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Methods for detecting, quantifying, and adjusting for dissemination bias in meta-analysis are described.

Abstract：

OBJECTIVE:To systematically review methodological articles which focus on nonpublication of studies and to describe methods of detecting and/or quantifying and/or adjusting for dissemination in meta-analyses. To evaluate whether the methods have been applied to an empirical data set for which one can be reasonably confident that all studies conducted have been included. STUDY DESIGN AND SETTING:We systematically searched Medline, the Cochrane Library, and Web of Science, for methodological articles that describe at least one method of detecting and/or quantifying and/or adjusting for dissemination bias in meta-analyses. RESULTS:The literature search retrieved 2,224 records, of which we finally included 150 full-text articles. A great variety of methods to detect, quantify, or adjust for dissemination bias were described. Methods included graphical methods mainly based on funnel plot approaches, statistical methods, such as regression tests, selection models, sensitivity analyses, and a great number of more recent statistical approaches. Only few methods have been validated in empirical evaluations using unpublished studies obtained from regulators (Food and Drug Administration, European Medicines Agency). CONCLUSION:We present an overview of existing methods to detect, quantify, or adjust for dissemination bias. It remains difficult to advise which method should be used as they are all limited and their validity has rarely been assessed. Therefore, a thorough literature search remains crucial in systematic reviews, and further steps to increase the availability of all research results need to be taken.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Mueller KF,Meerpohl JJ,Briel M,Antes G,von Elm E,Lang B,Motschall E,Schwarzer G,Bassler D

doi

10.1016/j.jclinepi.2016.04.015

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

25-33

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(16)30301-8

journal_volume

80

pub_type

杂志文章,评审

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