Abstract:
OBJECTIVES:The methodology for the critical assessment of medical interventions is well established. Regulatory agencies and institutions adhere, in principle, to the same standards. This consistency, however, is not always the case in practice. STUDY DESIGN AND SETTING:Using the evaluation of the CAPRIE (Clopidogrel versus Aspirin in Patients at risk of Ischemic Events) trial by the British National Institute for Health and Clinical Excellence (NICE) and the German Institute for Quality and Efficiency in Health Care (IQWiG), we illustrate that there was no consensus for the interpretation of possible heterogeneity in treatment comparisons across subgroups. RESULTS:The NICE concluded that CAPRIE demonstrated clinical benefit for the overall intention-to-treat (ITT) population with sufficient robustness to possible sources of heterogeneity. The IQWiG interpreted the alleged heterogeneity as implying that the clinical benefit only applied to the subgroup of patients with a statistically significant result irrespective of the results of the ITT analysis. CONCLUSION:International standards for the performance and interpretation of subgroup analyses as well as for the assessment of heterogeneity between strata are needed.
journal_name
J Clin Epidemioljournal_title
Journal of clinical epidemiologyauthors
Hasford J,Bramlage P,Koch G,Lehmacher W,Einhäupl K,Rothwell PMdoi
10.1016/j.jclinepi.2009.10.009subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1298-304issue
12eissn
0895-4356issn
1878-5921pii
S0895-4356(09)00365-5journal_volume
63pub_type
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journal_title:Journal of clinical epidemiology
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journal_title:Journal of clinical epidemiology
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVE:Graphical methods for generating explanatory hypotheses from limited categorical data are described and illustrated. STUDY DESIGN AND SETTING:Univariate, bivariate, multivariate, and multiplicative graphical methods were applied to clinical data regarding very ill older persons. The data to which these metho...
journal_title:Journal of clinical epidemiology
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abstract::The duration of protection offered by Pap screening for cervical cancer was examined using data on 101 cases of invasive cervical cancer and 396 controls from a Maryland case-control study. Receipt of a Pap test up to 4 years ago afforded significant protection, compared to women screened 11 or more years ago, or neve...
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of clinical epidemiology
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更新日期:2015-07-01 00:00:00
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2018-10-01 00:00:00
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journal_title:Journal of clinical epidemiology
pub_type: 杂志文章,多中心研究
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更新日期:2012-10-01 00:00:00
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更新日期:2006-09-01 00:00:00