Abstract:
AIM:Brain metabolism activated studies have indicated associations between memory and the anterior cingulate cortex and hippocampus in patients with depression. The aim of the present study was therefore to investigate memory function, measured as performance on the Wechsler Memory Scale-Revised (WMS-R), and its relationship to brain perfusion using single-photon emission computed tomography (SPECT) at rest in patients with depression. METHODS:The Hamilton Rating Scale for Depression (HAMD) and WMS-R were measured for 17 patients with depression by an independent clinical evaluation team. Voxel-based correlation analyses were performed with statistical parametric mapping at an extent threshold of 200 voxels. Associations were controlled for state and trait factors. RESULTS:WMS-R measurements of verbal, visual, and general memory were inversely correlated with brain perfusion in the right anterior cingulate cortex, left premotor cortices, and both regions, respectively. The HAMD directly correlated with brain perfusion in the right anterior cingulate cortex. CONCLUSION:Brain perfusion SPECT measurements of the anterior cingulate cortex at rest were associated with the severity of depression and immediate memory scores measured with the WMS-R.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Azuma H,Segawa K,Nakaaki S,Murata Y,Kawakami K,Tohyama J,Iidaka T,Shinagawa Y,Nakano Y,Yamada A,Watanabe N,Hongo J,Akechi T,Furukawa TAdoi
10.1111/j.1440-1819.2009.02013.xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
685-92issue
5eissn
1323-1316issn
1440-1819pii
PCN2013journal_volume
63pub_type
杂志文章abstract::Inpatients with sleep disturbances in a geriatric hospital received 1 h of exposure to approximately 8000 lx bright light per day for 3 weeks. Polysomnogram was recorded for four female patients. Two (aged 68 and 87 years) were non-demented patients with weak cataracts and the other two (aged 92 and 93 years) were dem...
journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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pub_type: 临床试验,杂志文章,随机对照试验
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