Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain.

abstract：AIM:In Japan, the government and media have become aware of the issues of early onset dementia (EOD), but policies for EOD have not yet been established and support systems are inadequate. To provide practical data about EOD, a two-step postal survey was performed. METHODS:A questionnaire requesting information on EOD...

journal_title：Psychiatry and clinical neurosciences

authors： Ikejima C,Ikeda M,Hashimoto M,Ogawa Y,Tanimukai S,Kashibayashi T,Miyanaga K,Yonemura K,Kakuma T,Murotani K,Asada T

更新日期：2014-03-01 00:00:00

abstract：:Open-system social skills training (SST) was performed in an open psychiatric ward of the hospital of Yokohama City University. Between June 1998 and March 2000, 223 patients were being treated for various mental disorders and 136 of these patients voluntarily participated in the open-system SST at least once. The SST...

journal_title：Psychiatry and clinical neurosciences

authors： Takahashi M,Kosaka K

更新日期：2003-06-01 00:00:00

abstract：:A high disease burden of mental disorders has been noted worldwide, including Japan. It is important to monitor mental disorder prevalence trends and the use of mental health services over time using epidemiological data and to plan appropriate policies and measures that consider mental health in each country. This re...

journal_title：Psychiatry and clinical neurosciences

authors： Nishi D,Ishikawa H,Kawakami N

更新日期：2019-08-01 00:00:00

abstract：AIM:Brain metabolism activated studies have indicated associations between memory and the anterior cingulate cortex and hippocampus in patients with depression. The aim of the present study was therefore to investigate memory function, measured as performance on the Wechsler Memory Scale-Revised (WMS-R), and its relati...

journal_title：Psychiatry and clinical neurosciences

authors： Azuma H,Segawa K,Nakaaki S,Murata Y,Kawakami K,Tohyama J,Iidaka T,Shinagawa Y,Nakano Y,Yamada A,Watanabe N,Hongo J,Akechi T,Furukawa TA

更新日期：2009-10-01 00:00:00

abstract：AIMS:Fluvoxamine, a selective serotonin reuptake inhibitor, is widely used to treat major depression. However, the symptomatological predictors of the response to fluvoxamine have not been studied. METHODS:This study included 100 Japanese patients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders...

journal_title：Psychiatry and clinical neurosciences

authors： Higuchi H,Sato K,Yoshida K,Takahashi H,Kamata M,Otani K,Yamaguchi N

更新日期：2008-06-01 00:00:00

abstract：:Of the epileptic patients who were treated for > or = 5 years until the end of 1990 and had more than four seizures in 1990, 63 patients had been treated without interruption until the end of 1995. We analyzed their clinical courses from 1990 to 1995 prospectively. More than half the subjects were diagnosed with tempo...

journal_title：Psychiatry and clinical neurosciences

authors： Wada K,Kiryu K,Kawata Y,Chiba T,Mizuno K,Okada M,Tasaki H,Fukushima Y,Saito F,Kaneko S

更新日期：1997-08-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of a group structured intervention on the mental and physical discomfort and immune function of 20 family caregivers. A structured intervention for caregivers consists of five sessions, each of which lasts 90 min. This was a modified version of the program th...

journal_title：Psychiatry and clinical neurosciences

authors： Hosaka T,Sugiyama Y

更新日期：2003-04-01 00:00:00

abstract：AIM:Obsessive-compulsive disorder (OCD) impacts family functioning as family members modify their personal and family routines, participate in rituals, and provide reassurance. These behaviors have been identified as family accommodation (FA), a phenomenon that, if ignored, may facilitate OCD symptoms and lead to poore...

journal_title：Psychiatry and clinical neurosciences

authors： Gomes JB,Van Noppen B,Pato M,Braga DT,Meyer E,Bortoncello CF,Cordioli AV

更新日期：2014-08-01 00:00:00

abstract：AIMS:Near-infrared spectroscopy has the potential for aiding the diagnosis of major depressive disorder. The purpose of this study was to systematically review the evidence from observational studies regarding the use of near-infrared spectroscopy in patients with major depressive disorder and to identify the character...

journal_title：Psychiatry and clinical neurosciences

authors： Zhang H,Dong W,Dang W,Quan W,Tian J,Chen R,Zhan S,Yu X

更新日期：2015-01-01 00:00:00

abstract：:The main purpose of the present study was to investigate the diagnostic concepts of taijin-kyofu-sho (TKS) and social phobia, by comparing the clinical diagnosis of TKS and the operational diagnosis of Diagnostic and Statistical Manual of Mental Disorders (3rd edition, revised; DSM-III-R). Three evaluators conducted s...

