High mortality in orthotopic liver transplant recipients who require hemodialysis.

Abstract:

:Acute renal failure is a significant risk factor for death in patients with liver failure. The goal of this study was to analyze the impact of peri-transplant dialysis on the long-term mortality of liver transplant recipients. We performed a single-center, retrospective cohort study of 743 adult liver transplants; patients who received first liver transplants were divided into four groups: those who received more than one dialysis treatment (hemodialysis [HD], continuous veno-venous hemodialysis [CVVH]) pre-orthotopic liver transplantation (OLT), post OLT, pre- and post OLT, and those not dialyzed. There was no statistically significant difference in the mean survival time for patients who were not dialyzed or dialyzed only pre-OLT. Mean survival times were markedly reduced in patients dialyzed post OLT or both pre- and post OLT compared with those never dialyzed. Mortality risk in a Cox proportional hazards model correlated with hemodialysis post OLT, intra-operative vasopressin or neosynephrine, donor age >50 yr, Cr >1.5 mg/dL at transplant, and need for subsequent retransplant. Risk of post-OLT dialysis was correlated with pre-OLT dialysis, intra-operative levophed, pre-OLT diabetes, African American race, pre-OLT Cr >1.5, and male gender. We conclude that renal failure requiring hemodialysis post liver transplant, irrespective of pre-transplant dialysis status, is a profound risk factor for death in liver transplant recipients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Zand MS,Orloff MS,Abt P,Patel S,Tsoulfas G,Kashyap R,Jain A,Safadjou S,Bozorgzadeh A

doi

10.1111/j.1399-0012.2010.01238.x

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

213-21

issue

2

eissn

0902-0063

issn

1399-0012

pii

CTR1238

journal_volume

25

pub_type

杂志文章
  • How does age affect the outcome of kidney transplantation in elderly recipients?

    abstract::The aging of the on-dialysis population raises the issue of whether to propose elderly patients for kidney transplantation and how to manage their immunosuppression. This study aimed to analyze the outcome of kidney transplantation on an Italian series of elderly recipients. We included in this retrospective study all...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13036

    authors: Neri F,Furian L,Cavallin F,Ravaioli M,Silvestre C,Donato P,La Manna G,Pinna AD,Rigotti P

    更新日期:2017-10-01 00:00:00

  • Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension.

    abstract::In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of po...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13360

    authors: Issa N,Sánchez OA,Kukla A,Riad SM,Berglund DM,Ibrahim HN,Matas AJ

    更新日期:2018-09-01 00:00:00

  • Prednisone-free maintenance immunosuppression in obese kidney transplant recipients.

    abstract::Obese transplant recipients (BMI ≥ 30 kg/m2 ) have decreased posttransplant patient and graft survival compared with their nonobese counterparts. At the same time, many prednisone-related side effects (eg, new-onset diabetes) are similar to those associated with obesity. Using SRTR data, we studied outcomes associated...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13668

    authors: Matas AJ,Vock DM

    更新日期:2019-10-01 00:00:00

  • Effect of storage temperature on early graft function following liver transplantation.

    abstract::The effect of storage temperature on early graft function following liver transplantation was investigated by analyzing the results following transplantation during three periods in which different techniques for graft storage were used. The techniques involved ice-packing (period 1), storage in a standard operating ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Morino M,Adam R,Diamond T,Castaing D,Reynes M,Bismuth H

    更新日期:1992-04-01 00:00:00

  • Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity?

    abstract::Calcineurin inhibitors (CNI) have been commonly used as pivotal immunosuppressive agents to renal transplant recipients and have contributed significantly to improving short-term allograft survival. However, long-term administration of CNI may cause an adverse effect on kidney function, known as chronic nephrotoxicity...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01474.x

    authors: Horike K,Takeda A,Yamaguchi Y,Ogiyama Y,Yamauchi Y,Murata M,Kawaguchi T,Suzuki T,Otsuka Y,Inaguma D,Goto N,Watarai Y,Uchida K,Morozumi K

    更新日期:2011-07-01 00:00:00

  • Impact of the new fast track kidney allocation scheme for declined kidneys in the United Kingdom.

    abstract:INTRODUCTION:A "new" fast track kidney allocation scheme (FTKAS) was implemented in the UK in 2012 for offering of previously declined kidneys. We evaluated the impact of the FTKAS in utilization of declined kidneys and outcome. METHODS:Adult renal transplant centers were surveyed. Overall utilization was evaluated us...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12576

    authors: White AD,Roberts H,Ecuyer C,Brady K,Pathak S,Clark B,Hostert LH,Attia MS,Wellberry-Smith M,Hudson A,Ahmad N

