Abstract:
:The first application of computed tomographic scan to the schizophrenic brain by Johnstone et al. initiated a new neuroscience research era with new perspectives on the neurobiological aspects of major psychoses. The most common paradigm in the flurry of brain imaging studies following the first report was the case-control study comparing controls and patients with major psychoses. However, some application was also made of sophisticated case-control paradigms, such as comparisons between affected and non-affected identical twins discordant for schizophrenia. Very few prospective cohort studies have been applied in this field. During the past two decades of studies, several brain morphological features have converged. Both schizophrenics and patients with affective disorders showed subtle but significant quantitative differences in brain structures compared with controls. For schizophrenia, the differences were in the lateral and third ventricles, medial temporal lobe, supratemporal gyrus, frontal lobe and such subcortical nuclei as striatum and thalamus. For affective disorders, they were in the cortical sulci, lateral ventricle, striatum, pituitary and adrenal glands. Generally, the differences were greater in schizophrenics, in males and on the left side than in patients with affective disorders, in females and on the right side. Qualitative morphological abnormalities such as T2-weighted hyperintensity were also demonstrated in elderly patients with affective disorders. For both schizophrenia and affective disorders, abnormal anatomical neurocircuit models of the respective pathophysiologies have been proposed to explain the brain multi-lesions. Some recommendations for future research in the structural brain imaging of major psychoses have also been proposed.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Okazaki Ydoi
10.1111/j.1440-1819.1998.tb03225.xsubject
Has Abstractpub_date
1998-12-01 00:00:00pages
S215-8eissn
1323-1316issn
1440-1819journal_volume
52 Supplpub_type
杂志文章,评审abstract::We present the case of a 71-year-old woman with an 11-year history of slowly progressive decline of motor speech. Normal clinical investigations including routine magnetic resonance imaging (MRI) at 7, 8 and 10 years after the onset of speech dysfunction led to the suggestion of a psychogenic disorder. Extensive clini...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2002.00938.x
更新日期:2002-02-01 00:00:00
abstract:AIMS:The aim of the present study was to examine how copy organization mediated immediate recall among patients with schizophrenia using the Rey-Osterrieth Complex Figure Test (ROCF). METHODS:The Boston Qualitative Scoring System (BQSS) was applied for qualitative and quantitative analyses of ROCF performances. Subjec...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2008.01821.x
更新日期:2008-08-01 00:00:00
abstract:AIM:The orexigenic hormone, ghrelin, is linked to learning and memory in animal studies. No previous study has investigated whether cognition is related to ghrelin in the non-demented elderly. METHODS:Thirty-five older adults underwent neuropsychological testing and fasting blood draw with subsequent serum ghrelin qua...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2010.02145.x
更新日期:2010-12-01 00:00:00
abstract::Behavior of event related potential (ERP) components in the drowsy state was examined in nine subjects using oddball paradigm. A component with peak latency of 300 msec, N300, was superimposed on ERP in the drowsy state. N300 appeared also in stage 1 of NREM sleep and closely resembled vertex sharp wave evoked by soun...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1998.tb00999.x
更新日期:1998-04-01 00:00:00
abstract::We had investigated the clinical characteristics of panic disorder (PD) in a Japanese outpatient population comprised of more than 250 patients diagnosed as having PD during a 13-year study period and observed that some PD patients had both panic attacks (PA) and limited symptom panic attacks (LPA). In the criteria fo...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1997.tb02906.x
更新日期:1997-04-01 00:00:00
abstract::We investigated the mechanism of abnormal P300 findings in the patients with severe sleep apnea syndrome (SAS). Compared with controls, SAS patients showed significantly longer latency of P300. Not the mean sleep latency in multiple sleep latency test but the percentage of total periods in which percentage desaturatio...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00844.x
更新日期:2001-06-01 00:00:00
abstract::Sporadic temporal slow waves are considered to be associated with mild cerebrovascular dysfunction. However, electroencephalogram (EEG) changes have not been consistently described by some investigators and correlations inferred on the basis of such data remain inconclusive. In the present study, we examined previousl...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00900.x
