Neuronal loss and neurofibrillary degeneration in the hippocampal cortex in late-onset sporadic Alzheimer's disease.

Abstract:

:To explore more fully the relationship between neuronal death and neurofibrillary degeneration, unaffected neurons, intracellular neurofibrillary tangles (i-NFT) and extracellular NFT (e-NFT) in 22 patients with late-onset sporadic Alzheimer's disease (AD) were morphometrically evaluated in eight subdivisions of the hippocampal cortex, using the Gallyas hematoxylin-eosin stain. The subdivisions examined included CA4, CA3, CA2, CA1 (CA: cornu ammonis), prosubiculum (PRO), subiculum and presubiculum (PRE), parasubiculum (PARA) and the entorhinal cortex (ENT). The unaffected neuron density was significantly lower and both i-NFT and e-NFT densities were significantly higher in subdivisions other than CA4 and CA3 in AD patients compared with those in the aged controls. Unaffected neuron density was significantly, inversely correlated with e-NFT density and with total NFT density in all subdivisions except for PRE in AD patients. Especially in CA2, CA1, PRO and ENT, there were strong correlations between the neuron density and these NFT densities. Both unaffected neuron and e-NFT densities in CA1 and ENT were significantly correlated with the disease duration. The i/e-NFT ratio, an index of the degree and/or rate of progress of neuronal death via neurofibrillary degeneration, showed the lowest value in ENT in AD patients. The findings suggest that neuronal death via neurofibrillary degeneration starts earliest and/or most rapidly progresses in ENT. Furthermore, the i/e-NFT ratios in both ENT and CA1 were significantly correlated with the disease duration, suggesting that the neuronal death pattern in the two subdivisions parallels disease progression.

authors

Fukutani Y,Cairns NJ,Shiozawa M,Sasaki K,Sudo S,Isaki K,Lantos PL

doi

10.1046/j.1440-1819.2000.00747.x

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

523-9

issue

5

eissn

1323-1316

issn

1440-1819

journal_volume

54

pub_type

杂志文章
  • A behavior therapy program combined with liquid nutrition designed for anorexia nervosa.

    abstract::We have introduced behavior therapy as standard in-patient treatment for anorexia nervosa and have modified the treatment program. At first, we used Fukamachi's activity restriction therapy (FT), followed by Token economy therapy (TET), which combined token economy with FT. Finally, we have developed Kyoto Prefectural...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1440-1819.2002.01047.x

    authors: Okamoto A,Yamashita T,Nagoshi Y,Masui Y,Wada Y,Kashima A,Arii I,Nakamura M,Fukui K

    更新日期:2002-10-01 00:00:00

  • Behavioral and neuroimaging studies on schizophrenia in Japan.

    abstract::Chronic methamphetamine psychotics became a major problem in Japan after World War II. On one hand, the clinical symptoms of chronic methamphetamine psychotics were noted to resemble those of schizophrenics quite closely but, on the other hand, their respective personality profiles appeared to differ. Recent research ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1819.1995.tb01849.x

    authors: Shimazono Y,Matsushima E

    更新日期:1995-03-01 00:00:00

  • Deficient neural activity subserving decision-making during reward waiting time in intertemporal choice in adult attention-deficit hyperactivity disorder.

    abstract:AIM:Impulsivity, which significantly affects social adaptation, is an important target behavioral characteristic in interventions for attention-deficit hyperactivity disorder (ADHD). Typically, people are willing to wait longer to acquire greater rewards. Impulsivity in ADHD may be associated with brain dysfunction in ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12668

    authors: Todokoro A,Tanaka SC,Kawakubo Y,Yahata N,Ishii-Takahashi A,Nishimura Y,Kano Y,Ohtake F,Kasai K

    更新日期:2018-08-01 00:00:00

  • Right hemispheric dominance and interhemispheric cooperation in gaze-triggered reflexive shift of attention.

    abstract:AIMS:The neural substrate for the processing of gaze remains unknown. The aim of the present study was to clarify which hemisphere dominantly processes and whether bilateral hemispheres cooperate with each other in gaze-triggered reflexive shift of attention. METHODS:Twenty-eight normal subjects were tested. The non-p...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2011.02302.x

    authors: Okada T,Sato W,Kubota Y,Toichi M,Murai T

    更新日期:2012-03-01 00:00:00

  • Surveys on the pregraduate and postgraduate education on child and adolescent psychiatry in Japan.

    abstract::The aim of the study is to clarify the results of Survey-1993 conducted by the committee on the education system in Japanese Society of Child and Adolescent Psychiatry regarding the present situation of education on child and adolescent psychiatry in Japan, and to compare these with the results of Survey-1982 conducte...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1998.tb03245.x

    authors: Hayashi M,Yamazaki K

    更新日期:1998-12-01 00:00:00

  • Psychological characteristics of eating disorders as evidenced by the combined administration of questionnaires and two projective methods: the Tree Drawing Test (Baum Test) and the Sentence Completion Test.