    更新日期:2015-10-01 00:00:00

  • Hospital admissions and emergency department visits among kidney transplant recipients.

    abstract::Reducing acute care utilization is a means of improving long-term patient outcomes. We sought to assess high inpatient (IP) admission and standalone emergency department (ED) utilization within a 9-month period post-kidney transplantation and to identify mutable factors to reduce utilization. In this ten-year retrospe...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13522

    authors: Weeda ER,Su Z,Taber DJ,Bian J,Morinelli TA,Pilch NA,Mauldin PD,DuBay DA

    更新日期:2019-05-01 00:00:00

  • Histoplasmosis in transplant recipients.

    abstract::Histoplasma capsulatum is a dimorphic fungus that most often causes asymptomatic infection in the immunocompetent population. In immunocompromised patients, including solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, however, it is likely to cause severe life-threatening infection. Post-...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.13087

    authors: Gajurel K,Dhakal R,Deresinski S

    更新日期:2017-10-01 00:00:00

  • Clinical outcomes of liver transplantation for HBV-related hepatocellular carcinoma: data from the NIH HBV OLT study.

    abstract:BACKGROUND:Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is an indication for orthotopic liver transplantation (OLT) in patients with tumor stage within the United Network for Organ Sharing criteria. The number of patients listed for HBV-related HCC is increasing, while the number of patients listed fo...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01349.x

    authors: Han SH,Reddy KR,Keeffe EB,Soldevila-Pico C,Gish R,Chung RT,Degertekin B,Lok A,NIH HBV OLT Study Group.

    更新日期:2011-03-01 00:00:00

  • Eliminating international normalized ratio threshold for transfusion in pediatric patients with acute liver failure.

    abstract:INTRODUCTION:Transfusion protocols are not well-studied for pediatric patients with acute liver failure (ALF). This study evaluates the utility of an international normalized ratio (INR)-based transfusion threshold for these patients. METHODS:Forty-four ALF pediatric patients from 2009 to 2018 were reviewed and divide...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13819

    authors: Lee A,Mendoza J,Brubaker AL,Stoltz DJ,McKenzie R,Bonham CA,Esquivel CO,Gallo AE

    更新日期:2020-04-01 00:00:00

  • Cervical human papillomavirus infection in the early postoperative period after liver transplantation: Prevalence, risk factors, and concordance with anal infections.

    abstract::Solid organ transplant recipients are at increased risk of developing several human papillomavirus (HPV)-related malignancies, including cervical and anal cancers. The purpose of this prospective study was to assess the initial prevalence and risk factors for high-risk HPV (HR-HPV) cervical infections in liver transpl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12894

    authors: Grąt K,Grąt M,Wronka KM,Pietrzak B,Suchońska B,Walter de Walthoffen S,Młynarczyk G,Krawczyk M,Wielgoś M

    更新日期:2017-03-01 00:00:00

  • Attitudes of commercial renal transplant recipients toward renal transplantation in India.

    abstract::Renal transplantation offers patients with end-stage renal disease the best opportunity for rehabilitation and long-term survival. However, there is a critical shortage of transplantable kidneys worldwide. This plays well into the hands of transplanters and entrepreneurs involved in commercial renal transplantation, p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Qunibi W,Abulrub D,Shaheen F,el-Din AB,Alfurayh O,Almeshari K

    更新日期:1995-08-01 00:00:00

  • The use of flow cytometry for the detection of CMV-specific antigen (pp65) in leukocytes of kidney recipients.

    abstract::Flow cytometric assay (FCA) was used to detect a cytomegalovirus (CMV) specific antigen (pp65) in CMV-infected fibroblast cells and in leukocytes of kidney recipients. FCA distinguished clearly between the infected and non-infected fibroblast cells. Regarding transplant patients, the FCA was positive when the number o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140208.x

    authors: Essa S,Pacsa AS,Al-Attiyah R,El-Shazly A,Raghupathy R,Said T

    更新日期:2000-04-01 00:00:00

  • Kidney allograft subclinical rejection modulates systemic inflammation measured by C-reactive protein at 1 year after transplantation.

    abstract::Kidney allograft inflammation is associated with proinflammatory modifications of peripheral blood mononuclear cells, suggesting that renal inflammation contributes to systemic inflammation. Thus, the aim of this study was to evaluate the relationship between subclinical inflammation in surveillance biopsies performed...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13196

    authors: García-Carro C,Dörje C,Åsberg A,Midtvedt K,Scott H,Reinholt FP,Holdaas H,Reisaeter AV,Seron D