更新日期:2001-10-01 00:00:00
abstract::Rapid eye movement sleep behavior disorder (RBD) is a parasomnia with clinical symptoms that include punching, kicking, yelling and leaping out of bed in sleep. Polysomnographic (PSG) finding showed REM sleep without muscle atonia. Clonazepam is generally used for treating RBD symptoms but melatonin was reported to be...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00854.x
更新日期:2001-06-01 00:00:00
abstract:AIM:Obsessive-compulsive disorder (OCD) impacts family functioning as family members modify their personal and family routines, participate in rituals, and provide reassurance. These behaviors have been identified as family accommodation (FA), a phenomenon that, if ignored, may facilitate OCD symptoms and lead to poore...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12172
更新日期:2014-08-01 00:00:00
abstract::The aim of this study was to investigate the relationship between panic attacks and hostility in patients with chronic schizophrenia. Thirty-two patients with a minimum 2-year history of treatment for schizophrenia were interviewed. The patients took mood stablizers lithium, carbamazepine and valproate adjunctively fo...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00879.x
更新日期:2001-08-01 00:00:00
abstract:AIM:Although peripheral low-grade inflammation and brain-derived neurotrophic factor (BDNF) levels have been implicated in schizophrenia (SCZ), the interactions between them remain to be fully revealed. We aimed to compare BDNF and cytokines in patients with SCZ and healthy controls (HC). Additionally, we aimed to inve...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12794
更新日期:2019-03-01 00:00:00
abstract::The initial stage of Alzheimer's disease is characterized by a neuropathological change in the entorhinal cortex. In a previous study it was shown that rats with excitotoxic lesion of entorhinal cortex showed an impaired acquisition of passive and active avoidance responses. In this study a rat with excitotoxic lesion...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1996.tb02746.x
更新日期:1996-08-01 00:00:00
abstract::In the catchment area of Matsumoto Public Health Center in Japan, 44 schizophrenic patients admitted between April 1992 and March 1997 under the national policy Involuntary Hospitalization Ordered by Prefectural Governor (IHOPG) were compared with 61 schizophrenic patients admitted under another policy, Hospitalizatio...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2004.01185.x
更新日期:2004-02-01 00:00:00
abstract::A medium-sized portable digital recorder with fully integrated circuit (IC) memories for sleep monitoring has been developed. It has five amplifiers for EEG, EMG, EOG, ECG, and a signal of body acceleration or respiration sound, four event markers, an 8 ch A/D converter, a digital signal processor (DSP), 192 Mbytes IC...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.1999.00526.x
更新日期:1999-04-01 00:00:00
abstract::To estimate the prevalence, severity, and treatment of Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) mental disorders in community populations in Japan, face-to-face household surveys were conducted in four community populations in Japan. A total of 1663 community adults responded (overall re...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2005.01397.x
更新日期:2005-08-01 00:00:00
abstract::An extensive survey of problems encountered by foreign students of the University of the Ryukyus and the resulting levels of stress was carried out in order to determine the main stressors hindering academic progress and personal adjustment. Subjectively perceived stress levels after arrival in Japan were obtained fro...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.1998.00396.x
更新日期:1998-06-01 00:00:00
abstract::The aim of this study was to test different definitions of depressive mixed state (DMX) (major depressive episode (MDE) with some concurrent hypomanic symptoms), to find which one could better define DMX. Unipolar and bipolar II MDE outpatients (n = 168) were interviewed with the DSM-IV Structured Clinical Interview. ...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00919.x
更新日期:2001-12-01 00:00:00
abstract::Inpatients with sleep disturbances in a geriatric hospital received 1 h of exposure to approximately 8000 lx bright light per day for 3 weeks. Polysomnogram was recorded for four female patients. Two (aged 68 and 87 years) were non-demented patients with weak cataracts and the other two (aged 92 and 93 years) were dem...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00864.x
更新日期:2001-06-01 00:00:00
