[Tacrine: progress in treatment of Alzheimer's disease?].

Abstract:

:The cholinesterase inhibitor tacrine exerts a marked therapeutic effect only at a dose which is not tolerated by many patients because of the gastrointestinal side effects and hepatotoxicity of the drug. In patients who tolerate a high dose of tacrine the mean increase in cognitive abilities is roughly equivalent to the decline which occurs within 1 year in an untreated group. At a high dose tacrine may also temporarily delay the progression of symptoms of Alzheimer's disease. Only a minority of patients with mild to moderate Alzheimer's disease can be treated with tacrine. For them, however, tacrine is the most promising treatment option presently available.

journal_name

Z Gerontol Geriatr

authors

Kurz A,Marquard R,Mösch D

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

163-8

issue

3

eissn

0948-6704

issn

1435-1269

journal_volume

28

pub_type

杂志文章,评审
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  • [Continued training of elderly workers with reference to changes in the organization of continuing vocational training].

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  • Type and course of symptoms demonstrated in the terminal and dying phases by people with dementia in nursing homes.

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    doi:10.1007/s00391-014-0668-z

    authors: Koppitz A,Bosshard G,Schuster DH,Hediger H,Imhof L

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  • [Delay and cessation of aging processes by manipulation of reproduction, food intake and development in insects].

    abstract::Insects can serve as excellent models to show that the genetically determined life span of organisms as well as that of other traits is characterized by high phenotypic plasticity. Depending on different environmental conditions the life cycle strategy can therefore be highly variable. Thus developmental and aging pro...

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    authors: Collatz KG

    更新日期:2004-06-01 00:00:00

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    authors: Polidori MC,Pientka L

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  • [Diabetes care and incidence of severe hypoglycemia in nursing home facilities and nursing services: The Heidelberg Diabetes Study].

    abstract:AIM:The goal of this study was to perform a structured analysis of the treatment quality and acute complications of geriatric patients with diabetes mellitus (DM) cared for by nursing services and nursing home facilities. Secondly, structural problems and potentials for improvement in the care of multimorbid older peop...

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    authors: Bahrmann A,Wörz E,Specht-Leible N,Oster P,Bahrmann P

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  • [Scabies in old age].

    abstract::Scabies is a frequent ectoparasitosis the prevalence of which also seems to increase in older patients. Correct and timely diagnosis of scabies in older age is hampered by atypical clinical manifestations, the potential lack of pruritus and a variety of differential diagnoses. Scabies crustosa, a highly contagious sub...

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    authors: Hamm H,Stoevesandt J,Sunderkötter C

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  • [Socio- and psychotherapy in patients with Alzheimer disease].

    abstract::Symptoms presented by patients with Alzheimer-type dementia do not only reflect organic disturbances only but require a holistic and person-oriented view. Affective and behavioral disturbances are not necessarily secondary to cognitive impairment. Guidelines are presented for a multidimensional treatment involving the...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    doi:10.1007/s003910170072

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  • Expected and preferred retirement age in Germany.

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    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    doi:10.1007/s00391-016-1053-x

    authors: Hess M

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  • [Determining the extent of nursing care need according to the nursing care insurance law in an interdisciplinary comparison].

    abstract::The quantifying of care needed is an important issue of the long-term care insurance act in Germany. In the last three decades limits of self-sufficiency have been defined in the context of law, medicine, social science and nursing science. Following these approaches this study distinguishes between determining the li...

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    doi:

    authors: Cappell E

    更新日期:1996-11-01 00:00:00

  • [Age related changes in cellular signal transduction of glucocorticoid hormones in rat brain].

    abstract::Chronic or repeated stress can induce a damage of neurons, especially in hippocampus, by which the degree of damage differs in various species. Sapolski has reported that there is a correlation between hippocampal degeneration, disturbed feedback reaction, and hypersecretion of glucocorticoids. The aim of this study w...

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  • Quality of life in an ageing society : a comparative analysis of age cohorts in Turkey.

    abstract::The aim of this study is to bring into focus the living conditions of the older adults in Turkey by using quality of life (QoL) criteria through which to highlight dimensions relating to their QoL status in comparison to other age cohorts. Are there specific QoL issues among older adults that would indicate that they ...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    authors: Arun Ö,Cakıroğlu-Çevik A

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  • Occurrence of chronic diseases and their impact on physical disability over the whole spectrum of aging: from 65 to over 100 years of age.

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    doi:10.1007/s003910050139

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  • [Neuropsychological diagnostics of cognitive deficits : Focus on dementia].

    abstract::Older people often report a decline in their cognitive functions - memory problems and difficulty finding words are frequently mentioned. In this context it is essential to differentiate between age-related cognitive decline and pathological processes as they occur in the context of dementia. Neuropsychological diagno...