    更新日期:2018-03-01 00:00:00

  • Factors related to attitudes toward organ donation after death in the immigrant population in Spain.

    abstract::Considering the relevance of the migratory processes in Western societies, the attitudes toward organ donation after death are analyzed by means of a survey applied to a representative random sample of the resident immigrant population in Spain, comprising 1202 subjects (estimated margin of error of ± 2.88%, p = q, p ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2011.01586.x

    authors: López JS,Valentín MO,Scandroglio B,Coll E,Martín MJ,Sagredo E,Martínez JM,Serna E,Matesanz R

    更新日期:2012-05-01 00:00:00

  • Incidence of leukopenia and cytomegalovirus disease in kidney transplants treated with mycophenolate mofetil combined with low cyclosporine and steroid doses.

    abstract::Mycophenolate mofetil (MMF) combined with conventional cyclosporine and steroids doses efficiently prevents acute rejection in kidney transplants. However, this regimen has been associated with an increased incidence of cytomegalovirus (CMV) disease and leukopenia, specially in patients receiving MMF at 3 g/d, suggest...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Moreso F,Serón D,Morales JM,Cruzado JM,Gil-Vernet S,Pérez JL,Fulladosa X,Andrés A,Grinyó JM

    更新日期:1998-06-01 00:00:00

  • Bosentan in heart transplantation candidates with severe pulmonary hypertension: efficacy, safety and outcome after transplantation.

    abstract:BACKGROUND:Increased pulmonary vascular resistance (PVR) is associated with increased right ventricular failure and mortality after heart transplantation. METHODS:In this prospective study, 22 patients considered high-risk candidates for heart transplantation because of severe pulmonary hypertension (PVR = 6 ± 2 Wood ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01689.x

    authors: Perez-Villa F,Farrero M,Cardona M,Castel MA,Tatjer I,Penela D,Vallejos I

    更新日期:2013-01-01 00:00:00

  • Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients: Guidelines from the American Society of Transplantation Community of Practice.

    abstract::These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice address the prevention and management of Clostridium difficile infection in solid organ transplant (SOT) recipients. Clostridioides (formerly Clostridium) difficile infection (CDI) is among the most common h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13564

    authors: Mullane KM,Dubberke ER,AST ID Community of Practice.

    更新日期:2019-09-01 00:00:00

  • Micafungin as antifungal prophylaxis in recipients of allogeneic hematopoietic stem cell transplantation: results of different dosage levels in clinical practice.

    abstract::Micafungin has been approved for the prophylaxis of Candida infections in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we report a single-center experience of three different dose levels regarding efficacy, toxicity, and colonization with Candida ssp. in clinical practice. ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12310

    authors: Langebrake C,Rohde H,Lellek H,Wolschke C,Kröger NM

    更新日期:2014-03-01 00:00:00

  • Validity of patient skin cancer report among organ transplant recipients.

    abstract::Skin cancer is a common, potentially life-threatening malignancy in organ transplant recipients (OTR), and it is important for transplant physicians to be aware of patient history of skin cancer. Patient self-report represents a quick method of obtaining past medical history of skin cancer but no study has validated t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01601.x

    authors: Dybbro E,Mihalis E,Hirose R,Arron ST

    更新日期:2012-03-01 00:00:00

  • Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?

    abstract:INTRODUCTION:Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this study was to determine whether this policy shortens the DCD donors' life. METHODS:The authors retrospectively analy...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12276

    authors: Ledoux D,Delbouille MH,Deroover A,Lambermont B,Meurisse M,Damas P,Joris J,Detry O

    更新日期:2014-01-01 00:00:00

  • Quadruple immunosuppression with basiliximab, tacrolimus, mycophenolate mofetil and prednisone is safe and effective for renal transplantation.

    abstract:INTRODUCTION:Recent immunosuppression with tacrolimus and mycophenolate mofetil has improved the results of renal transplantation. In this study, we analyzed the effect and safety of basiliximab as an induction therapy. MATERIAL AND METHODS:Forty-nine kidney recipients were given tacrolimus, mycophenolate mofetil and ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00393.x

    authors: Miura M,Harada H,Fukuzawa N,Iwami D,Taniguchi A,Seki T,Togashi M,Ogawa Y,Satoh H,Hirano T

    更新日期:2005-01-01 00:00:00

  • Post-transplant lymphoproliferative disorders after live donor renal transplantation.