abstract::Research on the merits of long-term group residences is inconclusive. The purpose of the present paper was to investigate the effects of supported group residence on the symptoms, social function, quality of life, general health quality, and the medical/psychiatric cost in Japan of a large number of psychiatric beds a...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1440-1819.2007.01701.x
更新日期:2007-10-01 00:00:00
abstract::Among 448 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), 40 patients (8.9%) had been involved in one or more automobile accidents during the preceding 5 years. The main cause of these accidents was falling asleep while driving. Excessive sleepiness during driving was associated with an Epworth sleepi...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2002.01004.x
更新日期:2002-06-01 00:00:00
abstract::The objective of the present study was to analyze fractal structures of adult heart rate (HR) variability during a nap. Fractal analysis was carried out in one case over consecutive 10-min time series of HR, which were simultaneously recorded with electroencephalogram. Scaling relationships showed cross-over patterns ...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00814.x
更新日期:2001-06-01 00:00:00
abstract::The present article demonstrates the clinical application and the efficacy of relaxation techniques in general hospital psychiatry in Japan. During April to December 1993, 20 patients were treated with progressive muscle relaxation and "modified' autogenic training therapies. The targeted symptoms were anxiety attacks...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1995.tb01898.x
更新日期:1995-12-01 00:00:00
abstract::The main World Health Organization (WHO) activities of the Tokyo Center are as follows: (1) It performed the research project entitled 'A Bio-Psycho-Social Study on Children with Emotional and Behavioral Problems' in cooperation with the Beijing and Seoul Centers from 1985 to 1987. These results suggested that the dev...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1998.tb03265.x
更新日期:1998-12-01 00:00:00
abstract::While post-traumatic stress disorder (PTSD) is currently diagnosed based solely on classic psychological and behavioral symptoms, a growing body of evidence has highlighted a link between this disorder and alterations in the immune and inflammatory systems. Epidemiological studies have demonstrated that PTSD is associ...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,评审
doi:10.1111/pcn.12820
更新日期:2019-04-01 00:00:00
abstract:AIMS:The neural substrate for the processing of gaze remains unknown. The aim of the present study was to clarify which hemisphere dominantly processes and whether bilateral hemispheres cooperate with each other in gaze-triggered reflexive shift of attention. METHODS:Twenty-eight normal subjects were tested. The non-p...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2011.02302.x
更新日期:2012-03-01 00:00:00
abstract::We made an attempt to express a complaint of sleep disturbance by a self-rating scale of radar chart mode. The questionnaire for sleep disturbance is made up of eight items. Each item was scored from grade 1 to 4. The score of each item was projected to the MY radar chart, designed by us. It is noted that this method ...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1998.tb01009.x
更新日期:1998-04-01 00:00:00
abstract:AIMS:This paper examines the relationship between observational behavior and the observers' result assumptions, using a contained diagram that includes significant non-verbal information, such as gestures. The ability of care workers to assess a patient's mental status on the basis of non-verbal information would be co...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2010.02077.x
更新日期:2010-06-01 00:00:00
abstract::The aim of the present study was to provide basic descriptive data regarding utilization of 12-month mental health services in the Japanese community population. Face-to-face household surveys were carried out in four areas (two urban cities and two rural municipalities), and a total of 1663 persons participated (over...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2006.01492.x
更新日期:2006-04-01 00:00:00
abstract::Attentional processes play a central role in information selection, which is impaired in schizophrenic patients. In the present study, we attempted to characterize the attentional performance of chronic schizophrenics using a computerized assessment of the multiple components of attentional function. Two comparable sa...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2002.01031.x
更新日期:2002-08-01 00:00:00
abstract:AIM:Rare variations are suggested to play a role in the genetic etiology of schizophrenia; to further investigate their role, we performed a three-stage study in a Japanese population. METHODS:In the first stage, we performed whole-exome sequencing (WES) of two parent-affected offspring trios. In the second stage, we ...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12526
更新日期:2017-08-01 00:00:00