journal_title：Psychiatry and clinical neurosciences

authors： Nakamura K,Kitanishi K,Miyake Y,Hashimoto K,Kubota M

更新日期：2002-12-01 00:00:00

abstract：:The objective of the present study was to analyze fractal structures of adult heart rate (HR) variability during a nap. Fractal analysis was carried out in one case over consecutive 10-min time series of HR, which were simultaneously recorded with electroencephalogram. Scaling relationships showed cross-over patterns ...

journal_title：Psychiatry and clinical neurosciences

authors： Shono H,Shono M,Takasaki M,Iwasaka T,Sugimori H

更新日期：2001-06-01 00:00:00

abstract：AIM:The aim of our study was to understand the geographic characteristics of Japanese communities and the impact of these characteristics on suicide rates. METHODS:We calculated the standardized mortality ratio from suicide statistics of 3318 municipalities from 1972 to 2002. Correlation analysis, multi-regression ana...

journal_title：Psychiatry and clinical neurosciences

authors： Oka M,Kubota T,Tsubaki H,Yamauchi K

更新日期：2015-06-01 00:00:00

abstract：AIM:To evaluate the severity of depression by measuring alterations in prefrontal cortical activity associated with mood disorders, as assessed on near-infrared spectroscopy. METHODS:Ten of 27 subjects hospitalized for late-life depression from May 2006 to June 2007, were examined. In these 10 subjects changes in hemo...

journal_title：Psychiatry and clinical neurosciences

authors： Onishi Y,Kikuchi S,Watanabe E,Kato S

更新日期：2008-04-01 00:00:00

abstract：AIM:Psychiatric disorders are easily underestimated and under-recognized by physicians. The aim of the present study was to investigate the change in accuracy of recognizing psychiatric symptoms. METHODS:Consecutive 5-year consultation-liaison data were collected and patients with one of the five common psychiatric di...

journal_title：Psychiatry and clinical neurosciences

authors： Su JA,Tsai CS,Hung TH,Chou SY

更新日期：2011-12-01 00:00:00

abstract：AIM:Although peripheral low-grade inflammation and brain-derived neurotrophic factor (BDNF) levels have been implicated in schizophrenia (SCZ), the interactions between them remain to be fully revealed. We aimed to compare BDNF and cytokines in patients with SCZ and healthy controls (HC). Additionally, we aimed to inve...

journal_title：Psychiatry and clinical neurosciences

authors： Zhou Y,Peng W,Wang J,Zhou W,Zhou Y,Ying B

更新日期：2019-03-01 00:00:00

abstract：:Although atypical antipsychotics have been associated with improvements in cognitive function in schizophrenia, the neurochemical basis for such effects is not well understood. Candidate neurotransmitter systems primarily involve dopamine and serotonin. The current study explored this issue by examining the cognitive ...

journal_title：Psychiatry and clinical neurosciences

authors： Tyson PJ,Laws KR,Flowers KA,Tyson A,Mortimer AM

更新日期：2006-08-01 00:00:00

abstract：:Issues related to recovery of quality of life (QoL) in depressive outpatients have been raised. This descriptive correlation study investigated QoL in depressive outpatients in Taiwan. A total of 181 depressive outpatients participated in the study. Their QoL levels were measured using the Taiwanese version of the Sho...

journal_title：Psychiatry and clinical neurosciences

authors： Sung SC,Yeh MY

更新日期：2007-12-01 00:00:00

abstract：:MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta-analysis of genome-wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA-137. To explore additional risk variat...

journal_title：Psychiatry and clinical neurosciences

authors： Egawa J,Nunokawa A,Shibuya M,Watanabe Y,Kaneko N,Igeta H,Someya T

更新日期：2013-05-01 00:00:00

abstract：:The present study was aimed to clarify the differences in clinical implications between wrist- and arm-cutting. Subjects were 201 delinquent adolescents (178 males and 23 females) who had been admitted to a detention center from February to March 2003. A self-reporting questionnaire and the Adolescent Dissociative Exp...

journal_title：Psychiatry and clinical neurosciences

authors： Matsumoto T,Yamaguchi A,Chiba Y,Asami T,Iseki E,Hirayasu Y

更新日期：2004-08-01 00:00:00

abstract：AIMS:The objectives of this article are to discuss ethical issues of informed consent in cognitively impaired patients and review considerations for capacity determination. We will also discuss how to evaluate capacity, determine competence, and obtain informed consent when a patient is deemed incompetent. This review ...

