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Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs and health.

Abstract：

OBJECTIVES:To illustrate how multiple hypotheses testing can produce associations with no clinical plausibility. STUDY DESIGN AND SETTING:We conducted a study of all 10,674,945 residents of Ontario aged between 18 and 100 years in 2000. Residents were randomly assigned to equally sized derivation and validation cohorts and classified according to their astrological sign. Using the derivation cohort, we searched through 223 of the most common diagnoses for hospitalization until we identified two for which subjects born under one astrological sign had a significantly higher probability of hospitalization compared to subjects born under the remaining signs combined (P<0.05). RESULTS:We tested these 24 associations in the independent validation cohort. Residents born under Leo had a higher probability of gastrointestinal hemorrhage (P=0.0447), while Sagittarians had a higher probability of humerus fracture (P=0.0123) compared to all other signs combined. After adjusting the significance level to account for multiple comparisons, none of the identified associations remained significant in either the derivation or validation cohort. CONCLUSIONS:Our analyses illustrate how the testing of multiple, non-prespecified hypotheses increases the likelihood of detecting implausible associations. Our findings have important implications for the analysis and interpretation of clinical studies.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Austin PC,Mamdani MM,Juurlink DN,Hux JE

doi

10.1016/j.jclinepi.2006.01.012

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

964-9

issue

9

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(06)00124-7

journal_volume

59

pub_type

杂志文章

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