A case report of systemic capillary leak syndrome (Clarkson's disease).

Abstract:

:Systemic capillary leak syndrome (SCLS) is a very rare disorder also known as Clarkson's disease. The condition is characterized by recurrent episodes of severe capillary hyperpermeability resulting in severe hemoconcentration, hypoalbuminemia, hypovolemia and shock. We describe a 41-year-old previously healthy man who was admitted to hospital on several occasions with rapidly developing hypovolemic shock accompanied by extreme hemoconcentration and hypoalbuminemia. Our case is similar to other reports describing patients with SCLS where the initial suspicions have been pointing towards septic shock. He received a combination of prophylactic treatment with theophylline, beta-agonists, immunoglobulins and statins but eventually died after a severe episode of SCLS that ended with recurrent cardiac arrest. Clinical autopsy revealed pulmonary edema and acute and chronical organic fluid overload. SCLS should be kept in mind when treating patients suffering from attacks of severe idiopathic edema and mimics recurrent septic shock where no pathogen is found. The pathogenesis is unknown and the attacks may be lethal.

authors

Hollenberg J,Frykman J,Lundberg LG,Forsberg S

doi

10.1111/j.1399-6576.2010.02214.x

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

649-52

issue

5

eissn

0001-5172

issn

1399-6576

pii

AAS2214

journal_volume

54

pub_type

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