journal_title：Psychiatry and clinical neurosciences

authors： Fields LM,Calvert JD

更新日期：2015-08-01 00:00:00

abstract：:Research on the merits of long-term group residences is inconclusive. The purpose of the present paper was to investigate the effects of supported group residence on the symptoms, social function, quality of life, general health quality, and the medical/psychiatric cost in Japan of a large number of psychiatric beds a...

journal_title：Psychiatry and clinical neurosciences

authors： Chan H,Inoue S,Shimodera S,Fujita H,Fukuzawa K,Kii M,Kamimura N,Kato K,Mino Y

更新日期：2007-10-01 00:00:00

abstract：:To estimate the prevalence, severity, and treatment of Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) mental disorders in community populations in Japan, face-to-face household surveys were conducted in four community populations in Japan. A total of 1663 community adults responded (overall re...

journal_title：Psychiatry and clinical neurosciences

authors： Kawakami N,Takeshima T,Ono Y,Uda H,Hata Y,Nakane Y,Nakane H,Iwata N,Furukawa TA,Kikkawa T

更新日期：2005-08-01 00:00:00

abstract：:In order to investigate mutual interactions between neuronal discharges in the mesencepahlic reticular formation, relative power contributions (RPC) were estimated during sleep-wake cycles and serotonin (5HT)-depleted conditions by the administration of parachlorophenylalanine (PCPA). The RPC for most of the neurons d...

journal_title：Psychiatry and clinical neurosciences

authors： Kodama T,Honda Y,Nakao M,Sato S,Yamamoto M

更新日期：2000-06-01 00:00:00

abstract：:Although a number of studies have examined anosognosia of cognitive deficits in patients with Alzheimer's disease (AD), not much is known about the anosognosia of behavioral symptoms in AD. The aims of the present study were to establish a Japanese version of the Anosognosia Questionnaire-Dementia (AQ-D) and to examin...

journal_title：Psychiatry and clinical neurosciences

authors： Sato J,Nakaaki S,Murata Y,Shinagawa Y,Matsui T,Hongo J,Tatsumi H,Akechi T,Furukawa TA

更新日期：2007-12-01 00:00:00

abstract：:In order to offer health education to the general population, taking into account not only their physical health but also their QOL (quality of life), it is necessary to clarify what guidance should be provided in the sight of QOL. In this study, the relationship between QOL and lifestyle was investigated in 615 Japan...

journal_title：Psychiatry and clinical neurosciences

authors： Matsushita T,Matsushima E

更新日期：2004-12-01 00:00:00

abstract：:The first application of computed tomographic scan to the schizophrenic brain by Johnstone et al. initiated a new neuroscience research era with new perspectives on the neurobiological aspects of major psychoses. The most common paradigm in the flurry of brain imaging studies following the first report was the case-co...

journal_title：Psychiatry and clinical neurosciences

authors： Okazaki Y

更新日期：1998-12-01 00:00:00

abstract：:Schizotypal personality disorder (SPD) has rarely been reported as an eating disorder-related personality trait. A 23-year-old woman was diagnosed as having anorexia nervosa binge eating/purging type. At the age of 53 years, she was admitted to Jikei University Hospital because of excessive bodyweight loss. She was di...

journal_title：Psychiatry and clinical neurosciences

authors： Nagata T,Ono K,Nakayama K

更新日期：2007-08-01 00:00:00

abstract：:Thirty case reports published in Japan that refer to psychiatric symptoms accompanying interferon (IFN) therapy were examined. These papers covered a total of 49 cases. We categorized these 49 cases into 35 cases of mood disorder, 10 of delirium and four of psychotic disorder. The key findings of our study of these ca...

journal_title：Psychiatry and clinical neurosciences

authors： Nozaki O,Takagi C,Takaoka K,Takata T,Yoshida M

更新日期：1997-08-01 00:00:00

abstract：:The purpose of the present study was to investigate the neural substrates underlying event-related potential (ERP) abnormalities, with respect to the generators of the ERP components in depressed patients. Using an oddball paradigm, ERP from auditory stimuli were recorded from 22 unmedicated patients with current depr...

journal_title：Psychiatry and clinical neurosciences

authors： Kawasaki T,Tanaka S,Wang J,Hokama H,Hiramatsu K

更新日期：2004-02-01 00:00:00

abstract：:The aim of this study is to show the clinical significance of the differences in arousal response at a termination of apnea/hypopnea between aged and middle-aged patients with obstructive sleep apnea syndrome (OSAS). We polygraphically assessed electrocardiographic (ECG) and electroencephalographic (EEG) arousal. Elec...

journal_title：Psychiatry and clinical neurosciences

authors： Okada T,Hanyu M,Noda A,Kayukawa Y,Ohta T

更新日期：1998-04-01 00:00:00