    abstract::The development of post-transplant lymphoproliferative disorders (PTLD) is a well-recognized complication of solid organ transplantation in patients receiving immunosuppressive therapy. The literature on PTLD in live renal allograft recipients is scarce and most of the data pertains to PTLD in cadaveric transplants. A...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00406.x

    authors: Jain M,Badwal S,Pandey R,Srivastava A,Sharma RK,Gupta RK

    更新日期:2005-10-01 00:00:00

  • Predicting and preventing readmissions in kidney transplant recipients.

    abstract::A lack of research exploring post-transplant process optimization to reduce readmissions and increasing readmission rates at our center from 2009 to 2013 led to this study, aimed at assessing the effect of patient and process factors on 30-d readmission rates after kidney transplantation. This was a retrospective case...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12748

    authors: Covert KL,Fleming JN,Staino C,Casale JP,Boyle KM,Pilch NA,Meadows HB,Mardis CR,McGillicuddy JW,Nadig S,Bratton CF,Chavin KD,Baliga PK,Taber DJ

    更新日期:2016-07-01 00:00:00

  • Therapeutic living donor nephrectomy.

    abstract::Therapeutic living donor nephrectomy is defined as a nephrectomy that is performed as therapy for an underlying medical condition. The patient directly benefits from having their kidney removed, but the kidney is deemed transplantable. The kidney is subsequently used as an allograft for an individual with advanced ren...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13715

    authors: Dale LA,Silva MV,Sandoval PR,Decastro J,Campenot ES,Ratner LE

    更新日期:2019-12-01 00:00:00

  • Screening for asymptomatic bacteruria at one month after adult kidney transplantation: Clinical factors and implications.

    abstract:OBJECTIVE:Urinary tract infections (UTIs) account for significant morbidity after kidney transplantation (KT). Screening for asymptomatic bacteruria (AB) has proven to be beneficial in certain population including pregnant women; however, it is not well-studied in KT population. We reviewed the incidence, clinical feat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12954

    authors: Goh YSB,Deng Z,Cheong PSC,Raman L,Goh THA,Vathsala A,Tiong HY

    更新日期:2017-05-01 00:00:00

  • Histological features of renal allograft biopsies in ABO minor-mismatched kidney transplantation.

    abstract::We examined histological features of allograft biopsies in ABO minor-mismatched kidney transplantation. Forty-five patients who underwent ABO minor-mismatched kidney transplantation between September 1999 and December 2001 at our institute. The mean age was 32.6 years, with 28 males and 17 females. We divided them int...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.17.s10.1.x

    authors: Shimizu T,Tanabe K,Tokumoto T,Shimmura H,Ishikawa N,Ishida H,Toma H,Kawaguchi H,Tokiwa M,Yamaguchi Y

    更新日期:2003-01-01 00:00:00

  • Variability in the reporting of renal function endpoints in immunosuppression trials in renal transplantation: time for consensus?

    abstract::Early measures of graft function are increasingly used to assess efficacy in clinical trials of kidney transplant immunosuppression. This study aimed to assess the variability and quality of reporting of these endpoints in contemporary trials. Data regarding renal function endpoints were extracted from 213 reports fro...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12861

    authors: Knight SR,Hussain S

    更新日期:2016-12-01 00:00:00

  • Pilot evaluation of 15-deoxyspergualin for refractory acute renal transplant rejection.

    abstract::15-deoxyspergualin (DSG) is a novel immunosuppressant which has been shown to be effective in preventing and treating rejection in animal allo- and xenotransplant models. Preliminary clinical studies suggest that DSG is an effective antirejection agent. In our study, 4 patients with biopsy-proven rejection episodes th...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Matas AJ,Gores PF,Kelley SL,Bielefield-Skrokov M,Kinaszczuk M,Gruessner RW,Najarian JS

    更新日期:1994-04-01 00:00:00

  • Effect of dexmedetomidine on hepatic ischemia-reperfusion injury in the setting of adult living donor liver transplantation.

    abstract:OBJECTIVE:The aim of this study was to investigate the hypothesis that intraoperative infusion of dexmedetomidine can exert a protective effect against hepatic ischemia-reperfusion injury (IRI) in adult living donor liver transplantation (LDLiver transplantation). PATIENTS AND METHODS:Forty recipients were allocated i...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ctr.12713

    authors: Fayed NA,Sayed EI,Saleh SM,Ehsan NA,Elfert AY

    更新日期:2016-04-01 00:00:00