    abstract::The objective of this study is to examine psychological/psychopathological characteristics of eating disorders and their subtypes through a combined administration of questionnaires and projective tests. Three questionnaires (Eating Disorder Inventory - 2, Social Adaptation Scale, Southern California University Eating...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2002.00928.x

    authors: Mizuta I,Inoue Y,Fukunaga T,Ishi R,Ogawa A,Takeda M

    更新日期:2002-02-01 00:00:00

  • Cognitive functions in bipolar affective disorder and schizophrenia: comparison.

    abstract:AIMS:Earlier comparisons of cognitive impairment among patients with bipolar disorder and schizophrenia have found a largely similar profile of deficits, but results have varied between studies. This prompted the current attempt at another such comparison. METHODS:Executive functions, memory, IQ, attention-concentrati...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2008.01844.x

    authors: Pradhan BK,Chakrabarti S,Nehra R,Mankotia A

    更新日期:2008-10-01 00:00:00

  • Latent cerebral artery stenoses on magnetic resonance angiography in a patient diagnosed as probable Alzheimer disease.

    abstract::A 65-year-old woman with hypertension developed slowly progressive memory disturbance and disorientation. She was diagnosed as having Alzheimer-type dementia according to clinical criteria. Later her cognitive deterioration was noted to fluctuate in parallel to her blood pressure. Magnetic resonance angiography and si...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1998.tb00979.x

    authors: Ishibashi K,Tanaka K,Nakabayashi T,Nakamura M,Uchiyama M,Okawa M

    更新日期:1998-02-01 00:00:00

  • Quality of life and lifestyle among city dwellers participating in the medical programs.

    abstract::In order to offer health education to the general population, taking into account not only their physical health but also their QOL (quality of life), it is necessary to clarify what guidance should be provided in the sight of QOL. In this study, the relationship between QOL and lifestyle was investigated in 615 Japan...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2004.01315.x

    authors: Matsushita T,Matsushima E

    更新日期:2004-12-01 00:00:00

  • A case of insufficient sleep syndrome.

    abstract::All night polysomnographic evaluation (PSG) soon after admission and at the late period of admission revealed an atypically high sleep efficiency and a prolonged total sleep time. Sleep onset latency and distribution of REM and NREM sleep stages were like those of normal sleepers. On REM latency, while it was remarkab...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1998.tb01029.x

    authors: Yoshikawa N,Suzuki S,Ishimoto T,Matsumoto M,Miyagishi T

    更新日期:1998-04-01 00:00:00

  • Pulmonary hypertension in patients with severe obstructive sleep apnea.

    abstract::Thirty-seven patients (35 men and two women) with obstructive sleep apnea-hypopnea syndrome (OSAHS) without any known cardiovascular and lung diseases were examined by Doppler echocardiography. Eight of the 37 (21.6%) patients experienced daytime pulmonary hypertension (PH), and all of them had severe OSAHS with an ap...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1046/j.1440-1819.2002.00957.x

    authors: Yamakawa H,Shiomi T,Sasanabe R,Hasegawa R,Ootake K,Banno K,Wakayama H,Katada M,Kobayashi T

    更新日期:2002-06-01 00:00:00

  • Impact of behavioral/developmental disorders comorbid with conduct disorder.

    abstract:AIMS:The aim of the present study was to verify the comorbidity of conduct disorder (CD) and behavioral/developmental disorders in children and adolescents, and to examine the traits of CD comorbid with them. METHODS:Subjects were 64 children (60 boys, four girls) who were resident at three institutions for delinquent...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2009.02029.x

    authors: Harada Y,Hayashida A,Hikita S,Imai J,Sasayama D,Masutani S,Tomita T,Saitoh K,Washizuka S,Amano N

    更新日期:2009-12-01 00:00:00

  • Polysomnography in patients with post-traumatic stress disorder.

    abstract:AIMS:The purpose of the present study was to investigate sleep structure in post-traumatic stress disorder (PTSD) patients with and without any psychiatric comorbidities. The relationship between sleep variables and measurements of clinical symptom severity were also investigated. METHODS:Sleep patterns of 24 non-medi...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2010.02084.x

    authors: Yetkin S,Aydin H,Ozgen F

    更新日期:2010-06-01 00:00:00

  • Clinical evaluation of percutaneous endoscopic gastrostomy tube feeding in Japanese patients with dementia.

