both the significance of objective living conditions claimed in the Swedish level of living approach and the significance of processes of subjective perceptions and judgements accentuated in the American quality of life approac...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-006-0408-0
更新日期:2006-10-01 00:00:00
abstract::The aim of the present study was to describe the course and outcome of rehabilitation using a national recommended assessment program (AGAST). In our study 162 patients with stroke were included. Nearly all patients had improvement of activities of daily living (Barthel Index) and mobility (Tinetti Gait and Balance Sc...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s003910050105
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:The number of patients with a cognitive disorder will increase significantly in the coming years due to demographic changes. The number of patients from this group requiring stationary treatment will inevitably increase in all medical specialties. The aim of our survey was to examine how hospitals are prepar...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章
doi:10.1007/s00391-013-0482-z
更新日期:2013-04-01 00:00:00
abstract::From its origin to its death the human organism is submitted to functional, material and morphological changes that are perceptible. These changes permit classifying an individual as young, adult, old, active or infirm. But this estimation is not always correct. Some appear younger, some older than expected from their...
journal_title:Zeitschrift fur Gerontologie und Geriatrie
pub_type: 杂志文章,评审
doi:10.1007/s003910070001
更新日期:2000-01-01 00:00:00