Metoclopramide reduces the induction dose of propofol.

Abstract:

BACKGROUND:Metoclopramide has been shown to reduce the dose of thiopentone required for induction of anaesthesia. When propofol is used, there have been conflicting results with one small study showing a reduction in the anaesthetic dose and one study failing to demonstrate any effect. METHODS:Two groups of 30 patients were studied. The patients were randomised to receive either saline 0.03 ml/mg or metoclopramide 0.15 mg/kg 5 min before a manual injection of propofol at a set rate. RESULTS:This study shows a reduction in the dose of propofol required for the induction of general anaesthesia following an intravenous dose of metoclopramide. The induction dose of propofol was reduced by 24%. CONCLUSION:The mechanism of reduction of propofol dose by metoclopramide is unknown; it may involve GABA or result from a more complex interaction involving dopamine blockade by metoclopramide.

authors

Page VJ,Chhipa JH

doi

10.1111/j.1399-6576.1997.tb04676.x

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

256-9

issue

2

eissn

0001-5172

issn

1399-6576

journal_volume

41

pub_type

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