    abstract:AIM:The aim of this study was to clinically evaluate percutaneous endoscopic gastrostomy (PEG) tube feeding of elderly Japanese patients with dementia. METHOD:The records of the 155 patients with dementia who underwent PEG in Juntendo Tokyo Koto Geriatric Medical Center were reviewed for pertinent clinical data, inclu...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2012.02378.x

    authors: Kumagai R,Kubokura M,Sano A,Shinomiya M,Ohta S,Ishibiki Y,Narumi K,Aiba M,Ichimiya Y

    更新日期:2012-08-01 00:00:00

  • HIV infection and depression.

    abstract::Major depression is highly prevalent among HIV-positive patients (HIVpp). The prevalence of depression ranges between 18% and 81%, depending on the population studied and the methodology of the study. The etiology of depression in HIVpp is likely determined by: (i) biological factors (alterations in the white matter s...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章,评审

    doi:10.1111/pcn.12097

    authors: Arseniou S,Arvaniti A,Samakouri M

    更新日期:2014-02-01 00:00:00

  • Pharmacokinetics and efficacy of a direct switch from conventional depot to risperidone long-acting injection in Chinese patients with schizophrenic and schizoaffective disorders.

    abstract:AIMS:This 12-week open-label study was designed to investigate the pharmacokinetics and efficacy of a direct switch from a conventional depot to long-acting injectable risperidone in patients with schizophrenia and schizoaffective disorder. METHODS:Men or women from 18 to 65 years old with a diagnosis of schizophrenia...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2009.01977.x

    authors: Lai YC,Huang MC,Chen CH,Tsai CJ,Pan CH,Chiu CC

    更新日期:2009-08-01 00:00:00

  • One-year follow up of PTSD and depression in elderly aboriginal people in Taiwan after Typhoon Morakot.

    abstract:AIM:This paper describes a 1-year follow-up of post-traumatic stress disorder (PTSD) symptomatology and depression in an elderly minority population who experienced Typhoon Morakot in Taiwan. METHODS:The PTSD Symptom Scale--Interview and the 10-item short form Center for Epidemiological Studies Depression Scale were u...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12227

    authors: Chen YL,Hsu WY,Lai CS,Tang TC,Wang PW,Yeh YC,Huang MF,Yen CF,Chen CS

    更新日期:2015-01-01 00:00:00

  • Effects of entorhinal cortex lesion on learning behavior and on hippocampus in the rat.

    abstract::The initial stage of Alzheimer's disease is characterized by a neuropathological change in the entorhinal cortex. In a previous study it was shown that rats with excitotoxic lesion of entorhinal cortex showed an impaired acquisition of passive and active avoidance responses. In this study a rat with excitotoxic lesion...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1996.tb02746.x

    authors: Miwa C,Ueki A

    更新日期:1996-08-01 00:00:00

  • Patient and family factors associated with family accommodation in obsessive-compulsive disorder.

    abstract:AIM:Obsessive-compulsive disorder (OCD) impacts family functioning as family members modify their personal and family routines, participate in rituals, and provide reassurance. These behaviors have been identified as family accommodation (FA), a phenomenon that, if ignored, may facilitate OCD symptoms and lead to poore...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12172

    authors: Gomes JB,Van Noppen B,Pato M,Braga DT,Meyer E,Bortoncello CF,Cordioli AV

    更新日期:2014-08-01 00:00:00

  • Unipolar depression with racing thoughts: a bipolar spectrum disorder?

    abstract::Major depressive disorder (MDD) with racing/crowded thoughts is understudied. Kraepelin classified 'depression with flight of ideas' in the mixed states of his manic-depressive insanity. The aim of the study was to test whether MDD with racing/crowded thoughts was close to bipolar disorders. Consecutive 379 bipolar-II...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2005.01416.x

    authors: Benazzi F

    更新日期:2005-10-01 00:00:00

  • Psychiatric manifestations accompanying interferon therapy for patients with chronic hepatitis C: an overview of cases in Japan.

    abstract::Thirty case reports published in Japan that refer to psychiatric symptoms accompanying interferon (IFN) therapy were examined. These papers covered a total of 49 cases. We categorized these 49 cases into 35 cases of mood disorder, 10 of delirium and four of psychotic disorder. The key findings of our study of these ca...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1997.tb02579.x

    authors: Nozaki O,Takagi C,Takaoka K,Takata T,Yoshida M

    更新日期:1997-08-01 00:00:00

  • DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies.

    abstract:AIM:It is difficult to diagnose dementia with Lewy bodies (DLB) because it exhibits clinical and neuropathological overlap with both Alzheimer's disease and Parkinson's disease. The α-synuclein protein is a major component of Lewy bodies, and accumulation of α-synuclein aggregates causes synaptic dysfunction in DLB. Ep...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/pcn.12462

    authors: Funahashi Y,Yoshino Y,Yamazaki K,Mori Y,Mori T,Ozaki Y,Sao T,Ochi S,Iga JI,Ueno SI