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  • [Wife against advance directive: a case-inspired legal and ethical clarification].

    abstract::Advance directives and durable powers of attorney are two increasingly used tools for patients' precedent autonomy; however, their combined use, as recommended by major institutions in Germany, might in reality result in various discrepancies between the wording and interpretation of the directive and the surrogate's ...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    authors: Schöne-Seifert B,Gutmann T,Klother K,Kolb G

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  • [Graduate and continuing education as a contribution to quality assurance in geriatric nursing--results of an empirical study on the current status and the need for change].

    abstract::Efforts to improve the quality of care mainly depend on sufficient capacities of staff qualifications. Professional training is of primary importance to prepare for new tasks and to reduce educational deficits. The results of an empirical study carried out by the Federal Department of Family Affairs and the Kuratorium...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    doi:

    authors: Kühnert S,Gassmann R

    更新日期:1997-03-01 00:00:00

  • Dementia among older in-hospital patients with obstructive airway disease: frequency and consequences.

    abstract:BACKGROUND:Dementia may influence as a co-morbid condition the management of chronic obstructive airway disease. However, the frequency and the consequences of dementia in older people with chronic obstructive airway disease are largely unknown. PATIENTS AND METHODS:The frequency and the severity of dementia in geriat...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    authors: Frohnhofen H,Heuer HC,Willschrei HP,Falkenhahn C

    更新日期:2011-08-01 00:00:00

  • [Remapping age(ing) : Additional value of an affect-based and inequality-sensitive determination of the relationship between space and age(ing)].

    abstract:BACKGROUND:The study of housing and living spaces has always played a central role in sociogerontological research. For example, living environments are seen as essential influencing factors on the quality of life and personal well-being (or the lack of it) of older people. The study of the relationship between space a...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    authors: Höppner G,Richter AS

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  • [Enzyme adaptation and "vitauct" process].

    abstract::The existence of a so-called "vitauct process" is discussed by means of the glucocorticoid-induced stimulation of tyrosine aminotransferase activity. Own experiments show that the highest possible stimulation of the enzyme by cortisol and stress in the liver of old Wistar rats is not lower than in young-adult animals....

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    doi:

    authors: Martin H,Benedix M,Dörfelt G,Martin R

    更新日期:1996-07-01 00:00:00

  • [Duodenal ulcers, gastric ulcers and Helicobacter pylori].

    abstract::The mortality in elderly patients over the age of 80 years with peptic ulcers in the case of complications, such as bleeding and perforation is higher than in the general population. Duodenal ulcers are associated with Helicobacter pylori infections in 90% of cases and in 70% of gastric ulcers. The treatment of elderl...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    更新日期:2017-02-01 00:00:00

  • Polypharmacy and older people--the GP perspective.

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    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    authors: Vass M,Hendriksen C

    更新日期:2005-09-01 00:00:00

  • [Special care requirements of elderly and old people: as reflected in the new Council of Experts Report].

    abstract::This contribution refers to the 2009 Council of Experts Report on health system development and discusses the special care requirements of old people. This includes the geriatric phenomenon of multimorbidity, polypharmacy in old people with multiple diseases, and the need for care. The probability and complexity of mu...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    doi:10.1007/s00391-009-0072-2

    authors: Kuhlmey A

    更新日期:2009-12-01 00:00:00

  • Predictors for occasional and recurrent falls in community-dwelling older people.

    abstract:BACKGROUND:Little is known about the prevalence of falls and the related risk factors in the general population of community-living older people in Germany. OBJECTIVES:To assess the prevalence and related predictors of different types of falls in a sample of community-dwelling 65 years and older people in Germany livi...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

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    authors: Gassmann KG,Rupprecht R,Freiberger E,IZG Study Group.

    更新日期:2009-02-01 00:00:00

  • Professional caregivers' knowledge in dermatology : Improving knowledge and communication to dermatologists in geriatric facilities.

    abstract:BACKGROUND:Research regarding effective collaboration and communication between professional caregivers and dermatologists and the need for further education and training for caregivers in the field of geriatric dermatology still remains relatively scarce. OBJECTIVE:To document the state of knowledge of professional c...

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  • [Identification of functional deficits in the acute hospital by geriatric assessment].

    abstract::Functional deficits of elderly patients are often not recognized during routine treatment in acute hospital care. In Germany, there are only limited experiences with the use of standardized assessment-scales in this health care setting. In this study, 112 patients were recruited for a very broad geriatric assessment f...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:

    authors: Pientka L,Scholten T,Füsgen I

    更新日期:1995-01-01 00:00:00

  • [The impact of different reference groups for the assessment of quality of life in people suffering from dementia-determination of competence groups with HILDE].

    abstract::The HILDE project proceeds from a theoretical conception of quality of life which considers both the significance of objective living conditions claimed in the Swedish level of living approach and the significance of processes of subjective perceptions and judgements accentuated in the American quality of life approac...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

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    doi:10.1007/s00391-006-0408-0

    authors: Becker S,Kaspar R,Kruse A

    更新日期:2006-10-01 00:00:00

  • [Geriatric assessment--description of functional deficits and follow-up assessment of elderly stroke patients].

    abstract::The aim of the present study was to describe the course and outcome of rehabilitation using a national recommended assessment program (AGAST). In our study 162 patients with stroke were included. Nearly all patients had improvement of activities of daily living (Barthel Index) and mobility (Tinetti Gait and Balance Sc...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s003910050105

    authors: Harlacher R,Pientka L,Füsgen I

    更新日期:1999-06-01 00:00:00

  • [Care situation for hospitalized patients with cognitive disorders].

    abstract:BACKGROUND:The number of patients with a cognitive disorder will increase significantly in the coming years due to demographic changes. The number of patients from this group requiring stationary treatment will inevitably increase in all medical specialties. The aim of our survey was to examine how hospitals are prepar...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章

    doi:10.1007/s00391-013-0482-z

    authors: Schütz D,Füsgen I

    更新日期:2013-04-01 00:00:00

  • [Significance of the markers of aging].

    abstract::From its origin to its death the human organism is submitted to functional, material and morphological changes that are perceptible. These changes permit classifying an individual as young, adult, old, active or infirm. But this estimation is not always correct. Some appear younger, some older than expected from their...

    journal_title:Zeitschrift fur Gerontologie und Geriatrie

    pub_type: 杂志文章,评审

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    更新日期:2000-01-01 00:00:00