    更新日期:2017-01-01 00:00:00

  • The hypnotic effects of melatonin treatment on diurnal sleep in humans.

    abstract::This study investigated the hypnotic effects of 10 mg melatonin and placebo, which were administered at 10.00 h, according to a single-blind crossover design, on an 8-h diurnal sleep from 11.00 to 19.00 h, following a full night of sleep. The subjects were six healthy male students, each of whom underwent polysomnogra...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1440-1819.1999.00480.x

    authors: Matsumoto M

    更新日期:1999-04-01 00:00:00

  • Lorazepam and diazepam rapidly relieve catatonic signs in patients with schizophrenia.

    abstract::The uses of lorazepam and electroconvulsive therapy (ECT) have been proven to be effective in treating catatonia. In the present study a modified treatment strategy (i.e. lorazepam i.m. injection or diazepam infused i.v. if lorazepam failed, not with ECT) was proposed to rapidly relieve catatonic signs in patients wit...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2005.01331.x

    authors: Huang TL

    更新日期:2005-02-01 00:00:00

  • Immunohistochemical examination of phosphorylated tau in granulovacuolar degeneration granules.

    abstract::Granulovacuolar degeneration (GVD) and neurofibrillary tangles (NFT) are neuropathological features in Alzheimer's disease (AD). The molecular mechanism of GVD formation remains unknown. Recent immunohistochemical investigations suggested a potential link of NFT to GVD formation. Enzyme histochemical studies and elect...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1996.tb01678.x

    authors: Ikegami K,Kimura T,Katsuragi S,Ono T,Yamamoto H,Miyamoto E,Miyakawa T

    更新日期:1996-06-01 00:00:00

  • How do general practitioners in Thailand diagnose and treat patients presenting with anxiety and depression?

    abstract:AIMS:To examine general practitioners' (GPs') diagnosis of a case vignette presenting both anxiety and depression symptoms, and to understand their treatment preferences for the case. METHODS:A total of 1193 copies of a questionnaire were sent to doctors in primary care settings throughout Thailand. The questionnaire ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2008.01903.x

    authors: Lotrakul M,Saipanish R

    更新日期:2009-02-01 00:00:00

  • Serotonin syndrome during clomipramine monotherapy: comparison of two diagnostic criteria.

    abstract::Incidence of serotonin syndrome was determined by two different diagnostic criteria during clomipramine monotherapy. Incidence, determined by Sternbach's criteria, was 12.1% (8/66 patients), and that determined by the criteria of Dursun et al. was 3.0% (2/66 patients). The two patients who met the latter criteria also...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1819.1997.tb02365.x

    authors: Kudo K,Sasaki I,Tsuchiyama K,Akiyoshi J,Nagayama H,Fujii I

    更新日期:1997-02-01 00:00:00

  • Two cases of burning mouth syndrome treated with olanzapine.

    abstract::Two case reports of patients suffering from burning mouth syndrome (BMS), a type of somatoform disorder, who were treated with olanzapine are discussed. One case was a 54-year-old female with BMS who failed to respond to milnacipran treatment. Olanzapine (2.5 mg/day) brought about dramatic improvement in the patient's...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2008.01806.x

    authors: Ueda N,Kodama Y,Hori H,Umene W,Sugita A,Nakano H,Yoshimura R,Nakamura J

    更新日期:2008-06-01 00:00:00

  • Suicidal ideation and associated factors among community-dwelling elders in Taiwan.

    abstract::The purpose of the present study was to explore the suicidal ideation of community-dwelling elderly and the factors associated with their intention to commit suicide. Using a multilevel stratified sampling strategy, 1000 elderly subjects were recruited (aged 65-74 years old) in Taiwan during the year 2001. The degree ...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.2005.01387.x

    authors: Yen YC,Yang MJ,Yang MS,Lung FW,Shih CH,Hahn CY,Lo HY

    更新日期:2005-08-01 00:00:00

  • A negative component on event related potential recorded in the drowsy state.

    abstract::Behavior of event related potential (ERP) components in the drowsy state was examined in nine subjects using oddball paradigm. A component with peak latency of 300 msec, N300, was superimposed on ERP in the drowsy state. N300 appeared also in stage 1 of NREM sleep and closely resembled vertex sharp wave evoked by soun...

    journal_title:Psychiatry and clinical neurosciences

    pub_type: 杂志文章

    doi:10.1111/j.1440-1819.1998.tb00999.x

    authors: Sekine A,Niiyama Y,Fujiwara R,Satoh N,Fushimi M,Kutsuzawa O,Hishikawa Y

    更新日期:1998-04-01 00:00:00